Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
December-2020 Volume 44 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 44 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1

  • Authors:
    • Chi Zhang
    • Qi Wang
    • Xiaowen Zhou
    • Lei Zhang
    • Ying Yao
    • Juan Gu
    • Huairui Chen
    • Jun Qian
    • Chun Luo
    • Qingke Bai
    • Guohan Hu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Changzheng Hospital, Navy Medical University, Shanghai 200003, P.R. China, Department of Neurosurgery, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China, Department of Neurology, Changzheng Hospital, Navy Medical University, Shanghai 200003, P.R. China, Department of Operating Room, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China, Department of Neurology, Pudong People's Hospital, Shanghai 201200, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2559-2568
    |
    Published online on: October 15, 2020
       https://doi.org/10.3892/or.2020.7809
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Alterations in the expression of microRNA (miR)‑138 have been demonstrated to result in the development of several malignant tumours. However, the possible function of miR‑138 in human glioma cells remains unclear. The present study demonstrated that miR‑138 was significantly downregulated in 48 human glioma specimens by quantitative PCR analysis. The upregulation of miR‑138 exerted significant antiproliferative and anti‑invasive effects on glioma cells and promoted their apoptosis. In addition, cAMP response element‑binding protein 1 (CREB1) was confirmed as a direct target gene of miR‑138 by luciferase gene reporter assay, and the antitumour effect of miR‑138 on glioma cells was significantly reversed by CREB1 overexpression. Moreover, the molecular mechanisms underlying the tumour‑suppressive role of miR‑138 in malignant glioma may be associated with the dephosphorylation of AKT/mTOR caused by the miR‑138 upregulation‑induced decrease in CREB1 expression in glioma cells. The results of the present study indicated that miR‑138 may affect CREB1/AKT/mTOR signalling to regulate the proliferation, apoptosis and invasion of glioma cells and the malignant progression of glioma, thereby suggesting that miR‑138 may be a potential target for the treatment of gliomas.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Fearon C, Loftus T, Byrne AL, Heffernan J, Cooney M, Heeney C, Walsh A, Lorigan J, Beausang A, Cryan J, et al: Impact of the 2016 world health organization classification of tumours of the central nervous system: An Irish experience. Ir J Med Sci. 189:799–803. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Siegelin MD, Schneider E, Westhoff MA, Wirtz CR and arpel-Massler G: Current state and future perspective of drug repurposing in malignant glioma. Semin Cancer Biol. Nov 14–2019.(Epub ahead of print). doi: 10.1016/j.semcancer.2019.10.018. View Article : Google Scholar : PubMed/NCBI

3 

Tamura R, Miyoshi H, Yoshida K, Okano H and Toda M: Recent progress in the research of suicide gene therapy for malignant glioma. Neurosurg Rev. Nov 28–2019.(Epub ahead of print). doi: 10.1007/s10143-019-01203-3. View Article : Google Scholar

4 

Song T, Zhang X, Wang C, Wu Y, Cai W, Gao J and Hong B: MiR-138 suppresses expression of hypoxia-inducible factor 1α (HIF-1α) in clear cell renal cell carcinoma 786-O cells. Asian Pac J Cancer Prev. 12:1307–1311. 2011.PubMed/NCBI

5 

Islam M, Datta J, Lang JC and Teknos TN: Down regulation of RhoC by microRNA-138 results in de-activation of FAK, Src and Erk1/2 signaling pathway in head and neck squamous cell carcinoma. Oral Oncol. 50:448–456. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Zhu Z, Tang J, Wang J, Duan G, Zhou L and Zhou X: MiR-138 acts as a tumor suppressor by targeting EZH2 and enhances cisplatin-induced apoptosis in osteosarcoma cells. PLoS One. 11:e01500262016. View Article : Google Scholar : PubMed/NCBI

7 

Xiao L, Zhou H, Li XP, Chen J, Fang C, Mao CX, Cui JJ, Zhang W, Zhou HH, Yin JY and Liu ZQ: MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1. Oncotarget. 7:40038–40046. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Ma F, Zhang M, Gong W, Weng M and Quan Z: MiR-138 suppresses cell proliferation by targeting Bag-1 in gallbladder carcinoma. PLoS One. 10:e01264992015. View Article : Google Scholar : PubMed/NCBI

9 

Jiang B, Mu W, Wang J, Lu J, Jiang S, Li L, Xu H and Tian H: MicroRNA-138 functions as a tumor suppressor in osteosarcoma by targeting differentiated embryonic chondrocyte gene 2. J Exp Clin Cancer Res. 35:692016. View Article : Google Scholar : PubMed/NCBI

10 

Xu Y, Pan ZG, Shu L and Li QJ: Podocalyxin-like, targeted by miR-138, promotes colorectal cancer cell proliferation, migration, invasion and EMT. Eur Rev Med Pharmacol Sci. 22:8664–8674. 2018.PubMed/NCBI

11 

Nama S, Muhuri M, Di Pascale F, Quah S, Aswad L, Fullwood M and Sampath P: MicroRNA-138 is a prognostic biomarker for triple-negative breast cancer and promotes tumorigenesis via TUSC2 repression. Sci Rep. 9:127182019. View Article : Google Scholar : PubMed/NCBI

12 

Stojcheva N, Schechtmann G, Sass S, Roth P, Florea AM, Stefanski A, Stühler K, Wolter M, Müller NS, Theis FJ, et al: MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM. Oncotarget. 7:12937–12950. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Sakamoto KM and Frank DA: CREB in the pathophysiology of cancer: Implications for targeting transcription factors for cancer therapy. Clin Cancer Res. 15:2583–2587. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Zhang JQ, Yao QH, Kuang YQ, Ma Y, Yang LB, Huang HD, Cheng JM, Yang T, Liu EY, Liang L, et al: Prognostic value of coexistence of abnormal expression of micro-RNA-200b and cyclic adenosine monophosphate-responsive element-binding protein 1 in human astrocytoma. Hum Pathol. 45:2154–2161. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Yu L, Guo X, Zhang P, Qi R, Li Z and Zhang S: Cyclic adenosine monophosphate-responsive element-binding protein activation predicts an unfavorable prognosis in patients with hepatocellular carcinoma. Onco Targets Ther. 7:873–879. 2014.PubMed/NCBI

16 

Seo HS, Liu DD, Bekele BN, Kim MK, Pisters K, Lippman SM, Wistuba II and Koo JS: Cyclic AMP response element-binding protein overexpression: A feature associated with negative prognosis in never smokers with non-small cell lung cancer. Cancer Res. 68:6065–6073. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Rodon L, Gonzàlez-Juncà A, Inda Mdel M, Sala-Hojman A, Martínez-Sáez E and Seoane J: Active CREB1 promotes a malignant TGFβ2 autocrine loop in glioblastoma. Cancer Discov. 4:1230–1241. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Wang Q, Zhang L, Cui Y, Zhang C, Chen H, Gu J, Qian J and Luo C: Increased RLIP76 expression in IDH1 wildtype glioblastoma multiforme is associated with worse prognosis. Oncol Rep. 43:188–200. 2020.PubMed/NCBI

19 

Qiu S, Huang D, Yin D, Li F, Li X, Kung HF and Peng Y: Suppression of tumorigenicity by microRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiforme. Biochim Biophys Acta. 1832:1697–1707. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Wang Q, Qian J, Wang J, Luo C, Chen J, Hu G and Lu Y: Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells. J Neurooncol. 112:73–82. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB and Taniguchi T: MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. Mol Cancer Res. 9:1100–1111. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Syed SN and Brune B: MicroRNAs as emerging regulators of signaling in the tumor microenvironment. Cancers (Basel). 12:9112020. View Article : Google Scholar

24 

SiamiGorji S, Jorjani I, Tahamtan A and Moradi A: Effects of microRNAs polymorphism in cancer progression. Med J Islam Repub Iran. 34:32020.PubMed/NCBI

25 

Sandiford OA, Moore CA, Du J, Boulad M, Gergues M, Eltouky H and Rameshwar P: Human aging and cancer: Role of miRNA in tumor microenvironment. Adv Exp Med Biol. 1056:137–152. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Yang Y, Liu X, Cheng L, Li L, Wei Z, Wang Z, Han G, Wan X, Wang Z, Zhang J and Chen C: Tumor suppressor microRNA-138 suppresses low-grade glioma development and metastasis via regulating IGF2BP2. Onco Targets Ther. 13:2247–2260. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Chan XH, Nama S, Gopal F, Rizk P, Ramasamy S, Sundaram G, Ow GS, Ivshina AV, Tanavde V, Haybaeck J, et al: Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas. Cell Rep. 2:591–602. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Alcantara Llaguno SR, Xie X and Parada LF: Cell of origin and cancer stem cells in tumor suppressor mouse models of glioblastoma. Cold Spring Harb Symp Quant Biol. 81:31–36. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Aldaz B, Sagardoy A, Nogueira L, Guruceaga E, Grande L, Huse JT, Aznar MA, Díez-Valle R, Tejada-Solís S, Alonso MM, et al: Involvement of miRNAs in the differentiation of human glioblastoma multiforme stem-like cells. PLoS One. 8:e770982013. View Article : Google Scholar : PubMed/NCBI

30 

Song H, Zhang Y, Liu N, Zhao S, Kong Y and Yuan L: MiR-92a-3p exerts various effects in glioma and glioma stem-like cells specifically targeting CDH1/β-catenin and Notch-1/Akt signaling pathways. Int J Mol Sci. 17:17992016. View Article : Google Scholar

31 

Sha HH, Wang DD, Chen D, Liu SW, Wang Z, Yan DL, Dong SC and Feng JF: MiR-138: A promising therapeutic target for cancer. Tumour Biol. 39:10104283176975752017. View Article : Google Scholar : PubMed/NCBI

32 

Huang H, Xiong Y, Wu Z, He Y, Gao X, Zhou Z and Wang T: MIR-138-5P inhibits the progression of prostate cancer by targeting FOXC1. Mol Genet Genomic Med. 8:e11932020. View Article : Google Scholar : PubMed/NCBI

33 

Hrdlickova R, Nehyba J, Bargmann W and Bose HR Jr: Multiple tumor suppressor microRNAs regulate telomerase and TCF7, an important transcriptional regulator of the Wnt pathway. PLoS One. 9:e869902014. View Article : Google Scholar : PubMed/NCBI

34 

Zheng KB, Xie J, Li YT, Yuan Y, Wang Y, Li C and Shi YF: Knockdown of CERB expression inhibits proliferation and migration of glioma cells line U251. Bratisl Lek Listy. 120:309–315. 2019.PubMed/NCBI

35 

Robison NJ and Kieran MW: Identification of novel biologic targets in the treatment of newly diagnosed diffuse intrinsic pontine glioma. Am Soc Clin Oncol Educ Book. 2012:625–628. 2012. View Article : Google Scholar

36 

Di Pascale F, Nama S, Muhuri M, Quah S, Ismail HM, Chan XH, Sundaram GM, Ramalingam R, Burke B and Sampath P: C/EBPβ mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas. Nucleic Acids Res. 46:336–349. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Vollmann-Zwerenz A, Leidgens V, Feliciello G, Klein CA and Hau P: Tumor cell invasion in glioblastoma. Int J Mol Sci. 21:19322020. View Article : Google Scholar

38 

Ferrer VP, Moura Neto V and Mentlein R: Glioma infiltration and extracellular matrix: Key players and modulators. Glia. 66:1542–1565. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Zhou W, Yu X, Sun S, Zhang X, Yang W, Zhang J, Zhang X and Jiang Z: Increased expression of MMP-2 and MMP-9 indicates poor prognosis in glioma recurrence. Biomed Pharmacother. 118:1093692019. View Article : Google Scholar : PubMed/NCBI

40 

Kast RE and Halatsch ME: Matrix metalloproteinase-2 and −9 in glioblastoma: A trio of old drugs-captopril, disulfiram and nelfinavir-are inhibitors with potential as adjunctive treatments in glioblastoma. Arch Med Res. 43:243–247. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Chintala SK, Tonn JC and Rao JS: Matrix metalloproteinases and their biological function in human gliomas. Int J Dev Neurosci. 17:495–502. 1999. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Wang Q, Zhou X, Zhang L, Yao Y, Gu J, Chen H, Qian J, Luo C, Bai Q, Bai Q, et al: MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1. Oncol Rep 44: 2559-2568, 2020.
APA
Zhang, C., Wang, Q., Zhou, X., Zhang, L., Yao, Y., Gu, J. ... Hu, G. (2020). MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1. Oncology Reports, 44, 2559-2568. https://doi.org/10.3892/or.2020.7809
MLA
Zhang, C., Wang, Q., Zhou, X., Zhang, L., Yao, Y., Gu, J., Chen, H., Qian, J., Luo, C., Bai, Q., Hu, G."MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1". Oncology Reports 44.6 (2020): 2559-2568.
Chicago
Zhang, C., Wang, Q., Zhou, X., Zhang, L., Yao, Y., Gu, J., Chen, H., Qian, J., Luo, C., Bai, Q., Hu, G."MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1". Oncology Reports 44, no. 6 (2020): 2559-2568. https://doi.org/10.3892/or.2020.7809
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Wang Q, Zhou X, Zhang L, Yao Y, Gu J, Chen H, Qian J, Luo C, Bai Q, Bai Q, et al: MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1. Oncol Rep 44: 2559-2568, 2020.
APA
Zhang, C., Wang, Q., Zhou, X., Zhang, L., Yao, Y., Gu, J. ... Hu, G. (2020). MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1. Oncology Reports, 44, 2559-2568. https://doi.org/10.3892/or.2020.7809
MLA
Zhang, C., Wang, Q., Zhou, X., Zhang, L., Yao, Y., Gu, J., Chen, H., Qian, J., Luo, C., Bai, Q., Hu, G."MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1". Oncology Reports 44.6 (2020): 2559-2568.
Chicago
Zhang, C., Wang, Q., Zhou, X., Zhang, L., Yao, Y., Gu, J., Chen, H., Qian, J., Luo, C., Bai, Q., Hu, G."MicroRNA‑138 modulates glioma cell growth, apoptosis and invasion through the suppression of the AKT/mTOR signalling pathway by targeting CREB1". Oncology Reports 44, no. 6 (2020): 2559-2568. https://doi.org/10.3892/or.2020.7809
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team