Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February-2023 Volume 49 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2023 Volume 49 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Methods

An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy

  • Authors:
    • Yicheng Ni
  • View Affiliations / Copyright

    Affiliations: Theragnostic Laboratory, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Group, KU Leuven, 3000 Leuven, Belgium
  • Article Number: 35
    |
    Published online on: December 23, 2022
       https://doi.org/10.3892/or.2022.8472
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer liquid biopsy (CLB) aims for the detection of circulating tumor cells, cell‑free DNA or RNA, and specifically expressed proteins, lipids and metabolites present in the bio‑fluids of patients. Rapid advances in technologies for sampling such bio‑specimens and for genomic sequencing have fostered the development of authority‑approved CLB tests in clinical practice for the early screening and diagnosis of malignancies. However, perhaps some solid tumors could have been reliably detected using CLB, while they were still too small to be found in patients using currently available imaging technologies. This could impose troublesome clinical scenarios. In this communication article, the author would like to propose a potential solution that eventually may be used to combat such unwanted embarrassing clinical issues by using one episode of targeted radiotheragnostics, namely OncoCiDia.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Marin JF, Nunes RF, Coutinho AM, Zaniboni EC, Costa LB, Barbosa FG, Queiroz MA, Cerri GG and Buchpiguel CA: Theranostics in nuclear medicine: Emerging and Re-emerging integrated imaging and therapies in the era of precision oncology. Radiographics. 40:1715–1740. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Frangos S and Buscombe JR: Why should we be concerned about a ‘g’? Eur J Nucl Med Mol Imaging. 46:5192019. View Article : Google Scholar : PubMed/NCBI

4 

Pinzani P, D'Argenio V, Del Re M, Pellegrini C, Cucchiara F, Salvianti F and Galbiati S: Updates on liquid biopsy: Current trends and future perspectives for clinical application in solid tumors. Clin Chem Lab Med. 59:1181–120. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Crosby D: Delivering on the promise of early detection with liquid biopsies. Br J Cancer. 126:313–315. 2022. View Article : Google Scholar : PubMed/NCBI

6 

Cona MM, Oyen R and Ni Y: Necrosis avidity of organic compounds: A natural phenomenon with exploitable theragnostic potentials. Curr Med Chem. 22:1829–1849. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Li J, Sun Z, Zhang J, Shao H, Cona MM, Wang H, Marysael T, Chen F, Prinsen K, Zhou L, et al: A dual targeting anticancer approach: Soil and seed principle. Radiology. 260:799–807. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ni Y: Oncocidia: A small molecule dual targeting pan-anticancer theragnostic strategy. Cancer Res. 74:17672014. View Article : Google Scholar

9 

Siemann DW, Chaplin DJ and Walicke PA: A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P). Expert Opin Investig Drugs. 18:189–197. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Ni Y, Huyghe D, Verbeke K, de Witte PA, Nuyts J, Mortelmans L, Chen F, Marchal G, Verbruggen AM and Bormans GM: First preclinical evaluation of mono-[123I]iodohypericin as a necrosis avid tracer agent. Eur J Nucl Med Mol. 33:595–601. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Cona MM, Feng YB, Verbruggen A, Oyen R and Ni Y: Improve clearance of radioiodinated hypericin as a targeted anticancer agent by using a duodenal drainage catheter in rats. Exp Biol Med (Maywood). 238:1437–1449. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Li Y, Jiang C, Jiang X, Sun Z, Cona MM, Liu W, Zhang J and Ni Y: Biliary and duodenal drainage for reducing the radiotoxic risk of antineoplastic 131I-hypericin in rat models. Exp Biol Med (Maywood). 240:1764–1773. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Verburg FA, Flux G, Giovanella L, van Nostrand D, Muylle K and Luster M: Differentiated thyroid cancer patients potentially benefitting from postoperative I-131 therapy: A review of the literature of the past decade. Eur J Nucl Med Mol Imaging. 47:78–83. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Liu Y, Yin T, De Keyzer F, Feng YB, Chen F, Liu JJ, Song SL, Yu J, Vandecaveye V, Swinnen J, et al: Micro-HCCs in rats with liver cirrhosis: paradoxical targeting effects with vascular disrupting agent CA4P. Oncotarget. 8:55204–55215. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Wang S, Liu Y, Feng Y, Zhang J, Swinnen J, Li Y and Ni Y: A review on curability of cancers: More efforts for novel therapeutic options are needed. Cancers (Basel). 11:17822019. View Article : Google Scholar : PubMed/NCBI

16 

Garon EB, Neidhart JD, Gabrail NY, de Oliveira MR, Balkissoon J and Kabbinavar F: A randomized Phase II trial of the tumor vascular disrupting agent CA4P (fosbretabulin tromethamine) with carboplatin, paclitaxel, and bevacizumab in advanced nonsquamous non-small-cell lung cancer. Onco Targets Ther. 9:7275–7283. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Folkman J, Long DM Jr and Becker FF: Growth and metastasis of tumor in organ culture. Cancer. 16:453–467. 1963. View Article : Google Scholar : PubMed/NCBI

18 

Sugimoto K, Kim SR, Imoto S, Tohyama M, Kim SK, Matsuoka T, Yano Y, Kudo M and Hayashi Y: Characteristics of hypo-vascular versus hypervascular well-differentiated hepatocellular carcinoma smaller than 2 cm-focus on tumor size, markers and imaging detectability. Dig Dis. 33:721–727. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Hori K, Nishihara M, Shiraishi K and Yokoyama M: The combretastatin derivative (Cderiv), a vascular disrupting agent, enables polymeric nanomicelles to accumulate in microtumors. J Pharm Sci. 99:2914–2925. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Maeda H: Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting. Proc Jpn Acad Ser B Phys Biol Sci. 88:53–71. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Ni Y: Treatment of avascular or hypovascular micro-tumors. US Patent 16/628,904, Filed. July 4–2018 issued. January 10–2019.

22 

Cacho-Díaz B, García-Botello DR, Wegman-Ostrosky T, Reyes-Soto G, Ortiz-Sánchez E and Herrera-Montalvo LA: Tumor microenvironment differences between primary tumor and brain metastases. J Transl Med. 18:12020. View Article : Google Scholar : PubMed/NCBI

23 

Osako T: How can we better distinguish metastatic tumors from primary tumors in the breast? Expert Rev Anticancer Ther. 21:913–916. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Kim R, Keam B, Kim S, Kim M, Kim SH, Kim JW, Kim YJ, Kim TM, Jeon YK, Kim DW, et al: Differences in tumor microenvironments between primary lung tumors and brain metastases in lung cancer patients: Therapeutic implications for immune checkpoint inhibitors. BMC Cancer. 19:192021. View Article : Google Scholar : PubMed/NCBI

25 

Ikarashi D, Okimoto T, Shukuya T, Onagi H, Hayashi T, Sinicropi-Yao SL, Amann JM, Nakatsura T, Kitano S and Carbone DP: Comparison of tumor microenvironments between primary tumors and brain metastases in patients with NSCLC. JTO Clin Res Rep. 2:1002302021.PubMed/NCBI

26 

Pearce OM, Delaine-Smith RM, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, et al: Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Dis. 8:304–319. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ni Y: An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy. Oncol Rep 49: 35, 2023.
APA
Ni, Y. (2023). An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy. Oncology Reports, 49, 35. https://doi.org/10.3892/or.2022.8472
MLA
Ni, Y."An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy". Oncology Reports 49.2 (2023): 35.
Chicago
Ni, Y."An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy". Oncology Reports 49, no. 2 (2023): 35. https://doi.org/10.3892/or.2022.8472
Copy and paste a formatted citation
x
Spandidos Publications style
Ni Y: An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy. Oncol Rep 49: 35, 2023.
APA
Ni, Y. (2023). An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy. Oncology Reports, 49, 35. https://doi.org/10.3892/or.2022.8472
MLA
Ni, Y."An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy". Oncology Reports 49.2 (2023): 35.
Chicago
Ni, Y."An emerging technique for the dual‑targeting chemo‑radio‑ablation of generic micro‑cancers in conjunction with cancer liquid biopsy". Oncology Reports 49, no. 2 (2023): 35. https://doi.org/10.3892/or.2022.8472
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team