Open Access

Safety and efficacy of anaplastic lymphoma kinase tyrosine kinase inhibitors in non‑small cell lung cancer (Review)

  • Authors:
    • Li Wang
    • Wen Wang
  • View Affiliations

  • Published online on: November 13, 2020     https://doi.org/10.3892/or.2020.7851
  • Pages: 13-28
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Since the discovery of targeted therapy with epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) have been introduced as the first‑line treatment for non‑small cell lung cancer (NSCLC) patients who carry sensitizing ALK‑activating mutations. Compared with conventional chemotherapeutic regimens, small‑molecule ALK‑TKIs exhibit excellent clinical efficacy in ALK‑positive NSCLC. A series of studies have indicated that ALK‑TKI agents as the first‑line treatment, including crizotinib, ceritinib, brigatinib, alectinib and entrectinib, can benefit patients with ALK‑positive NSCLC. However, resistance to ALK‑TKIs has emerged. ALK‑TKIs are associated with significantly disabling and undesirable effects that adversely impact quality of life and compliance. This study reviews the pharmacodynamics, efficacy and safety of ALK‑TKI agents in order to summarize these effects as well as the relevant management strategies. It is worth emphasizing that the frequency and severity of an adverse effect often varies across different trials.
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January-2021
Volume 45 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wang L and Wang L: Safety and efficacy of anaplastic lymphoma kinase tyrosine kinase inhibitors in non‑small cell lung cancer (Review). Oncol Rep 45: 13-28, 2021
APA
Wang, L., & Wang, L. (2021). Safety and efficacy of anaplastic lymphoma kinase tyrosine kinase inhibitors in non‑small cell lung cancer (Review). Oncology Reports, 45, 13-28. https://doi.org/10.3892/or.2020.7851
MLA
Wang, L., Wang, W."Safety and efficacy of anaplastic lymphoma kinase tyrosine kinase inhibitors in non‑small cell lung cancer (Review)". Oncology Reports 45.1 (2021): 13-28.
Chicago
Wang, L., Wang, W."Safety and efficacy of anaplastic lymphoma kinase tyrosine kinase inhibitors in non‑small cell lung cancer (Review)". Oncology Reports 45, no. 1 (2021): 13-28. https://doi.org/10.3892/or.2020.7851