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Article Open Access

KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway

  • Authors:
    • Qiang An
    • Ting Liu
    • Ming‑Yang Wang
    • Yu‑Jia Yang
    • Zhen‑Dong Zhang
    • Zhen‑Jiang Liu
    • Bing Yang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © An et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 481-492
    |
    Published online on: December 8, 2020
       https://doi.org/10.3892/or.2020.7886
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Abstract

Keratin 7 (KRT7) is a member of the keratin gene family. KRT7 is abnormally expressed in various types of cancer and promotes the malignant progression of tumors. However, the role of KRT7 in ovarian cancer remains unclear. The present study aimed to validate the role of KRT7 in ovarian cancer progression. KRT7 expression levels in patients with ovarian cancer were analyzed using data obtained from the Human Protein Atlas and The Cancer Genome Atlas databases. KRT7 mRNA and protein expression levels were upregulated in ovarian cancer tissue compared with normal tissue. KRT7 expression was associated with the grading, staging and poor prognosis of ovarian cancer. The differentially expressed genes affected by KRT7 were primarily enriched in the functions of cell migration, cell adhesion and cell growth. In vitro studies, including a CCK8 assay, were used to detect cell proliferation. In addition, wound healing and transwell assays were performed to analyze cell migration. The results demonstrated that KRT7 overexpression was associated with increased proliferation, migration and epithelial‑mesenchymal transition (EMT) of ovarian cancer cells, and the migration and EMT of ovarian cancers cells were decreased following knockdown with KRT7 small interfering RNA. In vivo, knockdown of KRT7 inhibited tumor growth of ovarian cancer. Furthermore, KRT7 regulated EMT in ovarian cancer via the TGF‑β/Smad2/3 pathway, and regulated cell‑matrix adhesion through integrin‑β1‑focal adhesion kinase signaling. These results suggest that KRT7 may be a potential molecular marker for prognosis prediction in patients with ovarian cancer.
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1 

Coukos G, Tanyi J and Kandalaft LE: Opportunities in immunotherapy of ovarian cancer. Ann Oncol. 27 (Suppl 1):i11–i15. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Smith RA, Andrews KS, Brooks D, Fedewa SA, Manassaram-Baptiste D, Saslow D, Brawley OW and Wender RC: Cancer screening in the United States, 2017: A review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J Clin. 67:100–121. 2017. View Article : Google Scholar : PubMed/NCBI

3 

US Preventive Services Task Force, ; Grossman DC, Curry SJ, Owens DK, Barry MJ, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, Krist AH, et al: Screening for ovarian cancer: US preventive services task force recommendation statement. JAMA. 319:588–594. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Siegel RL, Miller KD and Jemal A: Cancer statistics. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Corrado G, Salutari V, Palluzzi E, Distefano MG, Scambia G and Ferrandina G: Optimizing treatment in recurrent epithelial ovarian cancer. Expert Rev Anticancer Ther. 17:1147–1158. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Bristow RE and Chi DS: Platinum-based neoadjuvant chemotherapy and interval surgical cytoreduction for advanced ovarian cancer: A meta-analysis. Gynecol Oncol. 103:1070–1076. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Derynck R and Weinberg RA: EMT and cancer: More than meets the eye. Dev Cell. 49:313–316. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Feng W, Dean DC, Hornicek FJ, Shi H and Duan Z: Exosomes promote pre-metastatic niche formation in ovarian cancer. Mol Cancer. 18:1242019. View Article : Google Scholar : PubMed/NCBI

9 

Javan Maasomi Z, Pilehvar Soltanahmadi Y, Dadashpour M, Alipour S, Abolhasani S and Zarghami N: Synergistic anticancer effects of silibinin and chrysin in T47D breast cancer cells. Asian Pac J Cancer Prev. 18:1283–1287. 2017.PubMed/NCBI

10 

Sandilands A, Smith FJ, Lunny DP, Campbell LE, Davidson KM, MacCallum SF, Corden LD, Christie L, Fleming S, Lane EB and McLean WH: Generation and characterisation of keratin 7 (K7) knockout mice. PLoS One. 8:e644042013. View Article : Google Scholar : PubMed/NCBI

11 

Woods RSR, Keegan H, White C, Tewari P, Toner M, Kennedy S, O'Regan EM, Martin CM, Timon CVI and O'Leary JJ: Cytokeratin 7 in oropharyngeal squamous cell carcinoma: A junctional biomarker for human papillomavirus-related tumors. Cancer Epidemiol Biomarkers Prev. 26:702–710. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Hosoya A, Kwak S, Kim EJ, Lunny DP, Lane EB, Cho SW and Jung HS: Immunohistochemical localization of cytokeratins in the junctional region of ectoderm and endoderm. Anat Rec (Hoboken). 293:1864–1872. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Karantza V: Keratins in health and cancer: More than mere epithelial cell markers. Oncogene. 30:127–138. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Oue N, Noguchi T, Anami K, Kitano S, Sakamoto N, Sentani K, Uraoka N, Aoyagi K, Yoshida T, Sasaki H and Yasui W: Cytokeratin 7 is a predictive marker for survival in patients with esophageal squamous cell carcinoma. Ann Surg Oncol. 19:1902–1910. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Harbaum L, Pollheimer MJ, Kornprat P, Lindtner RA, Schlemmer A, Rehak P and Langner C: Keratin 7 expression in colorectal cancer-freak of nature or significant finding? Histopathology. 59:225–234. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Lambaudie E, Chereau E, Pouget N, Thomassin J, Minsat M, Charafe-Jauffret E, Jacquemier J and Houvenaeghel G: Cytokeratin 7 as a predictive factor for response to concommitant radiochemotherapy for locally advanced cervical cancer: A preliminary study. Anticancer Res. 34:177–181. 2014.PubMed/NCBI

17 

Kuroda H, Imai Y, Yamagishi H, Ueda Y, Kuroso K, Oishi Y, Ohashi H, Yamashita A, Yashiro Y and Fukushima H: Aberrant keratin 7 and 20 expression in triple-negative carcinoma of the breast. Ann Diagn Pathol. 20:36–39. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Wang P, Magdolen V, Seidl C, Dorn J, Drecoll E, Kotzsch M, Yang F, Schmitt M, Schilling O, Rockstroh A, et al: Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. Br J Cancer. 119:1–9. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, et al: Proteomics. Tissue-based map of the human proteome. Science. 347:12604192015. View Article : Google Scholar : PubMed/NCBI

21 

Chandrashekar DS, Bashel B, Balasubramanya SA, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BV and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10:15232019. View Article : Google Scholar : PubMed/NCBI

23 

Pastushenko I and Blanpain C: EMT transition states during tumor progression and metastasis. Trends Cell Biol. 29:212–226. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Kai F, Drain AP and Weaver VM: The extracellular matrix modulates the metastatic journey. Dev Cell. 49:332–346. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Cantelli G, Orgaz JL, Rodriguez-Hernandez I, Karagiannis P, Maiques O, Matias-Guiu X, Nestle FO, Marti RM, Karagiannis SN and Sanz-Moreno V: TGF-β-induced transcription sustains amoeboid melanoma migration and dissemination. Curr Biol. 25:2899–2914. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Huang B, Song JH, Cheng Y, Abraham JM, Ibrahim S, Sun Z, Ke X and Meltzer SJ: Long non-coding antisense RNA KRT7-AS-as is activated in gastric cancers and supports cancer cell progression by increasing krt7 expression. Oncogene. 35:4927–4936. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Tajima Y, Ito K, Umino A, Wilkinson AC, Nakauchi H and Yamazaki S: Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method. Sci Rep. 7:406842017. View Article : Google Scholar : PubMed/NCBI

28 

Lu P, Weaver VM and Werb Z: The extracellular matrix: A dynamic niche in cancer progression. J Cell Biol. 196:395–406. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Filipe EC, Chitty JL and Cox TR: Charting the unexplored extracellular matrix in cancer. Int J Exp Pathol. 99:58–76. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Alexander J and Cukierman E: Stromal dynamic reciprocity in cancer: Intricacies of fibroblastic-ECM interactions. Curr Opin Cell Biol. 42:80–93. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Byron A, Humphries JD and Humphries MJ: Defining the extracellular matrix using proteomics. Int J Exp Pathol. 94:75–92. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Pickup MW, Mouw JK and Weaver VM: The extracellular matrix modulates the hallmarks of cancer. EMBO Rep. 15:1243–1253. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Piwko-Czuchra A, Koegel H, Meyer H, Bauer M, Werner S, Brakebusch C and Fässler R: Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion. PLoS One. 4:e54882009. View Article : Google Scholar : PubMed/NCBI

34 

Khan Z and Marshall JF: The role of integrins in TGFβ activation in the tumour stroma. Cell Tissue Res. 365:657–673. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Golubovskaya V: Targeting FAK in human cancer: From finding to first clinical trials. Front Biosci (Landmark Ed). 19:687–706. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Peixoto P, Etcheverry A, Aubry M, Missey A, Lachat C, Perrard J, Hendrick E, Delage-Mourroux R, Mosser J, Borg C, et al: EMT is associated with an epigenetic signature of ECM remodeling genes. Cell Death Dis. 10:2052019. View Article : Google Scholar : PubMed/NCBI

37 

Cicchini C, Laudadio I, Citarella F, Corazzari M, Steindler C, Conigliaro A, Fantoni A, Amicone L and Tripodi M: TGFbeta-induced EMT requires focal adhesion kinase (FAK) signaling. Exp Cell Res. 314:143–152. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Attisano L and Wrana JL: Signal transduction by the TGF-beta superfamily. Science. 296:1646–1647. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Pardali E, Goumans MJ and Ten Dijke P: Signaling by members of the TGF-beta family in vascular morphogenesis and disease. Trends Cell Biol. 20:556–567. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Zavadil J and Böttinger EP: TGF-beta and epithelial-to-mesenchymal transitions. Oncogene. 24:5764–5774. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Hajra KM, Chen DY and Fearon ER: The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62:1613–1618. 2002.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
An Q, Liu T, Wang MY, Yang YJ, Zhang ZD, Liu ZJ and Yang B: KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. Oncol Rep 45: 481-492, 2021.
APA
An, Q., Liu, T., Wang, M., Yang, Y., Zhang, Z., Liu, Z., & Yang, B. (2021). KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. Oncology Reports, 45, 481-492. https://doi.org/10.3892/or.2020.7886
MLA
An, Q., Liu, T., Wang, M., Yang, Y., Zhang, Z., Liu, Z., Yang, B."KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway". Oncology Reports 45.2 (2021): 481-492.
Chicago
An, Q., Liu, T., Wang, M., Yang, Y., Zhang, Z., Liu, Z., Yang, B."KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway". Oncology Reports 45, no. 2 (2021): 481-492. https://doi.org/10.3892/or.2020.7886
Copy and paste a formatted citation
x
Spandidos Publications style
An Q, Liu T, Wang MY, Yang YJ, Zhang ZD, Liu ZJ and Yang B: KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. Oncol Rep 45: 481-492, 2021.
APA
An, Q., Liu, T., Wang, M., Yang, Y., Zhang, Z., Liu, Z., & Yang, B. (2021). KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. Oncology Reports, 45, 481-492. https://doi.org/10.3892/or.2020.7886
MLA
An, Q., Liu, T., Wang, M., Yang, Y., Zhang, Z., Liu, Z., Yang, B."KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway". Oncology Reports 45.2 (2021): 481-492.
Chicago
An, Q., Liu, T., Wang, M., Yang, Y., Zhang, Z., Liu, Z., Yang, B."KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway". Oncology Reports 45, no. 2 (2021): 481-492. https://doi.org/10.3892/or.2020.7886
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