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Article Open Access

Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress

  • Authors:
    • Thibault Carré
    • Jerome Thiery
    • Bassam Janji
    • Stéphane Terry
    • Gwendoline Gros
    • Guillaume Meurice
    • Claudine Kieda
    • Daniel Olive
    • Salem Chouaib
  • View Affiliations / Copyright

    Affiliations: INSERM U1186, Integrative Tumour Immunology and Immunotherapy, Gustave Roussy, Faculté de Médecine, Université Paris‑Sud, Université Paris‑Saclay, 94805 Villejuif Cedex, France, Tumor Immunotherapy and Microenvironment (TIME) group, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg, Luxembourg, Plateforme de Bioinformatique, UMS AMMICA, Gustave Roussy, 94805 Villejuif Cedex, France, Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine, 04‑141 Warsaw, Poland, Team Immunity and Cancer, Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS, UMR7258, Institut Paoli‑Calmettes, Aix‑Marseille University, UM 105, 13009 Marseille, France
    Copyright: © Carré et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 582-594
    |
    Published online on: November 27, 2020
       https://doi.org/10.3892/or.2020.7872
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Abstract

Resistance of tumor cells to cell‑mediated cytotoxicity remains an obstacle to the immunotherapy of cancer and its molecular basis is poorly understood. To investigate the acquisition of tumor resistance to cell‑mediated cytotoxicity, resistant variants were selected following long‑term natural killer (NK) cell selection pressure. It was observed that these variants were resistant to NK cell‑mediated lysis, but were sensitive to autologous cytotoxic T lymphocytes or cytotoxic drugs. This resistance appeared to be dependent, at least partly, on an alteration of target cell recognition by NK effector cells, but did not appear to involve any alterations in the expression of KIR, DNAM1 or NKG2D ligands on resistant cells, nor the induction of protective autophagy. In the present study, in order to gain further insight into the molecular mechanisms underlying the acquired tumor resistance to NK cell‑mediated cytotoxicity, a comprehensive analysis of the variant transcriptome was conducted. Comparative analysis identified an expression profile of genes that best distinguished resistant variants from parental sensitive cancer cells, with candidate genes putatively involved in NK cell‑mediated lysis resistance, but also in adhesion, migration and invasiveness, including upregulated genes, such as POT1, L1CAM or ECM1, and downregulated genes, such as B7‑H6 or UCHL1. Consequently, the selected variants were not only resistant to NK cell‑mediated lysis, but also displayed more aggressive properties. The findings of the present study emphasized that the role of NK cells may span far beyond the mere killing of malignant cells, and NK cells may be important effectors during cancer immunoediting.
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1 

Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ and Schreiber RD: Pillars article: IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature. 2001. 410: 1107-1111. J Immunol. 201:827–831. 2018.PubMed/NCBI

2 

Dunn GP, Old LJ and Schreiber RD: The three Es of cancer immunoediting. Annu Rev Immunol. 22:329–360. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Vesely MD, Kershaw MH, Schreiber RD and Smyth MJ: Natural innate and adaptive immunity to cancer. Annu Rev Immunol. 29:235–271. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Dunn GP, Bruce AT, Ikeda H, Old LJ and Schreiber RD: Cancer immunoediting: From immunosurveillance to tumor escape. Nat Immunol. 3:991–998. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Dunn GP, Old LJ and Schreiber RD: The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 21:137–148. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Abouzahr S, Bismuth G, Gaudin C, Caroll O, Van Endert P, Jalil A, Dausset J, Vergnon I, Richon C, Kauffmann A, et al: Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure. Proc Natl Acad Sci USA. 103:1428–1433. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Khong HT and Restifo NP: Natural selection of tumor variants in the generation of ‘tumor escape’ phenotypes. Nat Immunol. 3:999–1005. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Trinchieri G: Biology of natural killer cells. Adv Immunol. 47:187–376. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Vivier E, Tomasello E, Baratin M, Walzer T and Ugolini S: Functions of natural killer cells. Nature Immunology. 9:503–510. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Coca S, Perez-Piqueras J, Martinez D, Colmenarejo A, Saez MA, Vallejo C, Martos JA and Moreno M: The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma. Cancer. 79:2320–2328. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Che X, Iwashige H, Aridome K, Hokita S and Aikou T: Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer. 88:577–583. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Villegas FR, Coca S, Villarrubia VG, Jiménez R, Chillón MJ, Jareño J, Zuil M and Callol L: Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer. Lung Cancer. 35:23–28. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Martín-Fontecha A, Thomsen LL, Brett S, Gerard C, Lipp M, Lanzavecchia A and Sallusto F: Induced recruitment of NK cells to lymph nodes provides IFN-γ for T(H)1 priming. Nat Immunol. 5:1260–1265. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Morandi B, Mortara L, Chiossone L, Accolla RS, Mingari MC, Moretta L, Moretta A and Ferlazzo G: Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response. PLoS One. 7:e391702012. View Article : Google Scholar : PubMed/NCBI

15 

Moretta L, Ferlazzo G, Bottino C, Vitale M, Pende D, Mingari MC and Moretta A: Effector and regulatory events during natural killer-dendritic cell interactions. Immunol Rev. 214:219–228. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Kijima M, Saio M, Oyang G-F, Suwa T, Miyauchi R, Kojima Y, Imai H, Nakagawa J, Nonaka K, Umemura N, et al: Natural killer cells play a role in MHC class I in vivo induction in tumor cells that are MHC negative in vitro. Int J Oncol. 26:679–684. 2005.PubMed/NCBI

17 

Farag SS, Fehniger TA, Ruggeri L, Velardi A and Caligiuri MA: Natural killer cell receptors: New biology and insights into the graft-versus-leukemia effect. Blood. 100:1935–1947. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Ferlazzo G and Moretta L: Dendritic cell editing by natural killer cells. Crit Rev Oncog. 19:67–75. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Dunn GP, Bruce AT, Sheehan KCF, Shankaran V, Uppaluri R, Bui JD, Diamond MS, Koebel CM, Arthur C, White JM and Schreiber RD: A critical function for type I interferons in cancer immunoediting. Nat Immunol. 6:722–729. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Smyth MJ, Dunn GP and Schreiber RD: Cancer immunosurveillance and immunoediting: The roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv Immunol. 90:1–50. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Smyth MJ, Swann J, Cretney E, Zerafa N, Yokoyama WM and Hayakawa Y: NKG2D function protects the host from tumor initiation. J Exp Med. 202:583–588. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Street SE, Hayakawa Y, Zhan Y, Lew AM, MacGregor D, Jamieson AM, Diefenbach A, Yagita H, Godfrey DI and Smyth MJ: Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells. J Exp Med. 199:879–884. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Crowe NY, Smyth MJ and Godfrey DI: A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J Exp Med. 196:119–127. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Takeda K, Smyth MJ, Cretney E, Hayakawa Y, Kayagaki N, Yagita H and Okumura K: Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med. 195:161–169. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Smyth MJ, Crowe NY and Godfrey DI: NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int Immunol. 13:459–463. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Ben Safta T, Ziani L, Favre L, Lamendour L, Gros G, Mami-Chouaib F, Martinvalet D, Chouaib S and Thiery J: Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis. J Immunol. 194:418–428. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Noman MZ, Janji B, Kaminska B, Van Moer K, Pierson S, Przanowski P, Buart S, Berchem G, Romero P, Mami-Chouaib F and Chouaib S: Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression. Cancer Res. 71:5976–5986. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Janji B, Viry E, Moussay E, Paggetti J, Arakelian T, Mgrditchian T, Messai Y, Noman MZ, Van Moer K, Hasmim M, et al: The multifaceted role of autophagy in tumor evasion from immune surveillance. Oncotarget. 7:17591–17607. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Dufour E, Carcelain G, Gaudin C, Flament C, Avril MF and Faure F: Diversity of the cytotoxic melanoma-specific immune response: Some CTL clones recognize autologous fresh tumor cells and not tumor cell lines. J Immunol. 158:3787–3795. 1997.PubMed/NCBI

30 

Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 3:Article32004. View Article : Google Scholar : PubMed/NCBI

31 

Le Maux Chansac B, Missé D, Richon C, Vergnon I, Kubin M, Soria JC, Moretta A, Chouaib S and Mami-Chouaib F: Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: Role of NKG2D-dependent pathway. Int Immunol. 20:801–810. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Weichold FF, Jiang YZ, Dunn DE, Bloom M, Malkovska V, Hensel NF and Barrett AJ: Regulation of a graft-versus-leukemia effect by major histocompatibility complex class II molecules on leukemia cells: HLA-DR1 expression renders K562 cell tumors resistant to adoptively transferred lymphocytes in severe combined immunodeficiency mice/nonobese diabetic mice. Blood. 90:4553–4558. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Wan SM, Tie J, Zhang YF, Guo J, Yang LQ, Wang J, Xia SH, Yang SM, Wang RQ and Fang DC: Silencing of the hPOT1 gene by RNA inference promotes apoptosis and inhibits proliferation and aggressive phenotype of gastric cancer cells, likely through up-regulating PinX1 expression. J Clin Pathol. 64:1051–1057. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Bellucci R, Nguyen HN, Martin A, Heinrichs S, Schinzel AC, Hahn WC and Ritz J: Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. J Clin Invest. 122:2369–2383. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Hai J, Zhu CQ, Bandarchi B, Wang YH, Navab R, Shepherd FA, Jurisica I and Tsao MS: L1 cell adhesion molecule promotes tumorigenicity and metastatic potential in non-small cell lung cancer. Clin Cancer Res. 18:1914–1924. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Meier F, Busch S, Gast D, Göppert A, Altevogt P, Maczey E, Riedle S, Garbe C and Schittek B: The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 119:549–555. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Stoeck A, Gast D, Sanderson MP, Issa Y, Gutwein P and Altevogt P: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Gynecol Oncol. 104:461–469. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Peric B, Zagar I, Novakovic S, Zgajnar J and Hocevar M: Role of serum S100B and PET-CT in follow-up of patients with cutaneous melanoma. BMC Cancer. 11:3282011. View Article : Google Scholar : PubMed/NCBI

39 

Xiong GP, Zhang JX, Gu SP, Wu YB and Liu JF: Overexpression of ECM1 contributes to migration and invasion in cholangiocarcinoma cell. Neoplasma. 59:409–415. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Stern N, Markel G, Arnon TI, Gruda R, Wong H, Gray-Owen SD and Mandelboim O: Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol. 174:6692–6701. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Wang WJ, Li QQ, Xu JD, Cao XX, Li HX, Tang F, Chen Q, Yang JM, Xu ZD and Liu XP: Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells. Int J Oncol. 33:1037–1045. 2008.PubMed/NCBI

42 

Wu QJ, Gong CY, Luo ST, Zhang DM, Zhang S, Shi HS, Lu L, Yan HX, He SS, Li DD, et al: AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model. BMC Cancer. 12:1292012. View Article : Google Scholar : PubMed/NCBI

43 

Iguchi-Manaka A, Kai H, Yamashita Y, Shibata K, Tahara-Hanaoka S, Honda S, Yasui T, Kikutani H, Shibuya K and Shibuya A: Accelerated tumor growth in mice deficient in DNAM-1 receptor. J Exp Med. 205:2959–2964. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Guillerey C and Smyth MJ: NK cells and cancer immunoediting. Curr Top Microbiol Immunol. 395:115–145. 2016.PubMed/NCBI

45 

Ferlazzo G, Tsang ML, Moretta L, Melioli G, Steinman RM and Münz C: Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J Exp Med. 195:343–351. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Brandt CS, Baratin M, Yi EC, Kennedy J, Gao Z, Fox B, Haldeman B, Ostrander CD, Kaifu T, Chabannon C, et al: The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J Exp Med. 206:1495–1503. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Balsamo M, Vermi W, Parodi M, Pietra G, Manzini C, Queirolo P, Lonardi S, Augugliaro R, Moretta A, Facchetti F, et al: Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor: Innate immunity. Eur J Immunol. 42:1833–1842. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Fiegler N, Textor S, Arnold A, Rölle A, Oehme I, Breuhahn K, Moldenhauer G, Witzens-Harig M and Cerwenka A: Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells. Blood. 122:684–693. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Kaifu T, Escalière B, Gastinel LN, Vivier E and Baratin M: B7-H6/NKp30 interaction: A mechanism of alerting NK cells against tumors. Cell Mol Life Sci. 68:3531–3539. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, et al: NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. J Clin Invest. 119:1251–1263. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Fang L, Lonsdorf AS and Hwang ST: Immunotherapy for advanced melanoma. J Invest Dermatol. 128:2596–2605. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Sutlu T and Alici E: Natural killer cell-based immunotherapy in cancer: Current insights and future prospects. J Intern Med. 266:154–181. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Ljunggren HG and Malmberg KJ: Prospects for the use of NK cells in immunotherapy of human cancer. Nat Rev Immunol. 7:329–339. 2007. View Article : Google Scholar : PubMed/NCBI

54 

Pachynski RK, Zabel BA, Kohrt HE, Tejeda NM, Monnier J, Swanson CD, Holzer AK, Gentles AJ, Sperinde GV, Edalati A, et al: The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses. J Exp Med. 209:1427–1435. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Albertsson PA, Basse PH, Hokland M, Goldfarb RH, Nagelkerke JF, Nannmark U and Kuppen PJK: NK cells and the tumour microenvironment: Implications for NK-cell function and anti-tumour activity. Trends Immunol. 24:603–609. 2003. View Article : Google Scholar : PubMed/NCBI

56 

Kim MH, Kitson RP, Albertsson P, Nannmark U, Basse PH, Kuppen PJ, Hokland ME and Goldfarb RH: Secreted and membrane-associated matrix metalloproteinases of IL-2-activated NK cells and their inhibitors. J Immunol. 164:5883–5889. 2000. View Article : Google Scholar : PubMed/NCBI

57 

Balsamo M, Scordamaglia F, Pietra G, Manzini C, Cantoni C, Boitano M, Queirolo P, Vermi W, Facchetti F, Moretta A, et al: Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity. Proc Natl Acad Sci USA. 106:20847–20852. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Drake CG, Jaffee E and Pardoll DM: Mechanisms of immune evasion by tumors. Adv Immunol. 90:51–81. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Rabinovich GA, Gabrilovich D and Sotomayor EM: Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol. 25:267–296. 2007. View Article : Google Scholar : PubMed/NCBI

60 

Pietra G, Manzini C, Rivara S, Vitale M, Cantoni C, Petretto A, Balsamo M, Conte R, Benelli R, Minghelli S, et al: Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity. Cancer Res. 72:1407–1415. 2012. View Article : Google Scholar : PubMed/NCBI

61 

Kaiser BK, Yim D, Chow IT, Gonzalez S, Dai Z, Mann HH, Strong RK, Groh V and Spies T: Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands. Nature. 447:482–486. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Soriani A, Zingoni A, Cerboni C, Iannitto ML, Ricciardi MR, Di Gialleonardo V, Cippitelli M, Fionda C, Petrucci MT, Guarini A, et al: ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood. 113:3503–3511. 2009. View Article : Google Scholar : PubMed/NCBI

63 

Valés-Gómez M, Chisholm SE, Cassady-Cain RL, Roda-Navarro P and Reyburn HT: Selective induction of expression of a ligand for the NKG2D receptor by proteasome inhibitors. Cancer Res. 68:1546–1554. 2008. View Article : Google Scholar : PubMed/NCBI

64 

Waldhauer I, Goehlsdorf D, Gieseke F, Weinschenk T, Wittenbrink M, Ludwig A, Stevanovic S, Rammensee H-G and Steinle A: Tumor-associated MICA is shed by ADAM proteases. Cancer Res. 68:6368–6376. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Burke S, Lakshmikanth T, Colucci F and Carbone E: New views on natural killer cell-based immunotherapy for melanoma treatment. Trends Immunol. 31:339–345. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Veuillen C, Aurran-Schleinitz T, Castellano R, Rey J, Mallet F, Orlanducci F, Pouyet L, Just-Landi S, Coso D, Ivanov V, et al: Primary B-CLL resistance to NK cell cytotoxicity can be overcome in vitro and in vivo by priming NK cells and monoclonal antibody therapy. J Clin Immunol. 32:632–646. 2012. View Article : Google Scholar : PubMed/NCBI

67 

Chouaib S, Pittari G, Nanbakhsh A, El Ayoubi H, Amsellem S, Bourhis JH and Spanholtz J: Improving the outcome of leukemia by natural killer cell-based immunotherapeutic strategies. Front Immunol. 5:952014. View Article : Google Scholar : PubMed/NCBI

68 

Terme M, Ullrich E, Delahaye NF, Chaput N and Zitvogel L: Natural killer cell-directed therapies: Moving from unexpected results to successful strategies. Nat Immunol. 9:486–494. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Carré T, Thiery J, Janji B, Terry S, Gros G, Meurice G, Kieda C, Olive D and Chouaib S: Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncol Rep 45: 582-594, 2021.
APA
Carré, T., Thiery, J., Janji, B., Terry, S., Gros, G., Meurice, G. ... Chouaib, S. (2021). Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncology Reports, 45, 582-594. https://doi.org/10.3892/or.2020.7872
MLA
Carré, T., Thiery, J., Janji, B., Terry, S., Gros, G., Meurice, G., Kieda, C., Olive, D., Chouaib, S."Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress". Oncology Reports 45.2 (2021): 582-594.
Chicago
Carré, T., Thiery, J., Janji, B., Terry, S., Gros, G., Meurice, G., Kieda, C., Olive, D., Chouaib, S."Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress". Oncology Reports 45, no. 2 (2021): 582-594. https://doi.org/10.3892/or.2020.7872
Copy and paste a formatted citation
x
Spandidos Publications style
Carré T, Thiery J, Janji B, Terry S, Gros G, Meurice G, Kieda C, Olive D and Chouaib S: Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncol Rep 45: 582-594, 2021.
APA
Carré, T., Thiery, J., Janji, B., Terry, S., Gros, G., Meurice, G. ... Chouaib, S. (2021). Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncology Reports, 45, 582-594. https://doi.org/10.3892/or.2020.7872
MLA
Carré, T., Thiery, J., Janji, B., Terry, S., Gros, G., Meurice, G., Kieda, C., Olive, D., Chouaib, S."Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress". Oncology Reports 45.2 (2021): 582-594.
Chicago
Carré, T., Thiery, J., Janji, B., Terry, S., Gros, G., Meurice, G., Kieda, C., Olive, D., Chouaib, S."Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress". Oncology Reports 45, no. 2 (2021): 582-594. https://doi.org/10.3892/or.2020.7872
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