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Review

Overview of serpin B9 and its roles in cancer (Review)

  • Authors:
    • Wen-Jun Wang
    • Jiao Wang
    • Chao Ouyang
    • Chong Chen
    • Xiao-Feng Xu
    • Xiao-Qun Ye
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Respiratory Diseases, Jiujiang First People's Hospital, Jiujiang, Jiangxi 332000, P.R. China
  • Article Number: 190
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    Published online on: July 12, 2021
       https://doi.org/10.3892/or.2021.8141
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Abstract

Serine proteinase inhibitor B9 (serpin B9) is a member of the serine protease inhibitor superfamily, which is widely found in animals, plants and microorganisms. Serpin B9 has been reported to protect cells from the immune‑killing effect of granzyme B (GrB) released by lymphocytes. In recent years, an increasing number of studies have indicated that serpin B9 is involved in tumour apoptosis, immune evasion, tumorigenesis, progression, metastasis, drug resistance and even in maintaining the stemness of cancer stem cells (CSCs). Moreover, according to clinical studies, serpin B9 has been demonstrated to be significantly associated with the development of precancerous lesions, a poor prognosis and ineffective therapies, suggesting that serpin B9 may be a potential target for cancer treatment and an indicator of cancer diagnosis; thus, it has begun to attract increased attention from scholars. The present review concisely described the structure and biological functions of the serpin superfamily and serpin B9. In addition, related research on serpins in cancer is discussed in order to provide a comprehensive understanding of the role of serpin B9 in cancer, as well as its clinical significance for cancer diagnosis and prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Wang J, Ouyang C, Chen C, Xu X and Ye X: Overview of serpin B9 and its roles in cancer (Review). Oncol Rep 46: 190, 2021.
APA
Wang, W., Wang, J., Ouyang, C., Chen, C., Xu, X., & Ye, X. (2021). Overview of serpin B9 and its roles in cancer (Review). Oncology Reports, 46, 190. https://doi.org/10.3892/or.2021.8141
MLA
Wang, W., Wang, J., Ouyang, C., Chen, C., Xu, X., Ye, X."Overview of serpin B9 and its roles in cancer (Review)". Oncology Reports 46.3 (2021): 190.
Chicago
Wang, W., Wang, J., Ouyang, C., Chen, C., Xu, X., Ye, X."Overview of serpin B9 and its roles in cancer (Review)". Oncology Reports 46, no. 3 (2021): 190. https://doi.org/10.3892/or.2021.8141
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Wang J, Ouyang C, Chen C, Xu X and Ye X: Overview of serpin B9 and its roles in cancer (Review). Oncol Rep 46: 190, 2021.
APA
Wang, W., Wang, J., Ouyang, C., Chen, C., Xu, X., & Ye, X. (2021). Overview of serpin B9 and its roles in cancer (Review). Oncology Reports, 46, 190. https://doi.org/10.3892/or.2021.8141
MLA
Wang, W., Wang, J., Ouyang, C., Chen, C., Xu, X., Ye, X."Overview of serpin B9 and its roles in cancer (Review)". Oncology Reports 46.3 (2021): 190.
Chicago
Wang, W., Wang, J., Ouyang, C., Chen, C., Xu, X., Ye, X."Overview of serpin B9 and its roles in cancer (Review)". Oncology Reports 46, no. 3 (2021): 190. https://doi.org/10.3892/or.2021.8141
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