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Article

Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer

  • Authors:
    • Ryo Tsumura
    • Takahiro Anzai
    • Shino Manabe
    • Hiroki Takashima
    • Yoshikatsu Koga
    • Masahiro Yasunaga
    • Yasuhiro Matsumura
  • View Affiliations / Copyright

    Affiliations: Division of Developmental Therapeutics, EPOC, National Cancer Center, Kashiwanoha, Kashiwa, Chiba 277‑8577, Japan, Laboratory of Functional Molecule Chemistry, Pharmaceutical Department and Institute of Medicinal Chemistry, Hoshi University, Ebara, Shinagawa, Tokyo 142‑8501, Japan, Department of Immune Medicine, National Cancer Center Research Institute, Tsukiji, Chuo‑ku, Tokyo 104‑0045, Japan
  • Pages: 329-336
    |
    Published online on: November 12, 2020
       https://doi.org/10.3892/or.2020.7850
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Abstract

Tissue factor (TF) is an attractive target for cancer therapy due to its overexpression in multiple types of malignancies. In addition, TF has been reported to play functional roles in both cancer development and metastasis. Several groups have already developed antibody‑drug conjugates (ADCs) against TF for use as cancer treatments, and have demonstrated their efficacies in conventional subcutaneous xenograft models and patient‑derived xenograft models. However, no previous studies have investigated the effectiveness of anti‑TF ADC in an advanced‑stage cancer model. The present study developed an original humanized anti‑TF monoclonal antibody conjugated with monomethyl auristatin E, and evaluated its in vivo efficacy in a pancreatic cancer xenograft model with peritoneal dissemination. In vitro assays demonstrated that the anti‑TF ADC had potent binding affinity and cytotoxic activity against human pancreatic cancer cells that strongly expressed TF antigens. The anti‑TF ADC also exhibited greater antitumor effect than that of a control ADC in conventional subcutaneous xenograft models, with efficacy depending on the TF expression in the tumor tissues. Furthermore, the anti‑TF ADC significantly inhibited tumor growth in an orthotopic xenograft model, and extended the survival period in a murine peritoneal dissemination model. These results indicated that anti‑TF ADC has the potential to be an effective treatment not only for primary tumors, but also for those that are widely disseminated. Therefore, it can be concluded that ADC targeting TF may be a promising agent for advanced pancreatic cancer therapy.
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1 

Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, et al: SEER Cancer Statistics Review. 1975-2014, National Cancer Institute; Bethesda, MD: simplehttps://seercancergov/csr/1975_2014/based on November 2016 SEER data submission, posted to the SEER web site, April 2017. May 11–2017

2 

Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, et al: EMT and dissemination precede pancreatic tumor formation. Cell. 148:349–361. 2012. View Article : Google Scholar

3 

Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA, Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, et al: Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure. Surgery. 152 (3 Suppl 1):S43–S49. 2012. View Article : Google Scholar

4 

Khorana AA and Fine RL: Pancreatic cancer and thromboembolic disease. Lancet Oncol. 5:655–663. 2004. View Article : Google Scholar

5 

Rak J, Yu JL, Luyendyk J and Mackman N: Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Res. 66:10643–10646. 2006. View Article : Google Scholar

6 

Stein PD, Beemath A, Meyers FA, Skaf E, Sanchez J and Olson RE: Incidence of venous thromboembolism in patients hospitalized with cancer. Am J Med. 119:60–68. 2006. View Article : Google Scholar

7 

Matsumura Y: Cancer stromal targeting (CAST) therapy. Adv Drug Deliv Rev. 64:710–719. 2012. View Article : Google Scholar

8 

Callander NS, Varki N and Rao LV: Immunohistochemical identification of tissue factor in solid tumors. Cancer. 70:1194–1201. 1992. View Article : Google Scholar

9 

Nitori N, Ino Y, Nakanishi Y, Yamada T, Honda K, Yanagihara K, Kosuge T, Kanai Y, Kitajima M and Hirohashi S: Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clin Cancer Res. 11:2531–2539. 2005. View Article : Google Scholar

10 

van den Berg YW, Osanto S, Reitsma PH and Versteeg HH: The relationship between tissue factor and cancer progression: Insights from bench and bedside. Blood. 119:924–932. 2012. View Article : Google Scholar

11 

Kasthuri RS, Taubman MB and Mackman N: Role of tissue factor in cancer. J Clin Oncol. 27:4834–4838. 2009. View Article : Google Scholar

12 

Bourcy M, Suarez-Carmona M, Lambert J, Francart ME, Schroeder H, Delierneux C, Skrypek N, Thompson EW, Jerusalem G, Berx G, et al: Tissue factor induced by epithelial-mesenchymal transition triggers a procoagulant state that drives metastasis of circulating tumor cells. Cancer Res. 76:4270–4282. 2016. View Article : Google Scholar

13 

Hisada Y and Mackman N: Tissue factor and cancer: Regulation, tumor growth, and metastasis. Semin Thromb Hemost. 45:385–395. 2019. View Article : Google Scholar

14 

Yamashita H, Kitayama J, Ishikawa M and Nagawa H: Tissue factor expression is a clinical indicator of lymphatic metastasis and poor prognosis in gastric cancer with intestinal phenotype. J Surg Oncol. 95:324–331. 2007. View Article : Google Scholar

15 

Sawada M, Miyake S, Ohdama S, Matsubara O, Masuda S, Yakumaru K and Yoshizawa Y: Expression of tissue factor in non-small-cell lung cancers and its relationship to metastasis. Br J Cancer. 79:472–477. 1999. View Article : Google Scholar

16 

Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J, Felding-Habermann B, Takada Y, Mueller BM and Ruf W: Inhibition of tissue factor signaling suppresses tumor growth. Blood. 111:190–199. 2008. View Article : Google Scholar

17 

Zhang X, Li Q, Zhao H, Ma L, Meng T, Qian J, Jin R, Shen J and Yu K: Pathological expression of tissue factor confers promising antitumor response to a novel therapeutic antibody SC1 in triple negative breast cancer and pancreatic adenocarcinoma. Oncotarget. 8:59086–59102. 2017. View Article : Google Scholar

18 

Breij EC, de Goeij BE, Verploegen S, Schuurhuis DH, Amirkhosravi A, Francis J, Miller VB, Houtkamp M, Bleeker WK, Satijn D and Parren PW: An antibody-drug conjugate that targets tissue factor exhibits potent therapeutic activity against a broad range of solid tumors. Cancer Res. 74:1214–1226. 2014. View Article : Google Scholar

19 

Koga Y, Manabe S, Aihara Y, Sato R, Tsumura R, Iwafuji H, Furuya F, Fuchigami H, Fujiwara Y, Hisada Y, et al: Antitumor effect of antitissue factor antibody-MMAE conjugate in human pancreatic tumor xenografts. Int J Cancer. 137:1457–1466. 2015. View Article : Google Scholar

20 

de Goeij BE, Satijn D, Freitag CM, Wubbolts R, Bleeker WK, Khasanov A, Zhu T, Chen G, Miao D, van Berkel PH and Parren PW: High turnover of tissue factor enables efficient intracellular delivery of antibody-drug conjugates. Mol Cancer Ther. 14:1130–1140. 2015. View Article : Google Scholar

21 

Theunissen JW, Cai AG, Bhatti MM, Cooper AB, Avery AD, Dorfman R, Guelman S, Levashova Z and Migone TS: Treating tissue factor-positive cancers with antibody-drug conjugates that do not affect blood clotting. Mol Cancer Ther. 17:2412–2426. 2018. View Article : Google Scholar

22 

Tsumura R, Manabe S, Takashima H, Koga Y, Yasunaga M and Matsumura Y: Influence of the dissociation rate constant on the intra-tumor distribution of antibody-drug conjugate against tissue factor. J Control Release. 284:49–56. 2018. View Article : Google Scholar

23 

Tsumura R, Manabe S, Takashima H, Koga Y, Yasunaga M and Matsumura Y: Evaluation of the antitumor mechanism of antibody-drug conjugates against tissue factor in stroma-rich allograft models. Cancer Sci. 110:3296–3305. 2019. View Article : Google Scholar

24 

Hong DS, Concin N, Vergote I, de Bono JS, Slomovitz BM, Drew Y, Arkenau HT, Machiels JP, Spicer JF, Jones R, et al: Tisotumab vedotin in previously treated recurrent or metastatic cervical cancer. Clin Cancer Res. 26:1220–1228. 2020. View Article : Google Scholar

25 

de Bono JS, Concin N, Hong DS, Thistlethwaite FC, Machiels JP, Arkenau HT, Plummer R, Jones RH, Nielsen D, Windfeld K, et al: Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): A first-in-human, multicentre, phase 1–2 trial. Lancet Oncol. 20:383–393. 2019. View Article : Google Scholar

26 

Badescu G, Bryant P, Bird M, Henseleit K, Swierkosz J, Parekh V, Tommasi R, Pawlisz E, Jurlewicz K, Farys M, et al: Bridging disulfides for stable and defined antibody drug conjugates. Bioconjug Chem. 25:1124–1136. 2014. View Article : Google Scholar

27 

Bryant P, Pabst M, Badescu G, Bird M, McDowell W, Jamieson E, Swierkosz J, Jurlewicz K, Tommasi R, Henseleit K, et al: In vitro and in vivo evaluation of cysteine rebridged trastuzumab-MMAE antibody drug conjugates with defined drug-to-antibody ratios. Mol Pharm. 12:1872–1879. 2015. View Article : Google Scholar

28 

Yasunaga M, Saijou S, Hanaoka S, Anzai T, Tsumura R and Matsumura Y: Significant antitumor effect of an antibody against TMEM180, a new colorectal cancer-specific molecule. Cancer Sci. 110:761–770. 2019. View Article : Google Scholar

29 

Kuramochi T, Igawa T, Tsunoda H and Hattori K: Humanization and simultaneous optimization of monoclonal antibody. Methods Mol Biol. 1060:123–137. 2014. View Article : Google Scholar

30 

Tsumura R, Sato R, Furuya F, Koga Y, Yamamoto Y, Fujiwara Y, Yasunaga M and Matsumura Y: Feasibility study of the Fab fragment of a monoclonal antibody against tissue factor as a diagnostic tool. Int J Oncol. 47:2107–2114. 2015. View Article : Google Scholar

31 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013. View Article : Google Scholar

32 

Saito Y, Hashimoto Y, Kuroda J, Yasunaga M, Koga Y, Takahashi A and Matsumura Y: The inhibition of pancreatic cancer invasion-metastasis cascade in both cellular signal and blood coagulation cascade of tissue factor by its neutralisation antibody. Eur J Cancer. 47:2230–2239. 2011. View Article : Google Scholar

33 

Jeffrey SC, Burke PJ, Lyon RP, Meyer DW, Sussman D, Anderson M, Hunter JH, Leiske CI, Miyamoto JB, Nicholas ND, et al: A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology. Bioconjug Chem. 24:1256–1263. 2013. View Article : Google Scholar

34 

Ogitani Y, Aida T, Hagihara K, Yamaguchi J, Ishii C, Harada N, Soma M, Okamoto H, Oitate M, Arakawa S, et al: DS-8201a, a novel HER2-targeting ADC with a Novel DNA topoisomerase I inhibitor, demonstrates a promising antitumor efficacy with differentiation from T-DM1. Clin Cancer Res. 22:5097–5108. 2016. View Article : Google Scholar

35 

Chen R, Hou J, Newman E, Kim Y, Donohue C, Liu X, Thomas SH, Forman SJ and Kane SE: CD30 downregulation, MMAE resistance, and MDR1 upregulation are all associated with resistance to brentuximab vedotin. Mol Cancer Ther. 14:1376–1384. 2015. View Article : Google Scholar

36 

Yu SF, Zheng B, Go M, Lau J, Spencer S, Raab H, Soriano R, Jhunjhunwala S, Cohen R, Caruso M, et al: A novel anti-CD22 anthracycline-based antibody-drug conjugate (ADC) that overcomes resistance to auristatin-based ADCs. Clin Cancer Res. 21:3298–3306. 2015. View Article : Google Scholar

37 

Liu-Kreyche P, Shen H, Marino AM, Iyer RA, Humphreys WG and Lai Y: Lysosomal P-gp-MDR1 confers drug resistance of brentuximab vedotin and its cytotoxic payload monomethyl auristatin e in tumor cells. Front Pharmacol. 10:7492019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Tsumura R, Anzai T, Manabe S, Takashima H, Koga Y, Yasunaga M and Matsumura Y: Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer. Oncol Rep 45: 329-336, 2021.
APA
Tsumura, R., Anzai, T., Manabe, S., Takashima, H., Koga, Y., Yasunaga, M., & Matsumura, Y. (2021). Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer. Oncology Reports, 45, 329-336. https://doi.org/10.3892/or.2020.7850
MLA
Tsumura, R., Anzai, T., Manabe, S., Takashima, H., Koga, Y., Yasunaga, M., Matsumura, Y."Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer". Oncology Reports 45.1 (2021): 329-336.
Chicago
Tsumura, R., Anzai, T., Manabe, S., Takashima, H., Koga, Y., Yasunaga, M., Matsumura, Y."Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer". Oncology Reports 45, no. 1 (2021): 329-336. https://doi.org/10.3892/or.2020.7850
Copy and paste a formatted citation
x
Spandidos Publications style
Tsumura R, Anzai T, Manabe S, Takashima H, Koga Y, Yasunaga M and Matsumura Y: Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer. Oncol Rep 45: 329-336, 2021.
APA
Tsumura, R., Anzai, T., Manabe, S., Takashima, H., Koga, Y., Yasunaga, M., & Matsumura, Y. (2021). Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer. Oncology Reports, 45, 329-336. https://doi.org/10.3892/or.2020.7850
MLA
Tsumura, R., Anzai, T., Manabe, S., Takashima, H., Koga, Y., Yasunaga, M., Matsumura, Y."Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer". Oncology Reports 45.1 (2021): 329-336.
Chicago
Tsumura, R., Anzai, T., Manabe, S., Takashima, H., Koga, Y., Yasunaga, M., Matsumura, Y."Antitumor effect of humanized anti‑tissue factor antibody‑drug conjugate in a model of peritoneal disseminated pancreatic cancer". Oncology Reports 45, no. 1 (2021): 329-336. https://doi.org/10.3892/or.2020.7850
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