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Article

Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study

  • Authors:
    • Dinghong Xiao
    • Xin Tong
    • Xiaoqin Yuan
    • Yunlin Wu
    • Ping Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Jiading Hospital of Traditional Chinese Medicine, Shanghai 201800, P.R. China, Department of Oncology, Jiading Hospital of Traditional Chinese Medicine, Shanghai 201800, P.R. China, Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201801, P.R. China
  • Pages: 1275-1281
    |
    Published online on: June 19, 2020
       https://doi.org/10.3892/or.2020.7651
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Abstract

Certain conflicting conclusions have been drawn that gastric xanthelasma is related to H. pylori, atrophic gastritis, intestinal metaplasia, and early gastric cancer. The aim of this study was to examine the relationship between gastric xanthelasma and upper gastrointestinal (GI) endoscopic or pathological features. A cross‑sectional study was completed. A total of 8,634 patients who underwent stomach biopsy and who had no gastrectomy history were enrolled in the study. The patients were divided into two groups according to the presence or absence of gastric xanthelasma. The relationship between gastric xanthelasma and demographic characteristics (including age and sex), endoscopic features (including peptic ulcer, bile reflux, and gastric poly), or pathological features (including atrophy, intestinal metaplasia, H. pylori, dysplasia, and gastric cancer) was analyzed. Age/sex matched analysis was also performed to exclude the influence of age and sex. The results revealed that out of the 8,634 patients, 3.54% patients had xanthelasma. Gastric xanthelasma was significantly associated with age (55.76 vs. 49.17 years, P<0.0001), duodenal ulcer (OR 0.860, 95% CI 0.369‑0.923), atrophy (OR 1.839, 95% CI 1.432‑2.362), and intestinal metaplasia (OR 3.296, 95% CI 2.612‑4.159). Binary logistic analysis revealed that age (OR 1.027, 95% CI 1.017‑1.037) and intestinal metaplasia (OR 2.700, 95% CI 2.090‑3.487) were independently related to gastric xanthelasma. Age/sex matched control binary logistic analysis revealed that gastric xanthelasma was significantly associated with presence of intestinal metaplasia (OR 2.338, 95% CI 1.659‑3.297). There was no difference in the number (P=0.427) and location (P>0.05) of gastric xanthelasma for intestinal metaplasia. In conclusion, gastric xanthelasma may be an independent endoscopic warning sign of intestinal metaplasia.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao D, Tong X, Yuan X, Wu Y and Chen P: Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study. Oncol Rep 44: 1275-1281, 2020.
APA
Xiao, D., Tong, X., Yuan, X., Wu, Y., & Chen, P. (2020). Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study. Oncology Reports, 44, 1275-1281. https://doi.org/10.3892/or.2020.7651
MLA
Xiao, D., Tong, X., Yuan, X., Wu, Y., Chen, P."Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study". Oncology Reports 44.3 (2020): 1275-1281.
Chicago
Xiao, D., Tong, X., Yuan, X., Wu, Y., Chen, P."Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study". Oncology Reports 44, no. 3 (2020): 1275-1281. https://doi.org/10.3892/or.2020.7651
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao D, Tong X, Yuan X, Wu Y and Chen P: Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study. Oncol Rep 44: 1275-1281, 2020.
APA
Xiao, D., Tong, X., Yuan, X., Wu, Y., & Chen, P. (2020). Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study. Oncology Reports, 44, 1275-1281. https://doi.org/10.3892/or.2020.7651
MLA
Xiao, D., Tong, X., Yuan, X., Wu, Y., Chen, P."Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study". Oncology Reports 44.3 (2020): 1275-1281.
Chicago
Xiao, D., Tong, X., Yuan, X., Wu, Y., Chen, P."Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study". Oncology Reports 44, no. 3 (2020): 1275-1281. https://doi.org/10.3892/or.2020.7651
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