Open Access

Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review)

  • Authors:
    • Na Chen
    • Yi-Shu Zhou
    • Li-Cui Wang
    • Jin-Bai Huang
  • View Affiliations

  • Published online on: January 18, 2022     https://doi.org/10.3892/or.2022.8266
  • Article Number: 55
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Therapeutic approaches that target the metabolism of tumor cells have been a popular research topic in recent years. Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. Metformin, a known inhibitor of mitochondrial OXPHOS, has been indicated to reduce NSCLC morbidity and mortality in clinical studies. The present article reviewed the therapeutic effects of metformin against NSCLC, both as a single agent and combined with other anticancer treatments, in order to provide a theoretical basis for its clinical use in adjuvant therapy for NSCLC.
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March-2022
Volume 47 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chen N, Zhou Y, Wang L and Huang J: Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review). Oncol Rep 47: 55, 2022
APA
Chen, N., Zhou, Y., Wang, L., & Huang, J. (2022). Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review). Oncology Reports, 47, 55. https://doi.org/10.3892/or.2022.8266
MLA
Chen, N., Zhou, Y., Wang, L., Huang, J."Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review)". Oncology Reports 47.3 (2022): 55.
Chicago
Chen, N., Zhou, Y., Wang, L., Huang, J."Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review)". Oncology Reports 47, no. 3 (2022): 55. https://doi.org/10.3892/or.2022.8266