Open Access

Dose adjustment for tyrosine kinase inhibitors in non‑small cell lung cancer patients with hepatic or renal function impairment (Review)

  • Authors:
    • Dehua Zhao
    • Jing Chen
    • Xiaoqing Long
    • Jisheng Wang
  • View Affiliations

  • Published online on: November 27, 2020     https://doi.org/10.3892/or.2020.7870
  • Pages: 413-426
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In recent years, a number of tyrosine kinase inhibitors (TKIs) have been approved for the treatment of non‑small cell lung cancer. These novel treatments exhibit improved efficacy and toxicity when compared to conventional chemotherapy agents. TKIs are administered orally, which has the advantages of improved flexibility and convenience for the patients. However, challenges have arisen in the use of these novel agents. Prescribing drugs for patients with hepatic or renal function impairment poses a challenge for clinicians due to the large pharmacokinetic variability in each individual patient. Moreover, several TKIs have been shown to cause laboratory test abnormalities normally associated with hepatic or renal injury. The aim of the present review was to discuss the effects of hepatic and renal function impairment on the pharmacokinetic variability of 17 TKIs and their potential hepatotoxicity and nephrotoxicity, and to recommend dose adjustment for patients with hepatic or renal impairment.
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February-2021
Volume 45 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao D, Chen J, Long X and Wang J: Dose adjustment for tyrosine kinase inhibitors in non‑small cell lung cancer patients with hepatic or renal function impairment (Review). Oncol Rep 45: 413-426, 2021
APA
Zhao, D., Chen, J., Long, X., & Wang, J. (2021). Dose adjustment for tyrosine kinase inhibitors in non‑small cell lung cancer patients with hepatic or renal function impairment (Review). Oncology Reports, 45, 413-426. https://doi.org/10.3892/or.2020.7870
MLA
Zhao, D., Chen, J., Long, X., Wang, J."Dose adjustment for tyrosine kinase inhibitors in non‑small cell lung cancer patients with hepatic or renal function impairment (Review)". Oncology Reports 45.2 (2021): 413-426.
Chicago
Zhao, D., Chen, J., Long, X., Wang, J."Dose adjustment for tyrosine kinase inhibitors in non‑small cell lung cancer patients with hepatic or renal function impairment (Review)". Oncology Reports 45, no. 2 (2021): 413-426. https://doi.org/10.3892/or.2020.7870