Value of methylation markers in colorectal cancer (Review)

  • Authors:
    • Can Kong
    • Tao Fu
  • View Affiliations

  • Published online on: June 30, 2021     https://doi.org/10.3892/or.2021.8128
  • Article Number: 177
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Abstract

Colorectal cancer (CRC) is a multifactorial and multistage process that occurs due to both genetic and epigenetic variations in normal epithelial cells. Analysis of the CRC epigenome has revealed that almost all CRC types have a large number of abnormally methylated genes. Hypermethylation of cell‑free DNA from CRC in the blood or stool is considered as a potential non‑invasive cancer biomarker, and various methylation markers have shown high sensitivity and specificity. The aim of the present review was to examine potential methylation markers in CRC that have been used or are expected to be used in the clinical setting, focusing on their screening, predictive, prognostic and therapeutic roles in CRC.
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August-2021
Volume 46 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Kong C and Kong C: Value of methylation markers in colorectal cancer (Review). Oncol Rep 46: 177, 2021
APA
Kong, C., & Kong, C. (2021). Value of methylation markers in colorectal cancer (Review). Oncology Reports, 46, 177. https://doi.org/10.3892/or.2021.8128
MLA
Kong, C., Fu, T."Value of methylation markers in colorectal cancer (Review)". Oncology Reports 46.2 (2021): 177.
Chicago
Kong, C., Fu, T."Value of methylation markers in colorectal cancer (Review)". Oncology Reports 46, no. 2 (2021): 177. https://doi.org/10.3892/or.2021.8128