PLAU is associated with cell migration and invasion and is regulated by transcription factor YY1 in cervical cancer
- Yanjun Gao
- Xinmei Ma
- Huanxi Lu
- Pan Xu
- Chengling Xu
Affiliations: Clinical Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China, Central Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China, Department of Gynecology, Dongchangfu People's Hospital, Liaocheng, Shandong 252000, P.R. China, Clinical Laboratory and Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China
- Published online on: December 13, 2022 https://doi.org/10.3892/or.2022.8462
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Cervical cancer, one of the most common malignancies, has a poor survival rate. The identification of more biomarkers for cervical cancer diagnosis and therapy is urgently needed. Plasminogen activator urokinase (PLAU) exerts multiple biological effects in various physiological and pathological processes; however the role of PLAU in cervical cancer progression is not fully understood. In the present study, the involvement and transcriptional regulation of PLAU in cervical cancer were explored. The expression of PLAU in cervical cancer was first analyzed, and PLAU was found to be overexpressed. In vitro experiments demonstrated that the migration and invasion of HeLa and HT3 cells were significantly suppressed by PLAU knockdown. Additionally, the core promoter of PLAU was confirmed, and the transcription factor YinYang 1 (YY1) was found to regulate PLAU mRNA expression. Overall, the present study elucidated the direct association between PLAU and cervical cancer, suggesting the YY1/PLAU axis as a potential novel therapeutic target for cervical cancer.