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Article Open Access

MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6

  • Authors:
    • Hongya Guan
    • Jia Liu
    • Pengju Lv
    • Lijuan Zhou
    • Jianying Zhang
    • Wei Cao
  • View Affiliations / Copyright

    Affiliations: Department of Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, P.R. China, Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1385-1392
    |
    Published online on: July 15, 2020
       https://doi.org/10.3892/or.2020.7692
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Abstract

MicroRNA‑590 (miR‑590) has been revealed as a tumor suppressor, while low‑density lipoprotein receptor‑related protein 6 (LRP6) is considered to act as a tumor promoter. However, their roles and underlying molecular regulatory mechanisms in esophageal squamous cell carcinoma (ESCC) have yet to be fully elucidated. Therefore, the present study aimed to investigate these mechanisms. The expression levels of miR‑590 and LRP6 in human ESCC samples and cell lines were determined using reverse transcription‑quantitative PCR. Bioinformatics analysis was used to predict the relationship between miR‑590 and LRP6, and luciferase assay was performed to validate the relationship between these factors. Transwell assays were used to determine cell migration and invasion, while western blotting assays were used to detect the protein expression levels of LRP6, E‑cadherin, N‑cadherin and Vimentin. The present study demonstrated that miR‑590 was downregulated and LRP6 was upregulated in ESCC tissues and cell lines. Furthermore, it was found that miR‑590 overexpression and LRP6 knockdown inhibited cell migration, invasion and epithelial‑to‑mesenchymal transition (EMT) in ESCC cell lines. Additional mechanistic studies identified that LRP6 was a target of, and was inhibited by, miR‑590. Collectively, the present findings suggested that miR‑590 inhibited the invasion, migration and EMT of ESCC cells by mediating LRP6.
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1 

Abnet CC, Arnold M and Wei WQ: Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 154:360–373. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Kong D, Li Y, Wang Z and Sarkar FH: Cancer stem cells and epithelial-to-mesenchymal transition (EMT)-phenotypic cells: Are they cousins or twins? Cancers (Basel). 3:716–729. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Radmark O, Kim S and Kim VN: The nuclear RNase III Drosha initiates microRNA processing. Nature. 425:415–419. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Lai EC: Micro RNAs are complementary to 3′UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet. 30:363–364. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Shim J and Nam JW: The expression and functional roles of microRNAs in stem cell differentiation. BMB Rep. 49:3–10. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Gu C, Xu Y, Zhang S, Guan H, Song S, Wang X, Wang Y, Li Y and Zhao G: miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARγ and GREM1. Sci Rep. 6:384912016. View Article : Google Scholar : PubMed/NCBI

7 

Wang Y, Zhang S, Xu Y, Zhang Y, Guan H, Li X, Li Y and Wang Y: Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 in human osteosarcoma. Tumour Biol. 37:15211–15220. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Yi Y, Chen J, Jiao C, Zhong J, Song Z, Yu X, Lu X and Lin B: Upregulated miR-193a-3p as an oncogene in esophageal squamous cell carcinoma regulating cellular proliferation, migration and apoptosis. Oncol Lett. 12:4779–4784. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Yan L, Hu F, Yan X, Wei Y, Ma W, Wang Y, Lu S and Wang Z: Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response. J Mol Med (Berl). 94:1063–1079. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Fan N and Wang J: MicroRNA 34a contributes to virus-mediated apoptosis through binding to its target gene Bax in influenza A virus infection. Biomed Pharmacother. 83:1464–1470. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Zhao X, Xu Y, Sun X, Ma Y, Zhang Y and Wang Y, Guan H, Jia Z, Li Y and Wang Y: miR-17-5p promotes proliferation and epithelial-mesenchymal transition in human osteosarcoma cells by targeting SRC kinase signaling inhibitor 1. J Cell Biochem. 120:5495–5504. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Svoronos AA, Engelman DM and Slack FJ: OncomiR or tumor suppressor? The duplicity of MicroRNAs in cancer. Cancer Res. 76:3666–3670. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Wang WT, Qi Q, Zhao P, Li CY, Yin XY and Yan RB: miR-590-3p is a novel microRNA which suppresses osteosarcoma progression by targeting SOX9. Biomed Pharmacother. 107:1763–1769. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Xu BB, Gu ZF, Ma M, Wang JY and Wang HN: MicroRNA-590-5p suppresses the proliferation and invasion of non-small cell lung cancer by regulating GAB1. Eur Rev Med Pharmacol Sci. 22:5954–5963. 2018.PubMed/NCBI

15 

Wang FF, Wang S, Xue WH and Cheng JL: microRNA-590 suppresses the tumorigenesis and invasiveness of non-small cell lung cancer cells by targeting ADAM9. Mol Cell Biochem. 423:29–37. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Ge X and Gong L: MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1. Tumour Biol. 39:10104283176959472017. View Article : Google Scholar : PubMed/NCBI

17 

Shan X, Miao Y, Fan R, Qian H, Chen P, Liu H, Yan X, Li J and Zhou F: MiR-590-5P inhibits growth of HepG2 cells via decrease of S100A10 expression and Inhibition of the Wnt pathway. Int J Mol Sci. 14:8556–8569. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Hong Z, Hong C, Ma B, Wang Q, Zhang X, Li L, Wang C and Chen D: MicroRNA-126-3p inhibits the proliferation, migration, invasion, and angiogenesis of triple negative breast cancer cells by targeting RGS3. Oncol Rep. 42:1569–1579. 2019.PubMed/NCBI

20 

Alcantara KMM and Garcia RL: MicroRNA-92a promotes cell proliferation, migration and survival by directly targeting the tumor suppressor gene NF2 in colorectal and lung cancer cells. Oncol Rep. 41:2103–2116. 2019.PubMed/NCBI

21 

Xiong W, Ran J, Jiang R, Guo P, Shi X, Li H, Lv X, Li J and Chen D: miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4. Oncol Rep. 39:1939–1947. 2018.PubMed/NCBI

22 

Zhang X, Xu X, Ge G, Zang X, Shao M, Zou S, Zhang Y, Mao Z, Zhang J, Mao F, et al: miR-498 inhibits the growth and metastasis of liver cancer by targeting ZEB2. Oncol Rep. 41:1638–1648. 2019.PubMed/NCBI

23 

Guan H, Mei Y, Mi Y, Li C, Sun X, Zhao X, Liu J, Cao W, Li Y and Wang Y: Downregulation of lncRNA ANRIL suppresses growth and metastasis in human osteosarcoma cells. Onco Targets Ther. 11:4893–4899. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Guan H, Shang G, Cui Y, Liu J, Sun X, Cao W, Wang Y and Li Y: Long noncoding RNA APTR contributes to osteosarcoma progression through repression of miR-132-3p and upregulation of yes-associated protein 1. J Cell Physiol. 2234:8998–9007. 2019. View Article : Google Scholar

25 

Chen Z, Lin J, Wu S, Xu C, Chen F and Huang Z: Up-regulated miR-548k promotes esophageal squamous cell carcinoma progression via targeting long noncoding RNA-LET. Exp Cell Res. 362:90–101. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Zhao H, Diao C, Wang X, Xie Y, Liu Y, Gao X, Han J and Li S: MiR-543 promotes migration, invasion and epithelial-mesenchymal transition of esophageal cancer cells by targeting phospholipase A2 Group IVA. Cell Physiol Biochem. 48:1595–1604. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Q, Gan H, Song W, Chai D and Wu S: MicroRNA-145 promotes esophageal cancer cells proliferation and metastasis by targeting SMAD5. Scand J Gastroenterol. 53:769–776. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Yan M, Ye L, Feng X, Shi R, Sun Z, Li Z and Liu T: MicroRNA-590-3p inhibits invasion and metastasis in triple-negative breast cancer by targeting slug. Am J Cancer Res. 10:965–974. 2020.PubMed/NCBI

29 

Xu Y, Han T, Zhu Y and Chen Q: miR-590-5P inhibits the progression of tongue squamous cell carcinoma by targeting FasL. Int J Clin Exp Pathol. 10:11880–11887. 2017.PubMed/NCBI

30 

Yao Q, An Y, Hou W, Cao YN, Yao MF, Ma NN, Hou L, Zhang H, Liu HJ and Zhang B: LRP6 promotes invasion and metastasis of colorectal cancer through cytoskeleton dynamics. Oncotarget. 8:109632–109645. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Ma J, Lu W, Chen D, Xu B and Li Y: Role of Wnt co-receptor LRP6 in triple negative breast cancer cell migration and invasion. J Cell Biochem. 118:2968–2976. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Hua Y, Yang Y, Li Q, He X, Zhu W, Wang J and Gan X: Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway. J Biol Chem. 293:19710–19724. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Lu W and Li Y: Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells. J Cell Biochem. 115:1799–807. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Pastushenko I and Blanpain C: EMT transition states during tumor progression and metastasis. Trends Cell Biol. 29:212–226. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Yilmaz M and Christofori G: EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28:15–33. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Paolillo M and Schinelli S: Extracellular matrix alterations in metastatic processes. Int J Mol Sci. 20:49472019. View Article : Google Scholar

37 

Arend RC, Londoño-Joshi AI, Straughn JM Jr and Buchsbaum DJ: The Wnt/β-catenin pathway in ovarian cancer: A review. Gynecol Oncol. 131:772–779. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Gonzalez DM and Medici D: Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal. 7:re82014. View Article : Google Scholar : PubMed/NCBI

39 

Zhang J, Tian XJ and Xing J: Signal transduction pathways of EMT induced by TGF-β, SHH, and WNT and their crosstalks. J Clin Med. 5:412016. View Article : Google Scholar

40 

Liu X, Yun F, Shi L, Li ZH, Luo NR and Jia YF: Roles of signaling pathways in the epithelial-mesenchymal transition in cancer. Asian Pac J Cancer Prev. 16:6201–6206. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Dong Y, Zhang Y, Kang W, Wang G, Chen H, Higashimori A, Nakatsu G, Go M, Tong JH, Zheng S, et al: VSTM2A suppresses colorectal cancer and antagonizes Wnt signaling receptor LRP6. Theranostics. 9:6517–6531. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guan H, Liu J, Lv P, Zhou L, Zhang J and Cao W: MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6. Oncol Rep 44: 1385-1392, 2020.
APA
Guan, H., Liu, J., Lv, P., Zhou, L., Zhang, J., & Cao, W. (2020). MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6. Oncology Reports, 44, 1385-1392. https://doi.org/10.3892/or.2020.7692
MLA
Guan, H., Liu, J., Lv, P., Zhou, L., Zhang, J., Cao, W."MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6". Oncology Reports 44.4 (2020): 1385-1392.
Chicago
Guan, H., Liu, J., Lv, P., Zhou, L., Zhang, J., Cao, W."MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6". Oncology Reports 44, no. 4 (2020): 1385-1392. https://doi.org/10.3892/or.2020.7692
Copy and paste a formatted citation
x
Spandidos Publications style
Guan H, Liu J, Lv P, Zhou L, Zhang J and Cao W: MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6. Oncol Rep 44: 1385-1392, 2020.
APA
Guan, H., Liu, J., Lv, P., Zhou, L., Zhang, J., & Cao, W. (2020). MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6. Oncology Reports, 44, 1385-1392. https://doi.org/10.3892/or.2020.7692
MLA
Guan, H., Liu, J., Lv, P., Zhou, L., Zhang, J., Cao, W."MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6". Oncology Reports 44.4 (2020): 1385-1392.
Chicago
Guan, H., Liu, J., Lv, P., Zhou, L., Zhang, J., Cao, W."MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6". Oncology Reports 44, no. 4 (2020): 1385-1392. https://doi.org/10.3892/or.2020.7692
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