Journal Articles

Review Open Access

Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors (Review)

Xiaojing Fu, Juanjuan Cui, Xiangjun Meng, Piyu Jiang, Qiuling Zheng, Wenwen Zhao, Xuehong Chen

Pages: 801-808 Published online on: 12 January 2021
Review Open Access

Role of chemokines in hepatocellular carcinoma (Review)

Dongdong Xue, Ya Zheng, Junye Wen, Jingzhao Han, Hongfang Tuo, Yifan Liu, Yanhui Peng

Pages: 809-823 Published online on: 22 December 2020
Review Open Access

Effects and mechanisms of Eps8 on the biological behaviour of malignant tumours (Review)

Kaili Luo, Lei Zhang, Yuan Liao, Hongyu Zhou, Hongying Yang, Min Luo, Chen Qing

Pages: 824-834 Published online on: 07 January 2021
Review

CD155/TIGIT, a novel immune checkpoint in human cancers (Review)

Lu Liu, Xuewu You, Sai Han, Yu Sun, Junhua Zhang, Youzhong Zhang

Pages: 835-845 Published online on: 19 January 2021
Review Open Access

Metabolic heterogeneity and immunocompetence of infiltrating immune cells in the breast cancer microenvironment (Review)

Hongdan Chen, Yizeng Sun, Zeyu Yang, Supeng Yin, Yao Li, Mi Tang, Junping Zhu, Fan Zhang

Pages: 846-856 Published online on: 22 January 2021
Article Open Access

Identification of a PLCE1‑regulated competing endogenous RNA regulatory network for esophageal squamous cell carcinoma

Zhihao Yang, Yi Hui, Hao Peng, Hongpan Zhang, Menglu Li, Lingxie Song, Feng Li, Xiaobin Cui

Pages: 857-868 Published online on: 04 January 2021
Article Open Access

Combination treatment with VPA and MSCs‑TRAIL could increase anti‑tumor effects against intracranial glioma

Soon A. Park, Hye Rim Han, Stephen Ahn, Chung Heon Ryu, Sin‑Soo Jeun

Pages: 869-878 Published online on: 14 January 2021
Article Open Access

Waterpipe smoke condensate influences epithelial to mesenchymal transition and interferes with the cytotoxic immune response in non-small cell lung cancer cell lines

Rania Faouzi Zaarour, Prathibha Prasad, Goutham Hassan Venkatesh, Raefa Abou Khouzam, Francis Amirtharaj, Nagwa Zeinelabdin, Ayesha Rifath, Stephane Terry, Husam Nawafleh, Yehya El Sayed, Salem Chouaib

Pages: 879-890 Published online on: 18 January 2021
Review

Potentially life‑threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors (Review)

Emily L. Coleman, Brianna Olamiju, Jonathan S. Leventhal

Pages: 891-898 Published online on: 24 December 2020
Article

HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer

Alessandra Verdina, Micol Di Segni, Carla Azzurra Amoreo, Isabella Sperduti, Simonetta Buglioni, Marcella Mottolese, Giuliana Di Rocco, Silvia Soddu

Pages: 899-910 Published online on: 24 December 2020
Article Open Access

MicroRNA‑34a‑5p serves as a tumor suppressor by regulating the cell motility of bladder cancer cells through matrix metalloproteinase‑2 silencing

Kuang‑Yu Chou, An‑Chen Chang, Te‑Fu Tsai, Yi‑Chia Lin, Hung‑En Chen, Chao‑Yen Ho, Po‑Chun Chen, Thomas I‑Sheng Hwang

Pages: 911-920 Published online on: 24 December 2020
Article Open Access

CDCA5 promotes the progression of prostate cancer by affecting the ERK signalling pathway

Junpeng Ji, Tianyu Shen, Yang Li, Yixi Liu, Zhiqun Shang, Yuanjie Niu

Pages: 921-932 Published online on: 04 January 2021
Article Open Access

MicroRNA‑642a‑5p inhibits colon cancer cell migration and invasion by targeting collagen type I α1

Xiaoguang Wang, Zhengwei Song, Biwen Hu, Zhenwei Chen, Fei Chen, Chenxi Cao

Pages: 933-944 Published online on: 18 December 2020
Article Open Access

Immunomodulatory potential of anticancer therapy composed of methotrexate nanoconjugate and dendritic cell‑based vaccines in murine colon carcinoma

Agnieszka Szczygieł, Natalia Anger‑Góra, Katarzyna Węgierek‑Ciura, Jagoda Mierzejewska, Joanna Rossowska, Tomasz M. Goszczyński, Marta Świtalska, Elżbieta Pajtasz‑Piasecka

Pages: 945-962 Published online on: 11 January 2021
Article Open Access

Use of miR‑145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer

Jin Zhu, Peibo Qin, Cheng Cao, Guangcheng Dai, Lijun Xu, Dongrong Yang

Pages: 963-974 Published online on: 05 January 2021
Article Open Access

VSP‑17 suppresses the migration and invasion of triple‑negative breast cancer cells through inhibition of the EMT process via the PPARγ/AMPK signaling pathway

Xiaotian Xu, Meng Liu, Yingying Yang, Chengqiong Wei, Xiyang Zhang, Hengzhi Song, Yuhui Wang, Xiaoqun Duan

Pages: 975-986 Published online on: 30 December 2020
Article Open Access

Beclin1‑armed oncolytic Vaccinia virus enhances the therapeutic efficacy of R‑CHOP against lymphoma in vitro and in vivo

Shufang Xie, Weimin Fan, Chen Yang, Wen Lei, Hongying Pan, Xiangmin Tong, Yi Wu, Shibing Wang

Pages: 987-996 Published online on: 19 January 2021
Article Open Access

GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer

Shu Ichimiya, Hideya Onishi, Shinjiro Nagao, Satoko Koga, Kukiko Sakihama, Kazunori Nakayama, Akiko Fujimura, Yasuhiro Oyama, Akira Imaizumi, Yoshinao Oda, Masafumi Nakamura

Pages: 997-1010 Published online on: 22 January 2021
Article Open Access

Dll4/Notch1 signalling pathway is required in collective invasion of salivary adenoid cystic carcinoma

Ke Wang, Hua‑Yang Fan, Xing Pang, Mei Zhang, Xiang‑Hua Yu, Jia‑Shun Wu, Bing‑Jun Chen, Jian Jiang, Xin‑Hua Liang, Ya‑Ling Tang

Pages: 1011-1022 Published online on: 18 January 2021
Article Open Access

Tissue factor pathway inhibitor‑2 is specifically expressed in ovarian clear cell carcinoma tissues in the nucleus, cytoplasm and extracellular matrix

Yukihide Ota, Shiro Koizume, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Tomoko Takahashi, Shinya Sato, Shohei Myoba, Norihisa Ohtake, Hisamori Kato, Tomoyuki Yokose, Etsuko Miyagi, Yohei Miyagi

Pages: 1023-1032 Published online on: 20 January 2021
Article Open Access

Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation

Min Jia, Bijia Su, Lijun Mo, Wen Qiu, Jiaxu Ying, Peng Lin, Bingxuan Yang, Danying Li, Dongxia Wang, Lili Xu, Hongwei Li, Zhongxin Zhou, Xing Li, Jinlong Li

Pages: 1033-1043 Published online on: 30 December 2020
Article Open Access

Nucleolar and spindle‑associated protein 1 promotes non‑small cell lung cancer progression and serves as an effector of myocyte enhancer factor 2D

Bo Ling, Pengya Wei, Juan Xiao, Bingkui Cen, Hong Wei, Xueping Feng, Guangbin Ye, Songbo Li, Zhongwei Zhang, Wei Liang, Suoyi Huang, Wei Huang

Pages: 1044-1058 Published online on: 30 December 2020
Article Open Access

Long non‑coding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTO‑mediated demethylation

Bo Qin, Meng Dong, Zhengyang Wang, Jiajia Wan, Yingying Xie, Yi Jiao, Dan Yan

Pages: 1059-1071 Published online on: 30 December 2020
Article Open Access

Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR‑153‑3p

Ge Yang, Xianyong Li, Jingbo Liu, Shengjie Huang, Yaguang Weng, Jing Zhu, Daiqiong Lin, Ou Jiang

Pages: 1072-1082 Published online on: 19 January 2021
Article Open Access

lncRNA HOTAIRM1 regulates cell proliferation and the metastasis of thyroid cancer by targeting Wnt10b

Chenyao Li, Xinxin Chen, Tao Liu, Guang Chen

Pages: 1083-1093 Published online on: 31 December 2020
Article Open Access

Long non‑coding RNA AFAP1‑AS1 facilitates the growth and invasiveness of oral squamous cell carcinoma by regulating the miR‑145/HOXA1 axis

Minghe Li, Dongsheng Yu, Zhihong Li, Cong Zhao, Chang Su, Jun Ning

Pages: 1094-1104 Published online on: 24 December 2020
Article Open Access

IL‑6 plays a crucial role in epithelial‑mesenchymal transition and pro‑metastasis induced by sorafenib in liver cancer

Ke‑Wei Zhang, Dong Wang, Hao Cai, Man‑Qing Cao, Yuan‑Yuan Zhang, Peng‑Yuan Zhuang, Jun Shen

Pages: 1105-1117 Published online on: 07 January 2021
Article Open Access

lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR‑18a‑5p/SOX6 signaling axis

Yan Zhao, Qing Zhang, Hongtao Liu, Ning Wang, Xiaosan Zhang, Shujun Yang

Pages: 1118-1132 Published online on: 11 January 2021
Article Open Access

Catechol enhances chemo‑ and radio‑sensitivity by targeting AMPK/Hippo signaling in pancreatic cancer cells

Jeong Yong Moon, Meran Keshawa Ediriweera, Ji Yeon Ryu, Hee Young Kim, Somi Kim Cho

Pages: 1133-1141 Published online on: 05 January 2021
Article Open Access

In vitro and ex vivo anti‑tumor effect and mechanism of Tucatinib in leukemia stem cells and ABCG2‑overexpressing leukemia cells

Wen Jing, Mao Zhou, Ruixia Chen, Xijiu Ye, Weixing Li, Xiangfei Su, Jianwei Luo, Zhi Wang, Shuling Peng

Pages: 1142-1152 Published online on: 30 December 2020
Article Open Access

Radiation exposure triggers the malignancy of non‑small cell lung cancer cells through the activation of visfatin/Snail signaling

Liang Xiao, Yiwen Mao, Zhuting Tong, Ye Zhao, Hao Hong, Fan Wang

Pages: 1153-1161 Published online on: 08 January 2021
Article Open Access

JMJD2C triggers the growth of multiple myeloma cells via activation of β‑catenin

Ming Lv, Qicai Liu

Pages: 1162-1170 Published online on: 14 January 2021
Article Open Access

Critical immunosuppressive effect of MDSC‑derived exosomes in the tumor microenvironment

Mohammad H. Rashid, Thaiz F. Borin, Roxan Ara, Raziye Piranlioglu, Bhagelu R. Achyut, Hasan Korkaya, Yutao Liu, Ali S. Arbab

Pages: 1171-1181 Published online on: 14 January 2021
Article Open Access

High expression of Rab31 confers a poor prognosis and enhances cell proliferation and invasion in oral squamous cell carcinoma

Xiaoguang Li, Fengshuo Zhu, Zhonglong Liu, Xiao Tang, Yu Han, Junjian Jiang, Chunyue Ma, Yue He

Pages: 1182-1192 Published online on: 18 January 2021
Article Open Access

Acanthopanax senticosus Harms extract causes G0/G1 cell cycle arrest and autophagy via inhibition of Rubicon in human liver cancer cells

Yutaka Kawano, Maki Tanaka, Masaki Fujishima, Eri Okumura, Hideo Takekoshi, Kohichi Takada, Osamu Uehara, Yoshihiro Abiko, Hidekatsu Takeda

Pages: 1193-1201 Published online on: 22 January 2021
Article Open Access

LINC00665 functions as a competitive endogenous RNA to regulate AGTR1 expression by sponging miR‑34a‑5p in glioma

Yongyue Dai, Yucheng Zhang, Maolin Hao, Renwu Zhu

Pages: 1202-1212 Published online on: 22 January 2021
Article Open Access

DDX41 regulates the expression and alternative splicing of genes involved in tumorigenesis and immune response

Kai Qin, Danni Jian, Yaqiang Xue, Yi Cheng, Peng Zhang, Yaxun Wei, Jing Zhang, Huihua Xiong, Yi Zhang, Xianglin Yuan

Pages: 1213-1225 Published online on: 25 January 2021
Article

ESM1/HIF‑1α pathway modulates chronic intermittent hypoxia‑induced non‑small‑cell lung cancer proliferation, stemness and epithelial‑mesenchymal transition

Xin Gu, Jie Zhang, Yuheng Shi, Haiji Shen, Yao Li, Yanyan Chen, Li Liang

Pages: 1226-1234 Published online on: 30 December 2020
Article

Low microRNA150 expression is associated with activated carcinogenic pathways and a poor prognosis in patients with breast cancer

San‑Qi An, Ke He, Fei Liu, Qian‑Shan Ding, Yan‑Li Wei, Zheng‑Lin Xia, Xiao‑Peng Duan, Rui Huang, Bo‑Wei Li, Hai‑He Wang, Yu Tian, Guo‑An Xiang, Wen‑Xing Li

Pages: 1235-1248 Published online on: 21 January 2021
Article

Metformin inhibits mTOR and c-Myc by decreasing YAP protein expression in OSCC cells

Ying Wang, Yafei Zhang, Xiaomei Feng, Hui Tian, Xucheng Fu, Weiting Gu, Yong Wen

Pages: 1249-1260 Published online on: 24 December 2020
Article

DMAPT‑D6 induces death‑receptor‑mediated apoptosis to inhibit glioblastoma cell oncogenesis via induction of DNA damage through accumulation of intracellular ROS

Ya‑Jun Zhang, Dong‑Lin Yang, Hong‑Xia Qin, Liu‑Jun He, Jiu‑Hong Huang, Dian‑Yong Tang, Zhi‑Gang Xu, Zhong‑Zhu Chen, Yong Li

Pages: 1261-1272 Published online on: 12 January 2021
Article

Expression of immune response biomarkers (PD‑L1, p16, CD3+ and CD8+ TILs) in recurrent head and neck squamous cell carcinoma within previously irradiated areas

Carole Pflumio, Jacques Thomas, Julia Salleron, Jean‑Christophe Faivre, Christian Borel, Gilles Dolivet, Xavier Sastre‑Garau, Lionnel Geoffrois

Pages: 1273-1283 Published online on: 07 January 2021
Article

Acidic microenvironment induction of interleukin-8 expression and matrix metalloproteinase-2/-9 activation via acid-sensing ion channel 1 promotes breast cancer cell progression

Masako Nakanishi, Ayaka Korechika, Haruka Yamakawa, Naoko Kawabe, Kazuma Nakai, Yasuteru Muragaki

Pages: 1284-1294 Published online on: 24 December 2020
Article

Role of ERCC5 polymorphisms in non‑small cell lung cancer risk and responsiveness/toxicity to cisplatin‑based chemotherapy in the Chinese population

Miao Li, Rong Chen, Baoyan Ji, Chunmei Fan, Guanying Wang, Chenli Yue, Guoquan Jin

Pages: 1295-1305 Published online on: 14 January 2021
Article

Repurposing of a monoamine oxidase A inhibitor‑heptamethine carbocyanine dye conjugate for paclitaxel‑resistant non‑small cell lung cancer

Xiao‑Guang Yang, Yan‑Yu Li, Dong‑Xue Zhao, Wei Cui, Han Li, Xin‑Yu Li, Yu‑Xin Li, Dun Wang

Pages: 1306-1314 Published online on: 22 January 2021
Correction Open Access

[Corrigendum] Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, migration effects and accelerates cell cycle progression in multiple myeloma cells via activating the Akt pathway

Dong Zheng, Ziang Chen, Jingfu Chen, Xiaomin Zhuang, Jianqiang Feng, Juan Li

Pages: 1315-1315 Published online on: 05 January 2021
Correction Open Access

[Corrigendum] siRNA-mediated inhibition of endogenous brain‑derived neurotrophic factor gene modulates the biological behavior of HeLa cells

Chun-Yan Sun, Zhang-Bo Chu, Jing Huang, Lei Chen, Jian Xu, Ao-Shuang Xu, Jun-Ying Li, Yu Hu

Pages: 1316-1316 Published online on: 05 January 2021
Journal Cover

March-2021
Volume 45 Issue 3

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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