Emerging roles of circular RNAs in non‑small cell lung cancer (Review)

Li,Shanshan; Liu,Yize; Qiu,Guanzhen; Luo,Yinzhou; Li,Xiang; Meng,Fei; Li,Nanyang; Xu,Tiance; Wang,Yong; Qin,Baoli; Xia,Shuyue

doi:10.3892/or.2021.7968

Emerging roles of circular RNAs in non‑small cell lung cancer (Review)

Authors:
- Shanshan Li
- Yize Liu
- Guanzhen Qiu
- Yinzhou Luo
- Xiang Li
- Fei Meng
- Nanyang Li
- Tiance Xu
- Yong Wang
- Baoli Qin
- Shuyue Xia
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Affiliations: Department of Respiratory, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China, Fourth Department of Orthopedic Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China, Department of Gynaecology and Obstetrics, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China, Department of Pathology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China, Second Department of Neurology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China, Department of Internal Medicine, Cancer Hospital of China Medical University/Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China
Published online on: February 3, 2021 https://doi.org/10.3892/or.2021.7968
Article Number: 17
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) are a class of novel endogenous transcripts with limited protein‑coding abilities. CircRNAs have been demonstrated to function as critical regulators of tumor development and distant metastasis through binding to microRNAs (miRNAs) and interacting with RNA‑binding proteins, thereby regulating transcription and translation. Emerging evidence has illustrated that certain circRNAs can serve as biomarkers for diagnosis and prognosis of cancer, and/or serve as potential therapeutic targets. Expression of functional circRNAs is commonly dysregulated in cancer and this is correlated with advanced Tumor‑Node‑Metastasis stage, lymph node status, distant metastasis, poor differentiation and shorter overall survival of cancer patients. Recently, an increasing number of studies have shown that circRNAs are closely associated with NSCLC. Functional experiments have revealed that circRNAs are intricately associated with the pathological progression of NSCLC. The present review provides an overview of the regulatory effect of circRNAs in the development and progression of NSCLC, taking into consideration various physiological and pathological processes, such as proliferation, apoptosis, invasion and migration, and their potential value as biomarkers and therapeutic targets.

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