Open Access

Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis

  • Authors:
    • Lu Xu
    • Jing‑Lei Qu
    • Na Song
    • Ling‑Yun Zhang
    • Xue Zeng
    • Xiao‑Fang Che
    • Ke‑Zuo Hou
    • Sha Shi
    • Zu‑Ying Feng
    • Xiu‑Juan Qu
    • Yun‑Peng Liu
    • Yue‑E Teng
  • View Affiliations

  • Published online on: October 16, 2020     https://doi.org/10.3892/or.2020.7812
  • Pages: 2443-2454
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Flap endonuclease‑1 (FEN1), a structure‑specific nuclease participating in DNA replication and repair processes, has been confirmed to promote the proliferation and drug resistance of tumor cells. However, the biological functions of FEN1 in cancer cell migration and invasion have not been defined. In the present study, using online database analysis and immunohistochemistry of the specimens, it was found that FEN1 expression was associated with a highly invasive triple‑negative breast cancer (TNBC) subtype in both breast cancer samples from the Oncomine database and from patients recruited into the study. Furthermore, FEN1 was an important biomarker of lymph node metastasis and poor prognosis in patients with TNBC. FEN1 promoted migration of TNBC cell lines and FEN1 knockdown reduced the number of spontaneous lung metastasis in vivo. Ingenuity Pathway Analysis of FEN1‑related transcripts in 198 patients with TNBC demonstrated that the polo‑like kinase family may be the downstream target of FEN1. PLK4 was further identified as a critical target of FEN1 mediating TNBC cell migration, by regulating actin cytoskeleton rearrangement. The results of the present study validate FEN1 as a therapeutic target in patients with TNBC and revealed a new role for FEN1 in regulating TNBC invasion and metastasis.
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December-2020
Volume 44 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Xu L, Qu JL, Song N, Zhang LY, Zeng X, Che XF, Hou KZ, Shi S, Feng ZY, Qu XJ, Qu XJ, et al: Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis. Oncol Rep 44: 2443-2454, 2020
APA
Xu, L., Qu, J., Song, N., Zhang, L., Zeng, X., Che, X. ... Teng, Y. (2020). Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis. Oncology Reports, 44, 2443-2454. https://doi.org/10.3892/or.2020.7812
MLA
Xu, L., Qu, J., Song, N., Zhang, L., Zeng, X., Che, X., Hou, K., Shi, S., Feng, Z., Qu, X., Liu, Y., Teng, Y."Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis". Oncology Reports 44.6 (2020): 2443-2454.
Chicago
Xu, L., Qu, J., Song, N., Zhang, L., Zeng, X., Che, X., Hou, K., Shi, S., Feng, Z., Qu, X., Liu, Y., Teng, Y."Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis". Oncology Reports 44, no. 6 (2020): 2443-2454. https://doi.org/10.3892/or.2020.7812