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Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy

  • Authors:
    • Dan Xu
    • Aju Baidya
    • Kai Deng
    • Yu‑Shuang Li
    • Bo Wu
    • Hai‑Bo Xu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Chemistry, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei 430072, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 547-556
    |
    Published online on: November 27, 2020
       https://doi.org/10.3892/or.2020.7871
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Abstract

Gliomas are one of the most common types of primary brain tumors. Despite recent advances in the combination of surgery, radiotherapy, systemic therapy (chemotherapy, targeted therapy) and supportive therapy in the multimodal treatment of gliomas, the overall prognosis remains poor and the long‑term survival rate is low. Thus, it is crucial to develop a novel glioma management method. Due to its relatively non‑invasive, selective and repeatable characteristics, photodynamic therapy (PDT) has been investigated for glioma therapy in the past decade, exhibiting higher selectivity and lower side effects compared with those of conventional therapy. However, most of the photosensitizers (PSs) are highly hydrophobic, leading to poor water solubility, rapid degradation with clearance in blood circulation and ultimately, low bioavailability. In the present study, hydrophilic polyethylene glycol (PEG)‑chlorin e6 (Ce6) chelated gadolinium ion (Gd3+) nanoparticles (PEG‑Ce6‑Gd NPs) were synthesized via a chelation and self‑assembly process. Initially, the cell cytotoxicity of PEG‑Ce6‑Gd NPs was evaluated with or without laser irradiation. The in vitro study demonstrated the lack of toxicity of PEG‑Ce6‑Gd NPs to tumor cells in the absence of laser irradiation. However, its toxicity was enhanced under laser irradiation. Moreover, the size and weight of brain tumors were significantly decreased in mice with glioma xenografts, which was further confirmed via histological analysis. Subsequently, the results indicated that the PEG‑Ce6‑Gd NPs had a favorable T1‑weighted contrast performance (0.43 mg ml‑1 s‑1) and were observed to have significant contrast enhancement at the tumor site from 0.25 to 1 h post‑injection in vivo. The favorable MRI, as well as the synergetic photodynamic antitumor effect and antineoplastic ability of PEG‑Ce6‑Gd NPs was identified. It was suggested that PEG‑Ce6‑Gd NPs had great potential in the diagnosis and PDT treatment of gliomas, and possibly other cancer types, with prospects of clinical application in the near future.
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View References

1 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Tan AC, Ashley DM, López GY, Malinzak M, Friedman HS and Khasraw M: Management of glioblastoma: State of the art and future directions. CA Cancer J Clin. 70:299–312. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW and Hasan T: Imaging and photodynamic therapy: Mechanisms, monitoring, and optimization. Chem Rev. 110:2795–2838. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Bhaumik J, Mittal AK, Banerjee A, Chisti Y and Banerjee UC: Applications of phototheranostic nanoagents in photodynamic therapy. Nano Res. 8:1373–1394. 2015. View Article : Google Scholar

5 

Lovell JF, Liu TW, Chen J and Zheng G: Activatable photosensitizers for imaging and therapy. Chem Rev. 110:2839–2857. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Hou W, Xia F, Alves CS, Qian X, Yang Y and Cui D: MMP2-Targeting and redox-responsive PEGylated chlorin e6 nanoparticles for cancer near-infrared imaging and photodynamic therapy. ACS Appl Mater Interfaces. 8:1447–1457. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Fan F, Yu Y, Zhong F, Gao M, Sun T, Liu J, Zhang H, Qian H, Tao W and Yang X: Design of tumor acidity-responsive sheddable nanoparticles for fluorescence/magnetic resonance imaging-guided photodynamic therapy. Theranostics. 7:1290–1302. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Dolmans DE, Fukumura D and Jain RK: Photodynamic therapy for cancer. Nat Rev Cancer. 3:380–387. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Castano AP, Demidova TN and Hamblin MR: Mechanisms in photodynamic therapy: Part two-cellular signaling, cell metabolism and modes of cell death. Photodiagnosis Photodyn Ther. 2:1–23. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Liu K, Xing R, Zou Q, Ma G, Möhwald H and Yan X: Simple peptide-tuned self-assembly of photosensitizers towards anticancer photodynamic therapy. Angew Chem Int Ed Engl. 55:3036–3039. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Xing R, Liu K, Jiao T, Zhang N, Ma K, Zhang R, Zou Q, Ma G and Yan X: An injectable self-assembling collagen-gold hybrid hydrogel for combinatorial antitumor photothermal/photodynamic therapy. Adv Mater. 28:3669–3676. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Liu Y, Ma K, Jiao T, Xing R, Shen G and Yan X: Water-insoluble photosensitizer nanocolloids stabilized by supramolecular interfacial assembly towards photodynamic therapy. Sci Rep. 7:429782017. View Article : Google Scholar : PubMed/NCBI

13 

Allison RR, Downie GH, Cuenca R, Hu XH, Childs CJ and Sibata CH: Photosensitizers in clinical PDT. Photodiagnosis Photodyn Ther. 1:27–42. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Vaidya A, Sun Y, Feng Y, Emerson L, Jeong EK and Lu ZR: Contrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer conjugate. Pharm Res. 25:2002–2011. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Yue C, Zhang C, Alfranca G, Yang Y, Jiang X, Yang Y, Pan F, de la Fuente JM and Cui D: Near-infrared light triggered ROS-activated theranostic platform based on Ce6-CPT-UCNPs for simultaneous fluorescence imaging and chemo-photodynamic combined therapy. Theranostics. 6:456–469. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Chen Q, Wang X, Wang C, Feng L, Li Y and Liu Z: Drug-induced self-assembly of modified albumins as nano-theranostics for tumor-targeted combination therapy. ACS Nano. 9:5223–5233. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Abbas M, Zou Q, Li S and Yan X: Self-assembled peptide- and protein-based nanomaterials for antitumor photodynamic and photothermal therapy. Adv Mater. 29:2017. View Article : Google Scholar

18 

Maeda H, Wu J, Sawa T, Matsumura Y and Hori K: Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. J Control Release. 65:271–284. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Vrouenraets MB, Visser GW, Snow GB and van Dongen GA: Basic principles, applications in oncology and improved selectivity of photodynamic therapy. Anticancer Res. 23:505–522. 2003.PubMed/NCBI

20 

Shiah JG, Sun Y, Peterson CM, Straight RC and Kopecek J: Antitumor activity of N-(2-hydroxypropyl) methacrylamide copolymer-Mesochlorine e6 and adriamycin conjugates in combination treatments. Clin Cancer Res. 6:1008–1015. 2000.PubMed/NCBI

21 

Jiang FN, Liu DJ, Neyndorff H, Chester M, Jiang SY and Levy JG: Photodynamic killing of human squamous cell carcinoma cells using a monoclonal antibody-photosensitizer conjugate. J Natl Cancer Inst. 83:1218–1225. 1991. View Article : Google Scholar : PubMed/NCBI

22 

van Nostrum CF: Polymeric micelles to deliver photosensitizers for photodynamic therapy. Adv Drug Deliv Rev. 56:9–16. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Derycke AS and de Witte PA: Liposomes for photodynamic therapy. Adv Drug Deliv Rev. 56:17–30. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Estelrich J, Sánchez-Martín MJ and Busquets MA: Nanoparticles in magnetic resonance imaging: From simple to dual contrast agents. Int J Nanomedicine. 10:1727–1741. 2015.PubMed/NCBI

25 

Sun BO, Fang Y, Li Z, Chen Z and Xiang J: Advances in the application of nanotechnology in the diagnosis and treatment of gastrointestinal tumors. Mol Clin Oncol. 3:274–280. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Huang J, Zhong X, Wang L, Yang L and Mao H: Improving the magnetic resonance imaging contrast and detection methods with engineered magnetic nanoparticles. Theranostics. 2:86–102. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Li G, Slansky A, Dobhal MP, Goswami LN, Graham A, Chen Y, Kanter P, Alberico RA, Spernyak J, Morgan J, et al: Chlorophyll-a analogues conjugated with aminobenzyl-DTPA as potential bifunctional agents for magnetic resonance imaging and photodynamic therapy. Bioconjug Chem. 16:32–42. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Kopelman R, Lee Koo YE, Philbert MA, Moffat B, Reddy GR, Mcconville P, Hall DE, Chenevert TL, Bhojani MS, Buck SM, et al: Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer. J Magn Magn Mater. 293:404–410. 2005. View Article : Google Scholar

29 

Gross S, Gilead A, Scherz A, Neeman M and Salomon Y: Monitoring photodynamic therapy of solid tumors online by BOLD-contrast MRI. Nat Med. 9:1327–1331. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Larson N and Ghandehari H: Polymeric Conjugates for Drug Delivery. Chem Mater. 24:840–853. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Wu B, Li XQ, Huang T, Lu ST, Wan B, Liao RF, Li YS, Baidya A, Long QY and Xu HB: MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin. Biomater Sci. 5:1746–1750. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Kim KS, Kim J, Kim DH, Hwang HS and Na K: Multifunctional trastuzumab-chlorin e6 conjugate for the treatment of HER2-positive human breast cancer. Biomater Sci. 6:1217–1226. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Shi H, Liu Q, Qin X, Wang P and Wang X: Pharmacokinetic study of a novel sonosensitizer chlorin-e6 and its sonodynamic anti-cancer activity in hepatoma-22 tumor-bearing mice. Biopharm Drug Dispos. 32:319–332. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Bourré L, Thibaut S, Briffaud A, Rousset N, Eléouet S, Lajat Y and Patrice T: Indirect detection of photosensitizer ex vivo. J Photochem Photobiol B. 67:23–31. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Lim CK, Heo J, Shin S, Jeong K, Seo YH, Jang WD, Park CR, Park SY, Kim S and Kwon IC: Nanophotosensitizers toward advanced photodynamic therapy of cancer. Cancer Lett. 334:176–187. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Lucky SS, Soo KC and Zhang Y: Nanoparticles in photodynamic therapy. Chem Rev. 115:1990–2042. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Xu D, Lu ST, Li YS, Baidya A, Mei H, He Y and Wu B: Evaluation of methotrexate-conjugated gadolinium(III) for cancer diagnosis and treatment. Drug Des Devel Ther. 12:3301–3309. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Mahmoudi K, Garvey KL, Bouras A, Cramer G, Stepp H, Jesu Raj JG, Bozec D, Busch TM and Hadjipanayis CG: 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas. J Neurooncol. 141:595–607. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu D, Baidya A, Deng K, Li YS, Wu B and Xu HB: Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy. Oncol Rep 45: 547-556, 2021.
APA
Xu, D., Baidya, A., Deng, K., Li, Y., Wu, B., & Xu, H. (2021). Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy. Oncology Reports, 45, 547-556. https://doi.org/10.3892/or.2020.7871
MLA
Xu, D., Baidya, A., Deng, K., Li, Y., Wu, B., Xu, H."Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy". Oncology Reports 45.2 (2021): 547-556.
Chicago
Xu, D., Baidya, A., Deng, K., Li, Y., Wu, B., Xu, H."Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy". Oncology Reports 45, no. 2 (2021): 547-556. https://doi.org/10.3892/or.2020.7871
Copy and paste a formatted citation
x
Spandidos Publications style
Xu D, Baidya A, Deng K, Li YS, Wu B and Xu HB: Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy. Oncol Rep 45: 547-556, 2021.
APA
Xu, D., Baidya, A., Deng, K., Li, Y., Wu, B., & Xu, H. (2021). Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy. Oncology Reports, 45, 547-556. https://doi.org/10.3892/or.2020.7871
MLA
Xu, D., Baidya, A., Deng, K., Li, Y., Wu, B., Xu, H."Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy". Oncology Reports 45.2 (2021): 547-556.
Chicago
Xu, D., Baidya, A., Deng, K., Li, Y., Wu, B., Xu, H."Multifunctional nanoparticle PEG‑Ce6‑Gd for MRI‑guided photodynamic therapy". Oncology Reports 45, no. 2 (2021): 547-556. https://doi.org/10.3892/or.2020.7871
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