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Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2

  • Authors:
    • Yi-Ching Chuang
    • Ming-Chang Hsieh
    • Chia-Chieh Lin
    • Yu-Sheng Lo
    • Hsin-Yu Ho
    • Ming-Ju Hsieh
    • Jen-Tsun Lin
  • View Affiliations / Copyright

    Affiliations: Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan, R.O.C., School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C., Post Baccalaureate Medicine, National Chung Hsing University, Taichung 40201, Taiwan, R.O.C.
    Copyright: © Chuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 143
    |
    Published online on: May 27, 2021
       https://doi.org/10.3892/or.2021.8094
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Abstract

Nasopharyngeal carcinoma (NPC) is a tumor located in the nasopharynx with highly invasive and metastatic properties. Metastasis is a primary cause of mortality in patients with NPC. The terpenoid polyphenol pinosylvin is a known functional compound of the Pinus species that exhibits anti‑inflammatory effects; however, the effect of pinosylvin on human NPC cell migration and invasion is unclear. The present study aimed to investigate the functional role of pinosylvin in NPC cells (NPC‑039, NPC‑BM and RPMI 2650). Gap closure and Transwell assay indicated that pinosylvin at increasing concentrations inhibited migration and invasion of NPC‑039 and NPC‑BM cells. In addition to inhibiting the enzyme activity of MMP‑2, pinosylvin also decreased the protein expression levels of MMP‑2 and MMP‑9. Pinosylvin decreased the expression of vimentin and N‑cadherin and significantly increased the expression of zonula occludens‑1 and E‑cadherin in NPC cells. Additionally, pinosylvin suppressed the invasion and migration ability of NPC‑039 and NPC‑BM cells by mediating the p38, ERK1/2 and JNK1/2 pathways. The present results revealed that pinosylvin inhibited migration and invasion in NPC cells.
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Copy and paste a formatted citation
Spandidos Publications style
Chuang Y, Hsieh M, Lin C, Lo Y, Ho H, Hsieh M and Lin J: Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2. Oncol Rep 46: 143, 2021.
APA
Chuang, Y., Hsieh, M., Lin, C., Lo, Y., Ho, H., Hsieh, M., & Lin, J. (2021). Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2. Oncology Reports, 46, 143. https://doi.org/10.3892/or.2021.8094
MLA
Chuang, Y., Hsieh, M., Lin, C., Lo, Y., Ho, H., Hsieh, M., Lin, J."Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2". Oncology Reports 46.1 (2021): 143.
Chicago
Chuang, Y., Hsieh, M., Lin, C., Lo, Y., Ho, H., Hsieh, M., Lin, J."Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2". Oncology Reports 46, no. 1 (2021): 143. https://doi.org/10.3892/or.2021.8094
Copy and paste a formatted citation
x
Spandidos Publications style
Chuang Y, Hsieh M, Lin C, Lo Y, Ho H, Hsieh M and Lin J: Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2. Oncol Rep 46: 143, 2021.
APA
Chuang, Y., Hsieh, M., Lin, C., Lo, Y., Ho, H., Hsieh, M., & Lin, J. (2021). Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2. Oncology Reports, 46, 143. https://doi.org/10.3892/or.2021.8094
MLA
Chuang, Y., Hsieh, M., Lin, C., Lo, Y., Ho, H., Hsieh, M., Lin, J."Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2". Oncology Reports 46.1 (2021): 143.
Chicago
Chuang, Y., Hsieh, M., Lin, C., Lo, Y., Ho, H., Hsieh, M., Lin, J."Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial‑mesenchymal transition and inhibition of MMP‑2". Oncology Reports 46, no. 1 (2021): 143. https://doi.org/10.3892/or.2021.8094
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