1
|
Yang D, Cao X, Wang F, Jiang, Feng D, Guo
H, Du L, Jin Y, Chen Y, Yin X and Li C: LFG-500, a novel synthetic
flavonoid, suppresses epithelial-mesenchymal transition in human
lung adenocarcinoma cells by inhibiting NLRP3 in inflammatory
microenvironment. Cancer Lett. 400:137–148. 2017. View Article : Google Scholar : PubMed/NCBI
|
2
|
Collins LG, Haines C, Perkel R and Enck
RE: Lung cancer: Diagnosis and management. Am Fam Physician.
75:56–63. 2007.PubMed/NCBI
|
3
|
Zhao Z, Cheng X, Wang Y, Han R, Li L,
Xiang T, He L, Long H, Zhu B and He Y: Metformin inhibits the
IL-6-induced epithelial-mesenchymal transition and lung
adenocarcinoma growth and metastasis. PLoS One. 9:e958842014.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Li J, Deng Z, Wang Z, Wang D, Zhang L, Su
Q, Lai Y, Li B, Luo Z, Chen X, et al: Zipper-Interacting protein
kinase promotes epithelial-mesenchymal transition, invasion and
metastasis through AKT and NF-kB signaling and is associated with
metastasis and poor prognosis in gastric cancer patients.
Oncotarget. 6:8323–8338. 2015. View Article : Google Scholar : PubMed/NCBI
|
5
|
Song J, Feng L, Zhong R, Xia Z, Zhang L,
Cui L, Yan H, Jia X and Zhang Z: Icariside II inhibits the EMT of
NSCLC cells in inflammatory microenvironment via down-regulation of
Akt/NF-kappaB signaling pathway. Mol Carcinog. 56:36–48. 2017.
View Article : Google Scholar : PubMed/NCBI
|
6
|
Zhao Y, Yao J, Wu XP, Zhao L, Zhou YX,
Zhang Y, You QD, Guo QL and Lu N: Wogonin suppresses human alveolar
adenocarcinoma cell A549 migration in inflammatory microenvironment
by modulating the IL-6/STAT3 signaling pathway. Mol Carcinog.
54:E81–E93. 2015. View
Article : Google Scholar : PubMed/NCBI
|
7
|
Micalizzi DS, Farabaugh SM and Ford HL:
Epithelial-mesenchymal transition in cancer: parallels between
normal development and tumor progression. J Mammary Gland Biol
Neoplasia. 15:117–134. 2010. View Article : Google Scholar : PubMed/NCBI
|
8
|
Mantovani A, Allavena P, Sica A and
Balkwill F: Cancer-Related inflammation. Nature. 454:436–444. 2008.
View Article : Google Scholar : PubMed/NCBI
|
9
|
DeNardo DG, Andreu P and Coussens LM:
Interactions between lymphocytes and myeloid cells regulate pro-
versus anti-tumor immunity. Cancer Metastasis Rev. 29:309–316.
2010. View Article : Google Scholar : PubMed/NCBI
|
10
|
Ostrand-Rosenberg S: Immune surveillance:
A balance between pro- and anti-tumor immunity. Curr Opin Genet
Dev. 18:11–18. 2008. View Article : Google Scholar : PubMed/NCBI
|
11
|
Park EJ, Lee JH, Yu GY, He G, Ali SR,
Holzer RG, Osterreicher CH, Takahashi H and Karin M: Dietary and
genetic obesity promote liver inflammation and tumorigenesis by
enhancing IL-6 and TNF expression. Cell. 140:197–208. 2010.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Yeh HH, Lai WW, Chen HH, Liu HS and Su WC:
Autocrine IL-6-induced Stat3 activation contributes to the
pathogenesis of lung adenocarcinoma and malignant pleural effusion.
Oncogene. 25:4300–4309. 2006. View Article : Google Scholar : PubMed/NCBI
|
13
|
Lederle W, Depner S, Schnur S, Obermueller
E, Catone N, Just A, Fusenig NE and Mueller MM: IL-6 promotes
malignant growth of skin SCCs by regulating a network of autocrine
and paracrine cytokines. Int J Cancer. 128:2803–2814. 2011.
View Article : Google Scholar : PubMed/NCBI
|
14
|
Bromberg J and Wang TC: Inflammation and
cancer: IL-6 and STAT3 complete the link. Cancer Cell. 15:79–80.
2009. View Article : Google Scholar : PubMed/NCBI
|
15
|
Heinrich PC, Behrmann I, Haan S, Hermanns
HM, Müller-Newen G and Schaper F: Principles of interleukin
(IL)-6-type cytokine signalling and its regulation. Biochem J.
374:1–20. 2003. View Article : Google Scholar : PubMed/NCBI
|
16
|
Huang C, Yang G, Jiang T, Zhu G, Li H and
Qiu Z: The effects and mechanisms of blockage of STAT3 signaling
pathway on IL-6 inducing EMT in human pancreatic cancer cells in
vitro. Neoplasma. 58:396–405. 2011. View Article : Google Scholar : PubMed/NCBI
|
17
|
Yadav A, Kumar B, Datta J, Teknos TN and
Kumar P: IL-6 promotes head and neck tumor metastasis by inducing
epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling
pathway. Mol Cancer Res. 9:1658–1667. 2011. View Article : Google Scholar : PubMed/NCBI
|
18
|
Zhou G, Yang Z, Wang X, Tao R and Zhou Y:
TRAIL Enhances shikonin induced apoptosis through ros/jnk signaling
in cholangiocarcinoma cells. Cell Physiol Biochem. 42:1073–1086.
2017. View Article : Google Scholar : PubMed/NCBI
|
19
|
Andujar I, Ríos JL, Giner RM and Recio MC:
Pharmacological properties of shikonin - A review of literature
since 2002. Planta Med. 79:1685–1697. 2013. View Article : Google Scholar : PubMed/NCBI
|
20
|
Chen X, Yang L, Oppenheim JJ and Howard
MZ: Cellular pharmacology studies of shikonin derivatives.
Phytother Res. 16:199–209. 2002. View Article : Google Scholar : PubMed/NCBI
|
21
|
Chen J, Xie J, Jiang Z, Wang B, Wang Y and
Hu X: Shikonin and its analogs inhibit cancer cell glycolysis by
targeting tumor pyruvate kinase-M2. Oncogene. 30:4297–4306. 2011.
View Article : Google Scholar : PubMed/NCBI
|
22
|
Yeh YC, Liu TJ and Lai HC: Shikonin
induces apoptosis, necrosis, and premature senescence of human a549
lung cancer cells through upregulation of p53 expression. Evid
Based Complement Alternat Med. 2015:6203832015. View Article : Google Scholar : PubMed/NCBI
|
23
|
Andújar I, Recio MC, Giner RM and Ríos JL:
Traditional Chinese medicine remedy to jury: The pharmacological
basis for the use of shikonin as an anticancer therapy. Curr Med
Chem. 20:2892–2898. 2013. View Article : Google Scholar : PubMed/NCBI
|
24
|
Heinrich EL, Walser TC, Krysan K, Liclican
EL, Grant JL, Rodriguez NL and Dubinett SM: The inflammatory tumor
microenvironment, epithelial mesenchymal transition and lung
carcinogenes. Cancer microenvironment: official journal of the
International Cancer Microenv. 5:5–18. 2012. View Article : Google Scholar
|
25
|
Zheng Y, Guo J, Zhou J, Lu J, Chen Q,
Zhang C, Qing C, Koeffler HP and Tong Y: FoxM1 transactivates PTTG1
and promotes colorectal cancer cell migration and invasion. BMC Med
Genomics. 8:492015. View Article : Google Scholar : PubMed/NCBI
|
26
|
Kuo CL, Lai KC, Ma YS, Weng SW, Lin JP and
Chung JG: Gallic acid inhibits migration and invasion of SCC-4
human oral cancer cells through actions of NF-kappaB, ras and
matrix metalloproteinase-2 and −9. Oncol Rep. 32:355–361. 2014.
View Article : Google Scholar : PubMed/NCBI
|
27
|
Wallmeyer L, Dietert K, Sochorová M,
Gruber AD, Kleuser B, Vávrová K and Hedtrich S: TSLP is a direct
trigger for T cell migration in filaggrin-deficient skin
equivalents. Sci Rep. 7:7742017. View Article : Google Scholar : PubMed/NCBI
|
28
|
Schneider CA, Rasband WS and Eliceiri KW:
NIH Image to imagej: 25 years of image analysis. Nat Methods.
9:671–675. 2012. View Article : Google Scholar : PubMed/NCBI
|
29
|
Pan T, Zhang M, Zhang F, Yan G, Ru Y, Wang
Q, Zhang Y, Wei X, Xu X, Shen L, et al: NDRG2 overexpression
suppresses hepatoma cells survival during metabolic stress through
disturbing the activation of fatty acid oxidation. Biochem Biophys
Res Commun. 5:860–866. 2017. View Article : Google Scholar
|
30
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
31
|
Zhao M, Liu Y, Liu R, Qi J, Hou Y, Chang J
and Ren L: Upregulation of IL-11, an IL-6 family cytokine, promotes
tumor progression and correlates with poor prognosis in non-small
cell lung cancer. Cell Physiol Biochem. 45:2213–2224. 2018.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Thakur R, Trivedi R, Rastogi N, Singh M
and Mishra DP: Inhibition of STAT3, FAK and Src mediated signaling
reduces cancer stem cell load, tumorigenic potential and metastasis
in breast cancer. Sci Rep. 5:101942015. View Article : Google Scholar : PubMed/NCBI
|
33
|
Wang S, Wu X, Chen Y, Zhang J, Ding J,
Zhou Y, He S, Tan Y, Qiang F, Bai J, et al: Prognostic and
predictive role of JWA and XRCC1 expressions in gastric cancer.
Clin Cancer Res. 18:2987–2996. 2012. View Article : Google Scholar : PubMed/NCBI
|
34
|
Wang H, Wang HS, Zhou BH, Li CL, Zhang F,
Wang XF, Zhang G, Bu XZ, Cai SH and Du J: Epithelial-mesenchymal
transition (EMT) induced by TNF-alpha requires
AKT/GSK-3beta-mediated stabilization of snail in colorectal cancer.
PLoS One. 8:e566642013. View Article : Google Scholar : PubMed/NCBI
|
35
|
Johnson DE, O'Keefe RA and Grandis JR:
Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev
Clin oncol. 15:234–248. 2018. View Article : Google Scholar : PubMed/NCBI
|
36
|
Diakos CI, Charles KA, McMillan DC and
Clarke SJ: Cancer-Related inflammation and treatment effectiveness.
Lancet Oncol. 15:e493–e503. 2014. View Article : Google Scholar : PubMed/NCBI
|
37
|
Pietila M, Ivaska J and Mani SA: Whom to
blame for metastasis, the epithelial-mesenchymal transition or the
tumor microenvironment? Cancer Lett. 380:359–368. 2016. View Article : Google Scholar : PubMed/NCBI
|
38
|
Bingle L, Brown NJ and Lewis CE: The role
of tumour-associated macrophages in tumour progression:
Implications for new anticancer therapies. J Pathol. 196:254–265.
2002. View Article : Google Scholar : PubMed/NCBI
|
39
|
Dehai C, Bo P, Qiang T, Lihua S, Fang L,
Shi J, Jingyan C, Yan Y, Guangbin W and Zhenjun Y: Enhanced
invasion of lung adenocarcinoma cells after co-culture with
THP-1-derived macrophages via the induction of EMT by IL-6. Immunol
Lett. 160:1–10. 2014. View Article : Google Scholar : PubMed/NCBI
|
40
|
Xie YG, Yu Y, Hou LK, Wang X, Zhang B and
Cao XC: FYN promotes breast cancer progression through
epithelial-mesenchymal transition. Oncol Rep. 36:1000–1006. 2016.
View Article : Google Scholar : PubMed/NCBI
|
41
|
Budai MM, Varga A, Milesz S, Tőzsér J and
Benkő S: Aloe vera downregulates LPS-induced inflammatory cytokine
production and expression of NLRP3 inflammasome in human
macrophages. Mol Immunol. 56:471–479. 2013. View Article : Google Scholar : PubMed/NCBI
|
42
|
Wang HW, Wu T, Qi JY, Wang YQ, Luo XP and
Ning Q: Salidroside attenuates LPS-stimulated activation of THP-1
cell-derived macrophages through down-regulation of MAPK/NF-kB
signaling pathways. J Huazhong Univ Sci Technol Med Sci.
33:463–469. 2013. View Article : Google Scholar : PubMed/NCBI
|
43
|
Candido J and Hagemann T: Cancer-related
inflammation. J Clin Immunol. 33:S79–S84. 2013. View Article : Google Scholar : PubMed/NCBI
|
44
|
Lesina M, Wörmann SM, Neuhöfer P, Song L
and Algül H: Interleukin-6 in inflammatory and malignant diseases
of the pancreas. Semin Immunol. 26:80–87. 2014. View Article : Google Scholar : PubMed/NCBI
|
45
|
Wu YS, Chung I, Wong WF, Masamune A, Sim
MS and Looi CY: Paracrine IL-6 signaling mediates the effects of
pancreatic stellate cells on epithelial-mesenchymal transition via
Stat3/Nrf2 pathway in pancreatic cancer cells. Biochim Biophys Acta
Gen Subj. 1861:296–306. 2017. View Article : Google Scholar : PubMed/NCBI
|
46
|
Qiu HY, Zhu X, Luo YL, Lin HY, Tang CY, Qi
JL, Pang YJ, Yang RW, Lu GH, Wang XM and Yang Yh: Identification of
new shikonin derivatives as antitumor agents targeting stat3 sh2
domain. Sci Rep. 7:28632017. View Article : Google Scholar : PubMed/NCBI
|
47
|
Qiu HY, Fu JY, Yang MK, Han HW, Wang PF,
Zhang YH, Lin HY, Tang CY, Qi JL, Yang RW, et al: Identification of
new shikonin derivatives as STAT3 inhibitors. Biochem Pharmacol.
146:74–86. 2017. View Article : Google Scholar : PubMed/NCBI
|
48
|
Kim YI, Choi KH, Kim SR, Goo TW and Park
SW: Bombyx mori hemocyte extract has anti-inflammatory effects on
human phorbol myristate acetate-differentiated THP1 cells via
TLR4-mediated suppression of the NF-kappaB signaling pathway. Mol
Med Rep. 16:4001–4007. 2017. View Article : Google Scholar : PubMed/NCBI
|
49
|
Liu X, Yin S, Chen Y, Wu Y, Zheng W, Dong
H, Bai Y, Qin Y, Li J, Feng S and Zhao P: LPSinduced
proinflammatory cytokine expression in human airway epithelial
cells and macrophages via NFkappaB, STAT3 or AP1 activation. Mol
Med Rep. 17:5484–5491. 2018.PubMed/NCBI
|