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Article Open Access

High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma

  • Authors:
    • Zhen‑Peng Zhu
    • Lan‑Ruo Lin
    • Tong‑De Lv
    • Chun‑Ru Xu
    • Tian‑Yu Cai
    • Jian Lin
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Peking University First Hospital, Beijing 100034, P.R. China, College of Basic Medicine, Capital Medical University, Beijing 100069, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2056-2066
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    Published online on: August 18, 2020
       https://doi.org/10.3892/or.2020.7736
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Abstract

Clear cell renal cell carcinoma (ccRCC) is one of the most common types of malignant tumors and early detection contributes to a better prognosis. Finding new biomarkers for the diagnosis or treatment remains meaningful. DEF6 guanine nucleotide exchange factor (DEF6) is upregulated in ccRCC compared to normal controls, but the relationship between DEF6 expression and prognosis in ccRCC is unclear. Moreover, the potential biological functions of DEF6 in ccRCC remains unclear. In the present study, the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), TISIDB and the clinical database of the Peking University First Hospital were used to analyze DEF6 expression in ccRCC. Immunohistochemistry (IHC), western blotting and reverse transcription‑quantitative PCR were used to examine the DEF6 protein and mRNA expression levels in cell lines and clinical samples. Subsequently, the Kaplan‑Meier method and Cox regression analyses were used to determine the impact of DEF6 expression on the overall survival of patients alongside other clinical variables in both the TCGA database and the present clinical database. The results showed that both DEF6 mRNA and protein expression levels were upregulated in ccRCC compared to normal controls. The Kaplan‑Meier survival analysis showed that patients with high DEF6 expression had poor prognoses from both the TCGA database and the present clinical database. Univariate survival analysis and multivariate survival analysis revealed that DEF6 could be an independent prognostic factor for ccRCC. Additionally, bioinformatics analysis indicated that differentially expressed genes related to DEF6 expression influenced ccRCC by regulating the tumor immune microenvironment. In conclusion, overexpression of DEF6 is significantly correlated with a poor prognosis for patients with ccRCC and DEF6 may influence the biological processes involved with ccRCC by regulating the immune microenvironment.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S and Kaelin WG Jr: HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species. Sci Signal. 12:122019. View Article : Google Scholar

3 

Li QK, Pavlovich CP, Zhang H, Kinsinger CR and Chan DW: Challenges and opportunities in the proteomic characterization of clear cell renal cell carcinoma (ccRCC): A critical step towards the personalized care of renal cancers. Semin Cancer Biol. 55:8–15. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Cancer Genome Atlas Research Network, . Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 499:43–49. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, Shimamura T, Sato-Otsubo A, Nagae G, Suzuki H, et al: Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet. 45:860–867. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Oliver GR, Hart SN and Klee EW: Bioinformatics for clinical next generation sequencing. Clin Chem. 61:124–135. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Xuan J, Yu Y, Qing T, Guo L and Shi L: Next-generation sequencing in the clinic: Promises and challenges. Cancer Lett. 340:284–295. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Majer W, Kluzek K, Bluyssen H and Wesoły J: Potential Approaches and Recent Advances in Biomarker Discovery in Clear-Cell Renal Cell Carcinoma. J Cancer. 6:1105–1113. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Yoshihara K, Shahmoradgoli M, Martínez E, Vegesna R, Kim H, Torres-Garcia W, Treviño V, Shen H, Laird PW, Levine DA, et al: Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 4:26122013. View Article : Google Scholar : PubMed/NCBI

10 

Atkins MB, Regan M and McDermott D: Update on the role of interleukin 2 and other cytokines in the treatment of patients with stage IV renal carcinoma. Clin Cancer Res. 10:6342S–6346S. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Escudier B: Emerging immunotherapies for renal cell carcinoma. Ann Oncol. 23 (Suppl 8):viii35–viii40. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Şenbabaoğlu Y, Gejman RS, Winer AG, Liu M, Van Allen EM, de Velasco G, Miao D, Ostrovnaya I, Drill E, Luna A, et al: Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures. Genome Biol. 17:2312016. View Article : Google Scholar : PubMed/NCBI

13 

Gupta S, Lee A, Hu C, Fanzo J, Goldberg I, Cattoretti G and Pernis AB: Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system. Hum Immunol. 64:389–401. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Mavrakis KJ, McKinlay KJ, Jones P and Sablitzky F: DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. Exp Cell Res. 294:335–344. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Tanaka Y, Bi K, Kitamura R, Hong S, Altman Y, Matsumoto A, Tabata H, Lebedeva S, Bushway PJ and Altman A: SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. Immunity. 18:403–414. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Canonigo-Balancio AJ, Fos C, Prod'homme T, Bécart S and Altman A: SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis. J Immunol. 183:7259–7267. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Oka T, Ihara S and Fukui Y: Cooperation of DEF6 with activated Rac in regulating cell morphology. J Biol Chem. 282:2011–2018. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Samson T, Will C, Knoblauch A, Sharek L, von der Mark K, Burridge K and Wixler V: Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation. J Biol Chem. 282:15730–15742. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Lazer G and Katzav S: Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy? Cell Signal. 23:969–979. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Chen S, Han Q, Wang X, Yang M, Zhang Z, Li P, Chen A, Hu C and Li S: IBP-mediated suppression of autophagy promotes growth and metastasis of breast cancer cells via activating mTORC2/Akt/FOXO3a signaling pathway. Cell Death Dis. 4:e8422013. View Article : Google Scholar : PubMed/NCBI

21 

Xu Y, Hou Y, Liu T and Lou G: Overexpression and clinical significance of IBP in epithelial ovarian carcinoma. Oncol Lett. 15:6604–6610. 2018.PubMed/NCBI

22 

Zhang Z, Wang Q, Li P, Zhou Y, Li S, Yi W, Chen A, Kong P and Hu C: Overexpression of the Interferon regulatory factor 4-binding protein in human colorectal cancer and its clinical significance. Cancer Epidemiol. 33:130–136. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Otsubo T, Hida Y, Ohga N, Sato H, Kai T, Matsuki Y, Takasu H, Akiyama K, Maishi N, Kawamoto T, et al: Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells. Cancer Sci. 105:560–567. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Liao Y, Yin G, Wang X, Zhong P, Fan X and Huang C: Identification of candidate genes associated with the pathogenesis of small cell lung cancer via integrated bioinformatics analysis. Oncol Lett. 18:3723–3733. 2019.PubMed/NCBI

25 

Leek JT, Johnson WE, Parker HS, Jaffe AE and Storey JD: The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 28:882–883. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Zhu Z, He A, Lv T, Xu C, Lin L and Lin J: Overexpression of P4HB is correlated with poor prognosis in human clear cell renal cell carcinoma. Cancer Biomark. 26:431–439. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Martinez-Millana A, Hulst JM, Boon M, Witters P, Fernandez-Llatas C, Asseiceira I, Calvo-Lerma J, Basagoiti I, Traver V, De Boeck K, et al: Optimisation of children z-score calculation based on new statistical techniques. PLoS One. 13:e02083622018. View Article : Google Scholar : PubMed/NCBI

29 

Lv W, Yu X, Li W, Feng N, Feng T, Wang Y, Lin H and Qian B: Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma. Oncol Rep. 40:2698–2709. 2018.PubMed/NCBI

30 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Ru B, Wong CN, Tong Y, Zhong JY, Zhong SSW, Wu WC, Chu KC, Wong CY, Lau CY, Chen I, et al: TISIDB: An integrated repository portal for tumor-immune system interactions. Bioinformatics. 35:4200–4202. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Zheng Y: Dbl family guanine nucleotide exchange factors. Trends Biochem Sci. 26:724–732. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Cook DR, Rossman KL and Der CJ: Rho guanine nucleotide exchange factors: Regulators of Rho GTPase activity in development and disease. Oncogene. 33:4021–4035. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Vega FM and Ridley AJ: Rho GTPases in cancer cell biology. FEBS Lett. 582:2093–2101. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Jansen S, Gosens R, Wieland T and Schmidt M: Paving the Rho in cancer metastasis: Rho GTPases and beyond. Pharmacol Ther. 183:1–21. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Li H, Peyrollier K, Kilic G and Brakebusch C: Rho GTPases and cancer. Biofactors. 40:226–235. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Etienne-Manneville S and Hall A: Rho GTPases in cell biology. Nature. 420:629–635. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Hall A: Rho family GTPases. Biochem Soc Trans. 40:1378–1382. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Jaffe AB and Hall A: Rho GTPases: Biochemistry and biology. Annu Rev Cell Dev Biol. 21:247–269. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Chiyomaru T, Tatarano S, Kawakami K, Enokida H, Yoshino H, Nohata N, Fuse M, Seki N and Nakagawa M: SWAP70, actin-binding protein, function as an oncogene targeting tumor-suppressive miR-145 in prostate cancer. Prostate. 71:1559–1567. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Liew PL, Fang CY, Lee YC, Lee YC, Chen CL and Chu JS: DEF6 expression in ovarian carcinoma correlates with poor patient survival. Diagn Pathol. 11:682016. View Article : Google Scholar : PubMed/NCBI

44 

Worthmann K, Leitges M, Teng B, Sestu M, Tossidou I, Samson T, Haller H, Huber TB and Schiffer M: Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι. Am J Pathol. 183:1945–1959. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Lazo JS, McQueeney KE, Burnett JC, Wipf P and Sharlow ER: Small molecule targeting of PTPs in cancer. Int J Biochem Cell Biol. 96:171–181. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Porcu M, Kleppe M, Gianfelici V, Geerdens E, De Keersmaecker K, Tartaglia M, Foà R, Soulier J, Cauwelier B, Uyttebroeck A, et al: Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia. Blood. 119:4476–4479. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Reichardt P, Patzak I, Jones K, Etemire E, Gunzer M and Hogg N: A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. EMBO J. 32:829–843. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Merten C, Zuschratter W, et al: T cell activation results in conformational changes in the Src family kinase Lck to induce its activation. Sci Signal. 6:ra132013. View Article : Google Scholar : PubMed/NCBI

49 

Clarke CN, Lee MS, Wei W, Manyam G, Jiang ZQ, Lu Y, Morris J, Broom B, Menter D, Vilar-Sanchez E, et al: Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival. Ann Surg Oncol. 24:4051–4058. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Chakraborty G, Rangaswami H, Jain S and Kundu GC: Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis. J Biol Chem. 281:11322–11331. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Mahabeleshwar GH and Kundu GC: Tyrosine kinase p56lck regulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkappaBalpha following hypoxia/reoxygenation. J Biol Chem. 278:52598–52612. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Rowshanravan B, Halliday N and Sansom DM: CTLA-4: A moving target in immunotherapy. Blood. 131:58–67. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Poprach A, Lakomý R and Büchler T: Immunotherapy of Renal Cell Carcinoma. Klin Onkol. 30 (Suppl 3):55–61. 2017.(In Czech). View Article : Google Scholar : PubMed/NCBI

54 

Geissler K, Fornara P, Lautenschläger C, Holzhausen HJ, Seliger B and Riemann D: Immune signature of tumor infiltrating immune cells in renal cancer. OncoImmunology. 4:e9850822015. View Article : Google Scholar : PubMed/NCBI

55 

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, et al: PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 515:568–571. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, et al: Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 19:723–732. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu ZP, Lin LR, Lv TD, Xu CR, Cai TY and Lin J: High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma. Oncol Rep 44: 2056-2066, 2020.
APA
Zhu, Z., Lin, L., Lv, T., Xu, C., Cai, T., & Lin, J. (2020). High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma. Oncology Reports, 44, 2056-2066. https://doi.org/10.3892/or.2020.7736
MLA
Zhu, Z., Lin, L., Lv, T., Xu, C., Cai, T., Lin, J."High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma". Oncology Reports 44.5 (2020): 2056-2066.
Chicago
Zhu, Z., Lin, L., Lv, T., Xu, C., Cai, T., Lin, J."High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma". Oncology Reports 44, no. 5 (2020): 2056-2066. https://doi.org/10.3892/or.2020.7736
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu ZP, Lin LR, Lv TD, Xu CR, Cai TY and Lin J: High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma. Oncol Rep 44: 2056-2066, 2020.
APA
Zhu, Z., Lin, L., Lv, T., Xu, C., Cai, T., & Lin, J. (2020). High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma. Oncology Reports, 44, 2056-2066. https://doi.org/10.3892/or.2020.7736
MLA
Zhu, Z., Lin, L., Lv, T., Xu, C., Cai, T., Lin, J."High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma". Oncology Reports 44.5 (2020): 2056-2066.
Chicago
Zhu, Z., Lin, L., Lv, T., Xu, C., Cai, T., Lin, J."High expression levels of DEF6 predicts a poor prognosis for patients with clear cell renal cell carcinoma". Oncology Reports 44, no. 5 (2020): 2056-2066. https://doi.org/10.3892/or.2020.7736
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