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Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma

  • Authors:
    • Kang An
    • Yuehan Zhang
    • Yingjiao Liu
    • Shengxi Yan
    • Zhaowei Hou
    • Meng Cao
    • Guangkuo Liu
    • Congcong Dong
    • Juncha Gao
    • Gaifang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China
    Copyright: © An et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1116-1126
    |
    Published online on: July 7, 2020
       https://doi.org/10.3892/or.2020.7675
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Abstract

Current treatments for esophageal squamous cell carcinoma (ESCC) have limited efficacy. Therefore, the development of novel therapeutic targets to effectively manage the disease and boost survival rates is imperative Neferine, a natural product extracted from Nelumbo nucifera (lotus) leaves, has been revealed to inhibit the growth of hepatocarcinoma, breast cancer and lung cancer cells. However, its effect on ESCC is unknown. In the present study, it was revealed that neferine exerted anti‑proliferative effects in ESCC. It was also revealed that it triggered arrest of the G2/M phase and enhanced apoptosis of ESCC cell lines. Moreover, its ability to trigger accumulation of reactive oxygen species (ROS) and activate the c‑Jun N‑terminal kinase (JNK) pathway was demonstrated. Further study revealed how N‑acetyl cysteine (NAC), a ROS inhibitor, attenuated these effects, demonstrating that ROS and JNK inhibitors mediated a marked reversal of neferine‑triggered cell cycle arrest and apoptosis in ESCC cells. Finally, it was revealed that neferine was involved in the inhibition of Nrf2, an antioxidant factor. Collectively, these findings demonstrated the antitumor effect of neferine in ESCC, through the ROS‑mediated JNK pathway and inhibition of Nrf2, indicating its potential as a target for development of novel and effective therapeutic agents against ESCC.
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View References

1 

Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, Liu X and Zhan Q: Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma. Biomed Pharmacother. 102:502–509. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Yuan X, Liu Y, Li G, Lan Z, Ma M, Li H, Kong J, Sun J, Hou G, Hou X, et al: Blockade of immune-checkpoint B7-H4 and lysine demethylase 5B in esophageal squamous cell carcinoma confers protective immunity against P. gingivalis infection. Cancer Immunol Res. 7:1440–1456. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Yuan H, Zhou W, Yang Y, Xue L, Liu L and Song Y: ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway. Exp Cell Res. 367:47–55. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Zhu L and Chen L: Progress in research on paclitaxel and tumor immunotherapy. Cell Mol Biol Lett. 24:402019. View Article : Google Scholar : PubMed/NCBI

6 

Kundranda MN and Niu J: Albumin-bound paclitaxel in solid tumors: Clinical development and future directions. Drug Des Devel Ther. 9:3767–3777. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Scherz A, Feller K, Berezowska S, Genitsch V and Zweifel M: Successful treatment of pituitary germinoma with etoposide, cisplatin, vincristine, methotrexate and bleomycin chemotherapy without radiotherapy. Anticancer Res. 37:3111–3115. 2017.PubMed/NCBI

8 

Zhu B, Yu L and Yue Q: Co-delivery of vincristine and quercetin by nanocarriers for lymphoma combination chemotherapy. Biomed Pharmacother. 91:287–294. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Pham DC, Chang YC, Lin SR, Fuh YM, Tsai MJ and Weng CF: FAK and S6K1 inhibitor, neferine, dually induces autophagy and apoptosis in human neuroblastoma cells. Molecules. 23:31102018. View Article : Google Scholar

10 

Deng G, Zeng S, Ma J, Zhang Y, Qu Y, Han Y, Yin L, Cai C, Guo C and Shen H: The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma. Sci Rep. 7:416162017. View Article : Google Scholar : PubMed/NCBI

11 

Xu L, Zhang X, Li Y, Lu S, Lu S, Li J, Wang Y, Tian X, Wei JJ, Shao C and Liu Z: Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/JNK activation. Tumour Biol. 37:8721–8729. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Zhang X, Liu Z, Xu B, Sun Z, Gong Y and Shao C: Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. Eur J Pharmacol. 677:47–54. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT and Yaffe MB: A pleiotropic RNA-binding protein controls distinct cell cycle checkpoints to drive resistance of p53-defective tumors to chemotherapy. Cancer Cell. 28:8312015. View Article : Google Scholar : PubMed/NCBI

14 

Pan X, Liu W, Chai Y, Hu L, Wang J and Zhang Y: Identification of Hub genes in atypical teratoid/rhabdoid tumor by bioinformatics analyses. J Mol Neurosci. 2020:(Online ahead of print).

15 

Saldivar JC, Hamperl S, Bocek MJ, Chung M, Bass TE, Cisneros-Soberanis F, Samejima K, Xie L, Paulson JR, Earnshaw WC, et al: An intrinsic S/G2 checkpoint enforced by ATR. Science. 361:806–810. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Foijer F, Wolthuis RM, Doodeman V, Medema RH and te Riele H: Mitogen requirement for cell cycle progression in the absence of pocket protein activity. Cancer Cell. 8:455–466. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Liu W, Chai Y, Hu L, Wang J, Pan X, Yuan H, Zhao Z, Song Y and Zhang Y: Polyphyllin VI induces apoptosis and autophagy via reactive oxygen species mediated JNK and P38 activation in Glioma. Onco Targets Ther. 13:2275–2288. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Carneiro BA and El-Deiry WS: Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 2020.(Online ahead of print). View Article : Google Scholar : PubMed/NCBI

19 

Al Shahrani M, Balasubramaniam M, Alshahrani MY, Saif A, Dera AA, Alasmari S, Abohassan M, Makkawi M, Radhakrishnan S and Rajagopalan P: Computational and in vitro characterization of ICY-5: A potential candidate promoting mitochondrial apoptosis via the c-MET and STAT3 pathways. J Cell Physiol. 2020.(Online ahead of print). View Article : Google Scholar : PubMed/NCBI

20 

Buckley AM, Lynam-Lennon N, O'Neill H and O'Sullivan J: Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers. Nat Rev Gastroenterol Hepatol. 17:298–313. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Del Re DP, Amgalan D, Linkermann A, Liu Q and Kitsis RN: Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol Rev. 99:1765–1817. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Soteriou D and Fuchs Y: A matter of life and death: stem cell survival in tissue regeneration and tumour formation. Nat Rev Cancer. 18:187–201. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Fendt SM and Lunt SY: Dynamic ROS regulation by TIGAR: Balancing anti-cancer and pro-metastasis effects. Cancer Cell. 37:141–142. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Zhou Z, Song J, Nie L and Chen X: Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy. Chem Soc Rev. 45:6597–6626. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 9:537–549. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Kahroba H, Shirmohamadi M, Hejazi MS and Samadi N: The Role of Nrf2 signaling in cancer stem cells: From stemness and self-renewal to tumorigenesis and chemoresistance. Life Sci. 239:1169862019. View Article : Google Scholar : PubMed/NCBI

27 

Ferino A, Rapozzi V and Xodo LE: The ROS-KRAS-Nrf2 axis in the control of the redox homeostasis and the intersection with survival-apoptosis pathways: Implications for photodynamic therapy. J Photochem Photobiol B. 202:1116722020. View Article : Google Scholar : PubMed/NCBI

28 

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, et al: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 475:106–109. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, et al: Kupffer cell-derived tnf triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS. Cancer Cell. 31:771–789.e6. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Owusu-Ansah E, Yavari A, Mandal S and Banerjee U: Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nat Genet. 40:356–361. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Cui YJ, Ma CC, Zhang CM, Tang LQ and Liu ZP: The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo. Eur J Med Chem. 187:1119682020. View Article : Google Scholar : PubMed/NCBI

32 

Mondal A, Gandhi A, Fimognari C, Atanasov AG and Bishayee A: Alkaloids for cancer prevention and therapy: Current progress and future perspectives. Eur J Pharmacol. 858:1724722019. View Article : Google Scholar : PubMed/NCBI

33 

Salehi B, Selamoglu ZS, Mileski K, Pezzani R, Redaelli M, Cho WC, Kobarfard F, Rajabi S, Martorell M, Kumar P, et al: Liposomal Cytarabine as Cancer Therapy: From chemistry to medicine. Biomolecules. 9:7732019. View Article : Google Scholar

34 

Lin JH, Ting PC, Lee WS, Chiu HW, Chien CA, Liu CH, Sun LY and Yang KT: Palmitic acid methyl ester induces G2/M arrest in human bone marrow-derived mesenchymal stem cells via the p53/p21 pathway. Stem Cells Int. 2019:76062382019. View Article : Google Scholar : PubMed/NCBI

35 

Kreis NN, Louwen F and Yuan J: Less understood issues: p21(Cip1) in mitosis and its therapeutic potential. Oncogene. 34:1758–1767. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Kerr N, de Rivero Vaccari JP, Dietrich WD and Keane RW: Neural-respiratory inflammasome axis in traumatic brain injury. Exp Neurol. 323:1130802020. View Article : Google Scholar : PubMed/NCBI

37 

Wang Z, Yu K, Hu Y, Su F, Gao Z, Hu T, Yang Y, Cao X and Qian F: Schisantherin A induces cell apoptosis through ROS/JNK signaling pathway in human gastric cancer cells. Biochem Pharmacol. 173:1136732020. View Article : Google Scholar : PubMed/NCBI

38 

Yuan YL, Jiang N, Li ZY, Song ZZ, Yang ZH, Xue WH, Zhang XJ and Du Y: Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation. Drug Des Devel Ther. 13:3091–3103. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Zou P, Zhang J, Xia Y, Kanchana K, Guo G, Chen W, Huang Y, Wang Z, Yang S and Liang G: ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer. Oncotarget. 6:5860–5876. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Che Y, Wang J, Yuan Z, Li Y, Lu Z, Zhang Z, Zhang J, Wan J, Sun H, Chen Z, et al: The therapeutic effects of Longikaurin A, a natural ent-kauranoid, in esophageal squamous cell carcinoma depend on ROS accumulation and JNK/p38 MAPK activation. Toxicol Lett. 280:106–115. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Zhang X, Wang X, Wu T, Li B, Liu T, Wang R, Liu Q, Liu Z, Gong Y and Shao C: Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. Sci Rep. 5:125792015. View Article : Google Scholar : PubMed/NCBI

42 

Guo Z, Guozhang H, Wang H, Li Z and Liu N: Ampelopsin inhibits human glioma through inducing apoptosis and autophagy dependent on ROS generation and JNK pathway. Biomed Pharmacother. 116:1085242019. View Article : Google Scholar : PubMed/NCBI

43 

Wang H, Zhang T, Sun W, Wang Z, Zuo D, Zhou Z, Li S, Xu J, Yin F, Hua Y and Cai Z: Erianin induces G2/M-phase arrest, apoptosis, and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo. Cell Death Dis. 7:e22472016. View Article : Google Scholar : PubMed/NCBI

44 

Banerjee N, Wang H, Wang G and Khan MF: Enhancing the Nrf2 antioxidant signaling provides protection against trichloroethene-mediated inflammation and autoimmune response. Toxicol Sci. 175:64–74. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Zhou XL, Wu X, Zhu RR, Xu H, Li YY, Xu QR, Liu S, Lai SQ, Xu X, Wan L, et al: Notch1-Nrf2 signaling crosstalk provides myocardial protection by reducing ROS formation. Biochem Cell Biol. 98:106–111. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
An K, Zhang Y, Liu Y, Yan S, Hou Z, Cao M, Liu G, Dong C, Gao J, Liu G, Liu G, et al: Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma. Oncol Rep 44: 1116-1126, 2020.
APA
An, K., Zhang, Y., Liu, Y., Yan, S., Hou, Z., Cao, M. ... Liu, G. (2020). Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma. Oncology Reports, 44, 1116-1126. https://doi.org/10.3892/or.2020.7675
MLA
An, K., Zhang, Y., Liu, Y., Yan, S., Hou, Z., Cao, M., Liu, G., Dong, C., Gao, J., Liu, G."Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma". Oncology Reports 44.3 (2020): 1116-1126.
Chicago
An, K., Zhang, Y., Liu, Y., Yan, S., Hou, Z., Cao, M., Liu, G., Dong, C., Gao, J., Liu, G."Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma". Oncology Reports 44, no. 3 (2020): 1116-1126. https://doi.org/10.3892/or.2020.7675
Copy and paste a formatted citation
x
Spandidos Publications style
An K, Zhang Y, Liu Y, Yan S, Hou Z, Cao M, Liu G, Dong C, Gao J, Liu G, Liu G, et al: Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma. Oncol Rep 44: 1116-1126, 2020.
APA
An, K., Zhang, Y., Liu, Y., Yan, S., Hou, Z., Cao, M. ... Liu, G. (2020). Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma. Oncology Reports, 44, 1116-1126. https://doi.org/10.3892/or.2020.7675
MLA
An, K., Zhang, Y., Liu, Y., Yan, S., Hou, Z., Cao, M., Liu, G., Dong, C., Gao, J., Liu, G."Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma". Oncology Reports 44.3 (2020): 1116-1126.
Chicago
An, K., Zhang, Y., Liu, Y., Yan, S., Hou, Z., Cao, M., Liu, G., Dong, C., Gao, J., Liu, G."Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma". Oncology Reports 44, no. 3 (2020): 1116-1126. https://doi.org/10.3892/or.2020.7675
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