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Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide

  • Authors:
    • Zhang-Jian Yang
    • Le-Ling Zhang
    • Qiu-Chen Bi
    • Li-Jun Gan
    • Min-Jun Wei
    • Tao Hong
    • Ren-Jie Tan
    • Xue-Mei Lan
    • Li-Hua Liu
    • Xiao-Jian Han
    • Li-Ping Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Pharmaceutical Science, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Key Laboratory of Drug Targets and Drug Screening of Jiangxi Province, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 44
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    Published online on: February 25, 2021
       https://doi.org/10.3892/or.2021.7995
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Abstract

Glioblastoma is the most common and aggressive brain tumor and it is characterized by a high mortality rate. Temozolomide (TMZ) is an effective chemotherapy drug for glioblastoma, but the resistance to TMZ has come to represent a major clinical problem, and its underlying mechanism has yet to be elucidated. In the present study, the role of exosomal connexin 43 (Cx43) in the resistance of glioma cells to TMZ and cell migration was investigated. First, higher expression levels of Cx43 were detected in TMZ‑resistant U251 (U251r) cells compared with those in TMZ‑sensitive (U251s) cells. Exosomes from U251s or U251r cells (sExo and rExo, respectively) were isolated. It was found that the expression of Cx43 in rExo was notably higher compared with that in sExo, whereas treatment with rExo increased the expression of Cx43 in U251s cells. Additionally, exosomes stained with dioctadecyloxacarbocyanine (Dio) were used to visualized exosome uptake by glioma cells. It was observed that the uptake of Dio‑stained rExo in U251s cells was more prominent compared with that of Dio‑stained sExo, while 37,43Gap27, a gap junction mimetic peptide directed against Cx43, alleviated the rExo uptake by cells. Moreover, rExo increased the IC50 of U251s to TMZ, colony formation and Bcl‑2 expression, but decreased Bax and cleaved caspase‑3 expression in U251s cells. 37,43Gap27 efficiently inhibited these effects of rExo on U251s cells. Finally, the results of the wound healing and Transwell assays revealed that rExo significantly enhanced the migration of U251s cells, whereas 37,43Gap27 significantly attenuated rExo‑induced cell migration. Taken together, these results indicate the crucial role of exosomal Cx43 in chemotherapy resistance and migration of glioma cells, and suggest that Cx43 may hold promise as a therapeutic target for glioblastoma in the future.
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1 

Lara-Velazquez M, Al-Kharboosh R, Jeanneret S, Vazquez-Ramos C, Mahato D, Tavanaiepour D, Rahmathulla G and Quinones-Hinojosa A: Advances in brain tumor surgery for glioblastoma in adults. Brain Sci. 20:1662017. View Article : Google Scholar

2 

Iwadate Y: Epithelial-mesenchymal transition in glioblastoma progression. Oncol Lett. 11:1615–1620. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Bonavia R, Inda MM, Cavenee WK and Furnari FB: Heterogeneity maintenance in glioblastoma: A social network. Cancer Res. 71:4055–4060. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Alonso MM, Gomez-Manzano C, Bekele BN, Yung WK and Fueyo J: Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter. Cancer Res. 67:11499–11504. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Zhang J, Stevens MF and Bradshaw TD: Temozolomide: Mechanisms of action, repair and resistance. Curr Mol Pharmacol. 5:102–114. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Omar AI and Mason WP: Temozolomide: The evidence for its therapeutic efficacy in malignant astrocytomas. Core Evid. 4:93–111. 2010.PubMed/NCBI

8 

Neyns B, Tosoni A, Hwu WJ and Reardon DA: Dose-dense temozolomide regimens: Antitumor activity, toxicity, and immunomodulatory effects. Cancer. 116:2868–2877. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Garcia-Mayea Y, Mir C, Masson F, Paciucci R and ME LL: Insights into new mechanisms and models of cancer stem cell multidrug resistance. Semin Cancer Biol. 60:166–180. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Munoz JL, Walker ND, Mareedu S, Pamarthi SH, Sinha G, Greco SJ and Rameshwar P: Cycling quiescence in temozolomide resistant glioblastoma cells is partly explained by microRNA-93 and −193-mediated decrease of cyclin D. Front Pharmacol. 10:1342019. View Article : Google Scholar : PubMed/NCBI

11 

Cao X, Lu Y, Liu Y, Zhou Y, Song H, Zhang W, Davis D, Cui J, Hao S, Jung J, et al: Combination of PARP inhibitor and temozolomide to suppress chordoma progression. J Mol Med (Berl). 97:1183–1193. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Théry C, Zitvogel L and Amigorena S: Exosomes: Composition, biogenesis and function. Nat Rev Immunol. 2:569–579. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A and Ratajczak MZ: Membrane-derived microvesicles: Important and underappreciated mediators of cell-to-cell communication. Leukemia. 20:1487–1495. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Mathivanan S, Ji H and Simpson RJ: Exosomes: Extracellular organelles important in intercellular communication. J Proteomics. 73:1907–1920. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Cocucci E and Meldolesi J: Ectosomes and exosomes: Shedding the confusion between extracellular vesicles. Trends Cell Biol. 25:364–372. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Azmi AS, Bao B and Sarkar FH: Exosomes in cancer development, metastasis, and drug resistance: A comprehensive review. Cancer Metastasis Rev. 32:623–642. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Xiao GY, Cheng CC, Chiang YS, Cheng WT, Liu IH and Wu SC: Exosomal miR-10a derived from amniotic fluid stem cells preserves ovarian follicles after chemotherapy. Sci Rep. 6:231202016. View Article : Google Scholar : PubMed/NCBI

18 

Tanaka S, Hosokawa M, Ueda K and Iwakawa S: Effects of decitabine on invasion and exosomal expression of miR-200c and miR-141 in oxaliplatin-resistant colorectal cancer cells. Biol Pharm Bull. 38:1272–1279. 2015. View Article : Google Scholar : PubMed/NCBI

19 

O'Brien K, Lowry MC, Corcoran C, Martinez VG, Daly M, Rani S, Gallagher WM, Radomski MW, MacLeod RA and O'Driscoll L: MiR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity. Oncotarget. 6:32774–32789. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Santos JC, da Silva Lima N, Sarian LO, Matheu A, Ribeiro ML and Derchain SFM: Exosome-mediated breast cancer chemoresistance via miR-155 transfer. Sci Rep. 8:8292018. View Article : Google Scholar : PubMed/NCBI

21 

Mulcahy LA, Pink RC and Carter DR: Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles. 3:34022014. View Article : Google Scholar

22 

Feng D, Zhao WL, Ye YY, Bai XC, Liu RQ, Chang LF, Zhou Q and Sui SF: Cellular internalization of exosomes occurs through phagocytosis. Traffic. 11:675–687. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Mincheva-Nilsson L and Baranov V: Cancer exosomes and NKG2D receptor-ligand interactions: Impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance. Semin Cancer Biol. 28:24–30. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Soares AR, Martins-Marques T, Ribeiro-Rodrigues T, Ferreira JV, Catarino S, Pinho MJ, Zuzarte M, Anjo SI, Manadas B, Sluijter JP, et al: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells. Sci Rep. 5:132432015. View Article : Google Scholar : PubMed/NCBI

25 

Scemes E, Spray DC and Meda P: Connexins, pannexins, innexins: Novel roles of ‘hemi-channels’. Pflugers Arch. 457:1207–1226. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Maes M, Decrock E, Cogliati B, Oliveira AG, Marques PE, Dagli ML, Menezes GB, Mennecier G, Leybaert L, Vanhaecke T, et al: Connexin and pannexin (hemi)channels in the liver. Front Physiol. 4:4052014. View Article : Google Scholar : PubMed/NCBI

27 

Aasen T, Mesnil M, Naus CC, Lampe PD and Laird DW: Gap junctions and cancer: Communicating for 50 years. Nat Rev Cancer. 16:775–788. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Sin WC, Crespin S and Mesnil M: Opposing roles of connexin43 in glioma progression. Biochim Biophys Acta. 1818:2058–2067. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Gielen PR, Aftab Q, Ma N, Chen VC, Hong X, Lozinsky S, Naus CC and Sin WC: Connexin43 confers temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway. Neuropharmacology. 75:539–548. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Theis M and Giaume C: Connexin-based intercellular communication and astrocyte heterogeneity. Brain Res. 1487:88–98. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Caltabiano R, Torrisi A, Condorelli D, Albanese V and Lanzafame S: High levels of connexin 43 mRNA in high grade astrocytomas. Study of 32 cases with in situ hybridization. Acta Histochem. 112:529–535. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Munoz JL, Rodriguez-Cruz V, Greco SJ, Ramkissoon SH, Ligon KL and Rameshwar P: Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43. Cell Death Dis. 5:e11452014. View Article : Google Scholar : PubMed/NCBI

33 

Helwa I, Cai J, Drewry MD, Zimmerman A, Dinkins MB, Khaled ML, Seremwe M, Dismuke WM, Bieberich E, Stamer WD, et al: A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents. PLoS One. 12:e01706282017. View Article : Google Scholar : PubMed/NCBI

34 

Han XJ, Yang ZJ, Jiang LP, Wei YF, Liao MF, Qian Y, Li Y, Huang X, Wang JB, Xin HB and Wan YY: Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol. 46:691–700. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Konadu KA, Huang MB, Roth W, Armstrong W, Powell M, Villinger F and Bond V: Isolation of exosomes from the plasma of HIV-1 positive individuals. J Vis Exp. 5:534952016.

36 

Das A, Banik NL, Patel SJ and Ray SK: Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax:Bcl-2 ratio and preventing proteolytic activities. Mol Cancer. 3:362004. View Article : Google Scholar : PubMed/NCBI

37 

Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, et al: Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 3:ra812010. View Article : Google Scholar : PubMed/NCBI

38 

Chistiakov DA and Chekhonin VP: Extracellular vesicles shed by glioma cells: Pathogenic role and clinical value. Tumour Biol. 35:8425–8438. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Jia G, Han Y, An Y, Ding Y, He C, Wang X and Tang Q: NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo. Biomaterials. 178:302–316. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Goodenough DA and Paul DL: Beyond the gap: Functions of unpaired connexon channels. Nat Rev Mol Cell Biol. 4:285–294. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Murphy SF, Varghese RT, Lamouille S, Guo S, Pridham KJ, Kanabur P, Osimani AM, Sharma S, Jourdan J, Rodgers CM, et al: Connexin 43 inhibition sensitizes chemoresistant glioblastoma cells to temozolomide. Cancer Res. 76:139–149. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Ilvesaro J, Tavi P and Tuukkanen J: Connexin-mimetic peptide gap 27 decreases osteoclastic activity. BMC Musculoskelet Disord. 2:102001. View Article : Google Scholar : PubMed/NCBI

43 

Edwards G, Félétou M, Gardener MJ, Thollon C, Vanhoutte PM and Weston AH: Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries. Br J Pharmacol. 128:1788–1794. 1999. View Article : Google Scholar : PubMed/NCBI

44 

Faniku C, O'Shaughnessy E, Lorraine C, Johnstone SR, Graham A, Greenhough S and Martin PE: The connexin mimetic peptide gap27 and Cx43-knockdown reveal differential roles for connexin43 in wound closure events in skin model systems. Int J Mol Sci. 19:6042018. View Article : Google Scholar

45 

Hombach-Klonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, Siemianowicz K, Likus W, Wiechec E, Toyota BD, et al: Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response. Pharmacol Ther. 184:13–41. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Lu J, Yu M, Lin Z, Lue S, Zhang H, Zhao H, Xu Y and Liu H: Effects of connexin43 overexpression on U251 cell growth, migration, and apoptosis. Med Sci Monit. 23:2917–2923. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Ito A, Koma Y, Uchino K, Okada T, Ohbayashi C, Tsubota N and Okada M: Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: Significant correlation with poor prognosis. Cancer Lett. 234:239–248. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Kalra J, Shao Q, Qin H, Thomas T, Alaoui-Jamali MA and Laird DW: Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism. Carcinogenesis. 27:2528–2537. 2006. View Article : Google Scholar : PubMed/NCBI

49 

McLachlan E, Shao Q, Wang HL, Langlois S and Laird DW: Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis. Cancer Res. 66:9886–9894. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang Z, Zhang L, Bi Q, Gan L, Wei M, Hong T, Tan R, Lan X, Liu L, Han X, Han X, et al: Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide. Oncol Rep 45: 44, 2021.
APA
Yang, Z., Zhang, L., Bi, Q., Gan, L., Wei, M., Hong, T. ... Jiang, L. (2021). Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide. Oncology Reports, 45, 44. https://doi.org/10.3892/or.2021.7995
MLA
Yang, Z., Zhang, L., Bi, Q., Gan, L., Wei, M., Hong, T., Tan, R., Lan, X., Liu, L., Han, X., Jiang, L."Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide". Oncology Reports 45.4 (2021): 44.
Chicago
Yang, Z., Zhang, L., Bi, Q., Gan, L., Wei, M., Hong, T., Tan, R., Lan, X., Liu, L., Han, X., Jiang, L."Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide". Oncology Reports 45, no. 4 (2021): 44. https://doi.org/10.3892/or.2021.7995
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Z, Zhang L, Bi Q, Gan L, Wei M, Hong T, Tan R, Lan X, Liu L, Han X, Han X, et al: Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide. Oncol Rep 45: 44, 2021.
APA
Yang, Z., Zhang, L., Bi, Q., Gan, L., Wei, M., Hong, T. ... Jiang, L. (2021). Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide. Oncology Reports, 45, 44. https://doi.org/10.3892/or.2021.7995
MLA
Yang, Z., Zhang, L., Bi, Q., Gan, L., Wei, M., Hong, T., Tan, R., Lan, X., Liu, L., Han, X., Jiang, L."Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide". Oncology Reports 45.4 (2021): 44.
Chicago
Yang, Z., Zhang, L., Bi, Q., Gan, L., Wei, M., Hong, T., Tan, R., Lan, X., Liu, L., Han, X., Jiang, L."Exosomal connexin 43 regulates the resistance of glioma cells to temozolomide". Oncology Reports 45, no. 4 (2021): 44. https://doi.org/10.3892/or.2021.7995
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