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Review

PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review)

  • Authors:
    • Chia‑Jung Li
    • Li‑Te Lin
    • Ming‑Feng Hou
    • Pei‑Yi Chu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C., Division of Breast Surgery, Department of Surgery, Center for Cancer Research, Kaohsiung Medical University Chung‑Ho Memorial Hospital, Kaohsiung 807, Taiwan, R.O.C., School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, Taiwan, R.O.C.
  • Pages: 5-12
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    Published online on: November 3, 2020
       https://doi.org/10.3892/or.2020.7831
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Abstract

Breast cancer is a common malignant tumor in women. Triple‑negative breast cancer (TNBC) is highly invasive with a high rate of metastasis and poor prognosis. Programmed death ligand 1 (PD‑L1) plays an important role in mediating the escape of tumor cells from immune surveillance. There have been significant advances in understanding the biology of TNBC. This review presents a detailed discourse on the available data on the expression of PD‑L1 in breast cancer and preliminary clinical outcome of PD‑L1/PD‑1 inhibitors in breast cancer patients. Early clinical trials involving PD‑L1/PD‑1 inhibitors have exhibited efficacy in tumor response and/or disease control in patients with refractory metastatic breast cancer, particularly TNBC. Furthermore, the mechanisms and factors that influence the immunoediting process are summarized and their functions in detail are analyzed.
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Copy and paste a formatted citation
Spandidos Publications style
Li CJ, Lin LT, Hou MF and Chu PY: PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review). Oncol Rep 45: 5-12, 2021.
APA
Li, C., Lin, L., Hou, M., & Chu, P. (2021). PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review). Oncology Reports, 45, 5-12. https://doi.org/10.3892/or.2020.7831
MLA
Li, C., Lin, L., Hou, M., Chu, P."PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review)". Oncology Reports 45.1 (2021): 5-12.
Chicago
Li, C., Lin, L., Hou, M., Chu, P."PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review)". Oncology Reports 45, no. 1 (2021): 5-12. https://doi.org/10.3892/or.2020.7831
Copy and paste a formatted citation
x
Spandidos Publications style
Li CJ, Lin LT, Hou MF and Chu PY: PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review). Oncol Rep 45: 5-12, 2021.
APA
Li, C., Lin, L., Hou, M., & Chu, P. (2021). PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review). Oncology Reports, 45, 5-12. https://doi.org/10.3892/or.2020.7831
MLA
Li, C., Lin, L., Hou, M., Chu, P."PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review)". Oncology Reports 45.1 (2021): 5-12.
Chicago
Li, C., Lin, L., Hou, M., Chu, P."PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review)". Oncology Reports 45, no. 1 (2021): 5-12. https://doi.org/10.3892/or.2020.7831
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