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Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review)

  • Authors:
    • Sophia Themistocleous
    • Panayiota Christodoulou
    • Theodora-Christina Kyriakou
    • Charalampos Filippou
    • Apostolos Zaravinos
    • Andreas Yiallouris
  • View Affiliations / Copyright

    Affiliations: School of Medicine, European University Cyprus, 2404 Nicosia, Cyprus, Department of Life Sciences, School of Sciences, European University Cyprus, 1516 Nicosia, Cyprus
    Copyright: © Themistocleous et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 77
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    Published online on: March 2, 2023
       https://doi.org/10.3892/or.2023.8514
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Abstract

Cell fate is critically affected by mitochondrial activity, from ATP production to metabolism, Ca2+ homeostasis and signaling. These actions are regulated by proteins expressed in mitochondria (Mt)‑endoplasmic reticulum contact sites (MERCSs). The literature supports the fact that disruption to the physiology of the Mt and/or MERCSs can be due to alterations in the Ca2+ influx/efflux, which further regulates autophagy and apoptosis activity. The current review presents the findings of numerous studies with regard to the involvement of proteins positioned in MERCSs and how they express anti‑ and pro‑apoptotic properties by adjusting Ca2+ across membranes. The review also explores the involvement of mitochondrial proteins as hot spots in cancer development, cell death and/or survival, and the method via which they can potentially be targeted as a therapeutic option.
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1 

Vance JE: Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem. 265:7248–7256. 1990. View Article : Google Scholar : PubMed/NCBI

2 

Wieckowski MR, Giorgi C, Lebiedzinska M, Duszynski J and Pinton P: Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat Protoc. 4:1582–1590. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Sala-Vila A, Navarro-Lérida I, Sánchez-Alvarez M, Bosch M, Calvo C, López JA, Calvo E, Ferguson C, Giacomello M, Serafini A, et al: Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice. Sci Rep. 6:273512016. View Article : Google Scholar : PubMed/NCBI

4 

Missiroli S, Danese A, Iannitti T, Patergnani S, Perrone M, Previati M, Giorgi C and Pinton P: Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate. Biochim Biophys Acta Mol Cell Res. 1864:858–864. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Area-Gomez E, de Groof A, Bonilla E, Montesinos J, Tanji K, Boldogh I, Pon L and Schon EA: A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease. Cell Death Dis. 9:3352018. View Article : Google Scholar : PubMed/NCBI

6 

Gómez-Suaga P, Pedro JM, González-Polo RA, Fuentes JM and Niso-Santano M: ER-mitochondria signaling in Parkinson's disease. Cell Death Dis. 9:3372018. View Article : Google Scholar : PubMed/NCBI

7 

Annunziata I, Sano R and d'Azzo A: Mitochondria-associated ER membranes (MAMs) and lysosomal storage diseases. Cell Death Dis. 9:3282018. View Article : Google Scholar : PubMed/NCBI

8 

Lau DHW, Hartopp N, Welsh NJ, Mueller B, Glennon EB, Mórotz GM, Annibali A, Gomez-Suaga P, Stoica R, Paillusson S and Miller CCJ: Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis. Cell Death Dis. 9:3272018. View Article : Google Scholar : PubMed/NCBI

9 

Missiroli S, Patergnani S, Caroccia N, Pedriali G, Perrone M, Previati M, Wieckowski MR and Giorgi C: Mitochondria-associated membranes (MAMs) and inflammation. Cell Death Dis. 9:3292018. View Article : Google Scholar : PubMed/NCBI

10 

Sassano ML, van Vliet AR and Agostinis P: Mitochondria-associated membranes as networking platforms and regulators of cancer cell fate. Front Oncol. 7:1742017. View Article : Google Scholar : PubMed/NCBI

11 

Marchi S and Pinton P: Alterations of calcium homeostasis in cancer cells. Curr Opin Pharmacol. 29:1–6. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wang N, Wang C, Zhao H, He Y, Lan B, Sun L and Gao Y: The MAMs structure and its role in cell death. Cells. 10:6572021. View Article : Google Scholar : PubMed/NCBI

13 

Csordás G, Renken C, Várnai P, Walter L, Weaver D, Buttle KF, Balla T, Mannella CA and Hajnóczky G: Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol. 174:915–921. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Yu H, Sun C, Gong Q and Feng D: Mitochondria-associated endoplasmic reticulum membranes in breast cancer. Front Cell Dev Biol. 9:6296692021. View Article : Google Scholar : PubMed/NCBI

15 

Kang R, Zeh HJ, Lotze MT and Tang D: The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18:571–580. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Szabadkai G and Duchen MR: Mitochondria: The hub of cellular Ca2+ signaling. Physiology (Bethesda). 23:84–94. 2008.PubMed/NCBI

17 

Avalle L, Camporeale A, Morciano G, Caroccia N, Ghetti E, Orecchia V, Viavattene D, Giorgi C, Pinton P and Poli V: STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses. Cell Death Differ. 26:932–942. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Rimessi A, Pedriali G, Vezzani B, Tarocco A, Marchi S, Wieckowski MR, Giorgi C and Pinton P: Interorganellar calcium signaling in the regulation of cell metabolism: A cancer perspective. Semin Cell Dev Biol. 98:167–180. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Danese A, Patergnani S, Bonora M, Wieckowski MR, Previati M, Giorgi C and Pinton P: Calcium regulates cell death in cancer: Roles of the mitochondria and mitochondria-associated membranes (MAMs). Biochim Biophys Acta. 1858:615–627. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Patergnani S, Missiroli S, Marchi S and Giorgi C: Mitochondria-associated endoplasmic reticulum membranes microenvironment: Targeting autophagic and apoptotic pathways in cancer therapy. Front Oncol. 5:1732015. View Article : Google Scholar : PubMed/NCBI

21 

Giorgi C, Bonora M, Sorrentino G, Missiroli S, Poletti F, Suski JM, Ramirez FG, Rizzuto R, Di Virgilio F, Zito E, et al: p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner. Proc Natl Acad Sci U S A. 112:1779–1784. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Pinton P: Mitochondria-associated membranes (MAMs) and pathologies. Cell Death Dis. 9:4132018. View Article : Google Scholar : PubMed/NCBI

23 

Jacquemyn J, Cascalho A and Goodchild RE: The ins and outs of endoplasmic reticulum-controlled lipid biosynthesis. EMBO Rep. 18:1905–1921. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Watson H: Biological membranes. Essays Biochem. 59:43–69. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Gibellini F and Smith TK: The Kennedy pathway-De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life. 62:414–428. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Sano R, Annunziata I, Patterson A, Moshiach S, Gomero E, Opferman J, Forte M and d'Azzo A: GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis. Mol Cell. 36:500–511. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Li S and Rousseau D: ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression. J Bioenerg Biomembr. 44:189–197. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Rieusset J: The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: An update. Cell Death Dis. 9:3882018. View Article : Google Scholar : PubMed/NCBI

29 

Nikolova-Karakashian M, Karakashian A and Rutkute K: Role of neutral sphingomyelinases in aging and inflammation. Subcell Biochem. 49:469–486. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Dang D and Rao R: Calcium-ATPases: Gene disorders and dysregulation in cancer. Biochim Biophys Acta. 1863:1344–1350. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Patergnani S, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, Giorgi C, Marchi S, Missiroli S, Poletti F, et al: Calcium signaling around mitochondria associated membranes (MAMs). Cell Commun Signal. 9:192011. View Article : Google Scholar : PubMed/NCBI

32 

Glancy B and Balaban RS: Role of mitochondrial Ca2+ in the regulation of cellular energetics. Biochemistry. 51:2959–2973. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Giorgi C, Romagnoli A, Pinton P and Rizzuto R: Ca2+ signaling, mitochondria and cell death. Curr Mol Med. 8:119–130. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, et al: PML at mitochondria-associated membranes is critical for the repression of autophagy and cancer development. Cell Rep. 16:2415–2427. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Ahumada-Castro U, Silva-Pavez E, Lovy A, Pardo E, Molgό J and Cárdenas C: MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: A dead end in cancer cells. Autophagy. 15:358–361. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Manganelli V, Matarrese P, Antonioli M, Gambardella L, Vescovo T, Gretzmeier C, Longo A, Capozzi A, Recalchi S, Riitano G, et al: Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs. Autophagy. 17:2528–2548. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Mori T, Hayashi T, Hayashi E and Su TP: Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival. PLoS One. 8:e769412013. View Article : Google Scholar : PubMed/NCBI

38 

Shioda N, Ishikawa K, Tagashira H, Ishizuka T, Yawo H and Fukunaga K: Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis. J Biol Chem. 287:23318–23331. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Doghman-Bouguerra M, Granatiero V, Sbiera S, Sbiera I, Lacas-Gervais S, Brau F, Fassnacht M, Rizzuto R and Lalli E: FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria. EMBO Rep. 17:1264–1280. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, Piette J, Linehan C, Gupta S, Samali A and Agostinis P: PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ. 19:1880–1891. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Seervi M, Sobhan PK, Joseph J, Mathew KA and Santhoshkumar TR: ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 4:e9682013. View Article : Google Scholar : PubMed/NCBI

42 

Madreiter-Sokolowski CT, Gottschalk B, Sokolowski AA, Malli R and Graier WF: Dynamic control of mitochondrial Ca2+ levels as a survival strategy of cancer cells. Front Cell Dev Biol. 9:6146682021. View Article : Google Scholar : PubMed/NCBI

43 

Mondet J, Lo Presti C, Chevalier S, Bertrand A, Tondeur S, Blanchet S, Leer AM, Pernet-Gallay K and Mossuz P: Mitochondria in human acute myeloid leukemia cell lines have ultrastructural alterations linked to deregulation of their respiratory profiles. Exp Hematol. 98:53–62.e3. 2021. View Article : Google Scholar : PubMed/NCBI

44 

Bidaux G, Gordienko D, Shapovalov G, Farfariello V, Borowiec AS, Iamshanova O, Lemonnier L, Gueguinou M, Guibon R, Fromont G, et al: 4TM-TRPM8 channels are new gatekeepers of the ER-mitochondria Ca2+ transfer. Biochim Biophys Acta Mol Cell Res. 1865:981–994. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Singh K, Poteryakhina A, Zheltukhin A, Bhatelia K, Prajapati P, Sripada L, Tomar D and Singh R, Singh AK, Chumakov PM and Singh R: NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells. Biochim Biophys Acta. 1853:1073–1086. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Lee GH, Lee HY, Li B, Kim HR and Chae HJ: Bax inhibitor-1-mediated inhibition of mitochondrial Ca2+ intake regulates mitochondrial permeability transition pore opening and cell death. Sci Rep. 4:51942014. View Article : Google Scholar : PubMed/NCBI

47 

Elfawy HA and Das B: Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies. Life Sci. 218:165–184. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Wang C, Dai X, Wu S, Xu W, Song P and Huang K: FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis. Nat Commun. 12:26162021. View Article : Google Scholar : PubMed/NCBI

49 

Cui P, Chen F, Ma G, Liu W, Chen L, Wang S, Li W, Li Z and Huang G: Oxyphyllanene B overcomes temozolomide resistance in glioblastoma: Structure-activity relationship and mitochondria-associated ER membrane dysfunction. Phytomedicine. 94:1538162022. View Article : Google Scholar : PubMed/NCBI

50 

Betz C, Stracka D, Prescianotto-Baschong C, Frieden M, Demaurex N and Hall MN: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. PNAS. 110:12526–12534. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Fei SJ, Zhang XC, Dong S, Cheng H, Zhang YF, Huang L, Zhou HY, Xie Z, Chen ZH and Wu YL: Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells. PLoS One. 8:e691042013. View Article : Google Scholar : PubMed/NCBI

52 

Bononi A, Bonora M, Marchi S, Missiroli S, Poletti F, Giorgi C, Pandolfi PP and Pinton P: Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner. Cell Death Differ. 20:1631–1643. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Han T, Kang D, Ji D, Wang X, Zhan W, Fu M, Xin HB and Wang JB: How does cancer cell metabolism affect tumor migration and invasion? Cell Adh Migr. 7:395–403. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C and Pinton P: Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death. Cell Calcium. 69:62–72. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Gómez-Suaga P, Pérez-Nievas BG, Glennon EB, Lau DHW, Paillusson S, Mórotz GM, Calì T, Pizzo P, Noble W and Miller CCJ: The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity. Acta Neuropathol Commun. 7:352019. View Article : Google Scholar : PubMed/NCBI

56 

Koczian F, Nagło O, Vomacka J, Vick B, Servatius P, Zisis T, Hettich B, Kazmaier U, Sieber SA, Jeremias I, et al: Targeting the endoplasmic reticulum-mitochondria interface sensitizes leukemia cells to cytostatics. Haematologica. 104:546–555. 2019. View Article : Google Scholar : PubMed/NCBI

57 

Xu ZH, Liu CH, Hang JB, Gao BL and Hu JA: Rituximab effectively reverses Tyrosine kinase inhibitors (TKIs) resistance through inhibiting the accumulation of rictor on mitochondria-associated ER-membrane (MAM). Cancer Biomarkers. 20:581–588. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Chiang CT, Demetriou AN, Ung N, Choudhury N, Ghaffarian K, Ruderman DL and Mumenthaler SM: mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer. Cancer Lett. 434:152–159. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Çoku J, Booth DM, Skoda J, Pedrotty MC, Vogel J, Liu K, Vu A, Carpenter EL, Ye JC, Chen MA, et al: Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance. EMBO J. 41:e1082722022. View Article : Google Scholar : PubMed/NCBI

60 

Ciscato F, Filadi R, Masgras I, Pizzi M, Marin O, Damiano N, Pizzo P, Gori A, Frezzato F, Chiara F, et al: Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+ -dependent death of cancer cells. EMBO Rep. 21:e491172020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Themistocleous S, Christodoulou P, Kyriakou T, Filippou C, Zaravinos A and Yiallouris A: Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review). Oncol Rep 49: 77, 2023.
APA
Themistocleous, S., Christodoulou, P., Kyriakou, T., Filippou, C., Zaravinos, A., & Yiallouris, A. (2023). Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review). Oncology Reports, 49, 77. https://doi.org/10.3892/or.2023.8514
MLA
Themistocleous, S., Christodoulou, P., Kyriakou, T., Filippou, C., Zaravinos, A., Yiallouris, A."Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review)". Oncology Reports 49.4 (2023): 77.
Chicago
Themistocleous, S., Christodoulou, P., Kyriakou, T., Filippou, C., Zaravinos, A., Yiallouris, A."Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review)". Oncology Reports 49, no. 4 (2023): 77. https://doi.org/10.3892/or.2023.8514
Copy and paste a formatted citation
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Spandidos Publications style
Themistocleous S, Christodoulou P, Kyriakou T, Filippou C, Zaravinos A and Yiallouris A: Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review). Oncol Rep 49: 77, 2023.
APA
Themistocleous, S., Christodoulou, P., Kyriakou, T., Filippou, C., Zaravinos, A., & Yiallouris, A. (2023). Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review). Oncology Reports, 49, 77. https://doi.org/10.3892/or.2023.8514
MLA
Themistocleous, S., Christodoulou, P., Kyriakou, T., Filippou, C., Zaravinos, A., Yiallouris, A."Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review)". Oncology Reports 49.4 (2023): 77.
Chicago
Themistocleous, S., Christodoulou, P., Kyriakou, T., Filippou, C., Zaravinos, A., Yiallouris, A."Key genes expressed in mitochondria‑endoplasmic reticulum contact sites in cancer (Review)". Oncology Reports 49, no. 4 (2023): 77. https://doi.org/10.3892/or.2023.8514
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