Open Access

Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction

  • Authors:
    • Guangteng Wu
    • Ying Long
    • Yan Lu
    • Yiming Feng
    • Xinmei Yang
    • Xun Xu
    • Desheng Yao
  • View Affiliations

  • Published online on: May 4, 2020     https://doi.org/10.3892/or.2020.7603
  • Pages: 69-76
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Kindlin‑2 plays a carcinogenic or tumor‑suppressor role in various tumors. However, its role in cervical cancer remains unclear. In the present study, kindlin‑2 expression was first analyzed using public expression data and clinical specimens. It was revealed that kindlin‑2 was downregulated in cervical cancer tissues, and low expression of kindlin‑2 was associated with poor disease‑free survival. In addition, kindlin‑2 was overexpressed and knocked down in two cell lines to study its effect in cervical cancer cells. The results revealed that kindlin‑2 promoted cell autophagy and inactivated AKT/mTOR signaling. Rescue experiments indicated that the regulation of autophagy by kindlin‑2 was dependent on the AKT/mTOR signaling pathway. Furthermore, it was revealed that kindlin‑2 inhibited cell migration, and autophagy was required for this process. Collectively, these findings revealed the role and mechanism of kindlin‑2 in the autophagy and migration of cervical cancer cells.

Related Articles

Journal Cover

July 2020
Volume 44 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Wu, G., Long, Y., Lu, Y., Feng, Y., Yang, X., Xu, X., & Yao, D. (2020). Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction. Oncology Reports, 44, 69-76. https://doi.org/10.3892/or.2020.7603
MLA
Wu, G., Long, Y., Lu, Y., Feng, Y., Yang, X., Xu, X., Yao, D."Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction". Oncology Reports 44.1 (2020): 69-76.
Chicago
Wu, G., Long, Y., Lu, Y., Feng, Y., Yang, X., Xu, X., Yao, D."Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction". Oncology Reports 44, no. 1 (2020): 69-76. https://doi.org/10.3892/or.2020.7603