Potentially life‑threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors (Review)

  • Authors:
    • Emily L. Coleman
    • Brianna Olamiju
    • Jonathan S. Leventhal
  • View Affiliations

  • Published online on: December 24, 2020     https://doi.org/10.3892/or.2020.7911
  • Pages: 891-898
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Abstract

Tyrosine kinase inhibitors (TKIs) have emerged as a new frontier of cancer therapy. These agents include inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), BRAF, mitogen‑activated protein kinase kinase (also referred to as MEK), bcr‑abl, c‑KIT, platelet‑derived growth factor (PDGFR), fibroblast growth factor receptor (FGFR), anaplastic lymphoma kinase (ALK) and vascular endothelial growth factor (VEGF). Along with the evolving applications of TKIs, there has been an increased recognition of the breadth of potential cutaneous toxicities to these agents. In this review, we provide an overview of potentially life‑threatening severe cutaneous adverse reactions (SCARs) that may occur during therapy with TKIs. These toxicities include Stevens‑Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP).
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March-2021
Volume 45 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Coleman EL, Olamiju B and Leventhal JS: Potentially life‑threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors (Review). Oncol Rep 45: 891-898, 2021
APA
Coleman, E.L., Olamiju, B., & Leventhal, J.S. (2021). Potentially life‑threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors (Review). Oncology Reports, 45, 891-898. https://doi.org/10.3892/or.2020.7911
MLA
Coleman, E. L., Olamiju, B., Leventhal, J. S."Potentially life‑threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors (Review)". Oncology Reports 45.3 (2021): 891-898.
Chicago
Coleman, E. L., Olamiju, B., Leventhal, J. S."Potentially life‑threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors (Review)". Oncology Reports 45, no. 3 (2021): 891-898. https://doi.org/10.3892/or.2020.7911