Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
April-2021 Volume 45 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 45 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation

  • Authors:
    • Qian Guo
    • Yiwen Liu
    • Yiqing He
    • Yan Du
    • Guoliang Zhang
    • Cuixia Yang
    • Feng Gao
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory and Molecular Biology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 7
    |
    Published online on: February 1, 2021
       https://doi.org/10.3892/or.2021.7958
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The cell surface glycoprotein CD44 displays different active statuses; however, it remains unknown whether the activation process of CD44 is critical for tumor development and progression. The aim of the present study was to investigate whether breast cancer (BCa) cells with different activation states of CD44 show similar or distinct functional characteristics and to further examine the mechanisms regulating CD44 activities. A feature for the ‘activated’ state of CD44 is that it can bind to its principal ligand hyaluronan (HA). The binding of CD44 with HA is usually influenced by CD44 alternative splicing, resulting in multiple CD44 isoforms that determine CD44 activities. Flow cytometry was used to sort BCa cell subsets based on CD44‑HA binding abilities (HA‑/low vs. HAhigh). Subsequently, cell proliferation and colony formation assays were performed in vitro, and CD44 expression patterns were analyzed via western blotting. The results demonstrated that the CD44 variant isoform 10 (CD44v10) was highly expressed in a HA‑/low binding subset of BCa cells, which exhibited a significantly higher proliferation capacity compared with the HAhigh binding subpopulation. Knockdown of CD44v10 isoform in HA‑/low binding subpopulation induced an increase in HA binding ability and markedly inhibited proliferation. Furthermore, the mechanistic analysis identified that CD44v10 facilitated cell proliferation via activation of ERK/p38 MAPK and AKT/mTOR signaling. Moreover, the knockdown of CD44v10 expression downregulated the phosphorylation of ERK, AKT and mTOR, while no alteration was observed in p38 phosphorylation. Collectively, the present study identified a subset of fast‑growing BCa cells characterized by CD44v10 expression, which may serve as a specific therapeutic target for BCa.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Yeo SK and Guan JL: Breast cancer: Multiple subtypes within a tumor? Trends Cancer. 3:753–760. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Heldin P, Basu K, Kozlova I and Porsch H: HAS2 and CD44 in breast tumorigenesis. Adv Cancer Res. 123:211–229. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Senbanjo LT and Chellaiah MA: CD44: A multifunctional cell surface adhesion receptor is a regulator of progression and metastasis of cancer cells. Front Cell Dev Biol. 5:182017. View Article : Google Scholar : PubMed/NCBI

5 

DeGrendele HC, Estess P and Siegelman MH: Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science. 278:672–675. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Chanmee T, Ontong P and Itano N: Hyaluronan: A modulator of the tumor microenvironment. Cancer Lett. 375:20–30. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Toole BP: Hyaluronan-CD44 interactions in cancer: Paradoxes and possibilities. Clin Cancer Res. 15:7462–7468. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Karousou E, Misra S, Ghatak S, Dobra K, Götte M, Vigetti D, Passi A, Karamanos NK and Skandalis SS: Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol. 59:3–22. 2017. View Article : Google Scholar : PubMed/NCBI

9 

McDonald B and Kubes P: Interactions between CD44 and hyaluronan in leukocyte trafficking. Front Immunol. 6:682015. View Article : Google Scholar : PubMed/NCBI

10 

Lesley J, Kincade PW and Hyman R: Antibody-induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody. Eur J Immunol. 23:1902–1909. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Ogino S, Nishida N, Umemoto R, Suzuki M, Takeda M, Terasawa H, Kitayama J, Matsumoto M, Hayasaka H, Miyasaka M, et al: Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition. Structure. 18:649–656. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Lesley J and Hyman R: CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur J Immunol. 22:2719–2723. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Hiraga T, Ito S and Nakamura H: Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production. Cancer Res. 73:4112–4122. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Hu S, Cao M, He Y, Zhang G, Liu Y, Du Y, Yang C and Gao F: CD44v6 targeted by miR-193b-5p in the coding region Modulates the migration and invasion of breast cancer cells. J Cancer. 11:260–271. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Zhao P, Xu Y, Wei Y, Qiu Q, Chew TL, Kang Y and Cheng C: The CD44s splice isoform is a central mediator for invadopodia activity. J Cell Sci. 129:1355–1365. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, et al: Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Mol Cell. 13:483–496. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Liu D, Liu T, Li R and Sy MS: Mechanisms regulating the binding activity of CD44 to hyaluronic acid. Front Biosci. 3:d631–d636. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Louderbough JM and Schroeder JA: Understanding the dual nature of CD44 in breast cancer progression. Mol Cancer Res. 9:1573–1586. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Naor D, Nedvetzki S, Golan I, Melnik L and Faitelson Y: CD44 in cancer. Crit Rev Clin Lab Sci. 39:527–579. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Dougherty GJ, Cooper DL, Memory JF and Chiu RK: Ligand binding specificity of alternatively spliced CD44 isoforms. Recognition and binding of hyaluronan by CD44R1. J Biol Chem. 269:9074–9078. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Bennett KL, Modrell B, Greenfield B, Bartolazzi A, Stamenkovic I, Peach R, Jackson DG, Spring F and Aruffo A: Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons. J Cell Biol. 131:1623–1633. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Sleeman J, Rudy W, Hofmann M, Moll J, Herrlich P and Ponta H: Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity. J Cell Biol. 135:1139–1150. 1996. View Article : Google Scholar : PubMed/NCBI

23 

Orian-Rousseau V: CD44 Acts as a signaling platform controlling tumor progression and metastasis. Front Immunol. 6:1542015. View Article : Google Scholar : PubMed/NCBI

24 

Chen C, Zhao S, Karnad A and Freeman JW: The biology and role of CD44 in cancer progression: Therapeutic implications. J Hematol Oncol. 11:642018. View Article : Google Scholar : PubMed/NCBI

25 

Liu S and Cheng C: Akt Signaling is sustained by a CD44 splice isoform-mediated positive feedback loop. Cancer Res. 77:3791–3801. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Yang C, Cao M, Liu H, He Y, Xu J, Du Y, Liu Y, Wang W, Cui L, Hu J, et al: The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering. J Biol Chem. 287:43094–43107. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, Deng Y, Hu X, Zhang J, Gao XD, et al: CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 33:166–179. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Hu J, Li G, Zhang P, Zhuang X and Hu G: A CD44v+ subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis. 8:e26792017. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Lokeshwar VB, Iida N and Bourguignon LY: The cell adhesion molecule, GP116, is a new CD44 variant (ex14/v10) involved in hyaluronic acid binding and endothelial cell proliferation. J Biol Chem. 271:23853–23864. 1996. View Article : Google Scholar : PubMed/NCBI

31 

Aguirre-Ghiso JA, Estrada Y, Liu D and Ossowski L: ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res. 63:1684–1695. 2003.PubMed/NCBI

32 

Nan H, Han L, Ma J, Yang C, Su R and He J: STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells. Biochim Biophys Acta Mol Basis Dis. 1864:1684–1692. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Aguirre-Ghiso JA, Ossowski L and Rosenbaum SK: Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res. 64:7336–7345. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Dong Y, Poon GF, Arif AA, Lee-Sayer SS, Dosanjh M and Johnson P: The survival of fetal and bone marrow monocyte-derived alveolar macrophages is promoted by CD44 and its interaction with hyaluronan. Mucosal Immunol. 11:601–614. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Levesque MC and Haynes BF: Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13. J Immunol. 159:6184–6194. 1997.PubMed/NCBI

36 

Siegelman MH, DeGrendele HC and Estess P: Activation and interaction of CD44 and hyaluronan in immunological systems. J Leukoc Biol. 66:315–321. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Bachar G, Cohen K, Hod R, Feinmesser R, Mizrachi A, Shpitzer T, Katz O and Peer D: Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers. Biomaterials. 32:4840–4848. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Patrawala L, Calhoun T, Schneider-Broussard R, Li H, Bhatia B, Tang S, Reilly JG, Chandra D, Zhou J, Claypool K, et al: Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene. 25:1696–1708. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Misra S, Hascall VC, Markwald RR and Ghatak S: Interactions between hyaluronan and its receptors (CD44, RHAMM) regulate the activities of inflammation and cancer. Front Immunol. 6:2012015. View Article : Google Scholar : PubMed/NCBI

40 

Bartolazzi A, Peach R, Aruffo A and Stamenkovic I: Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J Exp Med. 180:53–66. 1994. View Article : Google Scholar : PubMed/NCBI

41 

Hanagiri T, Shinohara S, Takenaka M, Shigematsu Y, Yasuda M, Shimokawa H, Nagata Y, Nakagawa M, Uramoto H, So T, et al: Effects of hyaluronic acid and CD44 interaction on the proliferation and invasiveness of malignant pleural mesothelioma. Tumour Biol. 33:2135–2141. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Veiseh M, Kwon DH, Borowsky AD, Tolg C, Leong HS, Lewis JD, Turley EA and Bissell MJ: Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset. Proc Natl Acad Sci USA. 111:E1731–E1739. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Ahrens T, Sleeman JP, Schempp CM, Howells N, Hofmann M, Ponta H, Herrlich P and Simon JC: Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Oncogene. 20:3399–3408. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Song JM, Im J, Nho RS, Han YH, Upadhyaya P and Kassie F: Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells. Mol Carcinog. 58:321–333. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Peach RJ, Hollenbaugh D, Stamenkovic I and Aruffo A: Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol. 122:257–264. 1993. View Article : Google Scholar : PubMed/NCBI

46 

Stamenkovic I, Aruffo A, Amiot M and Seed B: The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J. 10:343–348. 1991. View Article : Google Scholar : PubMed/NCBI

47 

van der Voort R, Manten-Horst E, Smit L, Ostermann E, van den Berg F and Pals ST: Binding of cell-surface expressed CD44 to hyaluronate is dependent on splicing and cell type. Biochem Biophys Res Commun. 214:137–144. 1995. View Article : Google Scholar : PubMed/NCBI

48 

Weimann TK, Wagner C, Funk R, Hirche H, Goos M and Wagner SN: Hyaluronan-independent adhesion of CD44H+ and CD44v10+ lymphocytes to dermal microvascular endothelial cells and keratinocytes. J Invest Dermatol. 117:949–957. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Iida N and Bourguignon LY: Coexpression of CD44 variant (v10/ex14) and CD44S in human mammary epithelial cells promotes tumorigenesis. J Cell Physiol. 171:152–160. 1997. View Article : Google Scholar : PubMed/NCBI

50 

Katoh S, Zheng Z, Oritani K, Shimozato T and Kincade PW: Glycosylation of CD44 negatively regulates its recognition of hyaluronan. J Exp Med. 182:419–429. 1995. View Article : Google Scholar : PubMed/NCBI

51 

Bellerby R, Smith C, Kyme S, Gee J, Günthert U, Green A, Rakha E, Barrett-Lee P and Hiscox S: Overexpression of specific CD44 isoforms is associated with aggressive cell features in acquired endocrine resistance. Front Oncol. 6:1452016. View Article : Google Scholar : PubMed/NCBI

52 

Beham-Schmid C, Heider KH, Hoefler G and Zatloukal K: Expression of CD44 splice variant v10 in Hodgkin's disease is associated with aggressive behaviour and high risk of relapse. J Pathol. 186:383–389. 1998. View Article : Google Scholar : PubMed/NCBI

53 

Asosingh K, Günthert U, De Raeve H, Van Riet I, Van Camp B and Vanderkerken K: A unique pathway in the homing of murine multiple myeloma cells: CD44v10 mediates binding to bone marrow endothelium. Cancer Res. 61:2862–2865. 2001.PubMed/NCBI

54 

Megaptche AP, Erb U, Büchler MW and Zöller M: CD44v10, osteopontin and lymphoma growth retardation by a CD44v10-specific antibody. Immunol Cell Biol. 92:709–720. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Li N, Tsuji M, Kanda K, Murakami Y, Kanayama H and Kagawa S: Analysis of CD44 isoform v10 expression and its prognostic value in renal cell carcinoma. BJU Int. 85:514–518. 2000. View Article : Google Scholar : PubMed/NCBI

56 

Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, et al: CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(−) and thereby promotes tumor growth. Cancer Cell. 19:387–400. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Black EJ, Clark W and Gillespie DA: Transient deactivation of ERK signalling is sufficient for stable entry into G0 in primary avian fibroblasts. Curr Biol. 10:1119–1122. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Chen G, Hitomi M, Han J and Stacey DW: The p38 pathway provides negative feedback for Ras proliferative signaling. J Biol Chem. 275:38973–38980. 2000. View Article : Google Scholar : PubMed/NCBI

59 

Aguirre-Ghiso JA, Liu D, Mignatti A, Kovalski K and Ossowski L: Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell. 12:863–879. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guo Q, Liu Y, He Y, Du Y, Zhang G, Yang C and Gao F: CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation. Oncol Rep 45: 7, 2021.
APA
Guo, Q., Liu, Y., He, Y., Du, Y., Zhang, G., Yang, C., & Gao, F. (2021). CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation. Oncology Reports, 45, 7. https://doi.org/10.3892/or.2021.7958
MLA
Guo, Q., Liu, Y., He, Y., Du, Y., Zhang, G., Yang, C., Gao, F."CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation". Oncology Reports 45.4 (2021): 7.
Chicago
Guo, Q., Liu, Y., He, Y., Du, Y., Zhang, G., Yang, C., Gao, F."CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation". Oncology Reports 45, no. 4 (2021): 7. https://doi.org/10.3892/or.2021.7958
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Q, Liu Y, He Y, Du Y, Zhang G, Yang C and Gao F: CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation. Oncol Rep 45: 7, 2021.
APA
Guo, Q., Liu, Y., He, Y., Du, Y., Zhang, G., Yang, C., & Gao, F. (2021). CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation. Oncology Reports, 45, 7. https://doi.org/10.3892/or.2021.7958
MLA
Guo, Q., Liu, Y., He, Y., Du, Y., Zhang, G., Yang, C., Gao, F."CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation". Oncology Reports 45.4 (2021): 7.
Chicago
Guo, Q., Liu, Y., He, Y., Du, Y., Zhang, G., Yang, C., Gao, F."CD44 activation state regulated by the CD44v10 isoform determines breast cancer proliferation". Oncology Reports 45, no. 4 (2021): 7. https://doi.org/10.3892/or.2021.7958
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team