Role of hypoxia‑inducible factor‑2α in lung cancer (Review)

  • Authors:
    • Wen-Jun Wang
    • Chao Ouyang
    • Bin Yu
    • Chong Chen
    • Xiao-Feng Xu
    • Xiao-Qun Ye
  • View Affiliations

  • Published online on: March 9, 2021     https://doi.org/10.3892/or.2021.8008
  • Article Number: 57
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Abstract

Hypoxia is a common phenomenon during tumorigenesis and tumour development. In recent years, studies have found that hypoxia‑inducible factor (HIF)‑2α, also referred to as endothelial PAS domain protein‑1, plays an important role in tumours. HIF‑2α is an important oncogene and a critical prognostic indicator in non‑small cell lung cancer. However, no unified conclusion can be drawn concerning HIF‑2α and small cell lung cancer, since few studies to date have focused on their association. An increasing number of studies have confirmed that HIF‑2α is involved in tumorigenesis, cell proliferation, angiogenesis, metastasis, drug resistance and radiotherapy failure in lung cancer. Of note, HIF‑2α plays a crucial role in lung cancer to maintain cancer cell stemness. Based on the importance of HIF‑2α in lung cancer, HIF‑2α‑targeted therapy has been attracting increasing attention. Although this strategy currently appears to be promising in vitro, it has never been assessed as a therapy for lung cancer. The aim of the present review was to summarize the contribution of HIF‑2α to various aspects of lung cancer, as well as its potential as targeted therapy.
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May-2021
Volume 45 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wang W, Ouyang C, Yu B, Chen C, Xu X and Ye X: Role of hypoxia‑inducible factor‑2α in lung cancer (Review). Oncol Rep 45: 57, 2021
APA
Wang, W., Ouyang, C., Yu, B., Chen, C., Xu, X., & Ye, X. (2021). Role of hypoxia‑inducible factor‑2α in lung cancer (Review). Oncology Reports, 45, 57. https://doi.org/10.3892/or.2021.8008
MLA
Wang, W., Ouyang, C., Yu, B., Chen, C., Xu, X., Ye, X."Role of hypoxia‑inducible factor‑2α in lung cancer (Review)". Oncology Reports 45.5 (2021): 57.
Chicago
Wang, W., Ouyang, C., Yu, B., Chen, C., Xu, X., Ye, X."Role of hypoxia‑inducible factor‑2α in lung cancer (Review)". Oncology Reports 45, no. 5 (2021): 57. https://doi.org/10.3892/or.2021.8008