Open Access

STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway

  • Authors:
    • Yi Zhong
    • Zhengchao Hu
    • Jingcui Wu
    • Fan Dai
    • Feng Lee
    • Yangping Xu
  • View Affiliations

  • Published online on: September 16, 2020     https://doi.org/10.3892/or.2020.7769
  • Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Double‑stranded RNA‑binding protein Staufen homolog 1 (STAU1) is a highly conserved multifunctional double‑stranded RNA‑binding protein, and is a key factor in neuronal differentiation. RNA sequencing was used to analyze the overall transcriptional levels of the upregulated cells by STAU1 and control cells, and select alternative splicing (AS). It was determined that the high expression of STAU1 led to changes in the expression levels of a variety of inflammatory and immune response genes, including IFIT2, IFIT3, OASL, and CCL2. Furthermore, STAU1 was revealed to exert a significant regulatory effect on the AS of genes related to the ‘nerve growth factor receptor signaling pathway’. This is of significant importance for neuronal survival, differentiation, growth, post‑damage repair, and regeneration. In conclusion, overexpression of STAU1 was associated with immune response and regulated AS of pathways related to neuronal growth and repair. In the present study, the whole transcriptome of STAU1 expression was first analyzed, which laid a foundation for further understanding the key functions of STAU1.

Related Articles

Journal Cover

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhong Y, Hu Z, Wu J, Dai F, Lee F and Xu Y: STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway. Oncol Rep 0: 0-0, 1899
APA
Zhong, Y., Hu, Z., Wu, J., Dai, F., Lee, F., & Xu, Y. (1899). STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway. Oncology Reports, 0, 0-0. https://doi.org/10.3892/or.2020.7769
MLA
Zhong, Y., Hu, Z., Wu, J., Dai, F., Lee, F., Xu, Y."STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway". Oncology Reports 0.0 (1899): 0-0.
Chicago
Zhong, Y., Hu, Z., Wu, J., Dai, F., Lee, F., Xu, Y."STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway". Oncology Reports 0, no. 0 (1899): 0-0. https://doi.org/10.3892/or.2020.7769