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Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells

  • Authors:
    • Chao Li
    • Li Yuan
    • Shuangshuang Han
    • Mingda Xuan
    • Dehua Liu
    • Bo Tian
    • Weifang Yu
  • View Affiliations / Copyright

    Affiliations: Department of Endoscopy Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China, Department of Endoscopy Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1149-1157
    |
    Published online on: July 7, 2020
       https://doi.org/10.3892/or.2020.7676
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Abstract

Gastric cancer (GC) causes high morbidity and mortality in patients largely due to its invasion and metastasis. Kiss‑1 has been shown to be a metastasis suppressor in various malignancies. However, its clinical significance and biological functions in GC have not been thoroughly investigated. The present study investigated the association between Kiss‑1 expression and its methylation status and clinicopathological features in GC. Kiss‑1 expression was reduced in GC and its low expression was associated with poor histological grade, lymph node metastasis and TNM III+IV stage. Kiss‑1 overexpression in AGS GC cells significantly inhibited cell proliferation, migration and invasion in vitro. Kiss‑1 knockdown promoted the proliferation, migration and invasion of HGC‑27 cells. In summary, the data demonstrated that a low expression of Kiss‑1 played a suppressive role for the proliferation, migration and invasion of GC cells. Its expression and methylation levels were associated with the clinical progression of GC. Thus, Kiss‑1 is a potential diagnostic and prognostic marker as well as a new target for the treatment of GC.
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Copy and paste a formatted citation
Spandidos Publications style
Li C, Yuan L, Han S, Xuan M, Liu D, Tian B and Yu W: Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells. Oncol Rep 44: 1149-1157, 2020.
APA
Li, C., Yuan, L., Han, S., Xuan, M., Liu, D., Tian, B., & Yu, W. (2020). Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells. Oncology Reports, 44, 1149-1157. https://doi.org/10.3892/or.2020.7676
MLA
Li, C., Yuan, L., Han, S., Xuan, M., Liu, D., Tian, B., Yu, W."Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells". Oncology Reports 44.3 (2020): 1149-1157.
Chicago
Li, C., Yuan, L., Han, S., Xuan, M., Liu, D., Tian, B., Yu, W."Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells". Oncology Reports 44, no. 3 (2020): 1149-1157. https://doi.org/10.3892/or.2020.7676
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Yuan L, Han S, Xuan M, Liu D, Tian B and Yu W: Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells. Oncol Rep 44: 1149-1157, 2020.
APA
Li, C., Yuan, L., Han, S., Xuan, M., Liu, D., Tian, B., & Yu, W. (2020). Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells. Oncology Reports, 44, 1149-1157. https://doi.org/10.3892/or.2020.7676
MLA
Li, C., Yuan, L., Han, S., Xuan, M., Liu, D., Tian, B., Yu, W."Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells". Oncology Reports 44.3 (2020): 1149-1157.
Chicago
Li, C., Yuan, L., Han, S., Xuan, M., Liu, D., Tian, B., Yu, W."Reduced Kiss‑1 expression is associated with clinical aggressive feature of gastric cancer patients and promotes migration and invasion in gastric cancer cells". Oncology Reports 44, no. 3 (2020): 1149-1157. https://doi.org/10.3892/or.2020.7676
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