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Diagnostic and therapeutic role of microRNAs in oral cancer (Review)

  • Authors:
    • Jing Wang
    • Najun Lv
    • Xinxin Lu
    • Rongtao Yuan
    • Zhenggang Chen
    • Jiangbo Yu
  • View Affiliations / Copyright

    Affiliations: Oral Research Center, Qingdao Municipal Hospital, Qingdao, Shandong 266011, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 58-64
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    Published online on: November 13, 2020
       https://doi.org/10.3892/or.2020.7854
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Abstract

Oral cancer is one of the leading types of cancer and remains the most common cause of cancer‑related mortality in Asia. The pathogenesis of oral cancer is complicated and, due to lack of accurate diagnostic methods and efficient treatment strategies, oral cancer is responsible for a large number of deaths. Therefore, there is an urgent need for developing novel diagnostic tools and targeted therapies. MicroRNAs (miRNAs) represent a class of small non‑coding RNAs that are key elements and play critical regulatory roles in the pathological processes of various diseases. miRNAs are widely distributed in body fluids and are specifically expressed in different cancers, and they may represent effective biomarkers that may be used for early detection of oral cancer. In addition, miRNAs are involved in oral cancer development, progression and prognosis by targeting a broad range of mRNAs that may be of therapeutic value for oral cancer. The aim of the present review was to summarize the role of miRNAs as new diagnostic tools and potential therapeutic targets in oral cancer, and investigate the underlying molecular mechanisms.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Lv N, Lu X, Yuan R, Chen Z and Yu J: Diagnostic and therapeutic role of microRNAs in oral cancer (Review). Oncol Rep 45: 58-64, 2021.
APA
Wang, J., Lv, N., Lu, X., Yuan, R., Chen, Z., & Yu, J. (2021). Diagnostic and therapeutic role of microRNAs in oral cancer (Review). Oncology Reports, 45, 58-64. https://doi.org/10.3892/or.2020.7854
MLA
Wang, J., Lv, N., Lu, X., Yuan, R., Chen, Z., Yu, J."Diagnostic and therapeutic role of microRNAs in oral cancer (Review)". Oncology Reports 45.1 (2021): 58-64.
Chicago
Wang, J., Lv, N., Lu, X., Yuan, R., Chen, Z., Yu, J."Diagnostic and therapeutic role of microRNAs in oral cancer (Review)". Oncology Reports 45, no. 1 (2021): 58-64. https://doi.org/10.3892/or.2020.7854
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Lv N, Lu X, Yuan R, Chen Z and Yu J: Diagnostic and therapeutic role of microRNAs in oral cancer (Review). Oncol Rep 45: 58-64, 2021.
APA
Wang, J., Lv, N., Lu, X., Yuan, R., Chen, Z., & Yu, J. (2021). Diagnostic and therapeutic role of microRNAs in oral cancer (Review). Oncology Reports, 45, 58-64. https://doi.org/10.3892/or.2020.7854
MLA
Wang, J., Lv, N., Lu, X., Yuan, R., Chen, Z., Yu, J."Diagnostic and therapeutic role of microRNAs in oral cancer (Review)". Oncology Reports 45.1 (2021): 58-64.
Chicago
Wang, J., Lv, N., Lu, X., Yuan, R., Chen, Z., Yu, J."Diagnostic and therapeutic role of microRNAs in oral cancer (Review)". Oncology Reports 45, no. 1 (2021): 58-64. https://doi.org/10.3892/or.2020.7854
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