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Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin

  • Authors:
    • Ryosuke Takahashi
    • Koki Kamizaki
    • Keitaro Yamanaka
    • Yoshito Terai
    • Yasuhiro Minami
  • View Affiliations / Copyright

    Affiliations: Division of Cell Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe 650‑0017, Japan, Department of Obstetrics and Gynecology, Graduate School of Medicine, Kobe University, Kobe 650‑0017, Japan
    Copyright: © Takahashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 124
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    Published online on: May 5, 2023
       https://doi.org/10.3892/or.2023.8561
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Abstract

Ovarian cancer (OC) is a refractory cancer that shows recurrence due to the acquisition of resistance to anticancer drugs, including cisplatin. However, the molecular mechanism underlying the acquisition of cisplatin resistance by cancer cells remains largely unknown. In the present study, two sets of ovarian endometrioid carcinoma cell lines were used: The parental A2780 cell line, the OVK18 cell line, and their derived cisplatin‑resistant cells. It was found that cisplatin could induce ferroptosis in these parental cells by enhancing mitochondrial membrane potential and lipid peroxidation as assessed by flow cytometric analysis, and that expression of Ferredoxin1 (Fdx1), an iron‑sulfur protein localized to the mitochondria, could be upregulated in cisplatin‑resistant cells in the absence of cisplatin. Intriguingly, it was shown that the siRNA‑mediated depletion of Fdx1 in cisplatin‑resistant cells resulted in enhanced ferroptosis by increasing the mitochondrial membrane potential and lipid peroxidation induced by cisplatin. By examining Fdx1 expression with immunohistochemical analysis in clinical specimens from patients with OC, higher expression of Fdx1 was detected in cisplatin‑resistant specimens than in cisplatin‑sensitive specimens. Collectively, these results indicated that Fdx1 may be a novel and suitable diagnostic/prognostic marker and therapeutic molecular target for the treatment of cisplatin‑resistant OC.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Bristow RE, Tomacruz RS, Armstrong DK, Trimble EL and Montz FJ: Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: A meta-analysis. J Clin Oncol. 20:1248–1259. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Bookman MA, Brady MF, McGuire WP, Harper PG, Alberts DS, Friedlander M, Colombo N, Fowler JM, Argenta PA, De Geest K, et al: Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: A phase III trial of the gynecologic cancer intergroup. J Clin Oncol. 27:1419–1425. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Wilson MK, Pujade-Lauraine E, Aoki D, Mirza MR, Lorusso D, Oza AM, du Bois A, Vergote I, Reuss A, Bacon M, et al: Fifth ovarian cancer consensus conference of the gynecologic cancer Intergroup: Recurrent disease. Ann Oncol. 28:727–732. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Beesley VL, Green AC, Wyld DK, O'Rourke P, Wockner LF, DeFazio A, Butow PN, Price MA, Horwood KR, Clavarino AM, et al: Quality of life and treatment response among women with platinum-resistant versus platinum-sensitive ovarian cancer treated for progression: A prospective analysis. Gynecol Oncol. 132:130–136. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Pujade-Lauraine E, Hilpert F, Weber B, Reuss A, Poveda A, Kristensen G, Sorio R, Vergote I, Witteveen P, Bamias A, et al: Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial. J Clin Oncol. 32:1302–1308. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Marabelle A, Le DT, Ascierto PA, Di Giacomo AM, De Jesus-Acosta A, Delord JP, Geva R, Gottfried M, Penel N, Hansen AR, et al: Efficacy of pembrolizumab in patients with noncolorectal high microsatellite instability/mismatch repair-deficient cancer: Results from the phase II KEYNOTE-158 study. J Clin Oncol. 38:1–10. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, et al: Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 171:273–285. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al: Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Li Y, Feng D, Wang Z, Zhao Y, Sun R, Tian D, Liu D, Zhang F, Ning S, Yao J and Tian X: Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion. Cell Death Differ. 26:2284–2299. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Derry PJ, Hegde ML, Jackson GR, Kayed R, Tour JM, Tsai AL and Kent TA: Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. Prog Neurobiol. 184:1017162020. View Article : Google Scholar : PubMed/NCBI

12 

Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, et al: Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11. Cancer Discov. 9:1673–1685. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z and Wu G: Ferroptosis: A novel anti-tumor action for cisplatin. Cancer Res Treat. 50:445–460. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R and Tang D: Ferroptosis: Process and function. Cell Death Differ. 23:369–379. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Xie Z, Hou H, Luo D, An R, Zhao Y and Qiu C: ROS-dependent lipid peroxidation and reliant antioxidant ferroptosis-suppressor-protein 1 in rheumatoid arthritis: A covert clue for potential therapy. Inflammation. 44:35–47. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, et al: The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 575:688–692. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, et al: FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 575:693–698. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Ikeda Y, Hamano H, Horinouchi Y, Miyamoto L, Hirayama T, Nagasawa H, Tamaki T and Tsuchiya K: Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice. J Trace Elem Med Biol. 67:1267982021. View Article : Google Scholar : PubMed/NCBI

20 

Sato M, Kusumi R, Hamashima S, Kobayashi S, Sasaki S, Komiyama Y, Izumikawa T, Conrad M, Bannai S and Sato H: The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells. Sci Rep. 8:9682018. View Article : Google Scholar : PubMed/NCBI

21 

Wu X, Shen S, Qin J, Fei W, Fan F, Gu J, Shen T, Zhang T and Cheng X: High co-expression of SLC7A11 and GPX4 as a predictor of platinum resistance and poor prognosis in patients with epithelial ovarian cancer. BJOG. 129 (Suppl 2):S40–S49. 2022. View Article : Google Scholar

22 

Grinberg AV, Hannemann F, Schiffler B, Müller J, Heinemann U and Bernhardt R: Adrenodoxin: Structure, stability, and electron transfer properties. Proteins. 40:590–612. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Sheftel AD, Stehling O, Pierik AJ, Elsässer HP, Mühlenhoff U, Webert H, Hobler A, Hannemann F, Bernhardt R and Lill R: Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. Proc Natl Acad Sci USA. 107:11775–11780. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Shi Y, Ghosh M, Kovtunovych G, Crooks DR and Rouault TA: Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis. Biochim Biophys Acta. 1823:484–492. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Zhang C, Zeng Y, Guo X, Shen H, Zhang J, Wang K, Ji M and Huang S: Pan-cancer analyses confirmed the cuproptosis-related gene FDX1 as an immunotherapy predictor and prognostic biomarker. Front Genet. 13:9237372022. View Article : Google Scholar : PubMed/NCBI

26 

Zhang Z, Ma Y, Guo X, Du Y, Zhu Q, Wang X and Duan C: FDX1 can impact the prognosis and mediate the metabolism of lung adenocarcinoma. Front Pharmacol. 12:7491342021. View Article : Google Scholar : PubMed/NCBI

27 

Okamoto D, Yamauchi N, Takiguchi G, Nishita M, Kakeji Y, Minami Y and Kamizaki K: Autonomous and intercellular chemokine signaling elicited from mesenchymal stem cells regulates migration of undifferentiated gastric cancer cells. Genes Cells. 27:368–375. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Avincsal MO, Kamizaki K, Jimbo N, Shinomiya H, Nibu KI, Nishita M and Minami Y: Oncogenic E6 and/or E7 proteins drive proliferation and invasion of human papilloma virus-positive head and neck squamous cell cancer through upregulation of Ror2 expression. Oncol Rep. 46:1482021. View Article : Google Scholar : PubMed/NCBI

29 

Behrens BC, Hamilton TC, Masuda H, Grotzinger KR, Whang-Peng J, Louie KG, Knutsen T, McKoy WM, Young RC and Ozols RF: Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. Cancer Res. 47:414–418. 1987.PubMed/NCBI

30 

Chen L, Min J and Wang F: Copper homeostasis and cuproptosis in health and disease. Signal Transduct Target Ther. 7:3782022. View Article : Google Scholar : PubMed/NCBI

31 

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, et al: Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 375:1254–1261. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB and Jiang X: Role of mitochondria in ferroptosis. Mol Cell. 73:354–363.e3. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Siddik ZH: Cisplatin: Mode of cytotoxic action and molecular basis of resistance. Oncogene. 22:7265–7279. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Wang D and Lippard SJ: Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov. 4:307–320. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Ciriello G, Miller ML, Aksoy BA, Senbabaoglu Y, Schultz N and Sander C: Emerging landscape of oncogenic signatures across human cancers. Nat Genet. 45:1127–1133. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Cancer Genome Atlas Research Network, . Integrated genomic analyses of ovarian carcinoma. Nature. 474:609–615. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Hollis RL, Thomson JP, Stanley B, Churchman M, Meynert AM, Rye T, Bartos C, Iida Y, Croy I, Mackean M, et al: Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome. Nat Commun. 11:49952020. View Article : Google Scholar : PubMed/NCBI

38 

Noriega-Rivera R, Rivera-Serrano M, Rabelo-Fernandez RJ, Pérez-Santiago J, Valiyeva F and Vivas-Mejía PE: Upregulation of the long noncoding RNA CASC10 promotes cisplatin resistance in high-grade serous ovarian cancer. Int J Mol Sci. 23:77372022. View Article : Google Scholar : PubMed/NCBI

39 

Viscarra T, Buchegger K, Jofre I, Riquelme I, Zanella L, Abanto M, Parker AC, Piccolo SR, Roa JC, Ili C and Brebi P: Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line. Biol Res. 52:132019. View Article : Google Scholar : PubMed/NCBI

40 

Sun J, Cai X, Yung MM, Zhou W, Li J, Zhang Y, Li Z, Liu SS, Cheung ANY, Ngan HYS, et al: miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer. Oncogene. 38:564–580. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Meng Y, Chen CW, Yung MMH, Sun W, Sun J, Li Z, Li J, Li Z, Zhou W, Liu SS, et al: DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer. Cancer Lett. 428:104–116. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi R, Kamizaki K, Yamanaka K, Terai Y and Minami Y: Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin. Oncol Rep 49: 124, 2023.
APA
Takahashi, R., Kamizaki, K., Yamanaka, K., Terai, Y., & Minami, Y. (2023). Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin. Oncology Reports, 49, 124. https://doi.org/10.3892/or.2023.8561
MLA
Takahashi, R., Kamizaki, K., Yamanaka, K., Terai, Y., Minami, Y."Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin". Oncology Reports 49.6 (2023): 124.
Chicago
Takahashi, R., Kamizaki, K., Yamanaka, K., Terai, Y., Minami, Y."Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin". Oncology Reports 49, no. 6 (2023): 124. https://doi.org/10.3892/or.2023.8561
Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi R, Kamizaki K, Yamanaka K, Terai Y and Minami Y: Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin. Oncol Rep 49: 124, 2023.
APA
Takahashi, R., Kamizaki, K., Yamanaka, K., Terai, Y., & Minami, Y. (2023). Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin. Oncology Reports, 49, 124. https://doi.org/10.3892/or.2023.8561
MLA
Takahashi, R., Kamizaki, K., Yamanaka, K., Terai, Y., Minami, Y."Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin". Oncology Reports 49.6 (2023): 124.
Chicago
Takahashi, R., Kamizaki, K., Yamanaka, K., Terai, Y., Minami, Y."Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin". Oncology Reports 49, no. 6 (2023): 124. https://doi.org/10.3892/or.2023.8561
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