Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
February-2024 Volume 51 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2024 Volume 51 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling

  • Authors:
    • Xiaoting Zhou
    • Fengxi Meng
    • Binbin Xu
    • Ruiqi Ma
    • Yun Cheng
    • Jihong Wu
    • Jiang Qian
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, P.R. China
  • Article Number: 23
    |
    Published online on: December 14, 2023
       https://doi.org/10.3892/or.2023.8682
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Uveal melanoma (UM) is the most common intraocular malignant tumor in adults, with a lack of effective treatment for metastasis and a poor prognosis. Stimulator of interferon genes (STING, also known as TMEM173) plays an important role in tumor development by regulating cell proliferation, metastasis and other cellular processes. However, the function of STING in UM remains unclear and requires further investigation. The present study analyzed the expression status of STING to elucidate the mechanisms underlying UM. The correlation between STING and the prognosis of UM was evaluated based on UM RNA‑seq data and clinical information extracted from The Cancer Genome Atlas database. Quantification of STING in UM cell lines and tissues was performed using the Wes Separation protein immunoassay. The effects of STING on the proliferation, migration and invasion of UM cells were investigated using Cell Counting Kit‑8, Transwell and wound healing experiments. Survival analysis demonstrated that high levels of STING in UM tissues indicated a poor prognosis. The expression of STING in UM tissues was higher than that in the choroid membranes. Furthermore, it was found that downregulation of STING expression in UM cells suppressed migration and invasion, whereas overexpression of STING significantly promoted migration and invasion. Notably, STING had no significant effect on UM cell proliferation. It was also identified that STING positively upregulated the phosphorylation of p38 mitogen‑activated protein kinase (p38‑MAPK) in UM cells, enhancing cell migration and invasion, which the p38‑MAPK inhibitor SB203580 reversed. Finally, the results of the present study demonstrated that high STING expression in UM indicates a poor prognosis. STING was revealed to promote the migration and invasion of UM cells through p38‑MAPK signaling.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Kujala E, Mäkitie T and Kivelä T: Very long-term prognosis of patients with malignant uveal melanoma. Invest Ophth Vis Sci. 44:4651–4659. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Augsburger JJ, Correa ZM and Shaikh AH: Effectiveness of treatments for metastatic uveal melanoma. Am J Ophthalmol. 148:119–127. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Smit KN, Jager MJ, de Klein A and Kiliҫ E: Uveal melanoma: Towards a molecular understanding. Prog Retin Eye Res. 75:1008002020. View Article : Google Scholar : PubMed/NCBI

4 

Onken MD, Worley LA, Ehlers JP and Harbour JW: Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res. 64:7205–7209. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Zhang X, Bai XC and Chen ZJ: Structures and mechanisms in the cGAS-STING innate immunity pathway. Immunity. 53:43–53. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Falahat R, Perez-Villarroel P, Mailloux AW, Zhu G, Pilon-Thomas S, Barber GN and Mulé JJ: STING signaling in melanoma cells shapes antigenicity and can promote antitumor T-cell activity. Cancer Immunol Res. 7:1837–1848. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Xia T, Konno H, Ahn J and Barber GN: Deregulation of STING signaling in colorectal carcinoma constrains DNA damage responses and correlates with tumorigenesis. Cell Rep. 14:282–297. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Pantelidou C, Sonzogni O, De Oliveria Taveira M, Mehta AK, Kothari A, Wang D, Visal T, Li MK, Pinto J, Castrillon JA, et al: PARP inhibitor efficacy depends on CD8+ T-cell recruitment via intratumoral STING pathway activation in BRCA-deficient models of triple-negative breast cancer. Cancer Discov. 9:722–737. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Liang D, Xiao-Feng H, Guan-Jun D, Er-Ling H, Sheng C, Ting-Ting W, Qin-Gang H, Yan-Hong N and Ya-Yi H: Activated STING enhances Tregs infiltration in the HPV-related carcinogenesis of tongue squamous cells via the c-jun/CCL22 signal. Biochim Biophys Acta. 1852:2494–2503. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Ahn J, Xia T, Konno H, Konno K, Ruiz P and Barber GN: Inflammation-driven carcinogenesis is mediated through STING. Nat Commun. 5:51662014. View Article : Google Scholar : PubMed/NCBI

11 

Cai H, Yan L, Liu N, Xu M and Cai H: IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway. Biomed Pharmacother. 123:1097902020. View Article : Google Scholar : PubMed/NCBI

12 

Dai E, Han L, Liu J, Xie Y, Zeh HJ, Kang R, Bai L and Tang D: Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway. Nat Commun. 11:63392020. View Article : Google Scholar : PubMed/NCBI

13 

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, et al: Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 553:467–472. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Hamm M, Ha S and Rustandi RR: Automated capillary Western dot blot method for the identity of a 15-valent pneumococcal conjugate vaccine. Anal Biochem. 478:33–39. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Wang J, Valdez A and Chen Y: Evaluation of automated Wes system as an analytical and characterization tool to support monoclonal antibody drug product development. J Pharm Biomed Anal. 139:263–268. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Borcherding DC, Amin NV, He K, Zhang X, Lyu Y, Dehner C, Bhatia H, Gothra A, Daud L, Ruminski P, et al: MEK inhibition synergizes with TYK2 inhibitors in NF1-associated malignant peripheral nerve sheath tumors. Clin Cancer Res. 29:1592–1604. 2023. View Article : Google Scholar : PubMed/NCBI

18 

Neelature SS and Smalley K: MEK-ing the most of it: Strategies to Co-target Gαq and MAPK in uveal melanoma. Clin Cancer Res. 27:1217–1219. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Szalai E, Wells JR, Ward L and Grossniklaus HE: Uveal melanoma nuclear BRCA1-associated Protein-1 immunoreactivity is an indicator of metastasis. Ophthalmology. 125:203–209. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Wang J, Yi S, Zhou J, Zhang Y and Guo F: The NF-κB subunit RelB regulates the migration and invasion abilities and the radio-sensitivity of prostate cancer cells. Int J Oncol. 49:381–392. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Wang X, Belguise K, Kersual N, Kirsch KH, Mineva ND, Galtier F, Chalbos D and Sonenshein GE: Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol. 9:470–478. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, et al: STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity. 41:843–852. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Ding L, Wang Q, Martincuks A, Kearns MJ, Jiang T, Lin Z, Cheng X, Qian C, Xie S, Kim HJ, et al: STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer. J Immunother Cancer. 11:e0056272023. View Article : Google Scholar : PubMed/NCBI

24 

He L, Xiao X, Yang X, Zhang Z, Wu L and Liu Z: STING signaling in tumorigenesis and cancer therapy: A friend or foe? Cancer Lett. 402:203–212. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Viculin J, Degoricija M, Vilović K, Gabela I, Franković L, Vrdoljak E and Korac-Prlic J: Elevated tumor cell-intrinsic STING expression in advanced laryngeal cancer. Cancers (Basel). 15:35102023. View Article : Google Scholar : PubMed/NCBI

26 

Song S, Peng P, Tang Z, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, et al: Decreased expression of STING predicts poor prognosis in patients with gastric cancer. Sci Rep. 7:398582017. View Article : Google Scholar : PubMed/NCBI

27 

Lu C, Guan J, Lu S, Jin Q, Rousseau B, Lu T, Stephens D, Zhang H, Zhu J, Yang M, et al: DNA sensing in mismatch Repair-deficient tumor cells is essential for Anti-tumor immunity. Cancer Cell. 39:96–108. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Parkes EE, Humphries MP, Gilmore E, Sidi FA, Bingham V, Phyu SM, Craig S, Graham C, Miller J, Griffin D, et al: The clinical and molecular significance associated with STING signaling in breast cancer. NPJ Breast Cancer. 7:812021. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Y, Zhai Q, Feng X, Chen D, Lu Y, Hu J, Xie H, Zhou L, Wu J and Zheng S: Cancer cell-intrinsic STING is associated with CD8 + T-cell infiltration and might serve as a potential immunotherapeutic target in hepatocellular carcinoma. Clin Transl Oncol. 23:1314–1324. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Kol A, Lubbers JM, Terwindt ALJ, Workel HH, Plat A, Wisman GBA, Bart J, Nijman HW and De Bruyn M: Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer. Oncoimmunology. 10:19363912021. View Article : Google Scholar : PubMed/NCBI

31 

Cheradame L, Guerrera IC, Gaston J, Schmitt A, Jung V, Goudin N, Pouillard M, Radosevic-Robin N, Modesti M, Judde JG, et al: STING protects breast cancer cells from intrinsic and genotoxic-induced DNA instability via a non-canonical, cell-autonomous pathway. Oncogene. 40:6627–6640. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Huvila J, Cochrane DR, Ta M, Chow C, Greening K, Leung S, Karnezis AN, DiFeo A and Huntsman DG: STING pathway expression in low-grade serous carcinoma of the ovary: An unexpected therapeutic opportunity? J Pathol Clin Res. 7:548–555. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Zhang H, You Q and Xu X: Targeting stimulator of interferon genes (STING): A medicinal chemistry perspective. J Med Chem. 63:3785–3816. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Chen Q, Boire A, Jin X, Valiente M, Er EE, Lopez-Soto A, Jacob L, Patwa R, Shah H, Xu K, et al: Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 533:493–498. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Niederkorn JY: Immune escape mechanisms of intraocular tumors. Prog Retin Eye Res. 28:329–347. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Bakhoum MF, Francis JH, Agustinus A, Earlie EM, Di Bona M, Abramson DH, Duran M, Masilionis I, Molina E, Shoushtari AN, et al: Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. Nat Commun. 12:54022021. View Article : Google Scholar : PubMed/NCBI

37 

Hitchman TD, Bayshtok G, Ceraudo E, Moore AR, Lee C, Jia R, Wang N, Pachai MR, Shoushtari AN, Francis JH, et al: Combined inhibition of Gα(q) and MEK enhances therapeutic efficacy in uveal melanoma. Clin Cancer Res. 27:1476–1490. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer. 9:537–549. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Hsieh Y, Wu T, Huang C, Hsieh Y, Hwang J and Liu J: p38 mitogen-activated protein kinase pathway is involved in protein kinase C alpha-regulated invasion in human hepatocellular carcinoma cells. Cancer Res. 67:4320–4327. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Junttila MR, Ala-Aho R, Jokilehto T, Peltonen J, Kallajoki M, Grenman R, Jaakkola P, Westermarck J and Kähäri V-M: p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells. Oncogene. 26:5267–5279. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Demuth T, Reavie LB, Rennert JL, Nakada M, Nakada S, Hoelzinger DB, Beaudry CE, Henrichs AN, Anderson EM and Berens ME: MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Mol Cancer Ther. 6:1212–1222. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Li J-K, Chen C, Liu J-Y, Shi J-Z, Liu S-P, Liu B, Wu D-S, Fang Z-Y, Bao Y, Jiang M-M, et al: Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling. Mol Cancer. 16:1112017. View Article : Google Scholar : PubMed/NCBI

43 

Huang Q, Lan F, Wang X, Yu Y, Ouyang X, Zheng F, Han J, Lin Y, Xie Y, Xie F, et al: IL-1β-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9. Mol Cancer. 13:182014. View Article : Google Scholar : PubMed/NCBI

44 

Hu DN, Chen M, Zhang DY, Ye F, McCormick SA and Chan CC: Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway. Invest Ophthalmol Vis Sci. 52:3767–3774. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Gong C, Shen J, Fang Z, et al: Abnormally expressed JunB transactivated by IL-6/STAT3 signaling promotes uveal melanoma aggressiveness via epithelial-mesenchymal transition. Biosci Rep. 38:2018. View Article : Google Scholar

46 

Tao H, Tan J, Zhang H, Ren H, Cai Z, Liu H, Wen B, Du J, Li G, Chen S, et al: cGAS-STING pathway activation and systemic anti-tumor immunity induction via photodynamic nanoparticles with potent toxic platinum DNA intercalator against uveal melanoma. Adv Sci (Weinh). e23028952023. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Meng F, Xu B, Ma R, Cheng Y, Wu J and Qian J: STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling. Oncol Rep 51: 23, 2024.
APA
Zhou, X., Meng, F., Xu, B., Ma, R., Cheng, Y., Wu, J., & Qian, J. (2024). STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling. Oncology Reports, 51, 23. https://doi.org/10.3892/or.2023.8682
MLA
Zhou, X., Meng, F., Xu, B., Ma, R., Cheng, Y., Wu, J., Qian, J."STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling". Oncology Reports 51.2 (2024): 23.
Chicago
Zhou, X., Meng, F., Xu, B., Ma, R., Cheng, Y., Wu, J., Qian, J."STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling". Oncology Reports 51, no. 2 (2024): 23. https://doi.org/10.3892/or.2023.8682
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Meng F, Xu B, Ma R, Cheng Y, Wu J and Qian J: STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling. Oncol Rep 51: 23, 2024.
APA
Zhou, X., Meng, F., Xu, B., Ma, R., Cheng, Y., Wu, J., & Qian, J. (2024). STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling. Oncology Reports, 51, 23. https://doi.org/10.3892/or.2023.8682
MLA
Zhou, X., Meng, F., Xu, B., Ma, R., Cheng, Y., Wu, J., Qian, J."STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling". Oncology Reports 51.2 (2024): 23.
Chicago
Zhou, X., Meng, F., Xu, B., Ma, R., Cheng, Y., Wu, J., Qian, J."STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling". Oncology Reports 51, no. 2 (2024): 23. https://doi.org/10.3892/or.2023.8682
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team