Mechanisms and functions of long non‑coding RNAs in glioma (Review)

  • Authors:
    • Xingjie Chen
    • Gaochao Guo
    • Yalin Lu
    • Shuaishuai Wang
    • Yu Zhang
    • Qiang Huang
  • View Affiliations

  • Published online on: February 1, 2021     https://doi.org/10.3892/or.2021.7960
  • Article Number: 9
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Abstract

Glioma is one of the most common primary malignancies of the adult central nervous system with malignancy grades between I‑IV. Among these four grades, glioblastoma is the most malignant and aggressive type of tumor and is characterized by a poor prognosis, high recurrence rate and short median survival time after initial diagnosis. Existing treatments, such as radiotherapy, chemotherapy and surgical resection, have poor therapeutic effects; therefore, it is necessary to discover novel targeted therapies to enhance the curative effect and improve prognosis. Recently, increasing evidence has shown that long non‑coding RNAs (lncRNAs) participate in the vast majority of key physiological and pathological processes. Moreover, aberrant expression levels of lncRNAs are closely associated with the occurrence and development of glioma and other malignant phenotypes. The present review summarizes new insights into the functions and mechanisms of lncRNAs at the epigenetic, transcriptional and post‑transcriptional levels, describes their ability to encode functional peptides in glioma and discusses their clinical potential as new biomarkers and prospective therapeutic targets.
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April-2021
Volume 45 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Guo G, Lu Y, Wang S, Zhang Y and Huang Q: Mechanisms and functions of long non‑coding RNAs in glioma (Review). Oncol Rep 45: 9, 2021
APA
Chen, X., Guo, G., Lu, Y., Wang, S., Zhang, Y., & Huang, Q. (2021). Mechanisms and functions of long non‑coding RNAs in glioma (Review). Oncology Reports, 45, 9. https://doi.org/10.3892/or.2021.7960
MLA
Chen, X., Guo, G., Lu, Y., Wang, S., Zhang, Y., Huang, Q."Mechanisms and functions of long non‑coding RNAs in glioma (Review)". Oncology Reports 45.4 (2021): 9.
Chicago
Chen, X., Guo, G., Lu, Y., Wang, S., Zhang, Y., Huang, Q."Mechanisms and functions of long non‑coding RNAs in glioma (Review)". Oncology Reports 45, no. 4 (2021): 9. https://doi.org/10.3892/or.2021.7960