Open Access

Tetraspanin CD9: A friend or foe of head and neck cancer (Review)

  • Authors:
    • Suhasini P.C.
    • Shilpa S. Shetty
    • Suchetha Kumari Nalilu
    • Praveen Kumar Shetty
    • Prakash Patil
  • View Affiliations

  • Published online on: March 9, 2022     https://doi.org/10.3892/or.2022.8299
  • Article Number: 88
  • Copyright: © P.C. et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Head and neck cancers are diverse and complex diseases characterised by unregulated growth of tumour cells in various parts of the head and neck region, such as in the buccal mucosa, floor of the mouth, tongue, oropharynx, hypopharynx, oesophagus, nasopharynx and salivary glands. Partial or total glossectomy, radiation or chemotherapy greatly affect patient quality of life. However, even following treatment, patients may relapse. Nicotine‑derived nitrosamines and alcohol are the major etiological factors underlying this deadly disease. These compounds induce DNA damage that may lead to mutation in crucial genes, such as p53 and p21, which are important to regulate cell proliferation, thus leading to cancer. CD9 is a tetraspanin, which are a group of transmembrane proteins that have a role in cell motility and adhesion. The present review aimed to explore the role of CD9 in head and neck cancer. Epidermal growth factor receptor activity and cell proliferation are regulated by the CD9‑integrin/CD9‑transforming growth factor interaction. Hence, CD9 can play a dual role in various types of cancer.
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May-2022
Volume 47 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
P.C. S, Shetty SS, Nalilu SK, Shetty PK and Patil P: Tetraspanin CD9: A friend or foe of head and neck cancer (Review). Oncol Rep 47: 88, 2022
APA
P.C., S., Shetty, S.S., Nalilu, S.K., Shetty, P.K., & Patil, P. (2022). Tetraspanin CD9: A friend or foe of head and neck cancer (Review). Oncology Reports, 47, 88. https://doi.org/10.3892/or.2022.8299
MLA
P.C., S., Shetty, S. S., Nalilu, S. K., Shetty, P. K., Patil, P."Tetraspanin CD9: A friend or foe of head and neck cancer (Review)". Oncology Reports 47.5 (2022): 88.
Chicago
P.C., S., Shetty, S. S., Nalilu, S. K., Shetty, P. K., Patil, P."Tetraspanin CD9: A friend or foe of head and neck cancer (Review)". Oncology Reports 47, no. 5 (2022): 88. https://doi.org/10.3892/or.2022.8299