Open Access

Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors (Review)

  • Authors:
    • Xiaojing Fu
    • Juanjuan Cui
    • Xiangjun Meng
    • Piyu Jiang
    • Qiuling Zheng
    • Wenwen Zhao
    • Xuehong Chen
  • View Affiliations

  • Published online on: January 12, 2021     https://doi.org/10.3892/or.2021.7933
  • Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

External and internal stimuli are often involved in the pathogenesis of tumors, and the deterioration of endoplasmic reticulum (ER) function within cells is also an important etiological factor of tumorigenesis resulting in the impairment of the endoplasmic reticulum, which is termed ER stress. The ER is an organelle that serves a crucial role in the process of protein synthesis and maturation, and also acts as a reservoir of calcium to maintain intracellular Ca2+ homeostasis. ER stress has been revealed to serve a critical role in tumorigenesis. In the present review, the association between ER stress‑related pathways and tumor cell apoptosis is examined. Primarily, the role of ER stress in tumor cell apoptosis is discussed, and it is stipulated that ER stress, induced by drugs both directly and indirectly, promotes tumor cell apoptosis.

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Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Fu X, Cui J, Meng X, Jiang P, Zheng Q, Zhao W and Chen X: Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors (Review). Oncol Rep 0: 0-0, 1899
APA
Fu, X., Cui, J., Meng, X., Jiang, P., Zheng, Q., Zhao, W., & Chen, X. (1899). Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors (Review). Oncology Reports, 0, 0-0. https://doi.org/10.3892/or.2021.7933
MLA
Fu, X., Cui, J., Meng, X., Jiang, P., Zheng, Q., Zhao, W., Chen, X."Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors (Review)". Oncology Reports 0.0 (1899): 0-0.
Chicago
Fu, X., Cui, J., Meng, X., Jiang, P., Zheng, Q., Zhao, W., Chen, X."Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors (Review)". Oncology Reports 0, no. 0 (1899): 0-0. https://doi.org/10.3892/or.2021.7933