Open Access

Screening of hub genes and evaluation of the growth regulatory role of CD44 in metastatic prostate cancer

Corrigendum in: /10.3892/or.2022.8343

  • Authors:
    • Junhao Lin
    • Zhi Chen
    • Zuan Li
    • Deyong Nong
    • Ximing Li
    • Guihai Huang
    • Nan Hao
    • Jianbo Liang
    • Wei Li
  • View Affiliations

  • Published online on: July 19, 2021     https://doi.org/10.3892/or.2021.8147
  • Article Number: 196
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prostate cancer (PCa) is the most common cancer type in men worldwide. Currently, the management of metastatic PCa (mPCa) remains a challenge to urologists. The analysis of hub genes and pathways may facilitate the understanding of the molecular mechanism of PCa. In the present study, to identify the hub genes in the mPCa, the three datasets GSE3325, GSE6919 and GSE38241 were downloaded from the platform of the Gene Expression Omnibus and function enrichment analysis of differentially expressed genes (DEGs) was performed. A total of 168 DEGs were obtained and the DEGs were significantly enriched in ‘cell junction’ and ‘cell adhesion’, among others. The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis demonstrated that DEGs were enriched in three pathways including ‘focal adhesion’, ‘renal cell carcinoma’ and ‘Hippo signaling pathway’. The results of the protein‑protein interaction network revealed that the hub genes in mPCa were separately PTEN, Rac GTPase‑activating protein 1, protein regulator of cytokinesis 1, PDZ binding kinase, centromere‑associated protein E, NUF2 component of NDC80 kinetochore complex, TPX2 microtubule nucleation factor, SOX2, CD44 and ubiquitin‑like with PHD and ring finger domains 1. As a hub gene, CD44 was differentially expressed in PCa, as determined by Oncomine analysis. Further experiments in vivo demonstrated that SB‑3CT, a selective matrix metalloproteinase inhibitor that has been reported to block CD44 cleavage and inhibit the downstream signaling pathway, suppressed the tumorigenicity of PCa cells by decreasing the expression levels of pyruvate dehydrogenase kinase 1 and 6‑phosphofructo‑2‑kinase/fructose‑2,6‑biphosphatase 4. Moreover, the combination therapy with SB‑3CT and docetaxel was more effective in inhibiting PCa compared with monotherapy. In conclusion, the identification of DEGs and the in vivo experimental results helped to elucidate the molecular mechanisms of PCa and provided a potential strategy for the treatment of PCa.
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September-2021
Volume 46 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Lin J, Chen Z, Li Z, Nong D, Li X, Huang G, Hao N, Liang J and Li W: Screening of hub genes and evaluation of the growth regulatory role of CD44 in metastatic prostate cancer Corrigendum in /10.3892/or.2022.8343. Oncol Rep 46: 196, 2021
APA
Lin, J., Chen, Z., Li, Z., Nong, D., Li, X., Huang, G. ... Li, W. (2021). Screening of hub genes and evaluation of the growth regulatory role of CD44 in metastatic prostate cancer Corrigendum in /10.3892/or.2022.8343. Oncology Reports, 46, 196. https://doi.org/10.3892/or.2021.8147
MLA
Lin, J., Chen, Z., Li, Z., Nong, D., Li, X., Huang, G., Hao, N., Liang, J., Li, W."Screening of hub genes and evaluation of the growth regulatory role of CD44 in metastatic prostate cancer Corrigendum in /10.3892/or.2022.8343". Oncology Reports 46.3 (2021): 196.
Chicago
Lin, J., Chen, Z., Li, Z., Nong, D., Li, X., Huang, G., Hao, N., Liang, J., Li, W."Screening of hub genes and evaluation of the growth regulatory role of CD44 in metastatic prostate cancer Corrigendum in /10.3892/or.2022.8343". Oncology Reports 46, no. 3 (2021): 196. https://doi.org/10.3892/or.2021.8147