Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August-2020 Volume 44 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 44 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma

  • Authors:
    • Dan Guo
    • Fangyuan Li
    • Xiaoxiao Zhao
    • Bo Long
    • Sumei Zhang
    • Anqi Wang
    • Dingyan Cao
    • Jian Sun
    • Binglu Li
  • View Affiliations / Copyright

    Affiliations: Medical Science Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 519-532
    |
    Published online on: May 27, 2020
       https://doi.org/10.3892/or.2020.7626
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Circular RNAs (circRNAs) are a novel class of RNAs, with higher stability and tissue specificity, which may be of value as novel clinical markers. High‑throughput RNA sequencing was used to profile the expression of circRNAs in 5 pairs of cancer and normal tissues, and reverse transcription‑quantitative PCR (RT‑qPCR) analysis was employed to verify the results of the RNA sequencing in 45 cases of PTC. The dysregulated circRNA expression and clinicopathological characteristics were assessed and the potential roles of circRNAs in the cellular miRNA and mRNA network were predicted using bioinformatics analysis. The results demonstrated that, compared with normal tissues, a total of 53 circRNAs were dysregulated in tumour tissues, and 8 circRNAs were validated at the mRNA level (P<0.001 and P<0.01). Among those, the expression of chr5:161330882‑161336769‑ (P=0.015), chr9:22046750‑22097364+ (P=0.041) and chr8:18765448‑18804898‑ (P=0.036) were obviously associated with the BRAFV600E mutation, chr12:129699809‑129700698‑ was associated with capsular invasion (P=0.025) and chr5:38523418‑38530666‑ was associated with pT stage (P=0.037) and lymph node metastasis (P=0.002). Therefore, some dysregulated circRNAs were found to be associated with BRAFV600E mutation, capsular invasion, advanced pT stage and lymph node metastasis of PTC, indicating that circRNAs may be involved in tumourigenesis and cancer progression, and they may be putative biomarkers for the diagnosis and evaluation of progression of PTC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Lam AK, Lo CY and Lam KS: Papillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants. Endocr Pathol. 16:323–330. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B and Hashim OH: Papillary thyroid cancer: Genetic alterations and molecular biomarker investigations. Int J Med Sci. 16:450–460. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Ng SC, Kuo SF, Hua CC, Huang BY, Chiang KC, Chu YY, Hsueh C and Lin JD: Differentiation of the follicular variant of papillary thyroid carcinoma from classic papillary thyroid carcinoma: An ultrasound analysis and complement to fine-needle aspiration cytology. J Ultrasound Med. 37:667–674. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Lin JD: Thyroglobulin and human thyroid cancer. Clin Chim Acta. 388:15–21. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Tuttle RM, Leboeuf R and Martorella AJ: Papillary thyroid cancer: Monitoring and therapy. Endocrinol Metabol Clin North Amer. 36:753–778. 2007. View Article : Google Scholar

6 

Hurtado-Lopez LM, Fernandez-Ramirez F, Martinez-Penafiel E, Carrillo Ruiz JD and Herrera Gonzalez NE: Molecular analysis by gene expression of mitochondrial ATPase subunits in papillary thyroid cancer: Is ATP5E transcript a possible early tumor marker? Med Sci Monit. 21:1745–1751. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Tang KT and Lee CH: BRAF mutation in papillary thyroid carcinoma: Pathogenic role and clinical implications. J Chin Med Assoc. 73:113–128. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and Cancer: A new paradigm. Cancer Res. 77:3965–3981. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Qu S, Yang X, Li X, Wang J, Gao Y, Shang R, Sun W, Dou K and Li H: Circular RNA: A new star of noncoding RNAs. Cancer Lett. 365:141–148. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Guo JU, Agarwal V, Guo H and Bartel DP: Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 15:4092014. View Article : Google Scholar : PubMed/NCBI

13 

Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, et al: Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 7:112152016. View Article : Google Scholar : PubMed/NCBI

16 

Bachmayr-Heyda A, Reiner AT, Auer K, Sukhbaatar N, Aust S, Bachleitner-Hofmann T, Mesteri I, Grunt TW, Zeillinger R and Pils D: Correlation of circular RNA abundance with proliferation-exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues. Sci Rep. 5:80572015. View Article : Google Scholar : PubMed/NCBI

17 

Qin M, Liu G, Huo X, Tao X, Sun X, Ge Z, Yang J, Fan J, Liu L and Qin W: Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomarkers. 16:161–169. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ and Liang L: Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget. 7:26680–26691. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Wang X, Zhang Y, Huang L, Zhang J, Pan F, Li B, Yan Y, Jia B, Liu H, Li S and Zheng W: Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances. Int J Clin Exp Pathol. 8:16020–16025. 2015.PubMed/NCBI

20 

Li P, Chen S, Chen H, Mo X, Li T, Shao Y, Xiao B and Guo J: Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Clin Chim Acta. 444:132–136. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Tian M, Chen R, Li T and Xiao B: Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance. J Clin Lab Anal. 32:e222812017. View Article : Google Scholar

22 

Bi W, Huang J, Nie C, Liu B, He G, Han J, Pang R, Ding Z, Xu J and Zhang J: CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. J Exp Clin Cancer Res. 37:2752018. View Article : Google Scholar : PubMed/NCBI

23 

Wei H, Pan L, Tao D and Li R: Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression. Biochem Biophys Res Commun. 503:56–61. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Lan X, Cao J, Xu J, Chen C, Zheng C, Wang J, Zhu X, Zhu X and Ge M: Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma. J Clin Lab Anal. 32:e225732018. View Article : Google Scholar : PubMed/NCBI

25 

Wang M, Chen B, Ru Z and Cong L: CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/β-catenin pathway. Biochem Biophys Res Commun. 504:283–288. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Lan X, Xu J, Chen C, Zheng C, Wang J, Cao J, Zhu X and Ge M: The landscape of circular RNA expression profiles in papillary thyroid carcinoma based on RNA sequencing. Cell Physiol Biochem. 47:1122–1132. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Doescher J, Veit JA and Hoffmann TK: The 8th edition of the AJCC Cancer Staging Manual. Updates in otorhinolaryngology, head and neck surgery. HNO. 65:956–961. 2017.(In German). View Article : Google Scholar : PubMed/NCBI

28 

EI-Naggar AK, Chan JKC, Grandis JR, Takata T and Slootweg PJ: WHO Classification of Head and Neck Tumours. (Lyon). 2017.

29 

Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

30 

D SJ: The positive false discovery rate: A Bayesian interpretation and the q-value. Ann Statistics. 31:2013–2035. 2003. View Article : Google Scholar

31 

Panda AC and Gorospe M: Detection and analysis of circular RNAs by RT-PCR. Bio Protoc. 8(pii): e27752018.PubMed/NCBI

32 

Zhu M, Xu Y, Chen Y and Yan F: Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer. Biomed Pharmacother. 88:138–144. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Sui W, Gan Q, Liu F, Chen H, Liu J and Dai Y: The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma. Tumour Biol. 40:10104283187669282018. View Article : Google Scholar : PubMed/NCBI

34 

Shang X, Li G, Liu H, Li T, Liu J, Zhao Q and Wang C: Comprehensive circular RNA profiling reveals that hsa_circ_0005075, a new circular RNA biomarker, is involved in hepatocellular crcinoma development. Medicine (Baltimore). 95:e38112016. View Article : Google Scholar : PubMed/NCBI

35 

Ren H, Liu Z, Liu S, Zhou X, Wang H, Xu J, Wang D and Yuan G: Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma. PeerJ. 6:e53632018. View Article : Google Scholar : PubMed/NCBI

36 

Ouyang Q, Huang Q, Jiang Z, Zhao J, Shi GP and Yang M: Using plasma circRNA_002453 as a novel biomarker in the diagnosis of lupus nephritis. Mol Immunol. 101:531–538. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Peng Y, Song X, Zheng Y, Cheng H and Lai W: circCOL3A1-859267 regulates type I collagen expression by sponging miR-29c in human dermal fibroblasts. Eur J Dermatol. 28:613–620. 2018.PubMed/NCBI

38 

Hu J, Li C, Liu C, Zhao S, Wang Y and Fu Z: Expressions of miRNAs in papillary thyroid carcinoma and their associations with the clinical characteristics of PTC. Cancer Biomark. 18:87–94. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Hoo ZH, Candlish J and Teare D: What is an ROC curve? Emerg Med J. 34:357–359. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Ebbesen KK, Hansen TB and Kjems J: Insights into circular RNA biology. RNA Biol. 14:1035–1045. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Dong Y, He D, Peng Z, Peng W, Shi W, Wang J, Li B, Zhang C and Duan C: Circular RNAs in cancer: An emerging key player. J Hematol Oncol. 10:22017. View Article : Google Scholar : PubMed/NCBI

42 

Chang TH, Huang HY, Hsu BK, Weng SL, Horng JT and Huang HD: An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs. BMC Bioinformatics. 14 (Suppl 2):S42013. View Article : Google Scholar

43 

Dudekula DB, Panda AC, Grammatikakis I, De S, Abdelmohsen K and Gorospe M: CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs. RNA Biol. 13:34–42. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Li JH, Liu S, Zhou H, Qu LH and Yang JH: starBase v2.0: Decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 42:D92–D97. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Backes C, Kehl T, Stöckel D, Fehlmann T, Schneider L, Meese E, Lenhof HP and Keller A: miRPathDB: A new dictionary on microRNAs and target pathways. Nucleic Acids Res. 45:D90–D96. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Liu R, Liu F, Li L, Sun M and Chen K: MiR-498 regulated FOXO3 expression and inhibited the proliferation of human ovarian cancer cells. Biomed Pharmacother. 72:52–57. 2015. View Article : Google Scholar : PubMed/NCBI

47 

You Y, Que K, Zhou Y, Zhang Z, Zhao X, Gong J and Liu Z: MicroRNA-766-3p inhibits tumour progression by targeting Wnt3a in hepatocellular carcinoma. Mol Cells. 41:830–841. 2018.PubMed/NCBI

48 

Chen C, Xue S, Zhang J, Chen W, Gong D and Zheng J, Ma J, Xue W, Chen Y, Zhai W and Zheng J: DNA-methylation-mediated repression of miR-766-3p promotes cell proliferation via targeting SF2 expression in renal cell carcinoma. Int J Cancer. 141:1867–1878. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Li Z, Liu YH, Diao HY, Ma J and Yao YL: MiR-661 inhibits glioma cell proliferation, migration and invasion by targeting hTERT. Biochem Biophys Res Commun. 468:870–876. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Reddy SD, Pakala SB, Ohshiro K, Rayala SK and Kumar R: MicroRNA-661, a c/EBPalpha target, inhibits metastatic tumor antigen 1 and regulates its functions. Cancer Res. 69:5639–5642. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Peng N, Shi L, Zhang Q, Hu Y, Wang N and Ye H: Microarray profiling of circular RNAs in human papillary thyroid carcinoma. PLoS One. 12:e01702872017. View Article : Google Scholar : PubMed/NCBI

52 

Jin X, Wang Z, Pang W, Zhou J, Liang Y, Yang J, Yang L and Zhang Q: Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1. Med Sci Monit. 24:5488–5500. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Hardee S, Prasad ML, Hui P, Dinauer CA and Morotti RA: Pathologic characteristics, natural history, and prognostic implications of BRAF(V600E) mutation in pediatric papillary thyroid carcinoma. Pediatr Dev Pathol. 20:206–212. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Walts AE, Mirocha JM and Bose S: Follicular variant of papillary thyroid carcinoma (FVPTC): Histological features, BRAF V600E mutation, and lymph node status. J Cancer Res Clin Oncol. 141:1749–1756. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Kim H, Kim BH, Kim YK, Kim JM, Oh SY, Kim EH, Lee MJ, Kim JH, Jeon YK, Kim SS, et al: Prevalence of BRAFV600E mutation in follicular variant of papillary thyroid carcinoma and non-invasive follicular tumor with papillary-like nuclear features (NIFTP) in a BRAFV600E prevalent area. J Korean Med Sci. 33:e752018. View Article : Google Scholar : PubMed/NCBI

56 

Jin Y, Jin W, Zheng Z, Chen E, Wang Q, Wang Y, Wang O and Zhang X: GABRB2 plays an important role in the lymph node metastasis of papillary thyroid cancer. Biochem Biophys Res Commun. 492:323–230. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Beltrami CM, Reis MBD, Barrosfilho MC, Marchi FA, Kuasne H, Pinto CAL, Ambatipudi S, Herceg Z, Kowalski LP and Rogatto SR: Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas. Clin Epigenetics. 9:452017. View Article : Google Scholar : PubMed/NCBI

58 

Furlan JC, Bedard YC and Rosen IB: Significance of tumor capsular invasion in well-differentiated thyroid carcinomas. Am Surg. 73:484–491. 2007.PubMed/NCBI

59 

Bolognamolina R, Gonzálezgonzález R, Mosquedataylor A, Molinafrechero N, Damiánmatsumura P and Dominguezmalagón H: Expression of syndecan-1 in papillary carcinoma of the thyroid with extracapsular invasion. Arch Med Res. 41:33–37. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Meng X, Zhu P, Li N, Hu J, Wang S, Pang S and Wang J: Expression of BMP-4 in papillary thyroid carcinoma and its correlation with tumor invasion and progression. Pathol Res Pract. 213:359–363. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Genpeng L, Jianyong L, Jiaying Y, Ke J, Zhihui L, Rixiang G, Lihan Z and Jingqiang Z: Independent predictors and lymph node metastasis characteristics of multifocal papillary thyroid cancer. Medicine (Baltimore). 97:e96192018. View Article : Google Scholar : PubMed/NCBI

62 

Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S, Specht M, Kohli MA, Kloiber S, Ising M, et al: TMEM132D, a new candidate for anxiety phenotypes: Evidence from human and mouse studies. Mol Psychiatr. 16:647–663. 2011. View Article : Google Scholar

63 

Karapetsas A, Giannakakis A, Dangaj D, Lanitis E, Kynigopoulos S, Lambropoulou M, Tanyi JL, Galanis A, Kakolyris S and Trypsianis G: Overexpression of GPC6 and TMEM132D in early stage ovarian cancer correlates with CD8+ T-lymphocyte infiltration and increased patient survival. Biomed Res Int. 2015:7124382015. View Article : Google Scholar : PubMed/NCBI

64 

Baek HJ, Kim DW and Ryu JH: Association between TNM staging system and histopathological features in patients with papillary thyroid carcinoma. Endocrine. 48:589–594. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC and Ma L: LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 18:1511–1517. 2012. View Article : Google Scholar : PubMed/NCBI

66 

Josson S, Gururajan M, Hu P, Shao C, Chu GY, Zhau HE, Liu C, Lao K, Lu CL, Lu YT, et al: miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer. Clin Cancer Res. 20:4636–4646. 2014. View Article : Google Scholar : PubMed/NCBI

67 

Josson S, Gururajan M, Sung SY, Hu P, Shao C, Zhau HE, Liu C, Lichterman J, Duan P, Li Q, et al: Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis. Oncogene. 34:2690–2699. 2015. View Article : Google Scholar : PubMed/NCBI

68 

Yu CY and Kuo HC: The emerging roles and functions of circular RNAs and their generation. J Biomed Sci. 26:292019. View Article : Google Scholar : PubMed/NCBI

69 

Li X, Yang L and Chen LL: The biogenesis, functions, and challenges of circular RNAs. Mol Cell. 71:428–442. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guo D, Li F, Zhao X, Long B, Zhang S, Wang A, Cao D, Sun J and Li B: Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma. Oncol Rep 44: 519-532, 2020.
APA
Guo, D., Li, F., Zhao, X., Long, B., Zhang, S., Wang, A. ... Li, B. (2020). Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma. Oncology Reports, 44, 519-532. https://doi.org/10.3892/or.2020.7626
MLA
Guo, D., Li, F., Zhao, X., Long, B., Zhang, S., Wang, A., Cao, D., Sun, J., Li, B."Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma". Oncology Reports 44.2 (2020): 519-532.
Chicago
Guo, D., Li, F., Zhao, X., Long, B., Zhang, S., Wang, A., Cao, D., Sun, J., Li, B."Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma". Oncology Reports 44, no. 2 (2020): 519-532. https://doi.org/10.3892/or.2020.7626
Copy and paste a formatted citation
x
Spandidos Publications style
Guo D, Li F, Zhao X, Long B, Zhang S, Wang A, Cao D, Sun J and Li B: Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma. Oncol Rep 44: 519-532, 2020.
APA
Guo, D., Li, F., Zhao, X., Long, B., Zhang, S., Wang, A. ... Li, B. (2020). Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma. Oncology Reports, 44, 519-532. https://doi.org/10.3892/or.2020.7626
MLA
Guo, D., Li, F., Zhao, X., Long, B., Zhang, S., Wang, A., Cao, D., Sun, J., Li, B."Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma". Oncology Reports 44.2 (2020): 519-532.
Chicago
Guo, D., Li, F., Zhao, X., Long, B., Zhang, S., Wang, A., Cao, D., Sun, J., Li, B."Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma". Oncology Reports 44, no. 2 (2020): 519-532. https://doi.org/10.3892/or.2020.7626
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team