Open Access

Regulators of epigenetic change in ferroptosis‑associated cancer (Review)

  • Authors:
    • Jiaming Wu
    • Shuang Zhu
    • Peng Wang
    • Jinge Wang
    • Jingjing Huang
    • Tong Wang
    • Lingfeng Guo
    • Desen Liang
    • Qinghui Meng
    • Huayang Pan
  • View Affiliations

  • Published online on: October 20, 2022     https://doi.org/10.3892/or.2022.8430
  • Article Number: 215
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The occurrence of tumors is associated with the upregulation or downregulation of certain genes. The identification of novel tumor therapies has revealed that regulation of tumor cell death can either promote or suppress the occurrence and development of tumors. Iron‑dependent lipid free oxygen radical accumulation causes tumor cells to die by ferroptosis, a form of regulated cell death. Multiple mechanisms mediate this mode of cell death, including redox homeostasis, iron metabolism, mitochondrial activity, breakdown of amino acids, lipids and sugars and epigenetic regulatory and disease‑associated signaling pathways. The present review discussed epigenetic mechanism of ferroptosis with the aim of providing novel insight for optimization of the effects of antitumor therapy.
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December-2022
Volume 48 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wu J, Zhu S, Wang P, Wang J, Huang J, Wang T, Guo L, Liang D, Meng Q, Pan H, Pan H, et al: Regulators of epigenetic change in ferroptosis‑associated cancer (Review). Oncol Rep 48: 215, 2022
APA
Wu, J., Zhu, S., Wang, P., Wang, J., Huang, J., Wang, T. ... Pan, H. (2022). Regulators of epigenetic change in ferroptosis‑associated cancer (Review). Oncology Reports, 48, 215. https://doi.org/10.3892/or.2022.8430
MLA
Wu, J., Zhu, S., Wang, P., Wang, J., Huang, J., Wang, T., Guo, L., Liang, D., Meng, Q., Pan, H."Regulators of epigenetic change in ferroptosis‑associated cancer (Review)". Oncology Reports 48.6 (2022): 215.
Chicago
Wu, J., Zhu, S., Wang, P., Wang, J., Huang, J., Wang, T., Guo, L., Liang, D., Meng, Q., Pan, H."Regulators of epigenetic change in ferroptosis‑associated cancer (Review)". Oncology Reports 48, no. 6 (2022): 215. https://doi.org/10.3892/or.2022.8430