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Article Open Access

SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4

  • Authors:
    • Wen-Kai Shi
    • Qiao-Li Shang
    • Yong-Fu Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, The Seventh Plastic Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 91
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    Published online on: March 15, 2022
       https://doi.org/10.3892/or.2022.8302
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Abstract

Hepatocellular carcinoma (HCC) is a malignant tumor with a high metastatic rate. Recent studies have shown that the mitosis‑associated spindle‑assembly checkpoint regulatory protein spindle pole body component 25 homolog (SPC25) promotes HCC progression, although the underlying mechanism has yet to be fully elucidated. The aim of the present study was to investigate the mechanism through which SPC25 may promote HCC progression in greater detail. First, the expression of SPC25 was analyzed in publicly available databases to explore the association between SPC25 and HCC metastasis. Western blotting was subsequently performed to examine the level of SPC25 expression in different HCC cell lines. SPC25 was then silenced in HCCLM3 and Huh7 cells, and the effects of SPC25 silencing were investigated using cell proliferation, wound‑healing, Transwell migration assays and an in vivo mouse model. Finally, the mechanism of SPC25 action with respect to the promotion of HCC metastasis was explored using microarray analysis and rescue experiments. The results obtained demonstrated that SPC25 is highly expressed in HCC, and this high level of expression is associated with poor prognosis and metastasis. Moreover, SPC25 silencing led to a marked inhibition of the invasion and migration of HCC cells both in vitro and in vivo. The gene‑expression profiling and mechanistic experiments suggest that SPC25 preferentially influences the expression of genes associated with extracellular matrix (ECM)‑integrin interactions, including integrin subunit β4 (ITGB4), an upstream element of the integrin pathway. ITGB4 upregulation partly reversed the decline in cell invasion and migration capacities that resulted from SPC25 silencing. Furthermore, deleting both SPC25 and ITGB4 caused a decrease in the phosphorylation of focal adhesion kinase (FAK), phosphoinositide 3‑kinase (PI3K) and AKT, which are downstream elements of the integrin pathway. Taken together, the results of the present study demonstrated the important role of SPC25 as a prognostic indicator and as a promoter of metastasis in HCC, and the underlying mechanism of its action has been partially elucidated, suggesting that SPC25 could be used as a biomarker and as a target for therapeutic intervention in the treatment of HCC.
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View References

1 

Hindson J: Lenvatinib plus EGFR inhibition for liver cancer. Nat Rev Gastroenterol Hepatol. 18:6752021. View Article : Google Scholar : PubMed/NCBI

2 

Villanueva A: Hepatocellular carcinoma. N Engl J Med. 380:1450–1462. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al: SHARP investigators study group: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, et al: Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: A randomised phase 3 non-inferiority trial. Lancet. 391:1163–1173. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Bruix J, da Fonseca LG and Reig M: Insights into the success and failure of systemic therapy for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 16:617–630. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Quail DF and Joyce JA: Microenvironmental regulation of tumor progression and metastasis. Nat Med. 19:1423–1437. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Holle AW, Young JL and Spatz JP: In vitro cancer cell-ECM interactions inform in vivo cancer treatment. Adv Drug Deliv Rev. 97:270–279. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Mitra SK and Schlaepfer DD: Integrin regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol. 18:516–523. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Kim SH, Turnbull J and Guimond S: Extracellular matrix and cell signalling: The dynamic cooperation of integrin, proteoglycan and growth factor receptor. J Endocrinol. 209:139–151. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Liang Y, Chen X, Wu Y, Li J, Zhang S, Wang K, Guan X, Yang K and Bai Y: LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein. Cell Death Differ. 25:1980–1995. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Tai YL, Chu PY, Lai IR, Wang MY, Tseng HY, Guan JL, Liou JY and Shen TL: An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer. Sci Rep. 5:164082015. View Article : Google Scholar : PubMed/NCBI

12 

Leng C, Zhang ZG, Chen WX, Luo HP, Song J, Dong W, Zhu XR, Chen XP, Liang HF and Zhang BX: An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway. Cancer Lett. 376:188–196. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Sun SC, Lee SE, Xu YN and Kim NH: Perturbation of Spc25 expression affects meiotic spindle organization, chromosome alignment and spindle assembly checkpoint in mouse oocytes. Cell Cycle. 9:4552–4559. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Aguilera A and García-Muse T: Causes of genome instability. Annu Rev Genet. 47:1–32. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Chen J, Chen H, Yang H and Dai H: SPC25 upregulation increases cancer stem cell properties in non-small cell lung adenocarcinoma cells and independently predicts poor survival. Biomed Pharmacother. 100:233–239. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Wang Q, Zhu Y, Li Z, Bu Q, Sun T, Wang H, Sun H and Cao X: Up-regulation of SPC25 promotes breast cancer. Aging (Albany NY). 11:5689–5704. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Cui F, Tang H, Tan J and Hu J: Spindle pole body component 25 regulates stemness of prostate cancer cells. Aging (Albany NY). 10:3273–3282. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Yang X, Sun H, Song Y, Yang L and Liu H: Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma. PeerJ. 8:e95352020. View Article : Google Scholar : PubMed/NCBI

19 

Zhang B, Zhou Q, Xie Q, Lin X, Miao W, Wei Z, Zheng T, Pang Z, Liu H and Chen X: SPC25 overexpression promotes tumor proliferation and is prognostic of poor survival in hepatocellular carcinoma. Aging (Albany NY). 13:2803–2821. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Chen F, Zhang K, Huang Y, Luo F, Hu K and Cai Q: SPC25 may promote proliferation and metastasis of hepatocellular carcinoma via p53. FEBS Open Bio. 10:1261–1275. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Shi WK, Zhu XD, Wang CH, Zhang YY, Cai H, Li XL, Cao MQ, Zhang SZ, Li KS and Sun HC: PFKFB3 blockade inhibits hepatocellular carcinoma growth by impairing DNA repair through AKT. Cell Death Dis. 9:4282018. View Article : Google Scholar : PubMed/NCBI

22 

Chiyonobu N, Shimada S, Akiyama Y, Mogushi K, Itoh K, Akahoshi K, Matsumura S, Ogawa K, Ono H, Mitsunori Y, et al: Fatty Acid Binding Protein 4 (FABP4) overexpression in intratumoral hepatic stellate cells within hepatocellular carcinoma with metabolic risk factors. Am J Pathol. 188:1213–1224. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Shimada S, Mogushi K, Akiyama Y, Furuyama T, Watanabe S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, et al: Comprehensive molecular and immunological characterization of hepatocellular carcinoma. EBioMedicine. 40:457–470. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Sun FX, Tang ZY, Lui KD, Ye SL, Xue Q, Gao DM and Ma ZC: Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues. Int J Cancer. 66:239–243. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Wang CH, Zhu XD, Ma DN, Sun HC, Gao DM, Zhang N, Qin CD, Zhang YY, Ye BG, Cai H, et al: Flot2 promotes tumor growth and metastasis through modulating cell cycle and inducing epithelial-mesenchymal transition of hepatocellular carcinoma. Am J Cancer Res. 7:1068–1083. 2017.PubMed/NCBI

27 

Lee JS and Thorgeirsson SS: Functional and genomic implications of global gene expression profiles in cell lines from human hepatocellular cancer. Hepatology. 35:1134–1143. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Li M, Jiang X, Wang G, Zhai C, Liu Y, Li H, Zhang Y, Yu W and Zhao Z: ITGB4 is a novel prognostic factor in colon cancer. J Cancer. 10:5223–5233. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Wu P, Wang Y, Wu Y, Jia Z, Song Y and Liang N: Expression and prognostic analyses of ITGA11, ITGB4 and ITGB8 in human non-small cell lung cancer. PeerJ. 7:e82992019. View Article : Google Scholar : PubMed/NCBI

30 

Wilkinson EJ, Woodworth AM, Parker M, Phillips JL, Malley RC, Dickinson JL and Holloway AF: Epigenetic regulation of the ITGB4 gene in prostate cancer. Exp Cell Res. 392:1120552020. View Article : Google Scholar : PubMed/NCBI

31 

Zhuang H, Zhou Z, Ma Z, Li Z, Liu C, Huang S, Zhang C and Hou B: Characterization of the prognostic and oncologic values of ITGB superfamily members in pancreatic cancer. J Cell Mol Med. 24:13481–13493. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Sung JS, Kang CW, Kang S, Jang Y, Chae YC, Kim BG and Cho NH: ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts. Oncogene. 39:664–676. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Li XL, Liu L, Li DD, He YP, Guo LH, Sun LP, Liu LN, Xu HX and Zhang XP: Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma. Sci Rep. 7:404642017. View Article : Google Scholar : PubMed/NCBI

34 

Wang W, Zuidema A, Te Molder L, Nahidiazar L, Hoekman L, Schmidt T, Coppola S and Sonnenberg A: Hemidesmosomes modulate force generation via focal adhesions. J Cell Biol. 219:e2019041372020. View Article : Google Scholar : PubMed/NCBI

35 

Walko G, Castañón MJ and Wiche G: Molecular architecture and function of the hemidesmosome. Cell Tissue Res. 360:363–378. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Xu L, Hou Y, Tu G, Chen Y, Du YE, Zhang H, Wen S, Tang X, Yin J, Lang L, et al: Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer. Cell Death Dis. 8:e26422017. View Article : Google Scholar : PubMed/NCBI

37 

Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, et al: Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436:123–127. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Walen KH: Genomic Instability in cancer I: DNA-Repair triggering primitive hereditary 4n-Skewed, amitotic division-system, the culprit in EMT/MET/Metaplasia cancer-concepts. J Cancer Ther. 9:974–997. 2018. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Shi W, Shang Q and Zhao Y: SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4. Oncol Rep 47: 91, 2022.
APA
Shi, W., Shang, Q., & Zhao, Y. (2022). SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4. Oncology Reports, 47, 91. https://doi.org/10.3892/or.2022.8302
MLA
Shi, W., Shang, Q., Zhao, Y."SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4". Oncology Reports 47.5 (2022): 91.
Chicago
Shi, W., Shang, Q., Zhao, Y."SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4". Oncology Reports 47, no. 5 (2022): 91. https://doi.org/10.3892/or.2022.8302
Copy and paste a formatted citation
x
Spandidos Publications style
Shi W, Shang Q and Zhao Y: SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4. Oncol Rep 47: 91, 2022.
APA
Shi, W., Shang, Q., & Zhao, Y. (2022). SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4. Oncology Reports, 47, 91. https://doi.org/10.3892/or.2022.8302
MLA
Shi, W., Shang, Q., Zhao, Y."SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4". Oncology Reports 47.5 (2022): 91.
Chicago
Shi, W., Shang, Q., Zhao, Y."SPC25 promotes hepatocellular carcinoma metastasis via activating the FAK/PI3K/AKT signaling pathway through ITGB4". Oncology Reports 47, no. 5 (2022): 91. https://doi.org/10.3892/or.2022.8302
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