Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February-2021 Volume 45 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2021 Volume 45 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells

  • Authors:
    • Ping Zhang
    • Yang Wang
    • Mengting Qin
    • Dandan Li
    • Woodvine Otieno Odhiambo
    • Meng Yuan
    • Zhuangwei Lv
    • Chengcheng Liu
    • Yunfeng Ma
    • Yanying Dong
    • Yanhong Ji
  • View Affiliations / Copyright

    Affiliations: Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi’an, Shaanxi 710061, P.R. China, Clinical Laboratory of The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 693-705
    |
    Published online on: December 8, 2020
       https://doi.org/10.3892/or.2020.7888
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oncogenic Bcr‑Abl kinase mimics pre‑B cell receptor (pre‑BCR) survival signals in BCR‑ABL1‑positive B‑cell acute lymphoblastic leukemia (BCR‑ABL1+ B‑ALL), driving B‑cell progenitor malignant transformation; thus, defining a particularly unfavorable prognosis for patients. During B‑cell development, pre‑BCR differentiation signaling components terminate proliferative expansion and promote B‑cell maturation. To study whether pre‑BCR differentiation signaling components regulate the initiation and development of BCR‑ABL1+ B‑ALL, the tumor suppression mechanism of differentiation‑related signaling molecules in BCR‑ABL1‑transformed pro‑B cells were analyzed. The results demonstrated that Bcr‑Abl kinase activated the PI3K/Akt pathway, promoting cell growth, and upregulated Aid expression, increasing genomic instability in pro‑B cells. These findings suggest that Bcr‑Abl kinase mediates pro‑B cell malignant transformation. Furthermore, the present data revealed that BCR‑ABL1 oncogenic stress triggered enhanced expression of B‑cell differentiation components B‑cell linker (Blnk) and forkhead box protein O1 (Foxo1) in BCR‑ABL1 transformed pro‑B cells. Using the CRISPR/Cas9‑mediated Blnk or Foxo1 knockout BCR‑ABL1‑transformed pro‑B cells, it was identified that, in BCR‑ABL1‑transformed pro‑B cells, Blnk and Foxo1 reduced Bcr‑Abl kinase activity to induce cell cycle arrest and decrease genomic instability. In addition, Blnk suppressed the PI3K/Akt pathway to reduce Foxo1 phosphorylation and heighten the Foxo1 activity, indicating that, in BCR‑ABL1‑transformed pro‑B cells, Foxo1 participated in the regulation of Bcr‑Abl kinase by Blnk. The present data highlighted the antitumor mechanisms of Blnk and Foxo1 in the regulation of Bcr‑Abl kinase, and thus, may offer an alternative therapeutic strategy to Bcr‑Abl kinase regulation in BCR‑ABL1+ B‑ALL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

El Fakih R, Jabbour E, Ravandi F, Hassanein M, Anjum F, Ahmed S and Kantarjian H: Current paradigms in the management of Philadelphia chromosome positive acute lymphoblastic leukemia in adults. Am J Hematol. 93:286–295. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Lee HJ, Thompson JE, Wang ES and Wetzler M: Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives. Cancer. 117:1583–1594. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Vinhas R, Lourenço A, Santos S, Lemos M, Ribeiro P, de Sousa AB, Baptista PV and Fernandes AR: A novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia. OncoTargets Ther. 11:8589–8598. 2018. View Article : Google Scholar

4 

Köhrer S, Havranek O, Seyfried F, Hurtz C, Coffey GP, Kim E, Ten HE, Jäger U, Vanura K and O'Brien S: Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1, and MYC, and can be targeted by SYK inhibition. Leukemia. 30:1246–1254. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Neshat MS, Raitano AB, Wang HG, Reed JC and Sawyers CL: The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: Roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol. 20:1179–1186. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Roumiantsev S, Aos IED, Varticovski L, Ilaria RL and Etten RAV: The Src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia–like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase. Blood. 97:4–13. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Sheng Z, Ma L, Sun JE, Zhu LJ and Green MR: BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood. 118:2840–2848. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE and Mccubrey JA: JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia. 18:189–218. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Iacobucci I, Lonetti A, Messa F, Ferrari A, Cilloni D, Soverini S, Paoloni F, Arruga F, Ottaviani E, Chiaretti S, et al: Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR-ABL1-positive acute lymphoblastic leukemia patients. Leukemia. 24:66–73. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh CL and Lieber MR: Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell. 135:1130–1142. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, et al: Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 16:766–774. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Dong Y, Liu F, Wu C, Li S, Zhao X, Zhang P, Jiao J, Yu X, Ji Y and Zhang M: Illegitimate RAG-mediated recombination events are involved in IKZF1 Δ3-6 deletion in BCR-ABL1 lymphoblastic leukaemia. Clin Exp Immunol. 185:320–331. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Gruber TA, Mi SC, Sposto R and Müschen M: Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B cell lineage acute lymphoblastic leukemia. Cancer Res. 70:7411–7420. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Klemm L, Duy C, Iacobucci I, Kuchen S, Levetzow GV, Feldhahn N, Henke N, Li Z, Hoffmann TK and Kim YM: The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell. 16:232–245. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Messina M, Chiaretti S, Iacobucci I, Tavolaro S, Lonetti A, Santangelo S, Elia L, Papayannidis C, Paoloni F, Vitale A, et al: AICDA expression in BCR/ABL1-positive acute lymphoblastic leukaemia is associated with a peculiar gene expression profile. Br J Haematol. 152:727–732. 2015. View Article : Google Scholar

16 

Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, Mcbride KM, Klein IA, Stone G, Eisenreich TR, et al: AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell. 36:631–641. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Fielding AK: Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: a broader range of options, improved outcomes, and more therapeutic dilemmas. Am Soc Clin Oncol Educ Book. 35:e352–9. 2015. View Article : Google Scholar

18 

Xing H, Yang X, Liu T, Lin J, Chen X and Gong Y: The study of resistant mechanisms and reversal in an imatinib resistant Ph+ acute lymphoblastic leukemia cell line. Leuk Res. 36:509–513. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Donahue AC and Fruman DA: Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J Immunol. 170:5851–5860. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Übelhart R, Werner M and Jumaa H: Assembly and function of the precursor B-cell receptor. Curr Top Microbiol Immunol. 393:3–25. 2016.PubMed/NCBI

21 

Burgering B: A brief introduction to FOXOlogy. Oncogene. 27:2258–2262. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Herzog S, Reth M and Jumaa H: Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat Rev Immunol. 9:195–205. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Koretzky GA, Abtahian F and Silverman MA: SLP76 and SLP65: Complex regulation of signalling in lymphocytes and beyond. Nat Rev Immunol. 6:67–78. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Garg M, Wahid M and Khan F: Regulation of peripheral and central immunity: Understanding the role of Src homology 2 domain-containing tyrosine phosphatases, SHP-1 & SHP-2. Immunobiology. 225:1518472020. View Article : Google Scholar : PubMed/NCBI

25 

Ochiai K, Maienschein-Cline M, Mandal M, Triggs JR, Bertolino E, Sciammas R, Dinner AR, Clark MR and Singh H: A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat Immunol. 13:300–307. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Feldhahn N, Klein F, Mooster JL, Hadweh P, Sprangers M, Wartenberg M, Bekhite MM, Hofmann WK, Herzog S, Jumaa H, et al: Mimicry of a constitutively active pre–B cell receptor in acute lymphoblastic leukemia cells. J Exp Med. 201:1837–1852. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Hickey FB, England K and Cotter TG: Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK. J Leukoc Biol. 78:289–300. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Kim E, Koehrer S, Wang Z, O'Brien S, Wierda WG, Thomas DA, Estrov Z, Kantarjian HM, Lannutti B and Davis RE: The PI3K delta inhibitor idelalisib interferes with pre-B cell receptor signaling in acute lymphoblastic leukemia (ALL): a new therapeutic concept. Blood. 122:26322013. View Article : Google Scholar

29 

Pellicano F, Scott MT, Helgason GV, Hopcroft LE, Allan EK, Aspinall-O'Dea M, Copland M, Pierce A, Huntly BJ, Whetton AD, et al: The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells. 32:2324–2337. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Szydlowski M, Kiliszek P, Sewastianik T, Jablonska E, Bialopiotrowicz E, Gorniak P, Polak A, Markowicz S, Nowak E, Grygorowicz MA, et al: FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas. Blood. 127:739–748. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Lowe SW, Cepero E and Evan G: Intrinsic tumour suppression. Nature. 432:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Flemming A, Brummer T, Reth M and Jumaa H: The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat Immunol. 4:38–43. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Hendriks RW and Kersseboom R: Involvement of SLP-65 and Btk in tumor suppression and malignant transformation of pre-B cells. Semin Immunol. 18:67–76. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Kersseboom R, Middendorp S, Dingjan GM, Dahlenborg K, Reth M, Jumaa H and Hendriks RW: Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells. J Exp Med. 198:91–98. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Ji Y, Resch W, Corbett E, Yamane A, Casellas R and Schatz DG: The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci. Cell. 141:419–431. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Zhang H, Peng C, Hu Y, Li H, Sheng Z, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, et al: The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nat Genet. 44:861–871. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE and Zhang F: Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Nat Protoc. 12:828–863. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, et al: Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 343:84–87. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

40 

de Jong R, ten Hoeve J, Heisterkamp N and Groffen J: ten HJ, Heisterkamp N and Groffen J: Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. Oncogene. 14:507–513. 1997. View Article : Google Scholar : PubMed/NCBI

41 

Huang R, Liu H, Chen Y, He Y, Kang Q, Tu S, He Y, Zhou X, Wang L, Yang J, et al: EPS8 regulates proliferation, apoptosis and chemosensitivity in BCR-ABL positive cells via the BCR-ABL/PI3K/AKT/mTOR pathway. Oncol Rep. 39:119–128. 2018.PubMed/NCBI

42 

Zhou Q, Chen Y, Chen X, Zhao W, Zhong Y, Wang R, Jin M, Qiu Y and Kong D: In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells. Int J Biol Sci. 12:631–638. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Giebel B: Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells. J Exp Med. 204:1157–1166. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Valdiglesias V, Giunta S, Fenech M, Neri M and Bonassi S: γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies. Mutat Res. 753:24–40. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Larsson LG: Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence. Semin Cancer Biol. 21:367–376. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Bassan R, Rohatiner AZ, Lerede T, Di BE, Rambaldi A, Pogliani E, Rossi G, Fabris P, Morandi S, Casula P, et al: Role of early anthracycline dose-intensity according to expression of Philadelphia chromosome/BCR-ABL rearrangements in B-precursor adult acute lymphoblastic leukemia. Hematol J Off J Eur Haematol Assoc. 1:226–234. 2000.

47 

Daenen S: Imatinib in Philadelphia chromosome positive acute lymphoblastic leukemia (ALL). Blood. 102:97–100. 2003.

48 

Signer RA, Montecino-Rodriguez E, Witte ON and Dorshkind K: Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 116:2522–2530. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Gishizky ML: Molecular mechanisms of Bcr-Abl-induced oncogenesis. Cytokines Mol Ther. 2:251–261. 1996.PubMed/NCBI

50 

Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B and Calabretta B: Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood. 86:726–736. 1995. View Article : Google Scholar : PubMed/NCBI

51 

Greaves MF and Wiemels J: Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer. 3:639–649. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Lieber MR, Yu K and Raghavan SC: Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. DNA Repair (Amst). 5:1234–1245. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui CH, et al: BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature. 453:110–114. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Collado M and Serrano M: Senescence in tumours: Evidence from mice and humans. Nat Rev Cancer. 10:51–57. 2010. View Article : Google Scholar : PubMed/NCBI

55 

d'Adda di Fagagna F: Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer. 8:512–522. 2008. View Article : Google Scholar : PubMed/NCBI

56 

Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW: Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88:593–602. 1997. View Article : Google Scholar : PubMed/NCBI

57 

Haigis KM and Sweet-Cordero A: New insights into oncogenic stress. Nat Genet. 43:177–178. 2011. View Article : Google Scholar : PubMed/NCBI

58 

Sharma N, Magistroni V, Piazza R, Citterio S, Mezzatesta C, Khandelwal P, Pirola A and Gambacorti-Passerini C: BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene. Mol Cancer. 14:1322015. View Article : Google Scholar : PubMed/NCBI

59 

Clapper E, Wang S, Raninga PV, Di TG and Tonissen KF: Cross-talk between Bcr-abl and the thioredoxin system in chronic myeloid leukaemia: implications for CML treatment. Antioxidants. 9:92020. View Article : Google Scholar

60 

Melo JV and Barnes DJ: Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer. 7:441–453. 2007. View Article : Google Scholar : PubMed/NCBI

61 

McCarron SL, Maher K, Kelly J, Ryan MF and Langabeer SE: Rapid evolution to blast crisis associated with a Q252H ABL1 kinase domain mutation in e19a2 BCR-ABL1 chronic myeloid leukaemia. Case Rep Hematol. 2013:4907402013.PubMed/NCBI

62 

Popp C, Dean W, Feng S, Cokus SJ, Andrews S, Pellegrini M, Jacobsen SE and Reik W: Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature. 463:1101–1105. 2010. View Article : Google Scholar : PubMed/NCBI

63 

Blake RA, Broome MA, Liu X, Wu J, Gishizky M, Sun L and Courtneidge SA: SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Mol Cell Biol. 20:9018–9027. 2000. View Article : Google Scholar : PubMed/NCBI

64 

Plas DR and Thompson CB: Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem. 278:12361–12366. 2003. View Article : Google Scholar : PubMed/NCBI

65 

Coffer PJ and Burgering BM: Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol. 4:889–899. 2004. View Article : Google Scholar : PubMed/NCBI

66 

Meixlsperger S, Köhler F, Wossning T, Reppel M, Müschen M and Jumaa H: Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Immunity. 26:323–333. 2007. View Article : Google Scholar : PubMed/NCBI

67 

Schmitt CA: Cellular senescence and cancer treatment. Biochim Biophys Acta. 1775:5–20. 2007.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Wang Y, Qin M, Li D, Odhiambo WO, Yuan M, Lv Z, Liu C, Ma Y, Dong Y, Dong Y, et al: Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells. Oncol Rep 45: 693-705, 2021.
APA
Zhang, P., Wang, Y., Qin, M., Li, D., Odhiambo, W.O., Yuan, M. ... Ji, Y. (2021). Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells. Oncology Reports, 45, 693-705. https://doi.org/10.3892/or.2020.7888
MLA
Zhang, P., Wang, Y., Qin, M., Li, D., Odhiambo, W. O., Yuan, M., Lv, Z., Liu, C., Ma, Y., Dong, Y., Ji, Y."Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells". Oncology Reports 45.2 (2021): 693-705.
Chicago
Zhang, P., Wang, Y., Qin, M., Li, D., Odhiambo, W. O., Yuan, M., Lv, Z., Liu, C., Ma, Y., Dong, Y., Ji, Y."Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells". Oncology Reports 45, no. 2 (2021): 693-705. https://doi.org/10.3892/or.2020.7888
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, Wang Y, Qin M, Li D, Odhiambo WO, Yuan M, Lv Z, Liu C, Ma Y, Dong Y, Dong Y, et al: Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells. Oncol Rep 45: 693-705, 2021.
APA
Zhang, P., Wang, Y., Qin, M., Li, D., Odhiambo, W.O., Yuan, M. ... Ji, Y. (2021). Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells. Oncology Reports, 45, 693-705. https://doi.org/10.3892/or.2020.7888
MLA
Zhang, P., Wang, Y., Qin, M., Li, D., Odhiambo, W. O., Yuan, M., Lv, Z., Liu, C., Ma, Y., Dong, Y., Ji, Y."Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells". Oncology Reports 45.2 (2021): 693-705.
Chicago
Zhang, P., Wang, Y., Qin, M., Li, D., Odhiambo, W. O., Yuan, M., Lv, Z., Liu, C., Ma, Y., Dong, Y., Ji, Y."Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells". Oncology Reports 45, no. 2 (2021): 693-705. https://doi.org/10.3892/or.2020.7888
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team