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Article Open Access

Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer

  • Authors:
    • Ye Zhang
    • Hongmin Yao
    • Ying Li
    • Lu Yang
    • Liang Zhang
    • Jinxin Chen
    • Yong Wang
    • Xia Li
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Cancer Hospital of China Medical University/Liaoning Cancer Hospital and Institute, Dadong, Shenyang, Liaoning 110042, P.R. China, First Department of Gastroenterology, Cancer Hospital of China Medical University/Liaoning Cancer Hospital and Institute, Dadong, Shenyang, Liaoning 110042, P.R. China, Department of Breast Internal Medicine, Cancer Hospital of China Medical University/Liaoning Cancer Hospital and Institute, Dadong, Shenyang, Liaoning 110042, P.R. China, Department of Gynecological Oncology, Cancer Hospital of China Medical University/Liaoning Cancer Hospital and Institute, Dadong, Shenyang, Liaoning 110042, P.R. China, Central Laboratory, Central Hospital Affiliated to Shenyang Medical College, Dadong, Shenyang, Liaoning 110024, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 201
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    Published online on: July 23, 2021
       https://doi.org/10.3892/or.2021.8152
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Abstract

Accumulating evidence indicates that circular (circ)RNAs exhibit complex functions in diverse malignant tumors, including non‑small cell lung cancer (NSCLC). The role of the circRNA transcription adaptor 2A (circTADA2A) in NSCLC remains unclear. The expression, function and mechanism of circTADA2A in NSCLC development were investigated in the present study. The results revealed that circTADA2A was upregulated in NSCLC, and that knockdown of circTADA2A inhibited cell proliferation and migration in the NSCLC cell lines A549 and H1299. Functional assays demonstrated that circTADA2A promoted proliferation and migration via interacting with microRNA (miR)‑638. Bioinformatics and reverse transcription‑quantitative PCR assay confirmed that miR‑638 was expressed at low levels in NSCLC. In addition, it was found that miR‑638 served a tumor‑suppressive role and suppressed proliferation and migration via PCNA clamp associated factor (KIAA0101) inhibition in A549 and H1299 cells. Lastly, it was verified that circTADA2A promoted cell proliferation and migration, at least partially, via miR‑638/KIAA0101 signaling in A549 and H1299 cells. In summary, the present study showed that circTADA2A promoted NSCLC cell proliferation and migration via modulating miR‑638/KIAA0101 signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Yao H, Li Y, Yang L, Zhang L, Chen J, Wang Y and Li X: Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer. Oncol Rep 46: 201, 2021.
APA
Zhang, Y., Yao, H., Li, Y., Yang, L., Zhang, L., Chen, J. ... Li, X. (2021). Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer. Oncology Reports, 46, 201. https://doi.org/10.3892/or.2021.8152
MLA
Zhang, Y., Yao, H., Li, Y., Yang, L., Zhang, L., Chen, J., Wang, Y., Li, X."Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer". Oncology Reports 46.3 (2021): 201.
Chicago
Zhang, Y., Yao, H., Li, Y., Yang, L., Zhang, L., Chen, J., Wang, Y., Li, X."Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer". Oncology Reports 46, no. 3 (2021): 201. https://doi.org/10.3892/or.2021.8152
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Yao H, Li Y, Yang L, Zhang L, Chen J, Wang Y and Li X: Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer. Oncol Rep 46: 201, 2021.
APA
Zhang, Y., Yao, H., Li, Y., Yang, L., Zhang, L., Chen, J. ... Li, X. (2021). Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer. Oncology Reports, 46, 201. https://doi.org/10.3892/or.2021.8152
MLA
Zhang, Y., Yao, H., Li, Y., Yang, L., Zhang, L., Chen, J., Wang, Y., Li, X."Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer". Oncology Reports 46.3 (2021): 201.
Chicago
Zhang, Y., Yao, H., Li, Y., Yang, L., Zhang, L., Chen, J., Wang, Y., Li, X."Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer". Oncology Reports 46, no. 3 (2021): 201. https://doi.org/10.3892/or.2021.8152
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