miRNAs and the Hippo pathway in cancer: Exploring the therapeutic potential (Review)

  • Authors:
    • Taruna Arora
    • Mohd. Adnan Kausar
    • Shimaa Mohammed Aboelnaga
    • Sadaf Anwar
    • Malik Asif Hussain
    • Sadaf Sadaf
    • Simran Kaur
    • Alaa Abdulaziz Eisa
    • Vyas Murti Madhavrao Shingatgeri
    • Mohammad Zeeshan Najm
    • Abdulaziz A. Aloliqi
  • View Affiliations

  • Published online on: June 10, 2022     https://doi.org/10.3892/or.2022.8346
  • Article Number: 135
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Abstract

Cancer is recognized as the leading cause of death worldwide. The hippo signaling pathway regulates organ size by balancing cell proliferation and cell death; hence dysregulation of the hippo pathway promotes cancer‑like conditions. miRNAs are a type of non‑coding RNA that have been shown to regulate gene expression. miRNA levels are altered in various classes of cancer. Researchers have also uncovered a crosslinking between miRNAs and the hippo pathway, which has been linked to cancer. The components of the hippo pathway regulate miRNA synthesis, and various miRNAs regulate the components of the hippo pathway both positively and negatively, which can lead to cancer‑like conditions. In the present review article, the mechanism behind the hippo signaling pathway and miRNAs biogenesis and crosslinks between miRNAs and the hippo pathway, which result in cancer, shall be discussed. Furthermore, the article will cover miRNA‑related therapeutics and provide an overview of the development of resistance to anticancer drugs. Understanding the underlying processes would improve the chances of developing effective cancer treatment therapies.
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July-2022
Volume 48 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Arora T, Kausar MA, Aboelnaga SM, Anwar S, Hussain MA, Sadaf S, Kaur S, Eisa AA, Shingatgeri VM, Najm MZ, Najm MZ, et al: miRNAs and the Hippo pathway in cancer: Exploring the therapeutic potential (Review). Oncol Rep 48: 135, 2022
APA
Arora, T., Kausar, M.A., Aboelnaga, S.M., Anwar, S., Hussain, M.A., Sadaf, S. ... Aloliqi, A.A. (2022). miRNAs and the Hippo pathway in cancer: Exploring the therapeutic potential (Review). Oncology Reports, 48, 135. https://doi.org/10.3892/or.2022.8346
MLA
Arora, T., Kausar, M. A., Aboelnaga, S. M., Anwar, S., Hussain, M. A., Sadaf, S., Kaur, S., Eisa, A. A., Shingatgeri, V. M., Najm, M. Z., Aloliqi, A. A."miRNAs and the Hippo pathway in cancer: Exploring the therapeutic potential (Review)". Oncology Reports 48.1 (2022): 135.
Chicago
Arora, T., Kausar, M. A., Aboelnaga, S. M., Anwar, S., Hussain, M. A., Sadaf, S., Kaur, S., Eisa, A. A., Shingatgeri, V. M., Najm, M. Z., Aloliqi, A. A."miRNAs and the Hippo pathway in cancer: Exploring the therapeutic potential (Review)". Oncology Reports 48, no. 1 (2022): 135. https://doi.org/10.3892/or.2022.8346