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Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review)

  • Authors:
    • Moumita Mukherjee
    • Swapnila Pramanick
    • Barsha Saha
    • Bishnupriya Chhatriya
    • Srikanta Goswami
  • View Affiliations / Copyright

    Affiliations: National Institute of Biomedical Genomics, Kalyani, West Bengal 741251, India
  • Article Number: 128
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    Published online on: May 14, 2021
       https://doi.org/10.3892/or.2021.8079
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Abstract

Inability of early detection as well as lack of proper therapeutic intervention, both add to the complexity of pancreatic cancer. Understanding of the basic cellular processes is of the utmost importance and autophagy is one of these processes. Considering the importance of this process in normal cellular functions as well as in pathological states, elaboration of the updated information on the mechanism of autophagy was initially carried out. Autophagy is a process for degradation of damaged cellular organelles, abnormal proteins and even nutrients which happen via formation of autophagosomes. Incidentally, autophagy has been shown to play both oncogenic and tumour‑suppressive functions in cancer and has also been shown to modulate stemness of cancer cells, recurrence and resistance to chemotherapeutic agents. The contribution of autophagy genes and pathways in pancreatic tumorigenesis was also evaluated. Regulation is the key step in any such cellular phenomenon and noncoding RNA‑mediated regulation is an emerging field. While miRNAs participate mainly in post‑transcriptional regulation, long noncoding RNAs and circular RNAs have more diverse regulatory functions. Noncoding RNAs are also shown to modulate both the tumour‑promoting and tumour‑suppressing functions of autophagy in pancreatic cancer. The implication of noncoding RNA‑mediated regulation with respect to radio‑resistance and chemo‑resistance of pancreatic cancer cells was also assessed. To the best of our knowledge, this is the first ever attempt trying to decipher the cross‑talk between autophagy‑noncoding RNAs and genes involved in the development and progression of pancreatic cancer.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, Gavin A, Visser O and Bray F: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer. 103:356–387. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Yang J, Ren B, Yang G, Wang H, Chen G, You L, Zhang T and Zhao Y: The enhancement of glycolysis regulates pancreatic cancer metastasis. Cell Mol Life Sci. 77:305–321. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Poruk KE, Firpo MA, Adler DG and Mulvihill SJ: Screening for pancreatic cancer: Why, how, and who? Ann Surg. 257:17–26. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Devenport SN and Shah YM: Functions and implications of autophagy in colon cancer. Cells. 8:13492019. View Article : Google Scholar : PubMed/NCBI

6 

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, et al: Pancreatic cancers require autophagy for tumor growth. Genes Dev. 25:717–729. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Chen L, Zhou Y, Sun Q, Zhou J, Pan H and Sui X: Regulation of autophagy by MiRNAs and their emerging roles in tumorigenesis and cancer treatment. Int Rev Cell Mol Biol. 334:1–26. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Dey BK, Mueller AC and Dutta A: Long non-coding RNAs as emerging regulators of differentiation, development, and disease. Transcription. 5:e9440142014. View Article : Google Scholar : PubMed/NCBI

9 

Sun T: Long noncoding RNAs act as regulators of autophagy in cancer. Pharmacol Res. 129:151–155. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Choudhry H, Harris AL and McIntyre A: The tumour hypoxia induced non-coding transcriptome. Mol Aspects Med. 47-48:35–53. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Levy JMM, Towers CG and Thorburn A: Targeting autophagy in cancer. Nat Rev Cancer. 17:528–542. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Herrera-Cruz MS and Simmen T: Of yeast, mice and men: MAMs come in two flavors. Biology Direct. 12:32017. View Article : Google Scholar : PubMed/NCBI

13 

Puri C, Renna M, Bento CF, Moreau K and Rubinsztein DC: Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell. 154:1285–1299. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Ge L, Melville D, Zhang M and Schekman R: The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. Elife. 2:e009472013. View Article : Google Scholar : PubMed/NCBI

15 

Graef M, Friedman JR, Graham C, Babu M and Nunnari J: ER exit sites are physical and functional core autophagosome biogenesis components. Mol Biol Cell. 24:2918–2931. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Ravikumar B, Moreau K, Jahreiss L, Puri C and Rubinsztein DC: Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol. 12:747–757. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Hailey DW, Rambold AS, Satpute-Krishnan P, Mitra K, Sougrat R, Kim PK and Lippincott-Schwartz J: Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell. 141:656–667. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Geng J, Nair U, Yasumura-Yorimitsu K and Klionsky DJ: Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell. 21:2257–2269. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Otomo C, Metlagel Z, Takaesu G and Otomo T: Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat Struct Mol Biol. 20:59–66. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Tanida I: Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal. 14:2201–2214. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Lamark T, Svenning S and Johansen T: Regulation of selective autophagy: The p62/SQSTM1 paradigm. Essays Biochem. 61:609–624. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Ganley IG: Autophagosome maturation and lysosomal fusion. Essays Biochem. 55:65–78. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Li X, He S and Ma B: Autophagy and autophagy-related proteins in cancer. Mol Cancer. 19:122020. View Article : Google Scholar : PubMed/NCBI

24 

Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, et al: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 112:1809–1820. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Kang MR, Kim MS, Oh JE, Kim YR, Song SY, Kim SS, Ahn CH, Yoo NJ and Lee SH: Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. J Pathol. 217:702–706. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Li YJ, Lei YH, Yao N, Wang CR, Hu N, Ye WC, Zhang DM and Chen ZS: Autophagy and multidrug resistance in cancer. Chin J Cancer. 36:522017. View Article : Google Scholar : PubMed/NCBI

27 

Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, et al: PKM1 confers metabolic advantages and promotes cell-autonomous tumor cell growth. Cancer Cell. 33:355–367.e7. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Mowers EE, Sharifi MN and Macleod KF: Autophagy in cancer metastasis. Oncogene. 36:1619–1630. 2017. View Article : Google Scholar : PubMed/NCBI

29 

El Hout M, Cosialls E, Mehrpour M and Hamai A: Crosstalk between autophagy and metabolic regulation of cancer stem cells. Mol Cancer. 19:272020. View Article : Google Scholar : PubMed/NCBI

30 

Kardideh B, Samimi Z, Norooznezhad F, Kiani S and Mansouri K: Autophagy, cancer and angiogenesis: Where is the link? Cell Biosci. 9:652019. View Article : Google Scholar : PubMed/NCBI

31 

Bhol CS, Panigrahi DP, Praharaj PP, Mahapatra KK, Patra S, Mishra SR, Behera BP and Bhutia SK: Epigenetic modifications of autophagy in cancer and cancer therapeutics. Semin Cancer Biol. 66:22–33. 2020. View Article : Google Scholar : PubMed/NCBI

32 

New M and Tooze S: The role of autophagy in pancreatic cancer-recent advances. Biology (Basel). 9:72019.PubMed/NCBI

33 

Gorgulu K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, et al: Levels of the autophagy-related 5 protein affect progression and metastasis of pancreatic tumors in mice. Gastroenterology. 156:203–217.e20. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Xu J, Song J, Yang X, Guo J, Wang T and Zhuo W: ProNGF siRNA inhibits cell proliferation and invasion of pancreatic cancer cells and promotes anoikis. Biomed Pharmacother. 111:1066–1073. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, et al: p53 status determines the role of autophagy in pancreatic tumour development. Nature. 504:296–300. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, et al: Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 524:361–365. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Wong PM, Feng Y, Wang J, Shi R and Jiang X: Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A. Nat Commun. 6:80482015. View Article : Google Scholar : PubMed/NCBI

38 

Biancur DE and Kimmelman AC: The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance. Biochim Biophys Acta Rev Cancer. 1870:67–75. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Tang D, Kang R, Livesey KM, Zeh HJ III and Lotze MT: High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress. Antioxid Redox Signal. 15:2185–2195. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, et al: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 536:479–483. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Gupta SK and Thum T: Non-coding RNAs as orchestrators of autophagic processes. J Mol Cell Cardiol. 95:26–30. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Bejerano G, Pheasant M, Makunin I, Stephen S, Kent WJ, Mattick JS and Haussler D: Ultraconserved elements in the human genome. Science. 304:1321–1335. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Cech TR and Steitz JA: The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 157:77–94. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Huang Y, Shen XJ, Zou Q, Wang SP, Tang SM and Zhang GZ: Biological functions of microRNAs: A review. J Physiol Biochem. 67:129–139. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Yamamura S, Imai-Sumida M, Tanaka Y and Dahiya R: Interaction and cross-talk between non-coding RNAs. Cell Mol Life Sci. 75:467–484. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Zhang J, Wang P, Wan L, Xu S and Pang D: The emergence of noncoding RNAs as Heracles in autophagy. Autophagy. 13:1004–1024. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X, Liu CG and Yang JM: Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy. 5:816–823. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Sun L, Hu L, Cogdell D, Lu L, Gao C, Tian W, Zhang Z, Kang Y, Fleming JB and Zhang W: MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway. Autophagy. 13:703–714. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Tan X, Zhou L, Wang H, Yang Y, Sun Y, Wang Z, Zhang X, Gao F and Li H: Differential expression profiles of microRNAs in highly and weakly invasive/metastatic pancreatic cancer cells. Oncol Lett. 16:6026–6038. 2018.PubMed/NCBI

50 

Yang Y, Sun Y, Wang H, Li H, Zhang M, Zhou L, Meng X, Wu Y, Liu P, Liu X, et al: MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer. Oncol Lett. 16:7295–7301. 2018.PubMed/NCBI

51 

Iwata A, Riley BE, Johnston JA and Kopito RR: HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem. 280:40282–4092. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Donadelli M and Palmieri M: Roles for microRNA 23b in regulating autophagy and development of pancreatic adenocarcinoma. Gastroenterology. 145:936–938. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Kwon JJ, Willy JA, Quirin KA, Wek RC, Korc M, Yin XM and Kota J: Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential. Oncotarget. 7:71635–71650. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Wang ZC, Huang FZ, Xu HB, Sun JC and Wang CF: MicroRNA-137 inhibits autophagy and chemosensitizes pancreatic cancer cells by targeting ATG5. Int J Biochem Cell Biol. 111:63–71. 2019. View Article : Google Scholar : PubMed/NCBI

55 

Gu DN, Jiang MJ, Mei Z, Dai JJ, Dai CY, Fang C, Huang Q and Tian L: microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression. Cancer Lett. 400:69–78. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Chen H, Zhang Z, Lu Y, Song K, Liu X, Xia F and Sun W: Downregulation of ULK1 by microRNA-372 inhibits the survival of human pancreatic adenocarcinoma cells. Cancer Sci. 108:1811–1819. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Tian S, Guo X, Yu C, Sun C and Jiang J: miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. Oncotarget. 8:11071–11082. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Xiong J, Wang D, Wei A, Ke N, Wang Y, Tang J, He S, Hu W and Liu X: MicroRNA-410-3p attenuates gemcitabine resistance in pancreatic ductal adenocarcinoma by inhibiting HMGB1-mediated autophagy. Oncotarget. 8:107500–107512. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Zhang X, Shi H, Lin S, Ba M and Cui S: MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy. Oncol Rep. 34:1557–1564. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Huang L, Hu C, Cao H, Wu X, Wang R, Lu H, Li H and Chen H: MicroRNA-29c increases the chemosensitivity of pancreatic cancer cells by inhibiting USP22 mediated autophagy. Cell Physiol Biochem. 47:747–758. 2018. View Article : Google Scholar : PubMed/NCBI

61 

Zhao SP, Yu C, Xiang KM, Yang MS, Liu ZL and Yang BC: miR-375 inhibits autophagy and further promotes inflammation and apoptosis of acinar cells by targeting ATG7. Pancreas. 49:543–551. 2020. View Article : Google Scholar : PubMed/NCBI

62 

Yan JW, Lin JS and He XX: The emerging role of miR-375 in cancer. Int J Cancer. 135:1011–1018. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Zhang X, Chu J, Sun H, Zhao D, Ma B, Xue D, Zhang W and Li Z: MiR-155 aggravates impaired autophagy of pancreatic acinar cells through targeting Rictor. Acta Biochim Biophys Sin (Shanghai). 52:192–199. 2020. View Article : Google Scholar : PubMed/NCBI

64 

Cao TT, Lin SH, Fu L, Tang Z, Che CM, Zhang LY, Ming XY, Liu TF, Tang XM, Tan BB, et al: Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells. Carcinogenesis. 38:94–104. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Wang T, Chen G, Ma X, Yang Y, Chen Y, Peng Y, Bai Z, Zhang Z, Pei H and Guo W: MiR-30a regulates cancer cell response to chemotherapy through SNAI1/IRS1/AKT pathway. Cell Death Dis. 10:1532019. View Article : Google Scholar : PubMed/NCBI

66 

Yang C, Zhang JJ, Peng YP, Zhu Y, Yin LD, Wei JS, Gao WT, Jiang KR and Miao Y: A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells. J Transl Med. 15:2112017. View Article : Google Scholar : PubMed/NCBI

67 

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, et al: The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res. 22:1775–1789. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Bermudez M, Aguilar-Medina M, Lizarraga-Verdugo E, Avendano-Felix M, Silva-Benitez E, Lopez-Camarillo C and Ramos-Payán R: LncRNAs as regulators of autophagy and drug resistance in colorectal cancer. Front Oncol. 9:10082019. View Article : Google Scholar : PubMed/NCBI

69 

Li L, Chen H, Gao Y, Wang YW, Zhang GQ, Pan SH, Ji L, Kong R, Wang G, Jia YH, et al: Long noncoding RNA MALAT1 promotes aggressive pancreatic cancer proliferation and metastasis via the stimulation of autophagy. Mol Cancer Ther. 15:2232–2243. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Wu C, Yang L, Qi X, Wang T, Li M and Xu K: Inhibition of long non-coding RNA HOTAIR enhances radiosensitivity via regulating autophagy in pancreatic cancer. Cancer Manag Res. 10:5261–5271. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Paraskevopoulou MD, Vlachos IS, Karagkouni D, Georgakilas G, Kanellos I, Vergoulis T, Zagganas K, Tsanakas P, Floros E, Dalamagas T and Hatzigeorgiou AG: DIANA-LncBase v2: Indexing microRNA targets on non-coding transcripts. Nucleic Acids Res. 44:D231–D238. 2016. View Article : Google Scholar : PubMed/NCBI

72 

Huang F, Chen W, Peng J, Li Y, Zhuang Y, Zhu Z, Shao C, Yang W, Yao H and Zhang S: LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis. Mol Cancer. 17:982018. View Article : Google Scholar : PubMed/NCBI

73 

Li C, Zhao Z, Zhou Z and Liu R: Linc-ROR confers gemcitabine resistance to pancreatic cancer cells via inducing autophagy and modulating the miR-124/PTBP1/PKM2 axis. Cancer Chemother Pharmacol. 78:1199–1207. 2016. View Article : Google Scholar : PubMed/NCBI

74 

Liu Y, Wang J, Dong L, Xia L, Zhu H, Li Z and Yu X: Long noncoding RNA HCP5 regulates pancreatic cancer gemcitabine (GEM) resistance by sponging Hsa-miR-214-3p To target HDGF. Onco Targets Ther. 12:8207–8216. 2019. View Article : Google Scholar : PubMed/NCBI

75 

Liu C, Wang JO, Zhou WY, Chang XY, Zhang MM, Zhang Y and Yang XH: Long non-coding RNA LINC01207 silencing suppresses AGR2 expression to facilitate autophagy and apoptosis of pancreatic cancer cells by sponging miR-143-5p. Mol Cell Endocrinol. 493:1104242019. View Article : Google Scholar : PubMed/NCBI

76 

Shao Y and Chen Y: Roles of circular RNAs in neurologic disease. Front Mol Neurosci. 9:252016. View Article : Google Scholar : PubMed/NCBI

77 

Jiang PC and Bu SR: Clinical value of circular RNAs and autophagy-related miRNAs in the diagnosis and treatment of pancreatic cancer. Hepatobiliary Pancreat Dis Int. 18:511–516. 2019. View Article : Google Scholar : PubMed/NCBI

78 

Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB and Kjems J: The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 20:675–691. 2019. View Article : Google Scholar : PubMed/NCBI

79 

Zhong Y, Du Y, Yang X, Mo Y, Fan C, Xiong F, Ren D, Ye X, Li C, Wang Y, et al: Circular RNAs function as ceRNAs to regulate and control human cancer progression. Mol Cancer. 17:792018. View Article : Google Scholar : PubMed/NCBI

80 

Wei DM, Jiang MT, Lin P, Yang H, Dang YW, Yu Q, Liao DY, Luo DZ and Chen G: Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentiallyexpressed circRNAs, lncRNAs, miRNAs and mRNAs. Int J Oncol. 54:600–626. 2019.PubMed/NCBI

81 

Li Z, Yanfang W, Li J, Jiang P, Peng T, Chen K, Zhao X, Zhang Y, Zhen P, Zhu J and Li X: Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. Cancer Lett. 432:237–250. 2018. View Article : Google Scholar : PubMed/NCBI

82 

Wu J, Zhang D, Li J, Deng X, Liang G, Long Y, He X, Dai T and Ren D: MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma. Oncol Rep. 38:2369–2377. 2017. View Article : Google Scholar : PubMed/NCBI

83 

Huang N, Wu J, Qiu W, Lyu Q, He J, Xie W, Xu N and Zhang Y: MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin. Cancer Biol Ther. 16:941–948. 2015. View Article : Google Scholar : PubMed/NCBI

84 

Guo S, Xu X, Ouyang Y, Wang Y, Yang J, Yin L, Ge J and Wang H: Microarray expression profile analysis of circular RNAs in pancreatic cancer. Mol Med Rep. 17:7661–7971. 2018.PubMed/NCBI

85 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

86 

Liu L, Liu FB, Huang M, Xie K, Xie QS, Liu CH, Shen MJ and Huang Q: Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway. Hepatobiliary Pancreat Dis Int. 18:580–586. 2019. View Article : Google Scholar : PubMed/NCBI

87 

Hu JL, He GY, Lan XL, Zeng ZC, Guan J, Ding Y, Qian XL, Liao WT, Ding YQ and Liang L: Inhibition of ATG12-mediated autophagy by miR-214 enhances radiosensitivity in colorectal cancer. Oncogenesis. 7:162018. View Article : Google Scholar : PubMed/NCBI

88 

Zheng S, Zhong YF, Tan DM, Xu Y, Chen HX and Wang D: miR-183-5p enhances the radioresistance of colorectal cancer by directly targeting ATG5. J Biosci. 44:922019. View Article : Google Scholar : PubMed/NCBI

89 

Wu Y, Tang Y, Xie S, Zheng X, Zhang S, Mao J, Wang B, Hou Y, Hu L, Chai K and Chen W: Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer. Theranostics. 10:1151–1165. 2020. View Article : Google Scholar : PubMed/NCBI

90 

Yang MC, Wang HC, Hou YC, Tung HL, Chiu TJ and Shan YS: Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine. Mol Cancer. 14:1792015. View Article : Google Scholar : PubMed/NCBI

91 

Zhang X, Zhao P, Wang C and Xin B: SNHG14 enhances gemcitabine resistance by sponging miR-101 to stimulate cell autophagy in pancreatic cancer. Biochem Biophys Res Commun. 510:508–514. 2019. View Article : Google Scholar : PubMed/NCBI

92 

Gaskill CE, Maxwell J, Ikoma N, Kim MP, Tzeng CW, Lee JE and Katz MHG: History of preoperative therapy for pancreatic cancer and the MD Anderson experience. J Surg Oncol. 123:1414–1422. 2021. View Article : Google Scholar : PubMed/NCBI

93 

Brown ZJ and Cloyd JM: Trends in the utilization of neoadjuvant therapy for pancreatic ductal adenocarcinoma. J Surg Oncol. 123:1432–1440. 2021. View Article : Google Scholar : PubMed/NCBI

94 

Cheng SW, Chen PC, Ger TR, Chiu HW and Lin YF: GBP5 serves as a potential marker to predict a favorable response in triple-negative breast cancer patients receiving a taxane-based chemotherapy. J Pers Med. 11:1972021. View Article : Google Scholar : PubMed/NCBI

95 

Saini H, Sharma H, Mukherjee S, Chowdhury S and Chowdhury R: Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells. Cancer Cell Int. 21:522021. View Article : Google Scholar : PubMed/NCBI

96 

YiRen H, YingCong Y, Sunwu Y, Keqin L, Xiaochun T, Senrui C, Ende C, XiZhou L and Yanfan C: Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer. Mol Cancer. 16:1742017. View Article : Google Scholar : PubMed/NCBI

97 

Xiong H, Ni Z, He J, Jiang S, Li X, Gong W, Zheng L, Chen S, Li B and Zhang N: LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells. Oncogene. 36:3528–3540. 2017. View Article : Google Scholar : PubMed/NCBI

98 

Tan S, Shi H, Ba M, Lin S, Tang H, Zeng X and Zhang X: miR-409-3p sensitizes colon cancer cells to oxaliplatin by inhibiting Beclin-1-mediated autophagy. Int J Mol Med. 37:1030–1038. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mukherjee M, Pramanick S, Saha B, Chhatriya B and Goswami S: Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review). Oncol Rep 46: 128, 2021.
APA
Mukherjee, M., Pramanick, S., Saha, B., Chhatriya, B., & Goswami, S. (2021). Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review). Oncology Reports, 46, 128. https://doi.org/10.3892/or.2021.8079
MLA
Mukherjee, M., Pramanick, S., Saha, B., Chhatriya, B., Goswami, S."Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review)". Oncology Reports 46.1 (2021): 128.
Chicago
Mukherjee, M., Pramanick, S., Saha, B., Chhatriya, B., Goswami, S."Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review)". Oncology Reports 46, no. 1 (2021): 128. https://doi.org/10.3892/or.2021.8079
Copy and paste a formatted citation
x
Spandidos Publications style
Mukherjee M, Pramanick S, Saha B, Chhatriya B and Goswami S: Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review). Oncol Rep 46: 128, 2021.
APA
Mukherjee, M., Pramanick, S., Saha, B., Chhatriya, B., & Goswami, S. (2021). Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review). Oncology Reports, 46, 128. https://doi.org/10.3892/or.2021.8079
MLA
Mukherjee, M., Pramanick, S., Saha, B., Chhatriya, B., Goswami, S."Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review)". Oncology Reports 46.1 (2021): 128.
Chicago
Mukherjee, M., Pramanick, S., Saha, B., Chhatriya, B., Goswami, S."Noncoding RNAs as key modulators of autophagy in pancreatic cancer (Review)". Oncology Reports 46, no. 1 (2021): 128. https://doi.org/10.3892/or.2021.8079
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