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Article Open Access

FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma

  • Authors:
    • Rongrong Li
    • Huan Wu
    • Huiyang Jiang
    • Qiuman Wang
    • Zhiyuan Dou
    • Hanlin Ma
    • Shi Yan
    • Cunzhong Yuan
    • Ning Yang
    • Beihua Kong
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2143-2151
    |
    Published online on: September 3, 2020
       https://doi.org/10.3892/or.2020.7749
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Abstract

High-grade serous ovarian carcinoma (HGSOC) is one of the most lethal gynecological malignancies; however, the precise molecular mechanisms have not been fully characterized. Fibulin‑5 (FBLN‑5) is an extracellular matrix (ECM) glycoprotein, and plays a crucial role in maintaining the stability of ECM structures, regulating cell proliferation and tumorigenesis. In the present study, the expression of FBLN‑5, as determined by western blot analysis and immunohistochemistry, was significantly increased in normal fallopian tube (FT) samples compared with that in HGSOC samples, and decreased FBLN5 expression was associated with unfavorable prognosis of HGSOC. Functional characterization revealed that FBLN5 overexpression significantly inhibited migration, invasion and proliferation abilities of ovarian cancer cells in vitro. Furthermore, micro (mi)RNA‑27a‑3p (miR‑27a‑3p) was revealed to be increased in HGSOC, and dual‑luciferase reporter assay indicated that miR‑27a‑3p was functioned as a negative regulator of FBLN5 by directly binding with its 3'‑untranslated region. Collectively, FBLN5 expression was associated with prognosis, proliferation, and metastasis in HGSOC. We hypothesized that FBLN5 was targeted by miR‑27a‑3p and may serve as a biomarker and provide a new therapeutic approach for the treatment of HGSOC.
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1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC Jr, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, et al: Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer. Nat Rev Cancer. 15:668–679. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Heo JH, Song JY, Jeong JY, Kim G, Kim TH, Kang H, Kwon AY and An HJ: Fibulin-5 is a tumour suppressor inhibiting cell migration and invasion in ovarian cancer. J Clin Pathol. 69:109–116. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Timpl R, Sasaki T, Kostka G and Chu ML: Fibulins: A versatile family of extracellular matrix proteins. Nat Rev Mol Cell Biol. 4:479–489. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Gallagher WM, Currid CA and Whelan LC: Fibulins and cancer: Friend or foe? Trends Mol Med. 11:336–340. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Obaya AJ, Rua S, Moncada-Pazos A and Cal S: The dual role of fibulins in tumorigenesis. Cancer Lett. 325:132–138. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Yanagisawa H, Schluterman MK and Brekken RA: Fibulin-5, an integrin-binding matricellular protein: Its function in development and disease. J Cell Commun Signal. 3:337–347. 2009. View Article : Google Scholar : PubMed/NCBI

9 

De Vega S, Iwamoto T and Yamada Y: Fibulins: Multiple roles in matrix structures and tissue functions. Cell Mol Life Sci. 66:1890–1902. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Albig AR and Schiemann WP: Fibulin-5 function during tumorigenesis. Future Oncol. 1:23–35. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Chen X, Song X, Yue W, Chen D, Yu J, Yao Z and Zhang L: Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer. Oncotarget. 6:150222015. View Article : Google Scholar : PubMed/NCBI

12 

Mohamedi Y, Fontanil T, Solares L, Garcia-Suárez O, García- Piqueras J, Vega JA, Cal S and Obaya AJ: Fibulin-5 downregulates Ki-67 and inhibits proliferation and invasion of breast cancer cells. Int J Oncol. 48:1447–1456. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Tu K, Dou C, Zheng X, Li C, Yang W, Yao Y and Liu Q: Fibulin-5 inhibits hepatocellular carcinoma cell migration and invasion by down-regulating matrix metalloproteinase-7 expression. BMC Cancer. 14:9382014. View Article : Google Scholar : PubMed/NCBI

14 

Yue W, Sun Q, Landreneau R, Wu C, Siegfried JM, Yu J and Zhang L: Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression. Cancer Res. 69:6339–6346. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S and Miyazono K: Modulation of microRNA processing by p53. Nature. 460:529–533. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Ranganathan K and Sivasankar V: MicroRNAs-biology and clinical applications. J Oral Maxillofac Pathol. 18:229–234. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Svoronos AA, Engelman DM and Slack FJ: OncomiR or tumor suppressor? The duplicity of microRNAs in cancer. Cancer Res. 76:3666–3670. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Guo D, Li Y, Chen Y, Zhang D, Wang X, Lu G, Ren M, Lu X and He S: DANCR promotes HCC progression and regulates EMT by sponging miR-27a-3p via ROCK1/LIMK1/COFILIN1 pathway. Cell Prolif. 52:e126282019. View Article : Google Scholar : PubMed/NCBI

19 

Li L and Luo Z: Dysregulated miR-27a-3p promotes nasopharyngeal carcinoma cell proliferation and migration by targeting Mapk10. Oncol Rep. 37:2679–2687. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Zeng G, Xun W, Wei K, Yang Y and Shen H: MicroRNA-27a-3p regulates epithelial to mesenchymal transition via targeting YAP1 in oral squamous cell carcinoma cells. Oncol Rep. 36:1475–1482. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Yamauchi Y, Tsuruga E, Nakashima K, Sawa Y and Ishikawa H: Fibulin-4 and-5, but not fibulin-2, are associated with tropoelastin deposition in elastin-producing cell culture. Acta Histochem Cytochem. 43:131–138. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45((W1)): W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 4:e050052015. View Article : Google Scholar

25 

Betel D, Wilson M, Gabow A, Marks DS and Sander C: The microRNA.org resource: Targets and expression. Nucleic Acids Res. 36((Database Issue)): D149–D153. 2008.PubMed/NCBI

26 

Li E, Han K and Zhou X: microRNA-27a-3p down-regulation inhibits malignant biological behaviors of ovarian cancer by targeting BTG1. Open Med (Wars). 14:577–585. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Wang Z, Ji G, Wu Q, Feng S, Zhao Y, Cao Z and Tao C: Integrated microarray meta-analysis identifies miRNA-27a as an oncogene in ovarian cancer by inhibiting FOXO1. Life Sci. 210:263–270. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Armstrong DK, Bundy B, Wenzel L, Huang HQ, Baergen R, Lele S, Copeland LJ, Walker JL and Burger RA; Gynecologic Oncology Group, : Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med. 354:34–43. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Chan JK, Cheung MK, Husain A, Teng NN, West D, Whittemore AS, Berek JS and Osann K: Patterns and progress in ovarian cancer over 14 years. Obstet Gynecol. 108:521–528. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Kurman RJ: Origin and molecular pathogenesis of ovarian high- grade serous carcinoma. Ann Oncol. 24 (Suppl 10):x16–x21. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Mezzanzanica D: Ovarian cancer: A molecularly insidious disease. Chin J Cancer. 34:1–3. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Schiemann WP, Blobe GC, Kalume DE, Pandey A and Lodish HF: Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. J Biol Chem. 277:27367–27377. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Li H, Guan H, Guo Y, Liang W, Liu L, He X, Ke W, Cao X, Xiao H and Li Y: CITED1 promotes proliferation of papillary thyroid cancer cells via the regulation of p21 and p27. Cell Biosci. 8:572018. View Article : Google Scholar : PubMed/NCBI

34 

Dongre A and Weinberg RA: New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol. 20:69–84. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Lee YH, Albig AR, Regner M, Schiemann BJ and Schiemann WP: Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis. 29:2243–2251. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Pastushenko I and Blanpain C: EMT transition states during tumor progression and metastasis. Trends Cell Biol. 29:212–226. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Wang W, Chen H, Gao W, Wang S, Wu K, Lu C, Luo X, Li L and Yu C: Girdin interaction with vimentin induces EMT and promotes the growth and metastasis of pancreatic ductal adenocarcinoma. Oncol Rep. 44:637–649. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Chong GO, Jeon H-S, Han HS, Son JW, Lee YH, Hong DG, Lee YS and Cho YL: Differential microRNA expression profiles in primary and recurrent epithelial ovarian cancer. Anticancer Res. 35:2611–2617. 2015.PubMed/NCBI

39 

Llauradó M, Majem B, Altadill T, Lanau L, Castellví J, Sánchez-Iglesias JL, Cabrera S, De la Torre J, Díaz-Feijoo B, Pérez-Benavente A, et al: MicroRNAs as prognostic markers in ovarian cancer. Mol Cell Endocrinol. 390:73–84. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Xu W, Liu M, Peng X, Zhou P, Zhou J, Xu K, Xu H and Jiang S: miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1. Int J Oncol. 42:757–766. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li R, Wu H, Jiang H, Wang Q, Dou Z, Ma H, Yan S, Yuan C, Yang N, Kong B, Kong B, et al: FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma. Oncol Rep 44: 2143-2151, 2020.
APA
Li, R., Wu, H., Jiang, H., Wang, Q., Dou, Z., Ma, H. ... Kong, B. (2020). FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma. Oncology Reports, 44, 2143-2151. https://doi.org/10.3892/or.2020.7749
MLA
Li, R., Wu, H., Jiang, H., Wang, Q., Dou, Z., Ma, H., Yan, S., Yuan, C., Yang, N., Kong, B."FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma". Oncology Reports 44.5 (2020): 2143-2151.
Chicago
Li, R., Wu, H., Jiang, H., Wang, Q., Dou, Z., Ma, H., Yan, S., Yuan, C., Yang, N., Kong, B."FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma". Oncology Reports 44, no. 5 (2020): 2143-2151. https://doi.org/10.3892/or.2020.7749
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Wu H, Jiang H, Wang Q, Dou Z, Ma H, Yan S, Yuan C, Yang N, Kong B, Kong B, et al: FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma. Oncol Rep 44: 2143-2151, 2020.
APA
Li, R., Wu, H., Jiang, H., Wang, Q., Dou, Z., Ma, H. ... Kong, B. (2020). FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma. Oncology Reports, 44, 2143-2151. https://doi.org/10.3892/or.2020.7749
MLA
Li, R., Wu, H., Jiang, H., Wang, Q., Dou, Z., Ma, H., Yan, S., Yuan, C., Yang, N., Kong, B."FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma". Oncology Reports 44.5 (2020): 2143-2151.
Chicago
Li, R., Wu, H., Jiang, H., Wang, Q., Dou, Z., Ma, H., Yan, S., Yuan, C., Yang, N., Kong, B."FBLN5 is targeted by microRNA‑27a‑3p and suppresses tumorigenesis and progression in high‑grade serous ovarian carcinoma". Oncology Reports 44, no. 5 (2020): 2143-2151. https://doi.org/10.3892/or.2020.7749
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