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Article

Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma

  • Authors:
    • Marlene Vierthaler
    • Priscila Campioni Rodrigues
    • Elias Sundquist
    • Maria Siponen
    • Tuula Salo
    • Maija Risteli
  • View Affiliations / Copyright

    Affiliations: Cancer Research and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, FI‑90014 Oulu, Finland, Institute of Dentistry, University of Eastern Finland, FI‑70211 Kuopio, Finland
  • Pages: 325-338
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    Published online on: May 11, 2020
       https://doi.org/10.3892/or.2020.7609
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Abstract

Oral tongue squamous cell carcinoma (OTSCC), the most common cancer in the oral cavity, is aggressive and its incidence is increasing globally. Human host defense cationic antimicrobial peptide‑18/antimicrobial peptide leucine‑leucine‑37 (hCAP18/LL‑37) plays a complex role in various types of cancers. In the present study, we characterized the effects of exogenous LL‑37 on three OTSCC cell lines and determined the expression of hCAP18/LL‑37 in oral dysplastic and OTSCC patient samples. Our data revealed that LL‑37, especially in high doses, mostly reduced the proliferation of OTSCC cells, but the effect was fluctuating. However, LL‑37 stimulated the migration and invasion of OTSCC cells. The high dose of LL‑37 also increased the amount of total epidermal growth factor receptor (EGFR) probably due to stabilization of the receptor to the plasma membrane. However, activation of EGFR downstream pathways was mostly decreased. Our immunohistochemical analysis showed that the hCAP18/LL‑37 expression was higher in normal/mild dysplasia than in moderate/severe dysplasia and OTSCC. The hCAP18/LL‑37 expression did not correlate with clinicopathological features or outcome of OTSCC patients. Our data suggest that LL‑37 has a fluctuating effect on proliferation, migration and invasion of OTSCC cells, but it does not seem to play a role in the progression of OTSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Vierthaler M, Rodrigues PC, Sundquist E, Siponen M, Salo T and Risteli M: Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma. Oncol Rep 44: 325-338, 2020.
APA
Vierthaler, M., Rodrigues, P.C., Sundquist, E., Siponen, M., Salo, T., & Risteli, M. (2020). Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma. Oncology Reports, 44, 325-338. https://doi.org/10.3892/or.2020.7609
MLA
Vierthaler, M., Rodrigues, P. C., Sundquist, E., Siponen, M., Salo, T., Risteli, M."Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma". Oncology Reports 44.1 (2020): 325-338.
Chicago
Vierthaler, M., Rodrigues, P. C., Sundquist, E., Siponen, M., Salo, T., Risteli, M."Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma". Oncology Reports 44, no. 1 (2020): 325-338. https://doi.org/10.3892/or.2020.7609
Copy and paste a formatted citation
x
Spandidos Publications style
Vierthaler M, Rodrigues PC, Sundquist E, Siponen M, Salo T and Risteli M: Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma. Oncol Rep 44: 325-338, 2020.
APA
Vierthaler, M., Rodrigues, P.C., Sundquist, E., Siponen, M., Salo, T., & Risteli, M. (2020). Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma. Oncology Reports, 44, 325-338. https://doi.org/10.3892/or.2020.7609
MLA
Vierthaler, M., Rodrigues, P. C., Sundquist, E., Siponen, M., Salo, T., Risteli, M."Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma". Oncology Reports 44.1 (2020): 325-338.
Chicago
Vierthaler, M., Rodrigues, P. C., Sundquist, E., Siponen, M., Salo, T., Risteli, M."Fluctuating role of antimicrobial peptide hCAP18/LL‑37 in oral tongue dysplasia and carcinoma". Oncology Reports 44, no. 1 (2020): 325-338. https://doi.org/10.3892/or.2020.7609
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