Tumorigenic effect of TERT and its potential therapeutic target in NSCLC (Review)
- Authors:
- Liu Yang
- Na Li
- Meng Wang
- Yan-Hua Zhang
- Lu-Da Yan
- Wen Zhou
- Zhi-Qiong Yu
- Xiao-Chun Peng
- Jun Cai
-
Affiliations: Department of Oncology, First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, P.R. China, Laboratory of Oncology, Center for Molecular Medicine, Yangtze University, Jingzhou, Hubei 434023, P.R. China - Published online on: July 6, 2021 https://doi.org/10.3892/or.2021.8133
- Article Number: 182
This article is mentioned in:
Abstract
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang X, Yin H, Zhang L, Zheng D, Yang Y, Zhang J, Jiang H, Ling X, Xin Y, Liang H, et al: The construction and analysis of the aberrant lncRNA-miRNA-mRNA network in non-small cell lung cancer. J Thorac Dis. 11:1772–1778. 2019. View Article : Google Scholar : PubMed/NCBI | |
Qiu M, Chen YB, Jin S, Fang XF, He XX, Xiong ZF and Yang SL: Research on circadian clock genes in non-small-cell lung carcinoma. Chronobiol Int. 36:739–750. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yu XJ, Chen G, Yang J, Yu GC, Zhu PF, Jiang ZK, Feng K, Lu Y, Bao B and Zhong FM: Smoking alters the evolutionary trajectory of non-small cell lung cancer. Exp Ther Med. 18:3315–3324. 2019.PubMed/NCBI | |
Nigro E, Imperlini E, Scudiero O, Monaco ML, Polito R, Mazzarella G, Orrù S, Bianco A and Daniele A: Differentially expressed and activated proteins associated with non small cell lung cancer tissues. Respir Res. 16:742015. View Article : Google Scholar : PubMed/NCBI | |
Braicu C, Zimta AA, Harangus A, Iurca I, Irimie A, Coza O and Berindan-Neagoe I: The function of non-coding RNAs in lung cancer tumorigenesis. Cancers (Basel). 11:6052019. View Article : Google Scholar : PubMed/NCBI | |
Narsule CK, Sridhar P, Nair D, Gupta A, Oommen RG, Ebright MI, Litle VR and Fernando HC: Percutaneous thermal ablation for stage IA non-small cell lung cancer: Long-term follow-up. J Thorac Dis. 9:4039–4045. 2017. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Shen WX, Zhou LN, Tang M, Tan Y, Feng CX, Li P, Wang LQ and Chen MB: The value of next-generation sequencing for treatment in non-small cell lung cancer patients: The observational, real-world evidence in China. Biomed Res Int. 2020:93871672020.PubMed/NCBI | |
Yeh J, Marrone KA and Forde PM: Neoadjuvant and consolidation immuno-oncology therapy in stage III non-small cell lung cancer. J Thorac Dis. 10 (Suppl 3):S451–S459. 2018. View Article : Google Scholar : PubMed/NCBI | |
Tan WL, Jain A, Takano A, Newell EW, Iyer NG, Lim WT, Tan EH, Zhai W, Hillmer AM, Tam WL and Tan DSW: Novel therapeutic targets on the horizon for lung cancer. Lancet Oncol. 17:e347–e362. 2016. View Article : Google Scholar : PubMed/NCBI | |
Smith RA, Andrews KS, Brooks D, Fedewa SA, Manassaram-Baptiste D, Saslow D, Brawley OW and Wender RC: Cancer screening in the United States, 2017: A review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J Clin. 67:100–121. 2017. View Article : Google Scholar : PubMed/NCBI | |
Dagogo-Jack I and Shaw AT: Crizotinib resistance: Implications for therapeutic strategies. Ann Oncol. 27 (Suppl 3):iii42–iii50. 2016. View Article : Google Scholar : PubMed/NCBI | |
Baird DM: Variation at the TERT locus and predisposition for cancer. Expert Rev Mol Med. 12:e162010. View Article : Google Scholar : PubMed/NCBI | |
Meena J, Rudolph KL and Gunes C: Telomere dysfunction, chromosomal instability and cancer. Recent Results Cancer Res. 200:61–79. 2015. View Article : Google Scholar : PubMed/NCBI | |
Cheng D, Zhao Y, Zhang F, Zhang J, Wang S and Zhu J: Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells. Sci Rep. 9:96832019. View Article : Google Scholar : PubMed/NCBI | |
Inada E, Saitoh I, Kubota N, Iwase Y, Kiyokawa Y, Shibasaki S, Noguchi H, Yamasaki Y and Sato M: piggyBac transposon-based immortalization of human deciduous tooth dental pulp cells with multipotency and non-tumorigenic potential. Int J Mol Sci. 20:49042019. View Article : Google Scholar : PubMed/NCBI | |
Muneer A and Minhas FA: Telomere biology in mood disorders: An updated, comprehensive review of the literature. Clin Psychopharmacol Neurosci. 17:343–363. 2019. View Article : Google Scholar : PubMed/NCBI | |
Campisi J: Aging, cellular senescence, and cancer. Annu Rev Physiol. 75:685–705. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL and Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science. 266:2011–2015. 1994. View Article : Google Scholar : PubMed/NCBI | |
Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al: The RNA component of human telomerase. Science. 269:1236–1241. 1995. View Article : Google Scholar : PubMed/NCBI | |
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB and Cech TR: Telomerase catalytic subunit homologs from fission yeast and human. Science. 277:955–959. 1997. View Article : Google Scholar : PubMed/NCBI | |
Tsang JYS, Hui YK, Lee MA, Lacambra M, Ni YB, Cheung SY, Wu C, Kwong A and Tse GMK: Association of clinicopathological features and prognosis of TERT alterations in phyllodes tumor of breast. Sci Rep. 8:38812018. View Article : Google Scholar : PubMed/NCBI | |
Mortazavi-Haghighat R, Taghipour-Khiabani K, David S, Kerrigan CL and Philip A: Rapid and dynamic regulation of TGF-beta receptors on blood vessels and fibroblasts during ischemia-reperfusion injury. Am J Physiol Cell Physiol. 282:C1161–C1169. 2002. View Article : Google Scholar : PubMed/NCBI | |
de Pedro N, Díez M, García I, García J, Otero L, Fernandez L, Garcia B, González R, Rincón S, Pérez D, et al: Analytical validation of telomere analysis technology® for the High-throughput analysis of multiple telomere-associated variables. Biol Proced Online. 22:22020. View Article : Google Scholar : PubMed/NCBI | |
Barthel FP, Wei W, Tang M, Martinez-Ledesma E, Hu X, Amin SB, Akdemir KC, Seth S, Song X, Wang Q, et al: Systematic analysis of telomere length and somatic alterations in 31 cancer types. Nat Genet. 49:349–357. 2017. View Article : Google Scholar : PubMed/NCBI | |
Jung SJ, Kim DS, Park WJ, Lee H, Choi IJ, Park JY and Lee JH: Mutation of the TERT promoter leads to poor prognosis of patients with non-small cell lung cancer. Oncol Lett. 14:1609–1614. 2017. View Article : Google Scholar : PubMed/NCBI | |
Leão R, Apolónio JD, Lee D, Figueiredo A, Tabori U and Castelo-Branco P: Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: Clinical impacts in cancer. J Biomed Sci. 25:222018. View Article : Google Scholar | |
da Silva EM, Selenica P, Vahdatinia M, Pareja F, Da Cruz Paula A, Ferrando L, Gazzo AM, Dopeso H, Ross DS, Bakhteri A, et al: TERT promoter hotspot mutations and gene amplification in metaplastic breast cancer. NPJ Breast Cancer. 7:432021. View Article : Google Scholar : PubMed/NCBI | |
Chen W, Xiong X, Zhou H and Zhou Q: Expression of telomerase activity, telomerase RNA component and telomerase catalytic subunit gene in lung cancer. Chin Med J (Engl). 115:290–292. 2002.PubMed/NCBI | |
Dobija-Kubica K, Zalewska-Ziob M, Brulinski K, Rogozinski P, Wiczkowski A, Gawrychowska A and Gawrychowski J: Telomerase activity in non-small cell lung cancer. Kardiochir Torakochirurgia Pol. 13:15–20. 2016.PubMed/NCBI | |
Liu H, Zhang W, Cai C, Xu J and Xu Y: Telomerase activity in human non-small cell lung cancer (NSCLC). Zhonghua Bing Li Xue Za Zhi. 29:89–91. 2000.(In Chinese). PubMed/NCBI | |
Yang HZ, Hu CP and Su XL: Detection of telomerase activity level in human non-small-cell lung cancer. Hunan Yi Ke Da Xue Xue Bao. 26:549–550. 2001.(In Chinese). PubMed/NCBI | |
Chen Q, He J and Yi H: Study on telomerase activity and its clinical value in human non small cell lung cancer. Hunan Yi Ke Da Xue Xue Bao. 26:221–222. 2001.(In Chinese). PubMed/NCBI | |
Wang J, Liu X, Jiang W and Liang L: Telomerase activity and expression of the telomerase catalytic subunit gene in non-small cell lung cancer: Correlation with decreased apoptosis and clinical prognosis. Chin Med J (Engl). 113:985–990. 2000.PubMed/NCBI | |
Fernandez-Marcelo T, Gomez A, Pascua I, de Juan C, Head J, Hernando F, Jarabo JR, Calatayud J, Torres-Garcia AJ and Iniesta P: Telomere length and telomerase activity in non-small cell lung cancer prognosis: Clinical usefulness of a specific telomere status. J Exp Clin Cancer Res. 34:782015. View Article : Google Scholar : PubMed/NCBI | |
Hara H, Yamashita K, Shinada J, Yoshimura H and Kameya T: Clinicopathologic significance of telomerase activity and hTERT mRNA expression in non-small cell lung cancer. Lung Cancer. 34:219–226. 2001. View Article : Google Scholar : PubMed/NCBI | |
Hashim M, Sayed M, Samy N and Elshazly S: Prognostic significance of telomerase activity and some tumor markers in non-small cell lung cancer. Med Oncol. 28:322–330. 2011. View Article : Google Scholar : PubMed/NCBI | |
Taga S, Osaki T, Ohgami A, Imoto H and Yasumoto K: Prognostic impact of telomerase activity in non-small cell lung cancers. Ann Surg. 230:715–720. 1999. View Article : Google Scholar : PubMed/NCBI | |
Wu TC, Lin P, Hsu CP, Huang YJ, Chen CY, Chung WC, Lee H and Ko JL: Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas. Lung Cancer. 41:163–169. 2003. View Article : Google Scholar : PubMed/NCBI | |
Hsu CP, Miaw J, Hsia JY, Shai SE and Chen CY: Concordant expression of the telomerase-associated genes in non-small cell lung cancer. Eur J Surg Oncol. 29:594–599. 2003. View Article : Google Scholar : PubMed/NCBI | |
Chen KY, Lee LN, Yu CJ, Lee YC, Kuo SH and Yang PC: Elevation of telomerase activity positively correlates to poor prognosis of patients with non-small cell lung cancer. Cancer Lett. 240:148–156. 2006. View Article : Google Scholar : PubMed/NCBI | |
Metzger R, Vallbohmer D, Muller-Tidow C, Higashi H, Bollschweiler E, Warnecke-Eberz U, Brabender J, Baldus SE, Xi H, Berdel WE, et al: Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancer. Anticancer Res. 29:1157–1162. 2009.PubMed/NCBI | |
Li L, Xiong YY, Liu L, Chen TX, Yao XF and Wang YW: Relationships among expressions of hTERT, MDR1, MRP mRNA, and C-myc protein in non-small cell lung cancer. Ai Zheng. 24:53–57. 2005.(In Chinese). PubMed/NCBI | |
Ding M, Li X and Qiu T: Combination of multiple gene markers to detect circulating tumor cells in the peripheral blood of patients with non-small cell lung cancer using real-time PCR. Genet Mol Res. 14:13033–13040. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zalewska-Ziob M, Dobija-Kubica K, Biernacki K, Adamek B, Kasperczyk J, Brulinski K and Ostrowska Z: Clinical and prognostic value of hTERT mRNA expression in patients with non-small-cell lung cancer. Acta Biochim Pol. 64:641–646. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Liu X and Fang J: Expression and clinical significance of telomerase catalytic subunit gene in lung cancer and its correlations with genes related to drug resistance and apoptosis. Zhonghua Zhong Liu Za Zhi. 21:350–353. 1999.(In Chinese). PubMed/NCBI | |
Cong YS, Wen J and Bacchetti S: The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter. Hum Mol Genet. 8:137–142. 1999. View Article : Google Scholar : PubMed/NCBI | |
Heidenreich B and Kumar R: TERT promoter mutations in telomere biology. Mutat Res. 771:15–31. 2017. View Article : Google Scholar : PubMed/NCBI | |
Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N and Cech TR: Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. Genes Dev. 29:2219–2224. 2015. View Article : Google Scholar : PubMed/NCBI | |
Akincilar SC, Unal B and Tergaonkar V: Reactivation of telomerase in cancer. Cell Mol Life Sci. 73:1659–1670. 2016. View Article : Google Scholar : PubMed/NCBI | |
Horn S, Figl A, Rachakonda PS, Fischer C, Sucker A, Gast A, Kadel S, Moll I, Nagore E, Hemminki K, et al: TERT promoter mutations in familial and sporadic melanoma. Science. 339:959–961. 2013. View Article : Google Scholar : PubMed/NCBI | |
Heidenreich B, Rachakonda PS, Hemminki K and Kumar R: TERT promoter mutations in cancer development. Curr Opin Genet Dev. 24:30–37. 2014. View Article : Google Scholar : PubMed/NCBI | |
Vinagre J, Almeida A, Populo H, Batista R, Lyra J, Pinto V, Coelho R, Celestino R, Prazeres H, Lima L, et al: Frequency of TERT promoter mutations in human cancers. Nat Commun. 4:21852013. View Article : Google Scholar : PubMed/NCBI | |
Hsu CP, Hsu NY, Lee LW and Ko JL: Ets2 binding site single nucleotide polymorphism at the hTERT gene promoter-effect on telomerase expression and telomere length maintenance in non-small cell lung cancer. Eur J Cancer. 42:1466–1474. 2006. View Article : Google Scholar : PubMed/NCBI | |
Ma X, Gong R, Wang R, Pan Y, Cai D, Pan B, Li Y, Xiang J, Li H, Zhang J, et al: Recurrent TERT promoter mutations in non-small cell lung cancers. Lung Cancer. 86:369–373. 2014. View Article : Google Scholar : PubMed/NCBI | |
Griewank KG, Murali R, Schilling B, Schimming T, Moller I, Moll I, Schwamborn M, Sucker A, Zimmer L, Schadendorf D and Hillen U: TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma. PLoS One. 8:e803542013. View Article : Google Scholar : PubMed/NCBI | |
Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA Jr, Friedman AH, Friedman H, Gallia GL, Giovanella BC, et al: TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci USA. 110:6021–6026. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yuan P, Cao JL, Abuduwufuer A, Wang LM, Yuan XS, Lv W and Hu J: Clinical characteristics and prognostic significance of TERT promoter mutations in cancer: A cohort study and a meta-analysis. PLoS One. 11:e01468032016. View Article : Google Scholar : PubMed/NCBI | |
Li C, Hao L, Li Y, Wang S, Chen H, Zhang L, Ke B, Yin Y, Suo H, Sun B, et al: Prognostic value analysis of mutational and clinicopathological factors in non-small cell lung cancer. PLoS One. 9:e1072762014. View Article : Google Scholar : PubMed/NCBI | |
Schwaederle M, Krishnamurthy N, Daniels GA, Piccioni DE, Kesari S, Fanta PT, Schwab RB, Patel SP, Parker BA and Kurzrock R: Telomerase reverse transcriptase promoter alterations across cancer types as detected by next-generation sequencing: A clinical and molecular analysis of 423 patients. Cancer. 124:1288–1296. 2018. View Article : Google Scholar : PubMed/NCBI | |
Cheng KA, Kurtis B, Babayeva S, Zhuge J, Tantchou I, Cai D, Lafaro RJ, Fallon JT and Zhong M: Heterogeneity of TERT promoter mutations status in squamous cell carcinomas of different anatomical sites. Ann Diagn Pathol. 19:146–148. 2015. View Article : Google Scholar : PubMed/NCBI | |
Feuk L, Carson AR and Scherer SW: Structural variation in the human genome. Nat Rev Genet. 7:85–97. 2006. View Article : Google Scholar : PubMed/NCBI | |
Yuan P, Huang S, Bao FC, Cao JL, Sheng HX, Shi L, Lv W and Hu J: Discriminating association of a common telomerase reverse transcriptase promoter polymorphism with telomere parameters in non-small cell lung cancer with or without epidermal growth factor receptor mutation. Eur J Cancer. 120:10–19. 2019. View Article : Google Scholar : PubMed/NCBI | |
Lewis KA and Tollefsbol TO: Regulation of the telomerase reverse transcriptase subunit through epigenetic mechanisms. Front Genet. 7:832016. View Article : Google Scholar : PubMed/NCBI | |
Sarne V, Huter S, Braunmueller S, Rakob L, Jacobi N, Kitzwogerer M, Wiesner C, Obrist P and Seeboeck R: Promoter methylation of selected genes in non-small-cell lung cancer patients and cell lines. Int J Mol Sci. 21:45952020. View Article : Google Scholar : PubMed/NCBI | |
Guilleret I, Yan P, Grange F, Braunschweig R, Bosman FT and Benhattar J: Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity. Int J Cancer. 101:335–341. 2002. View Article : Google Scholar : PubMed/NCBI | |
Devereux TR, Horikawa I, Anna CH, Annab LA, Afshari CA and Barrett JC: DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res. 59:6087–6090. 1999.PubMed/NCBI | |
Falkenberg KJ and Johnstone RW: Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov. 13:673–691. 2014. View Article : Google Scholar : PubMed/NCBI | |
Mamdani H and Jalal SI: Histone Deacetylase inhibition in non-small cell lung cancer: Hype or Hope? Front Cell Dev Biol. 8:5823702020. View Article : Google Scholar : PubMed/NCBI | |
Wu YF, Ou CC, Chien PJ, Chang HY, Ko JL and Wang BY: Chidamide-induced ROS accumulation and miR-129-3p-dependent cell cycle arrest in non-small lung cancer cells. Phytomedicine. 56:94–102. 2019. View Article : Google Scholar : PubMed/NCBI | |
Li CT, Hsiao YM, Wu TC, Lin YW, Yeh KT and Ko JL: Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non-small cell lung cancer cells. J Cell Biochem. 112:3044–3053. 2011. View Article : Google Scholar : PubMed/NCBI | |
Krupitsky EM, Rybakova KV, Skurat EP, Semenova NV and Neznanov NG: A double blind placebo controlled randomized clinical trial of the efficacy and safety of pregabalin in induction of remission in patients with alcohol dependence. Zh Nevrol Psikhiatr Im S S Korsakova. 120:33–43. 2020.(In Russian). View Article : Google Scholar : PubMed/NCBI | |
Zhu CQ, Cutz JC, Liu N, Lau D, Shepherd FA, Squire JA and Tsao MS: Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer. Br J Cancer. 94:1452–1459. 2006. View Article : Google Scholar : PubMed/NCBI | |
Zhang A, Zheng C, Lindvall C, Hou M, Ekedahl J, Lewensohn R, Yan Z, Yang X, Henriksson M, Blennow E, et al: Frequent amplification of the telomerase reverse transcriptase gene in human tumors. Cancer Res. 60:6230–6235. 2000.PubMed/NCBI | |
Takuma Y, Nouso K, Kobayashi Y, Nakamura S, Tanaka H, Matsumoto E, Fujikawa T, Suzuki M, Hanafusa T and Shiratori Y: Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma. J Gastroenterol Hepatol. 19:1300–1304. 2004. View Article : Google Scholar : PubMed/NCBI | |
Zhang A, Zheng C, Hou M, Lindvall C, Wallin KL, Angstrom T, Yang X, Hellstrom AC, Blennow E, Bjorkholm M, et al: Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas. Genes Chromosomes Cancer. 34:269–275. 2002. View Article : Google Scholar : PubMed/NCBI | |
Tsuda H, Akiyama F, Terasaki H, Hasegawa T, Kurosumi M, Shimadzu M, Yamamori S and Sakamoto G: Detection of HER-2/neu (c-erb B-2) DNA amplification in primary breast carcinoma. Interobserver reproducibility and correlation with immunohistochemical HER-2 overexpression. Cancer. 92:2965–2974. 2001. View Article : Google Scholar : PubMed/NCBI | |
Kang JU, Koo SH, Kwon KC, Park JW and Kim JM: Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer. Cancer Genet Cytogenet. 182:1–11. 2008. View Article : Google Scholar : PubMed/NCBI | |
Alidousty C, Baar T, Martelotto LG, Heydt C, Wagener S, Fassunke J, Duerbaum N, Scheel AH, Frank S, Holz B, et al: Genetic instability and recurrent MYC amplification in ALK-translocated NSCLC: A central role of TP53 mutations. J Pathol. 246:67–76. 2018. View Article : Google Scholar : PubMed/NCBI | |
Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Kramer A, Roncaioli JL, Sand F, Heuckmann JM, et al: Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature. 526:700–704. 2015. View Article : Google Scholar : PubMed/NCBI | |
Bayard Q, Meunier L, Peneau C, Renault V, Shinde J, Nault JC, Mami I, Couchy G, Amaddeo G, Tubacher E, et al: Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress. Nat Commun. 9:52352018. View Article : Google Scholar : PubMed/NCBI | |
Kawashima M, Kojima M, Ueda Y, Kurihara S and Hiyama E: Telomere biology including TERT rearrangements in neuroblastoma: A useful indicator for surgical treatments. J Pediatr Surg. 51:2080–2085. 2016. View Article : Google Scholar : PubMed/NCBI | |
Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, et al: Telomerase-mediated strategy for overcoming non-small cell lung cancer targeted therapy and chemotherapy resistance. Neoplasia. 20:826–837. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ward RJ and Autexier C: Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment. Mol Pharmacol. 68:779–786. 2005. View Article : Google Scholar : PubMed/NCBI | |
Meng E, Taylor B, Ray A, Shevde LA and Rocconi RP: Targeted inhibition of telomerase activity combined with chemotherapy demonstrates synergy in eliminating ovarian cancer spheroid-forming cells. Gynecol Oncol. 124:598–605. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhang G, Wu LW, Mender I, Barzily-Rokni M, Hammond MR, Ope O, Cheng C, Vasilopoulos T, Randell S, Sadek N, et al: Induction of telomere dysfunction prolongs disease control of therapy-resistant melanoma. Clin Cancer Res. 24:4771–4784. 2018. View Article : Google Scholar : PubMed/NCBI | |
Dikmen ZG, Gellert GC, Jackson S, Gryaznov S, Tressler R, Dogan P, Wright WE and Shay JW: In vivo inhibition of lung cancer by GRN163L: A novel human telomerase inhibitor. Cancer Res. 65:7866–7873. 2005. View Article : Google Scholar : PubMed/NCBI | |
Mender I, Gryaznov S, Dikmen ZG, Wright WE and Shay JW: Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2′-deoxyguanosine. Cancer Discov. 5:82–95. 2015. View Article : Google Scholar : PubMed/NCBI | |
Pascolo E, Wenz C, Lingner J, Hauel N, Priepke H, Kauffmann I, Garin-Chesa P, Rettig WJ, Damm K and Schnapp A: Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem. 277:15566–15572. 2002. View Article : Google Scholar : PubMed/NCBI | |
Liu W, Yin Y, Wang J, Shi B, Zhang L, Qian D, Li C, Zhang H, Wang S, Zhu J, et al: Kras mutations increase telomerase activity and targeting telomerase is a promising therapeutic strategy for Kras-mutant NSCLC. Oncotarget. 8:179–190. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ding X, Cheng J, Pang Q, Wei X, Zhang X, Wang P, Yuan Z and Qian D: BIBR1532, a selective telomerase inhibitor, enhances radiosensitivity of non-small cell lung cancer through increasing telomere dysfunction and ATM/CHK1 inhibition. Int J Radiat Oncol Biol Phys. 105:861–874. 2019. View Article : Google Scholar : PubMed/NCBI | |
Webb D, Gagnon MM and Rose T: Metabolic enzyme activities in black bream (Acanthopagrus butcheri) from the Swan-Canning Estuary, Western Australia. Comp Biochem Physiol C Toxicol Pharmacol. 141:356–365. 2005. View Article : Google Scholar : PubMed/NCBI | |
Gellert GC, Dikmen ZG, Wright WE, Gryaznov S and Shay JW: Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer. Breast Cancer Res Treat. 96:73–81. 2006. View Article : Google Scholar : PubMed/NCBI | |
Frink RE, Peyton M, Schiller JH, Gazdar AF, Shay JW and Minna JD: Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner. Oncotarget. 7:31639–31651. 2016. View Article : Google Scholar : PubMed/NCBI | |
Herbert BS, Gellert GC, Hochreiter A, Pongracz K, Wright WE, Zielinska D, Chin AC, Harley CB, Shay JW and Gryaznov SM: Lipid modification of GRN163, an N3′-->P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene. 24:5262–5268. 2005. View Article : Google Scholar : PubMed/NCBI | |
Mender I, Senturk S, Ozgunes N, Akcali KC, Kletsas D, Gryaznov S, Can A, Shay JW and Dikmen ZG: Imetelstat (a telomerase antagonist) exerts offtarget effects on the cytoskeleton. Int J Oncol. 42:1709–1715. 2013. View Article : Google Scholar : PubMed/NCBI | |
Chiappori AA, Kolevska T, Spigel DR, Hager S, Rarick M, Gadgeel S, Blais N, Von Pawel J, Hart L, Reck M, et al: A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer. Ann Oncol. 26:354–362. 2015. View Article : Google Scholar : PubMed/NCBI | |
Negrini S, De Palma R and Filaci G: Anti-cancer immunotherapies targeting telomerase. Cancers (Basel). 12:22602020. View Article : Google Scholar : PubMed/NCBI | |
Brunsvig PF, Kyte JA, Kersten C, Sundstrom S, Moller M, Nyakas M, Hansen GL, Gaudernack G and Aamdal S: Telomerase peptide vaccination in NSCLC: A phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial. Clin Cancer Res. 17:6847–6857. 2011. View Article : Google Scholar : PubMed/NCBI | |
Relitti N, Saraswati AP, Federico S, Khan T, Brindisi M, Zisterer D, Brogi S, Gemma S, Butini S and Campiani G: Telomerase-based cancer therapeutics: A review on their clinical trials. Curr Top Med Chem. 20:433–457. 2020. View Article : Google Scholar : PubMed/NCBI | |
Brunsvig PF, Aamdal S, Gjertsen MK, Kvalheim G, Markowski-Grimsrud CJ, Sve I, Dyrhaug M, Trachsel S, Moller M, Eriksen JA, et al: Telomerase peptide vaccination: A phase I/II study in patients with non-small cell lung cancer. Cancer Immunol Immunother. 55:1553–1564. 2006. View Article : Google Scholar : PubMed/NCBI | |
Hansen GL, Gaudernack G, Brunsvig PF, Cvancarova M and Kyte JA: Immunological factors influencing clinical outcome in lung cancer patients after telomerase peptide vaccination. Cancer Immunol Immunother. 64:1609–1621. 2015. View Article : Google Scholar : PubMed/NCBI | |
Vetsika EK, Konsolakis G, Aggouraki D, Kotsakis A, Papadimitraki E, Christou S, Menez-Jamet J, Kosmatopoulos K, Georgoulias V and Mavroudis D: Immunological responses in cancer patients after vaccination with the therapeutic telomerase-specific vaccine Vx-001. Cancer Immunol Immunother. 61:157–168. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kotsakis A, Papadimitraki E, Vetsika EK, Aggouraki D, Dermitzaki EK, Hatzidaki D, Kentepozidis N, Mavroudis D and Georgoulias V: A phase II trial evaluating the clinical and immunologic response of HLA-A2(+) non-small cell lung cancer patients vaccinated with an hTERT cryptic peptide. Lung Cancer. 86:59–66. 2014. View Article : Google Scholar : PubMed/NCBI | |
Bolonaki I, Kotsakis A, Papadimitraki E, Aggouraki D, Konsolakis G, Vagia A, Christophylakis C, Nikoloudi I, Magganas E, Galanis A, et al: Vaccination of patients with advanced non-small-cell lung cancer with an optimized cryptic human telomerase reverse transcriptase peptide. J Clin Oncol. 25:2727–2734. 2007. View Article : Google Scholar : PubMed/NCBI | |
Gridelli C, Ciuleanu T, Domine M, Szczesna A, Bover I, Cobo M, Kentepozidis N, Zarogoulidis K, Kalofonos C, Kazarnowisz A, et al: Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: Final results of a randomised phase 2 clinical trial. Br J Cancer. 122:1461–1466. 2020. View Article : Google Scholar : PubMed/NCBI | |
Yuan X, Larsson C and Xu D: Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: Old actors and new players. Oncogene. 38:6172–6183. 2019. View Article : Google Scholar : PubMed/NCBI | |
Lantuejoul S, Soria JC, Moro-Sibilot D, Morat L, Veyrenc S, Lorimier P, Brichon PY, Sabatier L, Brambilla C and Brambilla E: Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours. Br J Cancer. 90:1222–1229. 2004. View Article : Google Scholar : PubMed/NCBI | |
Marchetti A, Bertacca G, Buttitta F, Chella A, Quattrocolo G, Angeletti CA and Bevilacqua G: Telomerase activity as a prognostic indicator in stage I non-small cell lung cancer. Clin Cancer Res. 5:2077–2081. 1999.PubMed/NCBI | |
Tang H, Wang H, Cheng X, Fan X, Yang F, Zhang M, Chen Y, Tian Y, Liu C, Shao D, et al: HuR regulates telomerase activity through TERC methylation. Nat Commun. 9:22132018. View Article : Google Scholar : PubMed/NCBI | |
Baena-Del Valle JA, Zheng Q, Esopi DM, Rubenstein M, Hubbard GK, Moncaliano MC, Hruszkewycz A, Vaghasia A, Yegnasubramanian S, Wheelan SJ, et al: MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. J Pathol. 244:11–24. 2018. View Article : Google Scholar : PubMed/NCBI | |
Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, et al: CDK6 antagonizes p53-induced responses during tumorigenesis. Cancer Discov. 8:884–897. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wu XQ, Huang C, He X, Tian YY, Zhou DX, He Y, Liu XH and Li J: Feedback regulation of telomerase reverse transcriptase: New insight into the evolving field of telomerase in cancer. Cell Signal. 25:2462–2468. 2013. View Article : Google Scholar : PubMed/NCBI | |
Chen W, Lu J, Qin Y, Wang J, Tian Y, Shi D, Wang S, Xiao Y, Dai M, Liu L, et al: Ret finger protein-like 3 promotes tumor cell growth by activating telomerase reverse transcriptase expression in human lung cancer cells. Oncotarget. 5:11909–11923. 2014. View Article : Google Scholar : PubMed/NCBI | |
Lin C, Qin Y, Zhang H, Gao MY and Wang YF: EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in nonsmall cell lung cancer cells. Oncol Rep. 40:29–38. 2018.PubMed/NCBI | |
Guo W, Lu J, Dai M, Wu T, Yu Z, Wang J, Chen W, Shi D, Yu W, Xiao Y, et al: Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers. Oncotarget. 5:9349–9361. 2014. View Article : Google Scholar : PubMed/NCBI | |
Wang F, Fu P, Pang Y, Liu C, Shao Z, Zhu J, Li J, Wang T, Zhang X and Liu J: TERT rs2736100T/G polymorphism upregulates interleukin 6 expression in non-small cell lung cancer especially in adenocarcinoma. Tumour Biol. 35:4667–4672. 2014. View Article : Google Scholar : PubMed/NCBI | |
Maniwa Y, Yoshimura M, Obayashi C, Inaba M, Kiyooka K, Kanki M and Okita Y: Association of p53 gene mutation and telomerase activity in resectable non-small cell lung cancer. Chest. 120:589–594. 2001. View Article : Google Scholar : PubMed/NCBI | |
Kiyooka K, Maniwa Y and Okada M: Analysis of mutant p53 and telomerase activity in non-small cell lung cancer. Ann Thorac Cardiovasc Surg. 5:293–299. 1999.PubMed/NCBI |