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Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression

  • Authors:
    • Xiliang Guan
    • Yufen Xu
    • Jufen Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, People's Hospital of Rizhao, Rizhao, Shandong 276826, P.R. China, Department of Oncology, The First Hospital of Jiaxing and The Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314001, P.R. China, The Department of Bone, Zhejiang Hospital, Hangzhou, Zhejiang 310030, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2465-2474
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    Published online on: October 16, 2020
       https://doi.org/10.3892/or.2020.7813
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Abstract

Osteosarcoma is a severe malignant tumor. Several studies indicated that lncRNA prostate cancer‑associated transcript 6 (PCAT6) promoted the development of multiple types of cancers. Studies have also revealed that MDM2 could aggravate tumor symptoms inhibiting P53 expression. However, whether lncRNA PCAT6 could affect the proliferation and metastasis of osteosarcoma cells by regulating P53 expression is unclear. The present study established lncRNA PCAT6‑overexpressing osteosarcoma cells. Cell Counting Kit‑8, wound healing and Transwell assays were performed to detect the change in proliferation, migration and invasion of these cells, respectively. Subsequently, E3 ubiquitin‑protein ligase Mdm2 (MDM2), P53 and P21 expression were determined using western blotting. Finally, MDM2 expression was inhibited and the proliferation, migration and invasion of these cells was determined again. The present study found that the proliferation, migration and invasion of osteosarcoma cells increased following overexpression of lncRNA PCAT6. MDM2 expression was upregulated while the levels of P53 and P21 decreased following overexpression of lncRNA PCAT6. However, the proliferation, migration and invasion of osteosarcoma cells were inhibited following MDM2 knockdown. Additionally, P53 and P21 was rescued following MDM2 knockdown. To conclude, lncRNA PCAT6 promoted the proliferation, migration and invasion of osteosarcoma cells by promoting the expression of MDM2 and suppressing the expression of P53 and P21.
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1 

Ando K, Heymann MF, Stresing V, Mori K, Rédini F and Heymann D: Current therapeutic strategies and novel approaches in osteosarcoma. Cancers (Basel). 5:591–616. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Isakoff MS, Bielack SS, Meltzer P and Gorlick R: Osteosarcoma: Current treatment and a collaborative pathway to success. J Clin Oncol. 33:3029–3035. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Ottaviani G and Jaffe N: The epidemiology of osteosarcoma. Cancer Treat Res. 152:3–13. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Kong G, Qi XJ and Wang JF: Effect of lncRNA LET on proliferation and invasion of osteosarcoma cells. Eur Rev Med Pharmacol Sci. 22:1609–1614. 2018.PubMed/NCBI

5 

Yan L, Wu X, Liu Y and Xian W: LncRNA Linc00511 promotes osteosarcoma cell proliferation and migration through sponging miR-765. J Cell Biochem. Dec 28–2018.(Epub ahead of print).

6 

Li X, Wu Z, Fu X and Han W: Long noncoding RNAs: Insights from biological features and functions to diseases. Med Res Rev. 33:517–553. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Shi D, Wu F, Mu S, Hu B, Zhong B, Gao F, Qing X, Liu J, Zhang Z and Shao Z: LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway. J Exp Clin Cancer Res. 38:3752019. View Article : Google Scholar : PubMed/NCBI

9 

Jin Y, Feng SJ, Qiu S, Shao N and Zheng JH: LncRNA MALAT1 promotes proliferation and metastasis in epithelial ovarian cancer via the PI3K-AKT pathway. Eur Rev Med Pharmacol Sci. 21:3176–3184. 2017.PubMed/NCBI

10 

Liang H, Yu T, Han Y, Jiang H, Wang C, You T, Zhao X, Shan H, Yang R, Yang L, et al: LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression. Mol Cancer. 17:1192018. View Article : Google Scholar : PubMed/NCBI

11 

Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y and Liu XS: Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol. 20:908–913. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Kong FR, Lv YH, Yao HM, Zhang HY, Zhou Y and Liu SE: LncRNA PCAT6 promotes occurrence and development of ovarian cancer by inhibiting PTEN. Eur Rev Med Pharmacol Sci. 23:8230–8238. 2019.PubMed/NCBI

13 

Shi X, Liu Z, Liu Z, Feng X, Hua F, Hu X, Wang B, Lu K and Nie F: Long noncoding RNA PCAT6 functions as an oncogene by binding to EZH2 and suppressing LATS2 in non-small-cell lung cancer. EBioMedicine. 37:177–187. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Zhu C, Huang L, Xu F, Li P, Li P and Hu F: LncRNA PCAT6 promotes tumor progression in osteosarcoma via activation of TGF-β pathway by sponging miR-185-5p. Biochem Biophys Res Commun. 521:463–470. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Han R, Huang G, Wang Y, Xu Y, Hu Y, Jiang W, Wang T, Xiao T and Zheng D: Increased gene expression noise in human cancers is correlated with low p53 and immune activities as well as late stage cancer. Oncotarget. 7:72011–72020. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Sun X, Hu Y, Wu J, Shi L, Zhu L, Xi PW, Wei JF and Ding Q: RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer. J Exp Clin Cancer Res. 37:2982018. View Article : Google Scholar : PubMed/NCBI

17 

Hou PF, Jiang T, Chen F, Shi PC, Li HQ, Bai J and Song J: KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer. Cell Death Dis. 9:4772018. View Article : Google Scholar : PubMed/NCBI

18 

Kim EM, Jung CH, Kim J, Hwang SG, Park JK and Um HD: The p53/p21 complex regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins. Cancer Res. 77:3092–3100. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Seipel K, Marques MAT, Sidler C, Mueller BU and Pabst T: The cellular p53 inhibitor MDM2 and the growth factor receptor FLT3 as biomarkers for treatment responses to the MDM2-inhibitor idasanutlin and the MEK1 inhibitor cobimetinib in acute myeloid leukemia. Cancers (Basel). 10:1702018. View Article : Google Scholar

20 

Chen Y, Wang DD, Wu YP, Su D, Zhou TY, Gai RH, Fu YY, Zheng L, He QJ, Zhu H and Yang B: MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells. Br J Cancer. 117:1192–1201. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Deben C, Deschoolmeester V, Lardon F, Rolfo C and Pauwels P: TP53 and MDM2 genetic alterations in non-small cell lung cancer: Evaluating their prognostic and predictive value. Crit Rev Oncol Hematol. 99:63–73. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Mizoshiri N, Shirai T, Terauchi R, Tsuchida S, Mori Y, Hayashi D, Kishida T, Arai Y, Mazda O, Nakanishi T and Kubo T: The tetraspanin CD81 mediates the growth and metastases of human osteosarcoma. Cell Oncol (Dordr). 42:861–871. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Benassi MS, Gamberi G, Magagnoli G, Molendini L, Ragazzini P, Merli M, Chiesa F, Balladelli A, Manfrini M, Bertoni F, et al: Metalloproteinase expression and prognosis in soft tissue sarcomas. Ann Oncol. 12:75–80. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Wan L, Zhang L, Fan K, Cheng ZX, Sun QC and Wang JJ: Knockdown of long noncoding RNA PCAT6 inhibits proliferation and invasion in lung cancer cells. Oncol Res. 24:161–170. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Klein MJ and Siegal GP: Osteosarcoma: Anatomic and histologic variants. Am J Clin Pathol. 125:555–581. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Miller BJ, Gao Y and Duchman KR: Socioeconomic measures influence survival in osteosarcoma: An analysis of the national cancer data base. Cancer Epidemiol. 49:112–117. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Mirabello L, Troisi RJ and Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the surveillance, epidemiology, and end results program. Cancer. 115:1531–1543. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Mirabello L, Troisi RJ and Savage SA: International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer. 125:229–234. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Berger M, Fagioli F, Abate M, Riccardi R, Prete A, Cozza R, Bertulli R, Podda M, Ferrari S and Luksch R: Unusual sites of Ewing sarcoma (ES): A retrospective multicenter 30-year experience of the Italian association of pediatric hematology and oncology (AIEOP) and Italian sarcoma group (ISG). Eur J Cancer. 49:3658–3665. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Xu R, Feng F, Yu X, Liu Z and Lao L: LncRNA SNHG4 promotes tumour growth by sponging miR-224-3p and predicts poor survival and recurrence in human osteosarcoma. Cell Prolif. 51:e125152018. View Article : Google Scholar : PubMed/NCBI

32 

Chang L, Guo R, Yuan Z, Shi H and Zhang D: LncRNA HOTAIR regulates CCND1 and CCND2 expression by sponging miR-206 in ovarian cancer. Cell Physiol Biochem. 49:1289–1303. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Wu W, Gao H, Li X, Zhu Y, Peng S, Yu J, Zhan G, Wang J, Liu N and Guo X: LncRNA TPT1-AS1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT1 expression. Cancer Sci. 110:1587–1598. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Zhao H, Yu H, Zheng J, Ning N, Tang F, Yang Y and Wang Y: Lowly-expressed lncRNA GAS5 facilitates progression of ovarian cancer through targeting miR-196-5p and thereby regulating HOXA5. Gynecol Oncol. 151:345–355. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Li N and Zhan X and Zhan X: The lncRNA SNHG3 regulates energy metabolism of ovarian cancer by an analysis of mitochondrial proteomes. Gynecol Oncol. 150:343–354. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Wan L, Zhang L, Fan K and Wang JJ: Diagnostic significance of circulating long noncoding RNA PCAT6 in patients with non-small cell lung cancer. Onco Targets Ther. 10:5695–5702. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Shi Y, Lv C, Shi L and Tu G: MEG3 inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells. Oncol Lett. 15:1917–1923. 2018.PubMed/NCBI

38 

Wang B, Fang L, Zhao H, Xiang T and Wang D: MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. Acta Biochim Biophys Sin (Shanghai). 44:685–691. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Wang S, Zhao Y, Aguilar A, Bernard D and Yang CY: Targeting the MDM2-p53 protein-protein interaction for new cancer therapy: Progress and challenges. Cold Spring Harb Perspect Med. 7:a0262452017. View Article : Google Scholar : PubMed/NCBI

40 

Tovar C, Graves B, Packman K, Filipovic Z, Higgins B, Xia M, Tardell C, Garrido R, Lee E, Kolinsky K, et al: MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models. Cancer Res. 73:2587–2597. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Wang Y, Zeng X, Wang N, Zhao W, Zhang X, Teng S, Zhang Y and Lu Z: Long noncoding RNA DANCR, working as a competitive endogenous RNA, promotes ROCK1-mediated proliferation and metastasis via decoying of miR-335-5p and miR-1972 in osteosarcoma. Mol Cancer. 17:892018. View Article : Google Scholar : PubMed/NCBI

42 

Zhao W, Zhang D, Qin P, Zhang J, Cui X, Gao J, Wang J and Li J: Long non-coding RNA EPIC1 inhibits viability and invasion of osteosarcoma cells by promoting MEF2D ubiquitylation. Int J Biol Macromol. 128:566–573. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Hu T, Fei Z, Su H, Xie R and Chen L: Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling. Toxicol Appl Pharmacol. 371:55–62. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Li Z, Yang L, Liu X, Nie Z and Luo J: Long noncoding RNA MEG3 inhibits proliferation of chronic myeloid leukemia cells by sponging microRNA21. Biomed Pharmacother. 104:181–192. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Wang D and Hu Y: Long non-coding RNA PVT1 competitively binds MicroRNA-424-5p to regulate CARM1 in radiosensitivity of non-small-cell lung cancer. Mol Ther Nucleic Acids. 16:130–140. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Zhang Z, Zou G, Chen X, Lu W, Liu J, Zhai S and Qiao G: Knockdown of lncRNA PVT1 inhibits vascular smooth muscle cell apoptosis and extracellular matrix disruption in a murine abdominal aortic aneurysm model. Mol Cells. 42:218–227. 2019.PubMed/NCBI

47 

Finlay CA, Hinds PW and Levine AJ: The p53 proto-oncogene can act as a suppressor of transformation. Cell. 57:1083–1093. 1989. View Article : Google Scholar : PubMed/NCBI

48 

Bieging KT, Mello SS and Attardi LD: Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer. 14:359–370. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Wade M, Li YC and Wahl GM: MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer. 13:83–96. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Gunia S, Kakies C, Erbersdobler A, Hakenberg OW, Koch S and May M: Expression of p53, p21 and cyclin D1 in penile cancer: p53 predicts poor prognosis. J Clin Pathol. 65:232–236. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Li M, Li L, Zhang L, Hu W, Shen J, Xiao Z, Wu X, Chan FL and Cho CH: 1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21. Life Sci. 179:88–97. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Abolhasani M, Salarinejad S and Asgari M: P53 and MDM2 over-expression and five-year survival of kidney cancer patients undergoing radical nephrectomy-iranian experience. Asian Pac J Cancer Prev. 16:5043–5047. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Wu D, Niu X, Tao J, Li P, Lu Q, Xu A, Chen W and Wang Z: MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2. Oncol Rep. 37:3502–3508. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Chaar I, Amara S, Khiari M, Ounissi D, Dhraif M, Ben Hamida AE, Gharbi L, Mzabi S and Bouraoui S: Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population. Appl Immunohistochem Mol Morphol. 21:228–236. 2013.PubMed/NCBI

55 

Liu Y, Wang X, Wang G, Yang Y, Yuan Y and Ouyang L: The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy. Eur J Med Chem. 176:92–104. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Cui LH, Xu HR, Yang W and Yu LJ: lncRNA PCAT6 promotes non-small cell lung cancer cell proliferation, migration and invasion through regulating miR-330-5p. Onco Targets Ther. 11:7715–7724. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Wu H, Zou Q, He H, Liang Y, Lei M, Zhou Q, Fan D and Shen L: Long non-coding RNA PCAT6 targets miR-204 to modulate the chemoresistance of colorectal cancer cells to 5-fluorouracil-based treatment through HMGA2 signaling. Cancer Med. 8:2484–2495. 2019. View Article : Google Scholar : PubMed/NCBI

58 

Xin Y, He X, Zhao W, Zhan M, Li Y, Xiao J, He K and Lu L: LncRNA PCAT6 increased cholangiocarcinoma cell proliferation and invasion via modulating miR-330-5p. Am J Transl Res. 11:6185–6195. 2019.PubMed/NCBI

59 

Zhang J, Liu M, Liu W and Wang W: Ras-ERK1/2 signalling promotes the development of osteosarcoma through regulation of H4K12ac through HAT1. Artif Cells Nanomed Biotechnol. 47:1207–1215. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Chen W, Liu Q, Fu B, Liu K and Jiang W: Overexpression of GRIM-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization. Life Sci. 208:232–238. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guan X, Xu Y and Zheng J: Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression. Oncol Rep 44: 2465-2474, 2020.
APA
Guan, X., Xu, Y., & Zheng, J. (2020). Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression. Oncology Reports, 44, 2465-2474. https://doi.org/10.3892/or.2020.7813
MLA
Guan, X., Xu, Y., Zheng, J."Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression". Oncology Reports 44.6 (2020): 2465-2474.
Chicago
Guan, X., Xu, Y., Zheng, J."Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression". Oncology Reports 44, no. 6 (2020): 2465-2474. https://doi.org/10.3892/or.2020.7813
Copy and paste a formatted citation
x
Spandidos Publications style
Guan X, Xu Y and Zheng J: Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression. Oncol Rep 44: 2465-2474, 2020.
APA
Guan, X., Xu, Y., & Zheng, J. (2020). Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression. Oncology Reports, 44, 2465-2474. https://doi.org/10.3892/or.2020.7813
MLA
Guan, X., Xu, Y., Zheng, J."Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression". Oncology Reports 44.6 (2020): 2465-2474.
Chicago
Guan, X., Xu, Y., Zheng, J."Long non‑coding RNA PCAT6 promotes the development of osteosarcoma by increasing MDM2 expression". Oncology Reports 44, no. 6 (2020): 2465-2474. https://doi.org/10.3892/or.2020.7813
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