Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November-2020 Volume 44 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2020 Volume 44 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.xlsx
Article

Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

  • Authors:
    • Sona Vodenkova
    • Michal Kroupa
    • Zdenka Polivkova
    • Ludovit Musak
    • Miloslav Ambrus
    • Michaela Schneiderova
    • Renata Kozevnikovova
    • Ludmila Vodickova
    • Sivaramakrishna Rachakonda
    • Kari Hemminki
    • Rajiv Kumar
    • Pavel Vodicka
  • View Affiliations / Copyright

    Affiliations: Department of Medical Genetics, Third Faculty of Medicine, Charles University, Prague 100 00, Czech Republic, Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague 142 00, Czech Republic, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin 036 01, Slovakia, Department of Radiology and Oncology, Faculty Hospital Kralovske Vinohrady, Prague 100 34, Czech Republic, Department of Surgery, Faculty Hospital Kralovske Vinohrady, Prague 100 34, Czech Republic, Department of Oncosurgery, Medicon, Prague 140 00, Czech Republic, Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg 691 20, Germany, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen 323 00, Czech Republic
  • Pages: 2219-2230
    |
    Published online on: September 21, 2020
       https://doi.org/10.3892/or.2020.7774
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Accumulation of non‑specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer‑free control individuals were investigated. These results were then correlated with clinicopathological factors and follow‑up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid‑type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer.
View Figures

Figure 1

Figure 2

View References

1 

Schvartzman JM, Sotillo R and Benezra R: Mitotic chromosomal instability and cancer: Mouse modelling of the human disease. Nat Rev Cancer. 10:102–115. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Hasty P and Montagna C: Chromosomal rearrangements in cancer: Detection and potential causal mechanisms. Mol Cell Oncol. 1:e299042014. View Article : Google Scholar : PubMed/NCBI

3 

Chatterjee A, Rodger EJ and Eccles MR: Epigenetic drivers of tumourigenesis and cancer metastasis. Semin Cancer Biol. 51:149–159. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Obe G, Pfeiffer P, Savage JR, Johannes C, Goedecke W, Jeppesen P, Natarajan AT, Martínez-López W, Folle GA and Drets ME: Chromosomal aberrations: Formation, identification and distribution. Mutat Res. 504:17–36. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Natarajan AT and Palitti F: DNA repair and chromosomal alterations. Mutat Res. 657:3–7. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Bignold LP: Mechanisms of clastogen-induced chromosomal aberrations: A critical review and description of a model based on failures of tethering of DNA strand ends to strand-breaking enzymes. Mutat Res. 681:271–298. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Mateuca RA, Decordier I and Kirsch-Volders M: Cytogenetic methods in human biomonitoring: principles and uses. Methods Mol Biol. 817:305–334. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Musak L, Smerhovsky Z, Halasova E, Osina O, Letkova L, Vodickova L, Polakova V, Buchancova J, Hemminki K and Vodicka P: Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde. Scand J Work Environ Health. 39:618–630. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Hagmar L, Stromberg U, Bonassi S, Hansteen IL, Knudsen LE, Lindholm C and Norppa H: Impact of types of lymphocyte chromosomal aberrations on human cancer risk: Results from Nordic and Italian cohorts. Cancer Res. 64:2258–2263. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Bonassi S, Norppa H, Ceppi M, Strömberg U, Vermeulen R, Znaor A, Cebulska-Wasilewska A, Fabianova E, Fucic A, Gundy S, et al: Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: Results from a pooled cohort study of 22 358 subjects in 11 countries. Carcinogenesis. 29:1178–1183. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Vodicka P, Polivkova Z, Sytarova S, Demova H, Kucerova M, Vodickova L, Polakova V, Naccarati A, Smerhovsky Z, Ambrus M, et al: Chromosomal damage in peripheral blood lymphocytes of newly diagnosed cancer patients and healthy controls. Carcinogenesis. 31:1238–1241. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Vodenkova S, Polivkova Z, Musak L, Smerhovsky Z, Zoubkova H, Sytarova S, Kavcova E, Halasova E, Vodickova L, Jiraskova K, et al: Structural chromosomal aberrations as potential risk markers in incident cancer patients. Mutagenesis. 30:557–563. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Albertson DG, Collins C, McCormick F and Gray JW: Chromosome aberrations in solid tumors. Nat Genet. 34:369–376. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Boffetta P, van der Hel O, Norppa H, Fabianova E, Fucic A, Gundy S, Lazutka J, Cebulska-Wasilewska A, Puskailerova D, Znaor A, et al: Chromosomal aberrations and cancer risk: Results of a cohort study from Central Europe. Am J Epidemiol. 165:36–43. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Li H, Hilmarsen HT, Hossain MB, Björk J, Hansteen IL, Albin M, Furu Skjelbred C and Broberg K: Telomere length and LINE1 methylation is associated with chromosomal aberrations in peripheral blood. Genes Chromosomes Cancer. 52:1–10. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Xu L, Li S and Stohr BA: The role of telomere biology in cancer. Annu Rev Pathol. 8:49–78. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Hemminki K, Rachakonda S, Musak L, Vymetalkova V, Halasova E, Försti A, Vodickova L, Buchancova J, Vodicka P and Kumar R: Telomere length in circulating lymphocytes: Association with chromosomal aberrations. Genes Chromosomes Cancer. 54:194–196. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Heidenreich B and Kumar R: TERT promoter mutations in telomere biology. Mutat Res. 771:15–31. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Maciejowski J and de Lange T: Telomeres in cancer: Tumour suppression and genome instability. Nat Rev Mol Cell Biol. 18:175–186. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Shay JW: Role of telomeres and telomerase in aging and cancer. Cancer Discov. 6:584–593. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Ernst A, Jones DT, Maass KK, Rode A, Deeg KI, Jebaraj BM, Korshunov A, Hovestadt V, Tainsky MA, Pajtler KW, et al: Telomere dysfunction and chromothripsis. Int J Cancer. 138:2905–2914. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Rossner P, Cerna M, Bavorova H, Pastorkova A and Ocadlikova D: Monitoring of human exposure to occupational genotoxicants. Cent Eur J Public Health. 3:219–223. 1995.PubMed/NCBI

23 

Cawthon RM: Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res. 37:e212009. View Article : Google Scholar : PubMed/NCBI

24 

Heidenreich B, Rachakonda PS, Hosen I, Volz F, Hemminki K, Weyerbrock A and Kumar R: TERT promoter mutations and telomere length in adult malignant gliomas and recurrences. Oncotarget. 6:10617–10633. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Hosen I, Rachakonda PS, Heidenreich B, de Verdier PJ, Ryk C, Steineck G, Hemminki K and Kumar R: Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. Int J Cancer. 137:1621–1629. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Kroupa M, Polivkova Z, Rachakonda S, Schneiderova M, Vodenkova S, Buchler T, Jiraskova K, Urbanova M, Vodickova L, Hemminki K, et al: Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients. Genes Chromosomes Cancer. 57:61–69. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Lemon SC, Roy J, Clark MA, Friedmann PD and Rakowski W: Classification and regression tree analysis in public health: Methodological review and comparison with logistic regression. Ann Behav Med. 26:172–181. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Negrini S, Gorgoulis VG and Halazonetis TD: Genomic instability-an evolving hallmark of cancer. Nat Rev Mol Cell Biol. 11:220–228. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Gisselsson D: Chromosome instability in cancer: How, when, and why? Adv Cancer Res. 87:1–29. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Gay-Bellile M, Romero P, Cayre A, Véronèse L, Privat M, Singh S, Combes P, Kwiatkowski F, Abrial C, Bignon YJ, et al: ERCC1 and telomere status in breast tumours treated with neoadjuvant chemotherapy and their association with patient prognosis. J Pathol Clin Res. 2:234–246. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels P, Sayer AA, Barbieri M, et al: Gender and telomere length: systematic review and meta-analysis. Exp Gerontol. 51:15–27. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Mayer S, Bruderlein S, Perner S, Waibel I, Holdenried A, Ciloglu N, Hasel C, Mattfeldt T, Nielsen KV and Möller P: Sex-specific telomere length profiles and age-dependent erosion dynamics of individual chromosome arms in humans. Cytogenet Genome Res. 112:194–201. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Nawrot TS, Staessen JA, Gardner JP and Aviv A: Telomere length and possible link to X chromosome. Lancet. 363:507–510. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A and Inoue M: Estrogen activates telomerase. Cancer Res. 59:5917–5921. 1999.PubMed/NCBI

36 

Misiti S, Nanni S, Fontemaggi G, Cong YS, Wen J, Hirte HW, Piaggio G, Sacchi A, Pontecorvi A, Bacchetti S and Farsetti A: Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol. 20:3764–3771. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Svenson U, Nordfjall K, Stegmayr B, Manjer J, Nilsson P, Tavelin B, Henriksson R, Lenner P and Roos G: Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Res. 68:3618–3623. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Gramatges MM, Telli ML, Balise R and Ford JM: Longer relative telomere length in blood from women with sporadic and familial breast cancer compared with healthy controls. Cancer Epidemiol Biomarkers Prev. 19:605–613. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Levy T, Agoulnik I, Atkinson EN, Tong XW, Gause HM, Hasenburg A, Runnebaum IB, Stickeler E, Möbus VJ, Kaplan AL and Kieback DG: Telomere length in human white blood cells remains constant with age and is shorter in breast cancer patients. Anticancer Res. 18:1345–1349. 1998.PubMed/NCBI

40 

Pooley KA, Sandhu MS, Tyrer J, Shah M, Driver KE, Luben RN, Bingham SA, Ponder BA, Pharoah PD, Khaw KT, et al: Telomere length in prospective and retrospective cancer case-control studies. Cancer Res. 70:3170–3176. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Qu S, Wen W, Shu XO, Chow WH, Xiang YB, Wu J, Ji BT, Rothman N, Yang G, Cai Q, et al: Association of leukocyte telomere length with breast cancer risk: Nested case-control findings from the Shanghai Women's Health Study. Am J Epidemiol. 177:617–624. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Shen J, Terry MB, Gurvich I, Liao Y, Senie RT and Santella RM: Short telomere length and breast cancer risk: A study in sister sets. Cancer Res. 67:5538–5544. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Shen J, Gammon MD, Terry MB, Wang Q, Bradshaw P, Teitelbaum SL, Neugut AI and Santella RM: Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer. 124:1637–1643. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Zheng YL, Ambrosone C, Byrne C, Davis W, Nesline M and McCann SE: Telomere length in blood cells and breast cancer risk: Investigations in two case-control studies. Breast Cancer Res Treat. 120:769–775. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Bernadotte A, Mikhelson VM and Spivak IM: Markers of cellular senescence. Telomere shortening as a marker of cellular senescence. Aging (Albany NY). 8:3–11. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Xu X, Qu K, Pang Q, Wang Z, Zhou Y and Liu C: Association between telomere length and survival in cancer patients: A meta-analysis and review of literature. Front Med. 10:191–203. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Venkatesan S, Natarajan AT and Hande MP: Chromosomal instability-mechanisms and consequences. Mutat Res Genet Toxicol Environ Mutagen. 793:176–184. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Tanaka K and Hirota T: Chromosomal instability: A common feature and a therapeutic target of cancer. Biochim Biophys Acta. 1866:64–75. 2016.PubMed/NCBI

49 

Ennour-Idrissi K, Maunsell E and Diorio C: Telomere length and breast cancer prognosis: A systematic review. Cancer Epidemiol Biomarkers Prev. 26:3–10. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Kroupa M, Rachakonda SK, Liska V, Srinivas N, Urbanova M, Jiraskova K, Schneiderova M, Vycital O, Vymetalkova V, Vodickova L, et al: Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis. Br J Cancer. 121:344–350. 2019. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Vodenkova S, Kroupa M, Polivkova Z, Musak L, Ambrus M, Schneiderova M, Kozevnikovova R, Vodickova L, Rachakonda S, Hemminki K, Hemminki K, et al: Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients. Oncol Rep 44: 2219-2230, 2020.
APA
Vodenkova, S., Kroupa, M., Polivkova, Z., Musak, L., Ambrus, M., Schneiderova, M. ... Vodicka, P. (2020). Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients. Oncology Reports, 44, 2219-2230. https://doi.org/10.3892/or.2020.7774
MLA
Vodenkova, S., Kroupa, M., Polivkova, Z., Musak, L., Ambrus, M., Schneiderova, M., Kozevnikovova, R., Vodickova, L., Rachakonda, S., Hemminki, K., Kumar, R., Vodicka, P."Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients". Oncology Reports 44.5 (2020): 2219-2230.
Chicago
Vodenkova, S., Kroupa, M., Polivkova, Z., Musak, L., Ambrus, M., Schneiderova, M., Kozevnikovova, R., Vodickova, L., Rachakonda, S., Hemminki, K., Kumar, R., Vodicka, P."Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients". Oncology Reports 44, no. 5 (2020): 2219-2230. https://doi.org/10.3892/or.2020.7774
Copy and paste a formatted citation
x
Spandidos Publications style
Vodenkova S, Kroupa M, Polivkova Z, Musak L, Ambrus M, Schneiderova M, Kozevnikovova R, Vodickova L, Rachakonda S, Hemminki K, Hemminki K, et al: Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients. Oncol Rep 44: 2219-2230, 2020.
APA
Vodenkova, S., Kroupa, M., Polivkova, Z., Musak, L., Ambrus, M., Schneiderova, M. ... Vodicka, P. (2020). Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients. Oncology Reports, 44, 2219-2230. https://doi.org/10.3892/or.2020.7774
MLA
Vodenkova, S., Kroupa, M., Polivkova, Z., Musak, L., Ambrus, M., Schneiderova, M., Kozevnikovova, R., Vodickova, L., Rachakonda, S., Hemminki, K., Kumar, R., Vodicka, P."Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients". Oncology Reports 44.5 (2020): 2219-2230.
Chicago
Vodenkova, S., Kroupa, M., Polivkova, Z., Musak, L., Ambrus, M., Schneiderova, M., Kozevnikovova, R., Vodickova, L., Rachakonda, S., Hemminki, K., Kumar, R., Vodicka, P."Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients". Oncology Reports 44, no. 5 (2020): 2219-2230. https://doi.org/10.3892/or.2020.7774
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team