Open Access

Long non‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p

  • Authors:
    • Hao Jin
    • Huan Wang
    • Xin Jin
    • Wenbo Wang
  • View Affiliations

  • Published online on: July 28, 2021     https://doi.org/10.3892/or.2021.8158
  • Article Number: 207
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A prevalent type of bone tumor, osteosarcoma (OS) is prone to pulmonary metastasis, which results in a high relapse risk and poor prognosis for patients. The progression of OS is significantly associated with the expression of long non‑coding (lnc)RNA H19. To the best of our knowledge, however, the exact molecular mechanism of this lncRNA has not been fully investigated. The present study verified the effect of H19 on the proliferation and invasion of osteosarcoma cells via in vivo and in vitro experiments, including Cell Counting Kit‑8, western blot, reverse transcription‑quantitative PCR, wound healing and Transwell assays. H19 was found to be overexpressed in OS compared with corresponding normal adjacent tissue. In addition, H19 served as a competing endogenous ncRNA targeting microRNA‑29a‑3p and activating LIM and SH3 domain protein 1 and modulating the OS cell phenotype. The results of the present study may improve understanding of OS pathogenesis.
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September-2021
Volume 46 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Jin H, Wang H, Jin X and Wang W: Long non‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p. Oncol Rep 46: 207, 2021
APA
Jin, H., Wang, H., Jin, X., & Wang, W. (2021). Long non‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p. Oncology Reports, 46, 207. https://doi.org/10.3892/or.2021.8158
MLA
Jin, H., Wang, H., Jin, X., Wang, W."Long non‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p". Oncology Reports 46.3 (2021): 207.
Chicago
Jin, H., Wang, H., Jin, X., Wang, W."Long non‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p". Oncology Reports 46, no. 3 (2021): 207. https://doi.org/10.3892/or.2021.8158